A blender for preparing a solid preparation

Abstract

The utility model discloses a kind of mixers for preparing solid preparation, belong to solid preparation technical field.It aims to solve the problem of existing mixing equipment friction heat generation, heat-sensitive drug, exhaust dust odour, component maintenance inconvenient.The mixer includes support, support top end fixedly equipped with mixing bin and motor, rotatingly penetrated with stirring frame in mixing bin and with motor output shaft coaxial fixed, mixing bin bottom is connected with the exhaust pipe of control valve, top end hinged cover plate and is set on it and is opened to let go of slot, slot can be detachably installed exhaust pipe;Support side is equipped with air cooler, and its exhaust end is connected exhaust pipe through first hose, three-way pipe, second hose;Mixing bin other side is equipped with exhaust mechanism, including fixed fan and box, box is connected third hose to cover plate, filter box is inserted in box, filter box is with handle, handle is equipped with limit slot, box bolt shaft is engaged limit slot.The mixer is used for solid preparation raw material mixing, can realize cooling, exhaust filtration when mixing, and component is easy to disassemble and maintain.

Description

Technical Field

[0001] This utility model relates to the field of solid dosage form technology, and in particular to a mixer for preparing solid dosage forms. Background Technology

[0002] In the production of solid dosage forms, mixing (or homogenization) is one of the most crucial unit operations. Its purpose is to uniformly distribute the active pharmaceutical ingredient (API) and excipients (such as fillers, disintegrants, lubricants, etc.) together, ensuring that the content of the active ingredient in each unit dose (such as each tablet) meets stringent specifications. Inhomogeneous mixing directly leads to substandard product content uniformity, affecting not only efficacy but also potentially posing serious safety risks. Therefore, the selection of mixing equipment and the optimization of the mixing process are core aspects of ensuring the quality of solid dosage forms.

[0003] In the existing technology, the ribbon mixer is one of the commonly used mixing equipment. However, the ribbon mixer mainly relies on mechanical stirring, and the frictional heat generated by mechanical stirring and material friction may be detrimental to heat-sensitive drugs.

[0004] Therefore, we propose a mixer for preparing solid dosage forms. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a mixer for preparing solid dosage forms.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] A mixer for preparing solid dosage forms, comprising:

[0008] The support has a mixing hopper and a motor fixed at its top. A stirring rack is rotatably inserted between the inner walls of both sides of the mixing hopper. The output shaft of the motor and the stirring rack are fixedly coaxially. A discharge pipe with a control valve is fixedly connected to the bottom of the mixing hopper. A cover plate is hinged to the top of the mixing hopper. Two clearance grooves are opened at the top edge of the mixing hopper. An exhaust pipe is detachably installed in the clearance groove.

[0009] The air cooler is installed on one side of the bracket. The air outlet of the air cooler is fixedly connected to a first flexible hose. The other end of the first flexible hose is fixedly connected to a three-way pipe. Both ends of the three-way pipe are fixedly connected to second flexible hoses. The two second flexible hoses are respectively connected to two exhaust pipes.

[0010] The exhaust mechanism is located on the side of the mixing hopper away from the exhaust pipe and is used to exhaust the gas inside the mixing hopper.

[0011] In one possible design, the exhaust mechanism includes a fan and a housing fixed to one side of the outer wall of the mixing silo. The fan's air inlet pipe is connected to the housing. A third flexible hose is fixedly connected to one side of the housing. The other end of the third flexible hose is connected to the top of the cover plate. A filter box is inserted into the housing.

[0012] In one possible design, a handle is fixed to one side of the outer wall of the filter box, a limiting groove is formed at the top of the handle, and a pin is inserted into the top edge of the box body, with the bottom end of the pin located in the limiting groove.

[0013] In one possible design, a sealing ring is embedded in the inner wall of the box opening.

[0014] In one possible design, the bottom of the exhaust pipe is open, and multiple downward-sloping exhaust holes are provided on both sides of the exhaust pipe.

[0015] In one possible design, connecting blocks are fixed on both sides of the exhaust pipe, and countersunk holes are opened through the surface of the connecting blocks. The connecting blocks are located in the relief groove and are fixed to the mixing bin by bolts.

[0016] In this application, during use, the cover is opened, the material is put into the mixing chamber, the cover is closed, and then the motor is started to drive the mixing rack to rotate and mix the material. Then, the cold air fan is started, and the cold air enters the mixing chamber after passing through the first hose, the second hose, and the exhaust pipe to cool the material. A temperature sensor can be installed in the mixing chamber to detect the temperature information in real time. At the same time, the fan is started to draw air from the mixing chamber, so that the gas passes through the third hose and uses the activated carbon bag built into the filter box to filter and adsorb the slight odor mixed in the air, thereby expelling odorless air and reducing the impact on the surrounding environment of the workers. After the mixing is completed, the fan and the cold air fan are turned off, the motor is turned off, and then the discharge pipe is opened to discharge the mixed material into the pre-prepared collection container.

[0017] Beneficial effects: In this utility model, the mixer for preparing solid dosage forms, through the setting of structures such as a cold air blower, a first hose and a second hose, can exchange heat and cool down the material during the mixing process, avoiding the material from overheating due to friction, and the exhaust pipe is easy to disassemble, making it convenient for cleaning and maintenance.

[0018] In this invention, a mixer for preparing solid dosage forms, through the arrangement of a fan, housing, and filter box, can filter and adsorb the odor emitted by the material while ensuring air circulation, thereby reducing the impact on the working environment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the overall three-dimensional structure of a mixer for preparing solid dosage forms proposed in this utility model;

[0020] Figure 2 This is a partial three-dimensional structural schematic diagram of a mixer for preparing solid dosage forms according to the present invention.

[0021] Figure 3 This is a partial cross-sectional view of a mixer for preparing solid dosage forms according to the present invention.

[0022] Figure 4 This is a partially exploded structural diagram of a mixer for preparing solid dosage forms according to the present invention.

[0023] In the diagram: 1. Support frame; 2. Mixing hopper; 3. Discharge pipe; 4. Cover plate; 5. Motor; 6. Mixing rack; 7. Exhaust pipe; 8. Air cooler; 9. First flexible hose; 10. T-joint; 11. Second flexible hose; 12. Connecting block; 13. Exhaust port; 14. Fan; 15. Housing; 16. Third flexible hose; 17. Filter box; 18. Handle; 19. Limiting groove; 20. Pin; 21. Sealing ring. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0025] In one embodiment: Refer to Figures 1-4 A mixer includes: a support frame 1, which serves as the overall support structure and is made of 304 stainless steel. The bottom of the support frame 1 can be fixed to the ground with expansion bolts to ensure the overall structure is stable and does not wobble during use. A mixing chamber 2 and a motor 5 are both fixed to the top of the support frame 1. The mixing chamber 2 is also made of 304 stainless steel, with an open top and bearing holes on corresponding positions on both inner walls. The two ends of a mixing frame 6 rotate through these bearing holes via bearings. One end of the mixing frame 6 extends out of the outer wall of the mixing chamber 2 and is coaxially fixed to the output shaft of the motor 5 via a coupling. The motor 5 is a three-phase asynchronous motor, which, after starting, drives the mixing frame 6 to rotate stably within the mixing chamber 2.

[0026] A discharge pipe 3 is welded to the center of the bottom of the mixing silo 2. The discharge pipe 3 is connected to the interior of the mixing silo 2 and is made of 304 stainless steel. A control valve is installed on the pipe for operators to manually control the switch and adjust the discharge speed and discharge volume. A cover plate 4 is hinged to the top edge of the mixing silo 2. The cover plate 4 is made of the same material as the mixing silo 2 and its size matches the top opening of the mixing silo 2. A ring of nitrile rubber sealing strip is pasted around the edge of the cover plate 4 to reduce the spillage of material dust and the entry of external impurities during the mixing process. Two symmetrical relief grooves are also provided on the top edge of the mixing silo 2. The relief grooves have a cross-shaped cross section, and the exhaust pipe 7 can be detachably installed in the relief grooves.

[0027] The exhaust pipe 7 is also made of 304 stainless steel. Its bottom is open, and multiple exhaust holes 13 are located on both sides of the pipe. These exhaust holes 13 are angled downwards at an angle of 30-45 degrees, allowing the incoming airflow to be closer to the material surface inside the mixing chamber 2, thus improving cooling. A connecting block 12 is welded to each of the outer walls of the exhaust pipe 7. The connecting block 12 is a rectangular stainless steel block with countersunk holes through its surface. When the exhaust pipe 7 is placed in the clearance groove, the countersunk holes on the connecting block 12 align with the pre-set threaded holes at the top of the mixing chamber 2. M6-M8 hex bolts are passed through the countersunk holes and screwed into the threaded holes to secure the exhaust pipe 7. To disassemble, the bolts are unscrewed to remove the exhaust pipe 7 for easy cleaning and maintenance.

[0028] The air cooler 8 is placed on the ground to one side of the bracket 1. An industrial air cooler, specifically model SAC-35B or another suitable model, is selected. Its outlet is connected to a first flexible hose 9 via a hose clamp. The first flexible hose 9 is made of low-temperature resistant rubber with a smooth inner wall to reduce air resistance and possesses a certain degree of flexibility for easy adjustment of the air cooler 8's position. The other end of the first flexible hose 9 is connected to the main pipe of a three-way pipe 10 via a hose clamp. The three-way pipe 10 is made of stainless steel, and the diameters of its main and branch pipes match those of the first flexible hose 9. Two branch pipes of the three-way pipe 10 are respectively connected to second flexible hoses 11 via hose clamps. The second flexible hose 11 is made of the same material as the first flexible hose 9. Its end furthest from the three-way pipe 10 is connected to the top opening of the exhaust pipe 7 via a hose clamp, allowing the cold air generated by the air cooler 8 to sequentially pass through the first flexible hose 9, the three-way pipe 10, and the second flexible hose 11 into the exhaust pipe 7, and then into the mixing chamber 2 through the exhaust port 13.

[0029] The exhaust mechanism is located on the side of the mixing silo 2 away from the exhaust pipe 7, and is used to exhaust the gas inside the mixing silo 2. The fan 14 and the housing 15 in this exhaust mechanism are both bolted to the outer wall of one side of the mixing silo 2. The fan 14, located on one side of the housing 15, is a centrifugal fan, and its inlet pipe is connected to the top opening of the housing 15 via a flange. A sealing gasket is placed between the flanges to prevent air leakage. The housing 15 is a rectangular stainless steel structure with an interface on one side wall. One end of the third flexible hose 16 is connected to this interface via a hose clamp. The material of the third flexible hose 16 is the same as that of the first flexible hose 9. The other end of the third flexible hose 16 is connected to a vent hole at the top of the cover plate 4 via a hose clamp, allowing the gas inside the mixing silo 2 to enter the housing 15 through the third flexible hose 16. One side of the housing 15 is open, and the filter box 17 is inserted into the housing 15 through the opening. The filter box 17 is made of plastic or stainless steel and is filled with activated carbon filter cotton or HEPA filter material, which can filter the material dust in the gas and prevent odors from being emitted into the air.

[0030] This application can be used in the field of solid dosage forms, or in other fields applicable to this application.

[0031] In another embodiment: a mixer for preparing solid dosage forms, which is applied to the field of solid dosage forms;

[0032] In another aspect of this embodiment, a handle 18 is welded or bonded to one outer wall of the filter box 17. The handle 18 is made of plastic and has anti-slip texture on its surface to facilitate the operator to pull out the filter box 17. A limiting groove 19 is formed at the top of the handle 18. A through hole is formed on the top surface of the housing 15 corresponding to the position of the limiting groove 19. A pin 20 is inserted into the housing 15 through the through hole. The pin 20 is a steel cylindrical rod with a round handle at the top and the bottom end passing through the through hole and located in the limiting groove 19, which can fix the filter box 17 in the housing 15 to prevent the filter box 17 from shifting when the fan 14 is working. When it is necessary to replace the filter material, the pin 20 is pulled upward to disengage its bottom end from the limiting groove 19, and the filter box 17 can be pulled out through the handle 18.

[0033] An annular groove is provided on the inner wall of the opening of the housing 15, and the sealing ring 21 is embedded in the annular groove. The sealing ring 21 is made of nitrile rubber. When the filter box 17 is inserted into the housing 15, the outer wall of the filter box 17 is tightly fitted with the sealing ring 21 to ensure the airtightness of the housing 15 and prevent unfiltered gas from escaping from the gaps.

[0034] When using this mixer to prepare solid dosage forms, first pull out the pin 20 upwards, remove the filter box 17 and confirm that the internal filter material is installed properly, then insert the filter box 17 back into the housing 15 and insert the pin 20 to fix it; then open the cover plate 4 and pour the solid dosage form raw material into the mixing chamber 2. The amount of raw material added should not exceed two-thirds of the volume of the mixing chamber 2; then close the cover plate 4.

[0035] The motor 5 is started, driving the mixing rack 6 to rotate and agitate the raw materials in the mixing hopper 2. Simultaneously, the cooler 8 is started, and cool air enters the exhaust pipe 7 through the first hose 9, the three-way pipe 10, and the second hose 11, then is blown onto the surface of the raw materials through the downward-sloping exhaust port 13, reducing the temperature generated by friction during agitation. The blower 14 is started, and hot air containing dust from the mixing hopper 2 enters the housing 15 through the third hose 16. After being filtered by the filter material in the filter box 17, the clean air is discharged by the blower 14. During agitation, the agitation intensity can be controlled by adjusting the speed of the motor 5, the cool air temperature can be adjusted by the temperature control knob of the cooler 8, the raw material temperature can be monitored in real time by the temperature sensor installed in the mixing hopper 2, and the exhaust speed can be adjusted by the speed setting of the blower 14.

[0036] After the raw materials are mixed evenly, turn off motor 5, air cooler 8 and blower 14, open the control valve on discharge pipe 3, and discharge the mixed solid dosage form raw materials from discharge pipe 3. After collection, they can be used for subsequent tableting, granulation and other processes.

[0037] However, as is well known to those skilled in the art, the working principles and wiring methods of motor 5, air cooler 8 and fan 14 are all conventional means or common knowledge, and will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0038] The accompanying drawings in this application are for illustrative purposes only. The dimensions and shapes of the components shown are not actual limitations but are merely schematic representations. In actual implementation, the components can be reasonably configured and adjusted according to specific needs and actual conditions.

[0039] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A mixer for preparing solid dosage forms, characterized in that, include: A support (1) is provided with a mixing chamber (2) and a motor (5) fixed at the top of the support (1). A stirring rack (6) is rotatably passed between the inner walls of the two sides of the mixing chamber (2). The output shaft of the motor (5) and the stirring rack (6) are fixedly coaxially. A discharge pipe (3) with a control valve is fixedly connected to the bottom of the mixing chamber (2). A cover plate (4) is hinged to the top of the mixing chamber (2). Two clearance grooves are opened at the top edge of the mixing chamber (2). An exhaust pipe (7) is detachably installed in the clearance groove. A cold air blower (8) is set on one side of the bracket (1). The air outlet of the cold air blower (8) is fixedly connected to a first hose (9). The other end of the first hose (9) is fixedly connected to a three-way pipe (10). Both ends of the three-way pipe (10) are fixedly connected to second hoses (11). The two second hoses (11) are respectively connected to two exhaust pipes (7). The exhaust mechanism is located on the side of the mixing silo (2) away from the exhaust pipe (7) and is used to exhaust the gas inside the mixing silo (2).

2. The mixer for preparing solid dosage forms according to claim 1, characterized in that, The exhaust mechanism includes a fan (14) and a housing (15) fixed on one side of the outer wall of the mixing silo (2). The air inlet pipe of the fan (14) is connected to the housing (15). A third hose (16) is fixedly connected to one side of the housing (15). The other end of the third hose (16) is connected to the top of the cover plate (4). A filter box (17) is inserted inside the housing (15).

3. A mixer for preparing solid dosage forms according to claim 2, characterized in that, A handle (18) is fixed on one side of the outer wall of the filter box (17). A limiting groove (19) is opened at the top of the handle (18). A pin (20) is inserted into the top edge of the box body (15). The bottom end of the pin (20) is located in the limiting groove (19).

4. A mixer for preparing solid dosage forms according to claim 3, characterized in that, A sealing ring (21) is embedded in the inner wall of the opening of the box (15).

5. A mixer for preparing solid dosage forms according to claim 4, characterized in that, The bottom of the exhaust pipe (7) is open, and multiple downward-facing exhaust holes (13) are provided on both sides of the exhaust pipe (7).

6. A mixer for preparing solid dosage forms according to claim 5, characterized in that, Both sides of the exhaust pipe (7) are fixed with connecting blocks (12). The surface of the connecting block (12) is provided with a countersunk hole. The connecting block (12) is located in the relief groove and is fixed to the mixing bin (2) by bolts.

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