Homogenizer for small-scale synthesis of drug substance intermediates

Abstract

The utility model discloses a raw material medicine intermediate synthesis pilot test is with homogenizer, include: anti -drop mechanism, install on outer jar body, be used for cooperation spacing piece to inner jar gallbladder dismounting cleaning, the utility model discloses through outer jar body, inner jar gallbladder and the design of anti -drop mechanism etc. structure, through the separable structure of inner jar gallbladder and outer jar body, when needing cleaning, only need through anti -drop mechanism to remove positioning, can quickly take out inner jar gallbladder from outer jar body, need not with the help of special tool to go into the equipment internal operation, greatly simplify cleaning process, shorten equipment maintenance time, promote the overall efficiency of pilot test, in addition detachable inner jar gallbladder can realize all -round no -dead -angle cleaning, completely remove residual material, effectively avoid different batch material cross -contamination, ensure the cleanliness of raw material medicine intermediate synthesis process, reduce product impurity formation, guarantee the accuracy and reliability of experimental data.

Description

Technical Field

[0001] This utility model relates to the field of homogenization equipment technology, specifically a small-scale homogenization device for synthesizing active pharmaceutical ingredient intermediates. Background Technology

[0002] In the small-scale research stage of the synthesis of active pharmaceutical ingredient intermediates, homogenization is a key process to ensure the uniformity of material mixing and improve reaction stability. Its effect directly affects the conversion rate and product purity of subsequent synthesis reactions.

[0003] Currently, commonly used homogenization devices for small-scale synthesis of active pharmaceutical ingredient intermediates in laboratories generally adopt an integrated structural design with the inner liner fixedly connected to the main body of the equipment. However, in actual operation, since the inner liner cannot be disassembled, after each homogenization operation, residual materials inside the equipment tend to adhere to the inner wall of the inner liner. Staff need to use special tools to go deep into the equipment to clean it. This process is not only cumbersome and time-consuming, but also makes it difficult to completely remove residual materials in hidden areas. If the residual materials are not cleaned properly, they will cross-contaminate with new materials in subsequent batches, leading to an increase in the impurity content of the product and affecting the accuracy and reliability of experimental data. Therefore, we need to propose a small-scale homogenization device for the synthesis of active pharmaceutical ingredient intermediates. Utility Model Content

[0004] The purpose of this invention is to provide a homogenization device for small-scale synthesis of pharmaceutical intermediates, in order to solve the problems mentioned in the background art, such as the inner liner being unable to be disassembled, residual materials inside the equipment easily adhering to the inner wall of the inner liner, requiring workers to use special tools to go deep into the equipment for cleaning, which is a cumbersome and time-consuming process, and it is also difficult to completely remove residual materials in hidden parts.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A small-scale homogenization device for synthesizing active pharmaceutical ingredient intermediates includes: a base plate with an outer tank fixedly mounted on its top; an inner tank liner disposed inside the outer tank, wherein two sets of guide seats are symmetrically fixedly connected to the inner wall of the outer tank, and two sets of limiting blocks corresponding to the guide seats are symmetrically fixedly mounted on the surface of the inner tank liner, wherein the limiting blocks are inserted into the guide seats; and an anti-detachment mechanism installed on the outer tank, used to cooperate with the limiting blocks to disassemble and clean the inner tank liner.

[0007] Preferably, the limiting block has a limiting groove.

[0008] Preferably, the anti-detachment mechanism includes a storage base, an end cap, a push spring, a plug rod, a push block, and a limiting seat;

[0009] The storage base is fixedly connected to the surface of the outer can body. The end cap is threadedly installed in the storage base. The plug rod is movably inserted into the storage base, the end cap, and the outer can body. The push spring is sleeved on the plug rod. The push block is fixedly connected to the plug rod. One end of the push spring abuts against the side of the push block, and the other end of the push spring abuts against the side of the end cap. The limiting seat is fixedly connected to the end of the plug rod and is inserted into the inside of the limiting groove.

[0010] Preferably, the top of the limiting seat is inclined, and multiple sets of balls are provided on the inclined limiting seat, all of which are in contact with the surface of the limiting groove.

[0011] Preferably, the bottom of the limiting block is provided with an inclined portion.

[0012] Preferably, it also includes two sets of positioning blocks that are symmetrically and fixedly connected to the inner wall of the outer tank, and two sets of positioning seats that are symmetrically and fixedly connected to the surface of the inner tank, with the positioning seats sleeved on the positioning blocks.

[0013] Preferably, it also includes a stirring mechanism, which includes a guide rod, a lifting plate, a fixing component, a sealing plate, a drive motor, and a stirring rod;

[0014] The guide rod is fixedly connected to the top of the base plate, the lifting plate is sleeved on the guide rod, the lifting plate is fixed to the guide rod by a fastener, the sealing plate is fixedly connected to the lifting plate, the drive motor is fixedly installed on the top of the sealing plate, and the output shaft of the drive motor is fixedly connected to the output shaft of the stirring rod by a coupling.

[0015] Compared with the prior art, the beneficial effects of this utility model are:

[0016] This invention utilizes a design comprising an outer tank, an inner tank liner, and an anti-detachment mechanism. The inner tank liner is positioned inside the outer tank, and the anti-detachment mechanism secures the outer tank and inner tank liner together. The detachable structure of the inner and outer tanks allows for quick removal of the inner tank liner from the outer tank during cleaning, eliminating the need for specialized tools to access the equipment. This significantly simplifies the cleaning process, reduces equipment maintenance time, and improves the overall efficiency of small-scale experiments. Furthermore, the detachable inner tank liner enables comprehensive, thorough cleaning, effectively preventing cross-contamination between different batches of materials, ensuring the cleanliness of the pharmaceutical intermediate synthesis process, reducing product impurities, and guaranteeing the accuracy and reliability of experimental data. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model;

[0018] Figure 2 This is a schematic diagram of the stirring mechanism of this utility model;

[0019] Figure 3 This is a cross-sectional structural diagram of the present invention;

[0020] Figure 4 This is a schematic diagram of the structure of the outer tank of this utility model;

[0021] Figure 5 This is a schematic diagram of the structure of the inner tank liner of this utility model;

[0022] Figure 6 This utility model Figure 6 A magnified structural diagram of region A in the middle.

[0023] In the diagram: 1. Base plate; 2. Stirring mechanism; 21. Guide rod; 22. Lifting plate; 23. Fixing component; 24. Sealing plate; 25. Drive motor; 26. Stirring rod; 3. Outer tank; 4. Inner tank liner; 5. Positioning seat; 6. Positioning block; 7. Discharge pipe; 8. Discharge valve; 9. Limiting block; 10. Limiting groove; 11. Inclined part; 12. Anti-detachment mechanism; 121. Storage seat; 122. End cap; 123. Push spring; 124. Insert rod; 125. Push block; 126. Limiting seat; 13. Support seat; 14. Clearance through hole; 15. Ball bearing; 16. Guide seat. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0025] Please see Figure 1-6 This utility model provides a technical solution:

[0026] A small-scale homogenization device for synthesizing active pharmaceutical ingredient intermediates includes: a base plate 1, on which an outer tank 3 is fixedly mounted; an inner tank 4, located inside the outer tank 3, with two sets of guide seats 16 symmetrically fixedly connected to the inner wall of the outer tank 3, and two sets of limiting blocks 9 corresponding to the guide seats 16 symmetrically fixedly mounted on the surface of the inner tank 4, the limiting blocks 9 being inserted into the guide seats 16; and an anti-detachment mechanism 12, installed on the outer tank 3, used to cooperate with the limiting blocks 9 to disassemble and clean the inner tank 4.

[0027] It should be noted that when the limiting block 9 is installed inside the guide seat 16, the surface of the limiting block 9 contacts the inner side of the guide seat 16. Through the cooperation between the guide seat 16 and the limiting block 9, the inner tank 4 is positioned and supported, which can improve the stability of the inner tank 4.

[0028] Additionally, a support base 13 is fixedly installed at the bottom of the outer tank 3, and multiple sets of support legs are fixedly connected to the bottom of the inner tank 4. Multiple sets of clearance through holes 14 corresponding to the support legs are opened on the support base 13, and the support legs are inserted into the clearance through holes 14. The support base 13 plays a supporting role for the inner tank 4.

[0029] The bottom of the inner tank 4 is connected to a discharge pipe 7, and a discharge valve 8 is installed on the discharge pipe 7. After opening the discharge valve 8, the homogenized material inside the inner tank 4 is discharged through the discharge pipe 7.

[0030] In an optional embodiment: such as Figure 6 As shown, a limit slot 10 is provided on the limit block 9;

[0031] The anti-detachment mechanism 12 includes a storage base 121, an end cap 122, a push spring 123, a plug rod 124, a push block 125, and a limiting seat 126;

[0032] The storage base 121 is fixedly connected to the surface of the outer tank 3. The end cap 122 is threadedly installed in the storage base 121. The insertion rod 124 is movably inserted into the storage base 121, the end cap 122 and the outer tank 3. The push spring 123 is sleeved on the insertion rod 124. The push block 125 is fixedly connected to the insertion rod 124. One end of the push spring 123 abuts against the side of the push block 125, and the other end of the push spring 123 abuts against the side of the end cap 122. The limiting seat 126 is fixedly connected to the end of the insertion rod 124 and is inserted into the inside of the limiting groove 10.

[0033] It should be noted that the storage base 121, end cap 122, push spring 123, plug rod 124, push block 125 and limit seat 126 cooperate to fix the inner tank 4, which facilitates the installation and removal of the inner tank 4 and improves the convenience of installation and removal of the inner tank 4.

[0034] In an optional embodiment: such as Figure 6 As shown, the top of the limiting seat 126 is inclined, and multiple sets of balls 15 are provided on the inclined limiting seat 126. All sets of balls 15 are in contact with the surface of the limiting groove 10.

[0035] It should be noted that the setting of the ball bearing 15 prevents the limit seat 126 from directly contacting the limit groove 10, which facilitates the limit block 9 to push the limit seat 126.

[0036] In an optional embodiment: such as Figure 5 and 6 As shown, the bottom of the limiting block 9 is provided with an inclined part 11.

[0037] It should be noted that the inclined part 11 facilitates the pushing of the limiting seat 126, making it easier for the limiting seat 126 to be inserted into the limiting groove 10.

[0038] Specifically, when the inner tank 4 is installed inside the outer tank 3, the positioning seat 5 on the surface of the inner tank 4 is aligned with the positioning block 6, and the limiting block 9 is aligned with the guide seat 16. When the inner tank 4 is placed inside the outer tank 3, the inclined part 11 at the bottom of the limiting block 9 contacts the ball bearing 15 at the top of the limiting seat 126 and pushes the limiting seat 126, so that the limiting seat 126 drives the sealing plate 24 and the push block 125 to squeeze the push spring 123. When the limiting seat 126 moves into the limiting groove 10, the push spring 123 pushes the push block 125, so that the push block 125 drives the plug rod 124 and the limiting seat 126 to move, so that the limiting seat 126 moves into the limiting groove 10 and positions the limiting block 9.

[0039] In an optional embodiment: such as Figure 4 and Figure 5 As shown, it also includes two sets of positioning blocks 6 that are symmetrically and fixedly connected to the inner wall of the outer tank 3, and two sets of positioning seats 5 that are symmetrically and fixedly connected to the surface of the inner tank 4, with the positioning seats 5 sleeved on the positioning blocks 6.

[0040] It should be noted that when the positioning seat 5 is fitted onto the positioning block 6, the inner wall of the positioning seat 5 is in contact with the surface of the positioning block 6, and the top of the positioning block 6 is in contact with the inner top of the positioning seat 5. Through the cooperation of the positioning seat 5 and the positioning block 6, the outer tank 3 is positioned and supported, which can improve the stability of the inner tank 4.

[0041] In an optional embodiment: such as Figure 1 and Figure 2 As shown, it also includes a stirring mechanism 2, which includes a guide rod 21, a lifting plate 22, a fixing component 23, a sealing plate 24, a drive motor 25, and a stirring rod 26;

[0042] The guide rod 21 is fixedly connected to the top of the base plate 1. The lifting plate 22 is sleeved on the guide rod 21. The lifting plate 22 is fixed to the guide rod 21 by the fastener 23. The sealing plate 24 is fixedly connected to the lifting plate 22. The drive motor 25 is fixedly installed on the top of the sealing plate 24. The output shaft of the drive motor 25 is fixedly connected to the output shaft of the stirring rod 26 by the coupling.

[0043] It should be noted that the bottom of the sealing plate 24 is equipped with a sealing gasket. When the material is homogenized and stirred, the lifting plate 22 is adjusted so that the sealing gasket at the bottom of the sealing plate 24 is pressed against the top of the outer tank 3 and the inner tank 4, which can seal the outer tank 3 and the inner tank 4 and improve the sealing effect between the sealing plate 24 and the outer tank 3 and the inner tank 4. In addition, the fixing part 23 is set as a hand-tightening screw. After the sealing plate 24 is pressed against the top of the outer tank 3 and the inner tank 4, the fixing part 23 is tightened so that the end of the fixing part 23 abuts against the guide rod 21, thereby fixing the lifting plate 22 on the guide rod 21.

[0044] The usage process of this utility model is as follows: the material to be homogenized is poured into the inner tank 4. When the sealing plate 24 is moved to the top of the outer tank 3 and the inner tank 4 by sliding the lifting plate 22, the sealing gasket contacts the top of the outer tank 3 and the inner tank 4. By tightening the fixing part 23, the fixing part 23 is pressed against the guide rod 21, thereby adjusting and fixing the lifting plate 22.

[0045] Start the drive motor 25. The output shaft of the drive motor 25 drives the stirring rod 26 to rotate. When the stirring rod 26 rotates, it stirs and mixes the material in the inner tank 4. By opening the discharge valve 8, the homogenized material in the inner tank 4 can be discharged from the inner tank 4 through the discharge pipe 7.

[0046] When it is necessary to clean the inner wall of the inner tank 4, the plug rod 124 is dragged to move the limiting seat 126, so that the limiting seat 126 is moved out of the limiting groove 10. At this time, the inner tank 4 can be removed from the inside of the outer tank 3, so that the outer tank 3 and the inner tank 4 can be separated, and the inner wall of the inner tank 4 can be cleaned.

[0047] The control method in this application is automatic control through a controller. The control circuit of the controller can be implemented by simple programming by those skilled in the art and is common knowledge in the field. Furthermore, this application is mainly used to protect the structure, shape and their combination, so the control method and circuit connection will not be explained in detail in this application. The device is powered by an external power supply.

[0048] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates, characterized in that, include: The bottom plate (1) has an outer tank body (3) fixedly installed on its top; The inner tank (4) is located inside the outer tank (3). The inner wall of the outer tank (3) is symmetrically and fixedly connected with two sets of guide seats (16). The surface of the inner tank (4) is symmetrically and fixedly installed with two sets of limiting blocks (9) corresponding to the guide seats (16). The limiting blocks (9) are inserted into the guide seats (16). The anti-detachment mechanism (12) is installed on the outer tank (3) and is used to cooperate with the limiting block (9) to disassemble and clean the inner tank (4).

2. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 1, characterized in that: A limiting groove (10) is provided on the limiting block (9).

3. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 2, characterized in that: The anti-detachment mechanism (12) includes a storage base (121), an end cap (122), a push spring (123), a plug rod (124), a push block (125), and a limiting seat (126); The storage base (121) is fixedly connected to the surface of the outer can (3). The end cap (122) is threadedly installed in the storage base (121). The plug rod (124) is movably inserted into the storage base (121), the end cap (122) and the outer can (3). The push spring (123) is sleeved on the plug rod (124). The push block (125) is fixedly connected to the plug rod (124). One end of the push spring (123) abuts against the side of the push block (125). The other end of the push spring (123) abuts against the side of the end cap (122). The limiting seat (126) is fixedly connected to the end of the plug rod (124). The limiting seat (126) is inserted into the inside of the limiting groove (10).

4. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 3, characterized in that: The top of the limiting seat (126) is inclined, and multiple sets of balls (15) are provided on the inclined setting of the limiting seat (126), and the multiple sets of balls (15) are in contact with the surface of the limiting groove (10).

5. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 4, characterized in that: The bottom of the limiting block (9) is provided with an inclined part (11).

6. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 1, characterized in that: It also includes two sets of positioning blocks (6) that are symmetrically fixedly connected to the inner wall of the outer tank (3), and two sets of positioning seats (5) that are symmetrically fixedly connected to the surface of the inner tank (4), with the positioning seats (5) sleeved on the positioning blocks (6).

7. The small-scale homogenization apparatus for synthesizing active pharmaceutical ingredient intermediates according to claim 1, characterized in that: It also includes a stirring mechanism (2), which includes a guide rod (21), a lifting plate (22), a fixing member (23), a sealing plate (24), a drive motor (25), and a stirring rod (26); The guide rod (21) is fixedly connected to the top of the base plate (1), the lifting plate (22) is sleeved on the guide rod (21), the lifting plate (22) is fixed to the guide rod (21) by the fastener (23), the sealing plate (24) is fixedly connected to the lifting plate (22), the drive motor (25) is fixedly installed on the top of the sealing plate (24), and the output shaft of the drive motor (25) is fixedly connected to the output shaft of the stirring rod (26) by the coupling.

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