High-throughput light-driven reaction apparatus

Abstract

The application provides a high-throughput light-driven reaction device, and belongs to the technical field of chemical synthesis equipment. In view of the problems of low light energy utilization efficiency and poor reaction reliability of the light-driven reaction device, the application provides a high-throughput light-driven reaction device, which comprises a reaction layer and a light path layer arranged in layers. The reaction layer comprises a plurality of containing grooves for containing reaction bottles. The light path layer comprises a plurality of light sources and a light condensing structure corresponding to the plurality of containing grooves. The emitted light of the light source passes through the bottom of the containing groove to irradiate the reaction bottle after being focused by the light condensing structure. The light condensing structure comprises a reflecting surface arranged circumferentially around the light source and a convex lens located above the reflecting surface. The reflecting surface is arranged in a horn shape, and the small end of the reflecting surface is close to the light source, and the large end is close to the containing groove. By arranging the light condensing structure between the light source and the reaction bottle, the light intensity for light reaction of the reaction bottle is improved, the parallelism and consistency of the light path are good, and the light energy utilization efficiency and the reaction reliability are improved.

Description

Technical Field

[0001] This application relates to the field of chemical synthesis equipment technology, and in particular to high-throughput light-driven reaction devices. Background Technology

[0002] As a transformative field of light-driven reactions, photochemistry is seeing its application value increased exponentially through high-throughput technologies. For example, in the pharmaceutical industry, the use of photocatalytic combinatorial chemistry can shorten the drug development cycle by 40%, saving over $1.2 billion in R&D costs annually; in functional materials development, high-throughput photopolymerization technology increases the speed of new material discovery by 300%. In short, high-throughput photochemical technologies are undergoing a paradigm shift from "speed enhancement" to "intelligent creation," and with synergistic breakthroughs in device innovation, AI integration, and new material development, they are expected to act as a creative engine in the fields of drug development and new materials.

[0003] Despite the enormous potential of photochemical high-throughput technology, current reaction devices still face numerous challenges in their use. For instance, the use of LED chips as the light source results in diffused light, affecting light energy utilization efficiency and reaction reliability. Utility Model Content

[0004] The purpose of this application is to address the problems of low light energy utilization efficiency and poor reaction reliability in existing light-driven reaction devices. Therefore, this application provides a high-throughput light-driven reaction device, which improves the light intensity irradiated onto the reaction device for photoreaction by setting a focusing structure between the light source and the reaction flask, and has good optical path parallelism and consistency, thereby improving light energy utilization efficiency and reaction reliability.

[0005] This application provides a high-throughput optically driven reaction device, including a reaction layer and an optical path layer stacked together;

[0006] The reaction layer includes multiple receiving slots for accommodating reaction flasks;

[0007] The optical path layer includes multiple light sources and focusing structures corresponding one-to-one with the plurality of receiving slots. The emitted light from the light sources is focused by the focusing structure and passes through the bottom of the receiving slots to illuminate the reaction flask; wherein,

[0008] The light-concentrating structure includes a reflective surface arranged circumferentially around the light source and a convex lens located above the reflective surface. The reflective surface is arranged in a trumpet shape, with the small end of the reflective surface close to the light source and the large end close to the receiving groove.

[0009] By employing the above technical solution, the reflective surface and convex lens in the focusing structure achieve comprehensive focusing of the diffused light emitted from the light source, making the light spot more compatible with the reaction vessel. This increases the light intensity irradiated onto the reaction vessel for the photoreaction, thereby improving light energy utilization, accelerating the reaction rate, shortening the reaction time, and also improving the applicability of the device. At the same time, focusing improves the parallelism and consistency of the light path, eliminates experimental edge effects, promotes the repeatability of reaction experiments, and makes the data more accurate. It also prevents crosstalk, effectively avoids light source crossing, ensures that each reaction vessel is irradiated according to the design target, and improves the reliability of the reaction.

[0010] In some embodiments, the optical path layer includes a light source circuit board and a light-concentrating plate disposed above the light source circuit board, the plurality of light source arrays are arranged on the light source circuit board, and the light-concentrating structure is disposed on the light-concentrating plate;

[0011] The light-concentrating plate includes light-receiving slots that correspond one-to-one with the plurality of light sources. A funnel-shaped reflective slot is provided through the top of the light-receiving slot. The surface of the reflective slot is the reflective surface. A lens mounting slot is provided through the top of the reflective slot.

[0012] By adopting the above technical solution, the light source receiving slot, emission slot and lens mounting slot are formed on the light-concentrating plate, resulting in a simple structure, high integration and easy cleaning and maintenance. Furthermore, by forming a light source receiving slot on the light source circuit board to accommodate the light source on the light-concentrating plate, the mutual influence between adjacent light sources can be reduced, especially when the wavelengths of adjacent light sources are different.

[0013] In some embodiments, the depth of the lens mounting groove is greater than the thickness of the convex lens, and the convex lens is mounted in the lens mounting groove by means of washers, and the distance between the convex lens and the light source is adjusted by adjusting the number of washers.

[0014] By adopting the above technical solution, the light intensity can be adjusted by changing the distance, which improves the flexibility of use.

[0015] In some embodiments, a sealing ring groove is provided circumferentially in the lens mounting groove to install a sealing ring to seal the gap between the convex lens and the lens mounting groove.

[0016] By adopting the above technical solution, it is possible to avoid the reaction liquid from seeping into the contact light source and causing damage to the light source when it is accidentally splashed onto the optical path layer.

[0017] In some embodiments, the light-concentrating plate is made of aluminum alloy.

[0018] In some embodiments, the convex lens is made of quartz; the diameter of the convex lens is 5-15 mm, and the radius of curvature is 1-2 mm.

[0019] In some embodiments, the thickness of the light source circuit board is 0.8-1mm; the thickness of the light-concentrating plate is 4-6mm.

[0020] In some embodiments, the bottom of the receiving tank has an opening, and the size of the opening is smaller than the diameter of the reaction flask.

[0021] In some embodiments, the reaction layer is placed above the optical path layer, and a matching positioning groove and positioning pin are provided between the two.

[0022] In some embodiments, a heat dissipation layer is further included, which is disposed below the optical path layer and is provided with cooling pipes.

[0023] Other features and corresponding beneficial effects of this application will be described in the latter part of the specification, and it should be understood that at least some of the beneficial effects will become obvious from the description in this application. Attached Figure Description

[0024] Figure 1 This is a schematic diagram illustrating the usage status of this application;

[0025] Figure 2 This is a schematic diagram of the exploded structure of this application;

[0026] Figure 3 for Figure 1 Partial sectional view;

[0027] Figure 4 This is a schematic diagram of the structure of the light-concentrating plate in this application;

[0028] Figure 5 This is a structural schematic diagram of the light-concentrating plate from another angle.

[0029] Explanation of reference numerals in the attached figures:

[0030] 1. Reaction layer; 11. Receiving tank;

[0031] 2. Optical path layer; 21. Light source circuit board; 211. Light source; 212. Pin; 213. Cable interface; 22. Concentrating plate; 221. Light source receiving slot; 222. Reflection slot; 223. Lens mounting slot; 23. Convex lens; 24. Sealing ring; 25. Positioning pin;

[0032] 3. Heat dissipation layer; 31. Cooling interface;

[0033] 4. Reaction flask. Detailed Implementation

[0034] The following specific embodiments illustrate the implementation of this application. Those skilled in the art can easily understand other advantages and effects of this application from the content disclosed in this specification. Although the description of this application is presented in conjunction with preferred embodiments, this does not mean that the features of this application are limited to this embodiment. On the contrary, the purpose of describing the application in conjunction with embodiments is to cover other options or modifications that may be derived based on the claims of this application. To provide a thorough understanding of this application, many specific details will be included in the following description. This application may also be implemented without using these details. Furthermore, to avoid confusion or obscuring the focus of this application, some specific details will be omitted in the description. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other.

[0035] It should be noted that in this specification, similar reference numerals and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0036] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used solely for the convenience of describing this application and for simplification, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Therefore, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this application, unless otherwise stated, "a plurality of" means two or more. Unless otherwise explicitly specified and limited, the terms "installed," "connected," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; a mechanical connection or an electrical connection; a direct connection or an indirect connection through an intermediate medium; or a connection within two elements. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0037] This application provides a high-throughput light-driven reaction device. By focusing the light source, the local light intensity is increased, making the light spot more compatible with the reaction vessel, thus improving the light energy utilization rate. It also improves the applicability of the device, meaning that the same light source can be used to drive reactions that require higher light energy. At the same time, focusing improves the parallelism and consistency of the light path, which can eliminate experimental edge effects, promote the repeatability of reaction experiments, and make the data more accurate. It can also prevent crosstalk, effectively avoid light source crossing, and ensure that each reaction vessel is irradiated with light according to the design target, thereby improving the reliability of the reaction.

[0038] Meanwhile, theoretically, increasing light intensity can lead to increased photon capture by the photocatalyst, providing a higher concentration of excited-state matter and thus reducing reaction time. To this end, various light sources have been proposed in the prior art, such as light-emitting diode (LED) arrays with specific wavelengths and different intensities. However, simply increasing the light intensity often leads to a decrease in yield due to non-productive thermal pathways (i.e., heat generated by the light source), making it difficult to achieve a reduction in reaction time.

[0039] This application improves light energy utilization rather than light intensity, thereby accelerating the reaction rate and shortening the reaction time.

[0040] Please see Figure 1-2 , Figure 1 This is a schematic diagram illustrating the usage status of this application; Figure 2 This is a schematic diagram of the exploded structure of this application.

[0041] This reaction apparatus includes a reaction layer 1 and an optical path layer 2 stacked together.

[0042] The reaction layer 1 includes a plurality of receiving tanks 11 for accommodating the reaction flask 4. Preferably, the plurality of receiving tanks 11 are arranged in a rectangular array.

[0043] The optical path layer 2 includes multiple light sources 211 corresponding to multiple receiving slots 11 and a focusing structure. The emitted light from the light source 211 is focused by the focusing structure and passes through the bottom of the receiving slot 11 to irradiate the reaction bottle 4, so that the divergent light from the light source 211 is focused on the bottom of the reaction bottle 4, which increases the light intensity used for photoreaction, improves the light energy utilization rate, and has better optical path parallelism and consistency. It can eliminate experimental edge effects, prevent crosstalk, and improve reaction reliability.

[0044] In one embodiment, multiple light sources 211 are arranged in a rectangular array, and different columns or rows of light sources 211 can be set to different wavelengths, thereby meeting different reaction requirements and making the device more versatile.

[0045] In one embodiment, the bottom of the receiving tank 11 has an opening, and the size of the opening is smaller than the diameter of the reaction bottle 4, so that the reaction bottle 4 can be stably supported in the receiving tank 11, and the light emitted by the light source 211 can be directly irradiated to the bottom of the reaction bottle 4 through the focusing structure. This structure is simple and easy to manufacture.

[0046] In other alternative embodiments, the bottom of the receiving tank 11 is made of a light-transmitting material so that the light emitted by the light source 211 can be directly irradiated to the bottom of the reaction bottle 4 through the focusing structure, and the reaction layer 1 and the light path layer 2 are completely isolated, which can prevent the reaction liquid from accidentally leaking and flowing into the reaction layer 1 during the reaction process.

[0047] In one embodiment, the reaction layer 1 is placed above the optical path layer 2, and a matching positioning groove and positioning pin 25 are provided between the two.

[0048] In one specific embodiment, a positioning groove is provided at the bottom of the reaction layer 1 to keep its bottom flat and facilitate the individual placement of the reaction layer 1. A matching positioning pin 25 is provided above the optical path layer 2 to ensure that when the reaction layer 1 is placed on the optical path layer 2, the receiving groove 11 of both corresponds to the light source 211.

[0049] In one embodiment, the reaction apparatus further includes a heat dissipation layer 3, which is disposed below the optical path layer 2 and is equipped with cooling pipes to control the reaction environment temperature and achieve optimal reaction conditions.

[0050] In one specific embodiment, a cable interface 213 is provided outside the optical path layer 2 to supply power and control the light source 211 in the optical path layer 2. A cooling interface 31 is provided outside the heat dissipation layer 3 to connect the cooling pipes and the external cooling device.

[0051] The heat dissipation layer 3 can be water-cooled or air-cooled, with water cooling being preferred as it provides better heat dissipation.

[0052] Please see Figure 3-5 , Figure 3 for Figure 1 Partial sectional view; Figure 4 This is a schematic diagram of the structure of the light-concentrating plate 22 in this application; Figure 5 This is a structural schematic diagram of the light-concentrating plate 22 from another angle.

[0053] In one embodiment, the focusing structure includes a reflective surface arranged circumferentially around the light source 211 and a convex lens 23 located above the reflective surface. The divergent light emitted from the light source 211 is focused into a relatively parallel and concentrated beam after passing through the convex lens 23, thereby significantly improving the focusing ability of the light. Since the convex lens 23 has a limited size, any divergent light not focused by the convex lens 23 is reflected and focused by the reflective surface. Specifically, the reflective surface is funnel-shaped, comprising a small end and a large end that extend uniformly from the small end to the large end. The small end of the reflective surface is close to the light source 211, and the large end is close to the receiving groove 11, thus enabling the divergent light emitted from the light source 211 to be reflected inwards by the reflective surface and focused at the bottom of the reaction vessel 4.

[0054] Furthermore, by using the reflective surface and convex lens 23 in conjunction with the focusing light source 211 to emit light, the light source 211 with a divergence angle of 120° can be focused to 60°-80°, increasing the light intensity by 40%, thereby greatly shortening the reaction time.

[0055] Preferably, the convex lens 23 is made of quartz, which has good corrosion resistance and can avoid reacting with most reaction solutions.

[0056] Preferably, the diameter of the convex lens 23 is 5-15mm, such as 5, 6.5, 10, 15mm, etc.; the radius of curvature is 1-2mm, such as 1, 1.5, 1.8, 2mm, etc.

[0057] In one embodiment, the optical path layer 2 includes a light source circuit board 21 and a light-concentrating plate 22 disposed above the light source circuit board 21. A plurality of light sources 211 are arrayed on the light source circuit board 21, and a light-concentrating structure is disposed on the light-concentrating plate 22.

[0058] The light-collecting plate 22 includes light-receiving slots 221 corresponding to a plurality of light sources 211. A funnel-shaped reflective slot 222 is provided above the light-receiving slot 221, with the slot surface of the reflective slot 222 being a reflective surface. A lens mounting slot 223 is provided above the reflective slot 222. That is, by forming the light-receiving slots 221, the reflective slots, and the lens mounting slots 223 on the light-collecting plate 22, the optical path layer 2 has a simple structure, high integration, and is easy to clean and maintain. Furthermore, by forming the light-receiving slots 221 on the light-collecting plate 22 to accommodate the light sources 211 on the light source circuit board 21, the mutual interference between adjacent light sources 211 can be reduced, especially when the wavelengths of adjacent light sources 211 are different.

[0059] Preferably, the light-concentrating plate 22 is made of aluminum alloy, which can shield electromagnetic interference and ensure the stable operation of the light source circuit board 21. At the same time, aluminum alloy can also accelerate heat dissipation.

[0060] In one embodiment, the thickness of the light source circuit board 21 is 0.8-1 mm, and the thickness of the focusing plate 22 is 4-6 mm, which satisfies the requirements for the setting of the light source 211 and the focusing structure, and makes the optical path layer thinner, thus controlling the overall thickness of the device. In particular, when the reaction requires stirring of the liquid in the reaction flask, the device is preferably placed above the magnetic stirrer, and by controlling the overall thickness of the device, the stirring effect can be ensured.

[0061] In one embodiment, the light source 211 is an LED lamp bead, and the light source 211 is connected to the light source circuit board 21 via pins 212. In this case, the light source receiving slot 221 is elongated, so as to accommodate the pins 212 on both sides of the light source 211.

[0062] In one embodiment, the depth of the lens mounting groove 223 is greater than the thickness of the convex lens 23, and the convex lens 23 is mounted in the lens mounting groove 223 by means of washers. The distance between the convex lens 23 and the light source 211 can be adjusted by adjusting the number of washers, thereby adjusting the light intensity by adjusting the distance and improving the flexibility of use.

[0063] In one embodiment, a sealing ring groove is provided in the circumferential direction of the lens mounting groove 223 to install the sealing ring 24 to seal the gap between the convex lens 23 and the lens mounting groove 223. This can prevent the reaction liquid from accidentally splashing into the optical path layer 2 and causing damage to the light source 211, thereby improving safety.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this application.

Claims

1. A high-throughput light-driven reaction device, characterized in that, This includes a stacked reaction layer and an optical path layer; The reaction layer includes multiple receiving slots for accommodating reaction flasks; The optical path layer includes multiple light sources and focusing structures corresponding one-to-one with the plurality of receiving slots. The emitted light from the light sources is focused by the focusing structure and passes through the bottom of the receiving slots to illuminate the reaction flask; wherein, The light-concentrating structure includes a reflective surface arranged circumferentially around the light source and a convex lens located above the reflective surface. The reflective surface is arranged in a trumpet shape, with the small end of the reflective surface close to the light source and the large end close to the receiving groove.

2. The high-throughput photo-driven reaction device according to claim 1, characterized in that, The optical path layer includes a light source circuit board and a light-concentrating plate disposed above the light source circuit board. The plurality of light source arrays are arranged on the light source circuit board, and the light-concentrating structure is disposed on the light-concentrating plate. The light-concentrating plate includes light-source receiving slots that correspond one-to-one with the plurality of light sources. A funnel-shaped reflective groove is provided through the top of the light-source receiving slot. The groove surface of the reflective groove is the reflective surface. A lens mounting groove is provided through the top of the reflective groove.

3. The high-throughput photo-driven reaction device according to claim 2, characterized in that, The depth of the lens mounting groove is greater than the thickness of the convex lens, and the convex lens is mounted in the lens mounting groove by means of washers. The distance between the convex lens and the light source is adjusted by adjusting the number of washers.

4. The high-throughput photo-driven reaction device according to claim 2, characterized in that, A sealing ring groove is provided in the circumferential direction of the lens mounting groove to install a sealing ring to seal the gap between the convex lens and the lens mounting groove.

5. The high-throughput photo-driven reaction device according to claim 2, characterized in that, The light-concentrating plate is made of aluminum alloy.

6. The high-throughput photo-driven reaction device according to claim 1, characterized in that, The convex lens is made of quartz; the diameter of the convex lens is 5-15mm, and the radius of curvature is 1-2mm.

7. The high-throughput photo-driven reaction device according to claim 2, characterized in that, The thickness of the light source circuit board is 0.8-1mm; the thickness of the light-concentrating plate is 4-6mm.

8. The high-throughput photo-driven reaction device according to claim 1, characterized in that, The bottom of the container tank has an opening, and the size of the opening is smaller than the diameter of the reaction flask.

9. The high-throughput photo-driven reaction device according to claim 1, characterized in that, The reaction layer is placed above the optical path layer, and a matching positioning groove and positioning pin are provided between the two.

10. The high-throughput photo-driven reaction device according to claim 1, characterized in that, It also includes a heat dissipation layer, which is disposed below the optical path layer and is provided with cooling pipes.

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