MSI detection box for preventing confusion of samples

Abstract

The utility model provides a kind of MSI detection box body of anti-confusion sample, belong to MSI detection technical field, to solve the problem that the number of reaction tube is more likely to cause operator to add or miss reagent due to operation error repeatedly, including detection box main body, limit support frame, indicating label, transmission installation shaft, indicating baffle and limit storage hole;The limit support frame is bonded in the inside of the detection box main body;The front and back of the limit support frame are all bonded with the indicating label;The inside of the limit support frame is evenly distributed with a plurality of transmission installation shafts being rotatably connected;The upper portion of each transmission installation shaft is fixedly connected with an indicating baffle;The front and back of the limit support frame are evenly distributed with a plurality of limit storage holes being opened;The utility model is rotated automatically by indicating baffle to help operator to determine the placement position of reaction tube, prevent sample confusion, ensure the processing effect of sample, improve the accuracy of detection result.

Description

Technical Field

[0001] This utility model belongs to the field of MSI detection technology, and more specifically, it relates to an MSI detection box for preventing sample confusion. Background Technology

[0002] Microsatellite instability is a gene sequence abnormality caused by a problem with DNA mismatch repair. It is a core molecular marker for the diagnosis and treatment of solid tumors such as colorectal cancer and endometrial cancer, as well as for screening Lynch syndrome. The accuracy of the test results directly affects the formulation of clinical treatment plans. Currently, the main clinical method for this test is multiplex fluorescent PCR combined with capillary electrophoresis.

[0003] For example, CN217375256U discloses a reagent kit for detecting microsatellite instability, including a box body with a placement cavity at the top. The placement cavity contains a barrier mechanism composed of multiple partitions. Connecting plates are provided on both sides of the inner wall of the placement cavity, and slots are provided on the front of each connecting plate. The partitions are inserted into the inner walls of the corresponding slots. Limiting strips are fixedly connected to both sides of the partitions, and a fixing mechanism is provided between the connecting plates and the inner wall of the placement cavity. This invention utilizes two connecting plates, multiple slots, partitions, and limiting strips. By inserting the partitions into the corresponding slots and limiting the limiting strips with the connecting plates, the partitions can be adjusted and positioned within the placement cavity. This allows for adjustment according to different reagent bottles, improving the applicability of the reagent kit.

[0004] Based on the above, when processing samples in batches, reagents need to be added to the reaction tubes containing the samples one by one. With a large number of reaction tubes, operators may make mistakes by repeatedly adding or missing reagents, which will affect the sample processing effect and the accuracy of the test results. Utility Model Content

[0005] To address the aforementioned technical problems, this utility model provides an MSI detection kit for preventing sample confusion. This solves the problem that when processing samples in batches, reagents need to be added sequentially to reaction tubes containing samples. With a large number of reaction tubes, operators may make mistakes by repeatedly adding or missing reagents, affecting the sample processing effect and the accuracy of the detection results.

[0006] The purpose and effectiveness of this utility model's MSI detection box for preventing sample confusion are achieved through the following specific technical means: An MSI (Mean Separation and Interference) sample detection box for preventing sample confusion includes a detection box body, a limiting support frame, indicator labels, a prompting structure, a limiting structure, a transmission mounting shaft, an indicator baffle, and limiting storage holes. The limiting support frame is adhered to the inner side of the detection box body. The indicator labels are adhered to both the front and rear sides of the limiting support frame. The prompting structure is located on the inner side of the detection box body. Multiple transmission mounting shafts are evenly distributed and rotatably connected to the inner side of the limiting support frame. An indicator baffle is fixedly connected to the upper part of each transmission mounting shaft. The front side of the indicator baffle has a placement hole, and the inner surface of the placement hole is frosted. Multiple limiting storage holes are evenly distributed on both the front and rear sides of the limiting support frame. The limiting structure is located on the inner side of the detection box body.

[0007] Furthermore, the prompting structure includes a pressure-bearing mounting seat and a limiting pressure-bearing inclined block; multiple pressure-bearing mounting seats are evenly distributed and rotatably connected to the lower part of the limiting support frame, and the pressure-bearing mounting seats are sleeved on the outside of the transmission mounting shaft; the limiting pressure-bearing inclined block is fixedly connected to the upper end face of the pressure-bearing mounting seat.

[0008] Furthermore, the prompting structure also includes a guide mounting groove and a sliding pressure plate; multiple guide mounting grooves are evenly distributed on the front and rear sides of the limiting support frame; the sliding pressure plate is slidably connected to the inner side of the guide mounting groove.

[0009] Furthermore, the prompting structure also includes a limiting compression wedge, a reset elastic element, and a spiral spring; the limiting compression wedge is fixedly connected to the lower end face of the sliding pressure plate; the lower end of the reset elastic element is fixedly connected to the upper end face of the sliding pressure plate, and the upper end of the reset elastic element is fixedly connected to the inner side of the limiting support frame; the inner end of the spiral spring is fixedly connected to the lower part of the transmission mounting shaft, and the outer end of the spiral spring is fixedly connected to the inner side of the pressure mounting seat.

[0010] Furthermore, the limiting structure includes a positioning mounting base and a direction limiting pawl; multiple positioning mounting bases are evenly distributed and fixedly connected to the lower part of the limiting support frame; the direction limiting pawl is hinged to the lower part of the positioning mounting base by a torsion spring.

[0011] Furthermore, the limiting structure also includes an anti-slip rubber pad and a direction-limiting ratchet; the anti-slip rubber pad is adhered to the outer side of the pressure-bearing mounting base; the direction-limiting ratchet is fixedly connected to the lower end face of the pressure-bearing mounting base, and the direction-limiting ratchet and the direction-limiting pawl together form a ratchet transmission mechanism.

[0012] Compared with the prior art, the present invention has the following beneficial effects: This invention helps operators determine the placement of reaction tubes by automatically rotating an indicator baffle, preventing sample confusion and eliminating the need for operators to rely on experience or additional markings. This improves operational efficiency and reduces the probability of human error. It allows operators to intuitively distinguish between processed and unprocessed samples, avoiding the risk of repeated or missed reagent additions. It effectively prevents over-reaction, non-specific amplification, or invalid processing results caused by unbalanced reaction system concentrations, abnormal component ratios, or missed reagent additions, ensuring sample processing effectiveness and improving the accuracy of test results. The one-way locking action of the directional limiting pawl and directional limiting ratchet prevents the pressure mounting seat from reversing or shifting under the restoring force of the scroll spring, ensuring the stability and accuracy of the status indication. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0014] Figure 2 This is a schematic diagram showing the positional relationship between the limiting support frame, indicator label, indicator baffle, and limiting storage hole of this utility model.

[0015] Figure 3 This is a schematic diagram showing the positional relationship between the limiting support frame, the transmission mounting shaft, and the guide mounting groove of this utility model.

[0016] Figure 4 This is a schematic diagram showing the positional relationship between the transmission mounting shaft, the spiral spring, and the pressure mounting base of this utility model.

[0017] Figure 5 This is a schematic diagram showing the positional relationship between the positioning mounting base, the directional limiting pawl, and the directional limiting ratchet of this utility model.

[0018] In the diagram, the correspondence between component names and drawing numbers is as follows: 1. Detection box body; 2. Limiting support frame; 201. Positioning mounting seat; 202. Direction limiting pawl; 203. Pressure mounting seat; 204. Limiting pressure inclined block; 205. Anti-slip rubber pad; 206. Direction limiting ratchet; 207. Guide mounting groove; 208. Sliding pressure plate; 209. Limiting compression inclined block; 210. Reset elastic element; 3. Indicator label; 4. Transmission mounting shaft; 401. Scroll spring; 5. Indicator baffle; 6. Limiting storage hole. Detailed Implementation

[0019] The embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples.

[0020] Example 1: As attached Figure 1 To be continued Figure 4 As shown: This utility model provides an MSI test box for preventing sample confusion, including a test box body 1, a limiting support frame 2, an indicator label 3, a prompting structure, a transmission mounting shaft 4, an indicator baffle 5, and a limiting storage hole 6; the limiting support frame 2 is adhered to the inner side of the test box body 1; indicator labels 3 are adhered to both the front and rear sides of the limiting support frame 2; the prompting structure is located on the inner side of the test box body 1; multiple transmission mounting shafts 4 are evenly distributed and rotatably connected to the inner side of the limiting support frame 2; an indicator baffle 5 is fixedly connected to the upper part of each transmission mounting shaft 4, and a placement hole is opened on the front side of the indicator baffle 5, the inner side of the placement hole is frosted; multiple limiting storage holes 6 are evenly distributed on the front and rear sides of the limiting support frame 2.

[0021] The prompting structure includes a pressure-bearing mounting base 203 and a limiting pressure-bearing inclined block 204; multiple pressure-bearing mounting bases 203 are evenly distributed and rotatably connected to the lower part of the limiting support frame 2, and the pressure-bearing mounting bases 203 are sleeved on the outside of the transmission mounting shaft 4; the upper end face of the pressure-bearing mounting base 203 is fixedly connected to the limiting pressure-bearing inclined block 204.

[0022] The prompting structure also includes a guide mounting groove 207 and a sliding pressure plate 208; multiple guide mounting grooves 207 are evenly distributed on the front and rear sides of the limiting support frame 2; the sliding pressure plate 208 is slidably connected to the inner side of the guide mounting groove 207.

[0023] The prompting structure also includes a limiting compression wedge 209, a reset elastic element 210, and a spiral spring 401; the limiting compression wedge 209 is fixedly connected to the lower end face of the sliding pressure plate 208; the lower end of the reset elastic element 210 is fixedly connected to the upper end face of the sliding pressure plate 208, and the upper end of the reset elastic element 210 is fixedly connected to the inner side of the limiting support frame 2; the inner end of the spiral spring 401 is fixedly connected to the lower part of the transmission mounting shaft 4, and the outer end of the spiral spring 401 is fixedly connected to the inner side of the pressure mounting seat 203.

[0024] The specific usage and function of this embodiment are as follows: When processing samples, unused reaction tubes are removed from the front row of the limiting support frame 2. At this time, the sliding pressure plate 208 is no longer under pressure and resets under the restoring force of the reset elastic element 210. Simultaneously, the indicator baffle 5 is no longer blocked by the reaction tubes. The restoring force of the spiral spring 401 will drive the transmission mounting shaft 4 and the indicator baffle 5 to rotate, causing the placement hole to rotate above the limiting storage hole 6 at the rear of the limiting support frame 2, allowing the operator to place the processed reaction tubes into the limiting storage hole 6 at the rear. At this time, the reaction tube will press down on the sliding pressure plate 208. After being pressed, the sliding pressure plate 208 will drive the limiting pressure block 209 to move down along the guide mounting groove 207 to press the limiting pressure block 204. After being pressed, the limiting pressure block 204 will drive the pressure mounting seat 203 to rotate into the spiral spring 401 to store energy, waiting to remove the reaction tube. The frosted surface inside the storage hole will cause the reaction tube to be subjected to a large frictional force to overcome the restoring force of the reset elastic element 210. The indicator label 3 can help remind the operator of the processing status of the reaction tube.

[0025] Example 2: As attached Figure 3 To be continued Figure 5 As shown: Based on Embodiment 1, a limiting structure is also included; the limiting structure is disposed on the inner side of the detection box body 1.

[0026] The limiting structure includes a positioning mounting base 201 and a direction limiting pawl 202; multiple positioning mounting bases 201 are evenly distributed and fixedly connected to the lower part of the limiting support frame 2; the direction limiting pawl 202 is hinged to the lower part of the positioning mounting base 201 by a torsion spring.

[0027] The limiting structure also includes an anti-slip rubber pad 205 and a directional limiting ratchet 206; the anti-slip rubber pad 205 is bonded to the outer side of the pressure-bearing mounting base 203; the directional limiting ratchet 206 is fixedly connected to the lower end face of the pressure-bearing mounting base 203, and the directional limiting ratchet 206 and the directional limiting pawl 202 together form a ratchet transmission mechanism.

[0028] The specific usage and function of this embodiment: When the pressure mounting base 203 rotates, it will drive the direction limiting ratchet 206 to rotate. At this time, the direction limiting pawl 202 at the bottom of the positioning mounting base 201 will slide inside the direction limiting ratchet 206. The anti-slip rubber pad 205 can increase the friction between the pressure mounting base 203 and the limiting support frame 2, preventing the pressure mounting base 203 from moving when the spiral spring 401 returns to its original position. When the pressure mounting base 203 is subjected to the reverse pushing force of the spiral spring 401, the direction limiting pawl 202 will limit the direction limiting ratchet 206 to prevent the pressure mounting base 203 from reversing.

[0029] The following points should be noted in this article: 1. The accompanying drawings of this embodiment only involve the structures involved in this embodiment; other structures can refer to the general design.

[0030] 2. Where there is no conflict, this embodiment and the features in the embodiment can be combined with each other to obtain new embodiments.

[0031] The above are merely specific implementations of this embodiment, but the protection scope of this embodiment is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this embodiment should be included within the protection scope of this embodiment. Therefore, the protection scope of this embodiment should be determined by the protection scope of the claims.

Claims

1. An MSI detection box for preventing sample confusion, comprising a detection box body (1), a limiting support frame (2), an indicator label (3), a prompting structure, a limiting structure, a transmission mounting shaft (4), an indicator baffle (5), and a limiting storage hole (6); wherein the limiting support frame (2) is bonded to the inner side of the detection box body (1); characterized in that: The indicator label (3) is attached to both the front and rear sides of the limiting support frame (2); the prompting structure is located inside the main body (1) of the detection box; multiple transmission mounting shafts (4) are evenly distributed and rotatably connected to the inner side of the limiting support frame (2); an indicator baffle (5) is fixedly connected to the upper part of each transmission mounting shaft (4), and a storage hole is opened on the front side of the indicator baffle (5), with the inner side of the storage hole being frosted; multiple limiting storage holes (6) are evenly distributed on both the front and rear sides of the limiting support frame (2); the limiting structure is located inside the main body (1) of the detection box.

2. The MSI detection box for preventing sample confusion as described in claim 1, characterized in that: The prompting structure includes a pressure-bearing mounting base (203) and a limiting pressure-bearing inclined block (204); the lower part of the limiting support frame (2) is evenly distributed and rotatably connected with multiple pressure-bearing mounting bases (203), and the pressure-bearing mounting bases (203) are sleeved on the outside of the transmission mounting shaft (4); the upper end face of the pressure-bearing mounting base (203) is fixedly connected with the limiting pressure-bearing inclined block (204).

3. The MSI detection box for preventing sample confusion as described in claim 2, characterized in that: The prompting structure also includes a guide mounting groove (207) and a sliding pressure plate (208); the front and rear sides of the limiting support frame (2) are evenly provided with a plurality of the guide mounting grooves (207); the inner side of the guide mounting groove (207) is slidably connected to the sliding pressure plate (208).

4. The MSI detection box for preventing sample confusion as described in claim 3, characterized in that: The prompting structure also includes a limiting compression wedge (209), a reset elastic element (210), and a spiral spring (401); the limiting compression wedge (209) is fixedly connected to the lower end face of the sliding pressure plate (208); the lower end of the reset elastic element (210) is fixedly connected to the upper end face of the sliding pressure plate (208), and the upper end of the reset elastic element (210) is fixedly connected to the inner side of the limiting support frame (2); the inner end of the spiral spring (401) is fixedly connected to the lower part of the transmission mounting shaft (4), and the outer end of the spiral spring (401) is fixedly connected to the inner side of the pressure mounting seat (203).

5. The MSI detection box for preventing sample confusion as described in claim 4, characterized in that: The limiting structure includes a positioning mounting base (201) and a direction limiting pawl (202); multiple positioning mounting bases (201) are evenly distributed and fixedly connected to the lower part of the limiting support frame (2); the direction limiting pawl (202) is hinged to the lower part of the positioning mounting base (201) by a torsion spring.

6. The MSI detection box for preventing sample confusion as described in claim 5, characterized in that: The limiting structure also includes an anti-slip rubber pad (205) and a directional limiting ratchet (206); the anti-slip rubber pad (205) is bonded to the outer side of the pressure-bearing mounting base (203); the directional limiting ratchet (206) is fixedly connected to the lower end face of the pressure-bearing mounting base (203), and the directional limiting ratchet (206) and the directional limiting pawl (202) together form a ratchet transmission mechanism.

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