A sample tube holder for ultrasonic cell disruption

Abstract

The utility model discloses a kind of sample tube fixing devices for ultrasonic cell breaking, including bottom plate, the upper surface of the bottom plate is fixedly connected with symmetrical limit plate, the outer surface of two limit plates is equipped with positioning screw hole, the inside of two positioning screw holes is equipped with positioner, the inside of two positioners is equipped with clamping device, the upper surface of the bottom plate is placed with cooling barrel, the upper surface of the bottom plate is fixedly connected with fixed angle plate, the upper surface of the fixed angle plate is equipped with through-hole, the inside of the through-hole is equipped with lifter, the inside of the cooling barrel is equipped with sample tube main body, the positioner includes two positioning screw rod, the end of two positioning screw rod mutually close is inlaid with bearing, the end of two positioning screw rod mutually far away is fixedly connected with rotary block. The device uses the cooperation of buffer spring and damper, can buffer fixed plate, avoid excessive extrusion to sample tube main body.

Description

Technical Field

[0001] This utility model relates to the field of ultrasonic cell disruption, and in particular to a sample tube fixing device for ultrasonic cell disruption. Background Technology

[0002] Ultrasonic cell disruption utilizes the mechanical action of ultrasound waves to break down cells through high-frequency vibrations and shear forces. By placing cells in an ultrasonic field, the vibrations cause pressure changes and shear forces inside and outside the cells, thereby disrupting the cell structure and membrane, and releasing internal components. Ultrasonic cell disruption is a common method for cell disruption, primarily used for cell disruption and release of cell contents, DNA / RNA extraction, cell lysis, and extract processing. It can disrupt cells, release cellular components, and extract biological samples, and is widely used in biomedical research, bioengineering, and biopharmaceuticals.

[0003] Chinese Patent CN222226367U discloses a sample tube fixing device for ultrasonic cell disruption, comprising an ice water container, a metal module placed at the bottom of the inner wall of the ice water container, a pre-set hole on the top of the metal module, a sample tube body placed at the bottom of the inner wall of the pre-set hole, an ultrasonic probe placed at the bottom of the inner wall of the sample tube body, and two small side holes on the outer wall of the metal module. However, the sample tube fixing device for ultrasonic cell disruption in the above patent directly uses a screw to clamp and position the sample tube. The screw is relatively rigid and can easily cause excessive compression of the sample tube, leading to sample tube breakage and sample waste. Therefore, we propose a sample tube fixing device for ultrasonic cell disruption to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to provide a sample tube fixation device for ultrasonically disrupted cells, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A sample tube fixing device for ultrasonically disrupted cells includes a base plate, with symmetrical limiting plates fixedly connected to the upper surface of the base plate. Positioning screw holes are formed on the outer surfaces of both limiting plates, and locators are installed inside the two positioning screw holes. Clamping devices are installed inside the two locators. A cooling tank is placed on the upper surface of the base plate, and a fixing angle plate is fixedly connected to the upper surface of the base plate. A through hole is formed on the upper surface of the fixing angle plate, and a lifting device is installed inside the through hole. The sample tube body is located inside the cooling tank.

[0007] In a further embodiment, the positioner includes two positioning screws, each with a bearing embedded at its close end and a rotating block fixedly connected to its far end. A symmetrical rotating rod is fixedly connected to the outer surface of each of the two rotating blocks. Positioning plates are fixedly connected to the outer surfaces of each of the two bearings. A symmetrical buffer spring is fixedly connected to the close side of each of the two positioning plates. A damper is fixedly connected to the close side of each of the two positioning plates.

[0008] In a further embodiment, the clamp includes two fixing plates, the side of the two sets of fixing plates that are far apart from each other is fixedly connected to the side of the two sets of buffer springs that are close to each other, and the side of the two sets of fixing plates that are far apart from each other is fixedly connected to the side of the two dampers that are close to each other.

[0009] In a further embodiment, two positioning blocks are fixedly connected to one side of each of the two fixed plates that are close to each other, positioning clips are fixedly connected to one side of each of the two sets of positioning blocks that are close to each other, and fixing clamps are fixedly connected to one side of each of the two fixed plates that are close to each other.

[0010] In a further embodiment, the lifting device includes an electric push rod, the output end of which is fixedly connected to a fixed base, and an ultrasonic probe is installed inside the fixed base.

[0011] In a further embodiment, a controller is mounted on the front of the fixed corner plate, and a display screen is provided on the front of the controller. Four anti-slip seats are fixedly connected to the bottom surface of the base plate.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] This device uses an electric push rod to move the fixed base, facilitating the adjustment of the ultrasonic probe's position. The fixed base also allows for easy disassembly and installation of the ultrasonic probe. The positioning screw hole and positioning screw work together to position the positioning plate. The buffer spring and damper work together to cushion the fixed plate, preventing excessive pressure on the sample tube body and avoiding sample waste due to breakage. The positioning block and positioning clamp work together to position the sample tube body. The fixed clamp plate clamps and positions the cooling tank, improving its stability. Attached Figure Description

[0014] Figure 1 This is a three-dimensional structural diagram of a sample tube fixation device used for ultrasonic cell disruption.

[0015] Figure 2 This is a cross-sectional view of the base plate in a sample tube fixation device used for ultrasonic cell disruption.

[0016] Figure 3 This is a top view of the fixation plate in a sample tube fixation device used for ultrasonic cell disruption.

[0017] Figure 4 This is a side view of the positioning plate in a sample tube fixation device used for ultrasonic cell disruption.

[0018] In the diagram: 1. Base plate; 2. Positioner; 201. Positioning screw; 202. Bearing; 203. Positioning plate; 204. Rotating block; 205. Rotating rod; 206. Buffer spring; 207. Damper; 3. Clamping device; 301. Fixing plate; 302. Positioning block; 303. Positioning clamp; 304. Fixing clamp; 4. Limiting plate; 5. Lifter; 501. Electric push rod; 502. Fixing seat; 503. Ultrasonic probe; 6. Positioning screw hole; 7. Fixing angle plate; 8. Through hole; 9. Cooling tank; 10. Sample tube body; 11. Anti-slip seat; 12. Controller; 13. Display screen. Detailed Implementation

[0019] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating orientation or positional relationships based on the orientation or positional relationships shown in the accompanying drawings, are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0020] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0021] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0022] Please see Figure 1-4 In this utility model, a sample tube fixing device for ultrasonically disrupted cells includes a base plate 1. A symmetrical limiting plate 4 is fixedly connected to the upper surface of the base plate 1. The outer surfaces of the two limiting plates 4 are provided with positioning screw holes 6. The interior of the two positioning screw holes 6 is provided with a locator 2. The interior of the two locators 2 is provided with a clamping device 3. A cooling tank 9 is placed on the upper surface of the base plate 1. A fixing angle plate 7 is fixedly connected to the upper surface of the base plate 1. A through hole 8 is provided on the upper surface of the fixing angle plate 7. A lifting device 5 is provided inside the through hole 8. The sample tube body 10 is provided inside the cooling tank 9. The sample tube body 10 can be cooled and cooled by the cooling tank 9. Cell samples can be placed in the sample tube body 10.

[0023] The positioner 2 includes two positioning screws 201. Each of the two positioning screws 201 has a bearing 202 embedded at its close end and a rotating block 204 fixedly connected to its far end. Each of the two rotating blocks 204 has a symmetrical rotating rod 205 fixedly connected to its outer surface. Each of the two bearings 202 has a positioning plate 203 fixedly connected to its outer surface. Each of the two positioning plates 203 has a symmetrical buffer spring 206 fixedly connected to its close side and a damper 207 fixedly connected to its close side. Through the cooperation of the positioning screw hole 6 and the positioning screws 201, the positioning plate 203 can be positioned. The cooperation of the buffer spring 206 and the damper 207 can buffer the fixed plate 301 and prevent excessive compression of the sample tube body 10.

[0024] The clamping device 3 includes two fixing plates 301. The side of the two fixing plates 301 that is far apart from each other is fixedly connected to the side of the two buffer springs 206 that is close to each other. The side of the two fixing plates 301 that is far apart from each other is fixedly connected to the side of the two dampers 207 that is close to each other. Two positioning blocks 302 are fixedly connected to the side of the two fixing plates 301 that is close to each other. Positioning clamps 303 are fixedly connected to the side of the two positioning blocks 302 that is close to each other. Fixing clamps 304 are fixedly connected to the side of the two fixing plates 301 that is close to each other. Through the cooperation of the positioning blocks 302 and the positioning clamps 303, the sample tube body 10 can be positioned. The fixing clamps 304 can be used to clamp and position the cooling tank 9, thereby improving the stability of the cooling tank 9.

[0025] The lifting device 5 includes an electric push rod 501, the output end of which is fixedly connected to a fixed base 502. An ultrasonic probe 503 is installed inside the fixed base 502. A controller 12 is installed on the front of the fixed corner plate 7. A display screen 13 is provided on the front of the controller 12. Four anti-slip seats 11 are fixedly connected to the bottom surface of the base plate 1. The fixed base 502 can be moved by the electric push rod 501 to facilitate the adjustment of the position of the ultrasonic probe 503. The fixed base 502 facilitates the disassembly and installation of the ultrasonic probe 503. With the cooperation of the controller 12 and the display screen 13, the device can be easily controlled by the operator.

[0026] The working principle of this utility model is as follows:

[0027] In use, first connect the device to the corresponding power supply. Then, using the cooperation of the base plate 1 and the anti-slip seat 11, place the device stably in a suitable position. Next, put an appropriate amount of ice into the cooling tank 9, and then place the sample tube body 10 inside the cooling tank 9. Then, control the device through the cooperation of the controller 12 and the display screen 13. Then, the electric push rod 501 can push the fixed seat 502 to move, which facilitates the adjustment of the position of the ultrasonic probe 503. The fixed seat 502 facilitates the disassembly and installation of the ultrasonic probe 503. Then, the positioning plate 203 can be positioned by the cooperation of the positioning screw hole 6 and the positioning screw 201. The fixed plate 301 can be buffered by the cooperation of the buffer spring 206 and the damper 207 to avoid excessive compression of the sample tube body 10. The sample tube body 10 can be positioned by the cooperation of the positioning block 302 and the positioning clamp 303. The cooling tank 9 can be clamped and positioned by the fixed clamp plate 304 to improve the stability of the cooling tank 9.

[0028] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0029] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A sample tube fixation device for ultrasonically disrupted cells, characterized in that: The system includes a base plate (1), on the upper surface of which are fixedly connected symmetrical limiting plates (4). The outer surfaces of the two limiting plates (4) are provided with positioning screw holes (6). The interior of the two positioning screw holes (6) is provided with a locator (2). The interior of the two locators (2) is provided with a clamping device (3). A cooling tank (9) is placed on the upper surface of the base plate (1). A fixing angle plate (7) is fixedly connected to the upper surface of the base plate (1). The upper surface of the fixing angle plate (7) is provided with a through hole (8). The interior of the through hole (8) is provided with a lifting device (5). The interior of the cooling tank (9) is provided with a sample tube body (10).

2. The sample tube fixation device for ultrasonically disrupted cells according to claim 1, characterized in that: The positioner (2) includes two positioning screws (201), each of which has a bearing (202) embedded at the end close to each other, and a rotating block (204) fixedly connected at the end far from each other. The outer surfaces of the two rotating blocks (204) are fixedly connected with symmetrical rotating rods (205).

3. A sample tube fixation device for ultrasonically disrupted cells according to claim 2, characterized in that: Positioning plates (203) are fixedly connected to the outer surfaces of the two bearings (202), and symmetrical buffer springs (206) are fixedly connected to the side of the two positioning plates (203) that are close to each other. Dampers (207) are fixedly connected to the side of the two positioning plates (203) that are close to each other.

4. A sample tube fixation device for ultrasonically disrupted cells according to claim 3, characterized in that: The clamp (3) includes two fixing plates (301). The two sets of fixing plates (301) are respectively fixedly connected to the two sets of buffer springs (206) at their respective ends. The two sets of fixing plates (301) are respectively fixedly connected to the two dampers (207) at their respective ends.

5. A sample tube fixation device for ultrasonically disrupted cells according to claim 4, characterized in that: Two positioning blocks (302) are fixedly connected to one side of each of the two fixed plates (301) that are close to each other. Positioning clips (303) are fixedly connected to one side of each of the two sets of positioning blocks (302) that are close to each other. Fixing clamps (304) are fixedly connected to one side of each of the two fixed plates (301) that are close to each other.

6. A sample tube fixation device for ultrasonically disrupted cells according to claim 1, characterized in that: The lifting device (5) includes an electric push rod (501), the output end of which is fixedly connected to a fixed base (502), and an ultrasonic probe (503) is installed inside the fixed base (502).

7. A sample tube fixation device for ultrasonically disrupted cells according to claim 1, characterized in that: The front of the fixed corner plate (7) is equipped with a controller (12), the front of the controller (12) is provided with a display screen (13), and the bottom surface of the base plate (1) is fixedly connected with four anti-slip seats (11).

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