A bath plate and bath plate ejector plate for mating with a multi-well plate heating device

Abstract

The utility model relates to biological experiment temperature control device technical field, especially a kind of for matching the heating device of multi-well plate bath plate and bath plate ejection plate. Bath plate includes a by good heat-conducting material one processing and shaping bath plate body, multiple through settings bath holes of rectangular or annular arrangement are equipped on body, recess is equipped between adjacent bath holes. The side wall of bath hole can surround and adhere to the side wall of reagent card strip, realize its overall wrapping heating;Recess is used to accommodate the connecting portion of multiple reagent strip. The protruding structure corresponding with bath hole is equipped on bath plate ejection plate, the protruding structure can pass through through bath hole, for the reagent card strip of incubation completion from bath plate convenient ejection. The utility model solves the problems of slow, uneven, serious heat loss and inconvenient operation of reaction vessel in the prior art, has the beneficial effects of rapid and uniform heating, convenient and efficient operation, safe and labor-saving use.

Description

Technical Field

[0001] This utility model relates to the field of temperature control devices for biological experiments, and in particular to a temperature bath plate and a temperature bath plate top plate for use with a multi-well plate heating device. Background Technology

[0002] In experiments conducted in biomedicine, molecular diagnostics, and drug development, 96-well plates, PCR tubes, and multi-response reagent strips are widely used reaction containers. These experimental procedures, such as enzyme-linked immunosorbent assays (ELISA), chemiluminescence assays, and nucleic acid extraction and amplification, typically involve heating and incubating the reaction containers. Such incubation steps require extremely high precision, uniformity, and stability of temperature, as any temperature deviation can lead to inconsistent reaction rates, thus affecting the accuracy and reliability of the final detection results.

[0003] Currently, the conventional heating method involves placing disposable 96-well plates or reagent strips made of plastic materials such as polypropylene (PP) or polystyrene (PS) directly onto a flat, thermostatic metal heating module. This method primarily relies on heat conduction through the contact surface between the bottom of the reaction vessel and the heating module. However, this widely adopted heating method has drawbacks: First, the extremely low thermal conductivity of plastic materials results in a very slow heat transfer from the heating module to the liquid inside the reaction wells, requiring a long incubation time to reach the target temperature, thus reducing experimental efficiency. Second, there is the problem of uneven heating; heat is almost entirely transferred from the bottom of the reaction wells, while the sidewalls of the wells and the upper part of the liquid inside are directly exposed to the cooler ambient air. Due to the gaps between the sidewalls and wells, heat continuously dissipates outwards, causing the temperature inside the reaction wells, especially in the upper and edge regions, to be lower than that in the center and bottom regions, creating a temperature gradient. This uneven temperature distribution severely affects the synchronicity and consistency of temperature-sensitive biochemical reactions.

[0004] To improve the performance of heating modules, several improvements have emerged in the prior art. For example, Chinese utility model patent CN203018101U discloses a modular constant-temperature metal bath module. This solution designs a large heating module into multiple freely combinable smaller modules to accommodate reaction tubes of different specifications and quantities, thereby improving the applicability of the equipment and saving energy when processing small batches or mixed-specification samples. However, this solution mainly addresses the issues of configuration flexibility and energy saving of the heating module, and does not fundamentally solve the aforementioned technical problems of uneven heating and heat loss.

[0005] Therefore, there is an urgent need in this field for a new technical solution that can not only overcome the problems of slow heating, uneven temperature and heat loss caused by traditional bottom heating mode, and achieve rapid, stable and uniform overall heating of the reaction vessel, but also provide a convenient and reliable mechanism to facilitate users to safely and conveniently remove the reaction vessel after incubation. Utility Model Content

[0006] In order to solve the above-mentioned technical problems in the prior art, the present invention provides a bath plate and a bath plate top plate for matching a perforated plate heating device.

[0007] To achieve the above objectives, the technical solution of this utility model is as follows: In a first aspect, a heat bath plate for matching a perforated plate heating device includes a heat bath plate body, the heat bath plate body being integrally formed from a thermally conductive material; The bath plate body is provided with a plurality of bath holes, which are arranged through the bath plate body to accommodate reagent card strips, and the sidewalls of the bath holes surround and fit the sidewalls of the reagent card strips. The bath plate body is also provided with a groove, which is located between adjacent bath holes and is used to accommodate the connecting part of the reagent card strip.

[0008] Furthermore, the bath plate body can be rectangular or circular.

[0009] Furthermore, when the body of the hot water bath plate is rectangular, the plurality of hot water bath holes are distributed in a matrix on the body of the hot water bath plate; Alternatively, when the bath plate body is circular, the plurality of bath holes are arranged in a ring on the bath plate body.

[0010] Furthermore, when the bath plate body is rectangular, the grooves are arranged longitudinally along the bath plate body, or transversely along the bath plate body, or simultaneously along both the longitudinal and transverse directions of the bath plate body, to accommodate multi-unit reagent strips. Alternatively, when the bath plate body is circular, the grooves are arranged radially along the bath plate body to accommodate multi-unit reagent strips.

[0011] Furthermore, at least one side of the heated bath plate body is provided with a chamfer.

[0012] Furthermore, the bottom of the bath plate body is provided with an integrally formed boss structure or flat bottom structure, which is used to be adapted to the heating module of the heating device.

[0013] Furthermore, the thermal conductivity of the thermally conductive material is greater than or equal to 50 W / (m·K).

[0014] Furthermore, the thermally conductive material is selected from metals, thermally conductive ceramics, or thermally conductive polymers.

[0015] Secondly, a bath plate ejector plate for matching a multi-well plate heating device is used in conjunction with the aforementioned bath plate for matching a multi-well plate heating device. The bath plate ejector plate includes an ejector plate body, on which a plurality of protrusions are provided. The arrangement of the plurality of protrusions corresponds to the arrangement of the bath holes, and is used to eject the reagent strip contained in the bath holes through the bath holes.

[0016] Furthermore, the ejector plate body is also provided with a positioning structure, which is a limiting stop edge set at the four corners of the ejector plate body, and the limiting stop edge is higher than the horizontal height of the hot bath ejector plate.

[0017] Compared with the prior art, the present invention has the following beneficial effects: This utility model provides a bath plate and a bath plate top plate for matching a multi-hole plate heating device. The bath plate body is integrally formed from a high thermal conductivity material, which enables rapid heat transfer. The side walls of the bath holes can surround and fit the reagent card strip, so that heat can simultaneously wrap and heat the reagent card strip from the bottom and side walls, greatly reducing heat loss and achieving rapid and uniform overall heating.

[0018] This utility model provides a bath plate and a bath plate ejector plate for matching a multi-well plate heating device. The grooves set between the bath holes can perfectly accommodate the connecting part of the multi-reagent strip, so that the entire reagent strip can be easily put in and taken out, improving the operational efficiency of high-throughput experiments.

[0019] This utility model provides a bath plate and a bath plate ejector plate for matching a multi-well plate heating device. The matching bath plate ejector plate, through its protruding structure passing through the through-holes in the bath plate body, can uniformly and parallelly eject the reagent strip that is closely attached to the bath plate from the bottom, avoiding problems such as sample splashing and difficulty in handling when manually picking it up. The operation is safe, simple and labor-saving. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the rectangular heat bath plate in Example 1.

[0022] Figure 2 This is a schematic diagram of the rectangular hot water bath plate top plate in Example 1.

[0023] Figure 3 This is a schematic diagram of the rectangular bath plate and the top plate of the bath plate used in conjunction in Example 1.

[0024] Figure 4 This is a side sectional view of the rectangular hot water plate in Embodiment 1.

[0025] Figure 5 This is a schematic diagram of the circular bath plate in Example 2.

[0026] Figure 6 This is a schematic diagram of the structure of the circular hot water bath plate top plate in Example 2.

[0027] Figure 7 This is a schematic diagram of the use of the circular bath plate and the top plate of the bath plate in Example 2.

[0028] The annotations in the attached figures are explained as follows: 1-Hot bath plate, 11-Hot bath plate body, 12-Hot bath hole, 13-Groove, 14-Chamfer, 15-Boss structure, 2-Hot bath plate ejector plate, 21-Ejector plate body, 22-Protrusion structure, 23-Limiting stop edge. Detailed Implementation

[0029] The technical solution of this utility model will be clearly described below with reference to the accompanying drawings. Obviously, the described embodiments are not all embodiments of this utility model. All other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0030] It should be noted that, unless otherwise specifically stated, the relative arrangement and numerical expressions of the components and steps described in these embodiments should not be construed as limiting the scope of this utility model.

[0031] The following description of exemplary embodiments is merely illustrative and is not intended to limit the present invention or its application or use in any way. Techniques, methods, and apparatus known to those skilled in the art may not be discussed in detail herein, but where applicable, such techniques, methods, and apparatus should be considered part of this specification.

[0032] Example 1 This embodiment provides a heat bath plate and a heat bath plate ejector plate for matching a perforated plate heating device, including a heat bath plate 1 and a heat bath plate ejector plate 2. Preferably, this embodiment uses a 96-hole heat bath plate, and the heat bath plate 1 adopts a rectangular design. Figure 1As shown, the heated bath plate 1 includes a heated bath plate body 11. The heated bath plate body 11 is integrally formed from a thermally conductive material to ensure that heat can be conducted quickly and evenly throughout the entire plate. In specific implementations, the thermally conductive material can be a metal, such as aluminum, copper, or their alloys with excellent thermal conductivity, or a corrosion-resistant metal such as stainless steel. Alternatively, the thermally conductive material can also be a non-metallic material with a high thermal conductivity, such as thermally conductive ceramics like aluminum nitride ceramics or silicon carbide ceramics, or a thermally conductive polymer filled with highly thermally conductive fillers (such as graphite, metal powder, etc.). Preferably, to ensure high heat transfer efficiency, the selected thermally conductive material has a thermal conductivity greater than or equal to 50 W / (m·K), more preferably, the selected thermally conductive material has a thermal conductivity greater than or equal to 150 W / (m·K). The heated bath plate and the heated bath plate ejector plate themselves may or may not carry heating elements. When the plate does not carry heating elements, the heat of the heated bath is conducted from the components connected to it.

[0033] The bath plate body 11 has multiple bath holes 12. For example... Figure 4 As shown, the temperature bath holes 12 penetrate the temperature bath plate body 11, and their sidewalls can surround and tightly fit the sidewalls of the reagent strips placed therein. This enveloping structure allows heat to be conducted not only from the bottom of the reagent strip but also from its sidewalls, achieving multi-dimensional heating of the reagent strip and thus solving the problem of uneven heating caused by heat loss from the sidewalls in the prior art. The arrangement of the temperature bath holes 12 can be matched with the arrangement of standard 96-well plates, 8-well reagent strips, or 12-well reagent strips.

[0034] To facilitate the placement of multi-unit reagent strips with connecting parts, grooves 13 are provided between multiple heat bath holes 12 on the heat bath plate body 11. Figure 1 As shown, when it is necessary to place an 8-well reagent strip, a vertical groove 13 can be provided between the longitudinal holes to accommodate the connecting parts between the 8 strips. Similarly, a horizontal groove can be provided to accommodate the reagent strips, or both longitudinal and horizontal grooves can be provided to make it compatible with different types of multi-well reagent strips.

[0035] The hot water bath plate body 11 has chamfered corners 14 on both sides to facilitate operators to grasp and place the hot water bath plate 1 by hand. Figure 3 and Figure 4 As shown, the bottom of the bath plate body 11 can be provided with an integrally formed boss structure 15. The shape and size of the boss structure can be designed according to the groove of the heating module of the heating device to be matched, so as to ensure that the two can fit perfectly and achieve the most efficient heat transfer.

[0036] This embodiment also provides a hot water bath ejector plate 2 for use with the hot water bath plate 1. For example... Figure 2As shown, the hot bath plate ejector plate 2 includes an ejector plate body 21, on which multiple protrusions 22 are provided. The distribution and number of these protrusions 22 correspond exactly to the hot bath holes 12 on the hot bath plate 1. After the experimental incubation is completed, the hot bath plate 1 is removed from the heating device and placed on the hot bath plate ejector plate 2. At this time, the protrusions 22 on the hot bath plate ejector plate 2 will pass through the bottom of the hot bath holes 12 of the hot bath plate 1, pushing the reagent strips inside the holes upward to a certain height, so that the operator can easily remove all the reagent strips.

[0037] The ejector plate body 21 is also provided with limit stops 23, which are located at the four azimuth angles of the ejector plate body, such as... Figure 2 As shown, the size of the placement area defined by the limiting edge 23 is equal to the size of the bath plate 1. This design allows the bath plate 1 to be positioned quickly and accurately, preventing misalignment.

[0038] The usage process of this embodiment is as follows: 1. Place the reagent strips to be incubated (such as several 8-strips) into the encapsulated incubator hole 12 of the incubator plate 1, with the connecting part of the reagent strip falling exactly into the groove 13.

[0039] 2. Place the warm bath plate 1 on the constant temperature heating device, and make close contact with the heating module through the bottom boss structure 15 to start heating and incubation.

[0040] 3. After incubation is complete, move the bath plate 1 onto the bath plate top plate 2. The bath plate 1 is accurately positioned under the action of the limiting stop 23.

[0041] 4. The weight of the bath plate 1 itself causes it to press down, and the bath plate body 11 will pass through the protruding structure 22 to push out all the reagent strips simultaneously, making it convenient for operators to take them out.

[0042] Example 2 This embodiment provides a heat bath plate and a heat bath plate ejector plate for matching a perforated plate heating device, including a heat bath plate 1 and a heat bath plate ejector plate 2. Preferably, this embodiment uses an 80-hole heat bath plate, which has a circular design. Figure 5As shown, the bath plate 1 in this embodiment also includes a bath plate body 11 made of a highly thermally conductive material. Unlike Embodiment 1, the bath plate body 11 in this embodiment has a circular structure. Multiple bath holes 12 are arranged in a ring on the circular bath plate body 11 in a concentric circle arrangement. To accommodate multi-unit reagent strips, grooves 13 are provided between adjacent bath holes 12, arranged radially along the bath plate body 11. These grooves extend radially from the inner circle to the outer circle to accommodate the connecting portion of the reagent strips. In this embodiment, the bottom of the bath plate body 11 can have a flat bottom structure to accommodate the flat circular heating module, and its outer peripheral edge can also be chamfered 14 for easy placement and removal.

[0043] like Figure 6 and Figure 7 As shown, the hot water bath plate 2, which is matched with the circular hot water bath plate 1, is also circular in design. Its ejector plate body 21 has multiple protruding structures 22, and the arrangement of these protruding structures 22 is similar to... Figure 5 The annular arrangement of the medium-temperature bath holes 12 corresponds to ensure precise alignment and ejection of the reagent strip. Unlike Embodiment 1, the positioning structure in this embodiment is an integrally formed limiting baffle 23, which protrudes upwards along the outer edge of the ejector plate body 21. The inner diameter of the limiting baffle 23 matches the outer diameter of the circular bath plate 1, allowing the bath plate 1 to be precisely placed within the circular area defined by the annular baffle 23, thus achieving stable and reliable positioning.

[0044] The usage of this embodiment is similar to that of Embodiment 1. After incubation, the circular bath plate 1 is placed on the circular bath plate ejector plate 2. The bath plate 1 is accurately positioned under the guidance of the annular baffle 23. Its own gravity will cause the protruding structure 22 to pass through the through bath hole 12, and push out all the reagent strips at the same time, making it convenient for operators to take them out.

[0045] The above specific embodiments are only used to illustrate the technical solution of this utility model and are not intended to limit it. Although this utility model has been described in detail with reference to examples, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solution of this utility model without departing from the scope of the technical solution of this utility model, and all such modifications or substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A heat bath plate for use with a perforated plate heating device, comprising a heat bath plate body, characterized in that: The bath plate body is integrally formed from a material with good thermal conductivity. The bath plate body is provided with a plurality of bath holes, which are arranged through the bath plate body to accommodate reagent card strips, and the sidewalls of the bath holes surround and fit the sidewalls of the reagent card strips. The bath plate body is also provided with a groove, which is located between adjacent bath holes and is used to accommodate the connecting part of the reagent card strip.

2. A bath plate for matching a perforated plate heating device according to claim 1, characterized in that: The bath plate body can be rectangular or circular.

3. A bath plate for matching a perforated plate heating device according to claim 2, characterized in that: When the hot water bath plate body is rectangular, the multiple hot water bath holes are distributed in a matrix on the hot water bath plate body; Alternatively, when the bath plate body is circular, the plurality of bath holes are arranged in a ring on the bath plate body.

4. A bath plate for matching a perforated plate heating device according to claim 2, characterized in that: When the bath plate body is rectangular, the grooves are arranged longitudinally along the bath plate body, or transversely along the bath plate body, or simultaneously along both the longitudinal and transverse directions of the bath plate body, to accommodate multi-unit reagent strips. Alternatively, when the bath plate body is circular, the grooves are arranged radially along the bath plate body to accommodate multi-unit reagent strips.

5. A bath plate for matching a perforated plate heating device according to claim 1, characterized in that: At least one side of the bath plate body is chamfered.

6. A bath plate for matching a perforated plate heating device according to claim 1, characterized in that: The bottom of the bath plate body is provided with an integrally formed boss structure or flat bottom structure, which is used to adapt to the heating module of the heating device.

7. A bath plate for matching a perforated plate heating device according to claim 1, characterized in that: The thermal conductivity of the thermally conductive material is greater than or equal to 50 W / (m·K).

8. A bath plate for matching a perforated plate heating device according to claim 7, characterized in that: The thermally conductive material is selected from metals, thermally conductive ceramics, or thermally conductive polymers.

9. A bath plate ejector plate for use with a perforated plate heating device, used in conjunction with a bath plate for use with a perforated plate heating device as described in any one of claims 1 to 8, characterized in that: The hot bath ejector plate includes an ejector plate body, on which a plurality of protrusions are provided. The arrangement of the plurality of protrusions corresponds to the arrangement of the hot bath holes, and is used to eject the reagent strip contained in the hot bath holes through the hot bath holes.

10. A bath plate ejector plate for matching a perforated plate heating device according to claim 9, characterized in that: The ejector plate body is also provided with a positioning structure, which is a limiting stop edge set at the four corners of the ejector plate body. The limiting stop edge is higher than the horizontal height of the hot bath ejector plate.

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