A fermentation tank convenient for multi-level sampling for medical experiments

Abstract

The utility model discloses a kind of fermentation tanks for medical test with multiple levels sampling convenient, it is related to fermentation tank technical field.The utility model includes tank body: tank body is separately provided with feeding and discharging assembly, stirring assembly, driving assembly, transmission assembly and sampling assembly;The utility model rotates by starting driving assembly driving output end installed transmission assembly, to make transmission assembly drive internal installation sampling assembly to rotate, when sampling assembly rotates, according to its rotation angle can be opened and closed with the communication of tank body internal depth, to be fixedly installed by external extraction pump and sampling assembly, and start extraction pump cooperation sampling assembly to the culture of different depth inside tank body is extracted, and sampling assembly is in the state of not extraction closed state, to be able to avoid the culture of agglomeration and deposition to cause sampling assembly blockage, and cooperation stirring assembly scatters the culture of agglomeration and deposition, to improve the sampling efficiency of culture.

Description

Technical Field

[0001] This utility model belongs to the field of fermentation tank technology, and specifically relates to a fermentation tank for pharmaceutical experiments that facilitates multi-level sampling. Background Technology

[0002] Pharmaceutical experimental fermenters are mainly used to culture bacteria, yeast, mammalian cells or insect cells in a controlled environment to produce recombinant proteins, antibodies, vaccines, enzymes, antibiotics, viral vectors, etc.

[0003] In existing technologies, sampling pipes are typically installed inside fermenters to facilitate sampling of the cultures inside. However, during the growth process, cells are prone to clumping or culture medium precipitation. Consequently, when sampling the cultures, the clumps and precipitates can easily block one end of the sampling pipe, thus reducing the sampling efficiency. Utility Model Content

[0004] In view of the problem that cells in culture easily clump together or culture medium precipitates during the growth process, which can easily cause blockage of one end of the sampling tube when sampling the culture, thus reducing the sampling efficiency, this utility model proposes a fermenter for pharmaceutical experiments that facilitates multi-level sampling, in order to overcome the above-mentioned technical problems existing in the existing related technologies.

[0005] To solve the above-mentioned technical problems, this utility model is achieved through the following technical solution: This utility model relates to a fermentation tank for pharmaceutical testing that facilitates multi-level sampling, comprising a tank body: The tank is equipped with loading and unloading components, stirring components, driving components, transmission components, and sampling components. The loading and unloading assembly is internally connected to the interior of the tank, enabling the loading and unloading assembly to feed or discharge materials into the tank. The stirring assembly is fixedly installed at its bottom end to the top end of the tank so that the stirring assembly can agitate the culture inside the tank. The drive component has its output end fixedly installed inside the transmission component so that the drive component can drive the transmission component to rotate; The sampling component is fixedly mounted on its outer surface to the interior of the transmission component, so that the transmission component drives the sampling component to rotate, thereby opening and closing the sampling end of the sampling component.

[0006] Furthermore, the loading and unloading assembly includes a loading pipe and a unloading pipe. The bottom end of the loading pipe is fixedly connected to the top end of the tank, and the top end of the unloading pipe is fixedly connected to the bottom end of the tank. A solenoid valve is fixedly installed inside the unloading pipe.

[0007] Furthermore, the stirring assembly includes a mounting frame, the bottom end of which is fixedly mounted to the top end of the tank, a first motor is fixedly mounted on the top end of the mounting frame, a rotating rod is fixedly mounted on the output end of the first motor, and a stirring rod is fixedly mounted on the outer surface of the rotating rod.

[0008] Furthermore, the drive assembly includes a mounting plate, one side of which is fixedly connected to the inner wall of the tank, and a second motor is fixedly mounted on the top of the mounting plate.

[0009] Furthermore, the transmission assembly includes a drive gear, the interior of which is fixedly mounted to the output end of the second motor, and a driven gear is meshed with the surface of the drive gear.

[0010] Furthermore, the sampling assembly includes a mounting base, one side of which is fixedly connected to the inner wall of the tank. An installation cylinder is fixedly connected inside the mounting base, and a sampling tube is fixedly connected inside the installation cylinder. A sealing cylinder is rotatably connected to the outer surface of the installation cylinder. A through hole is opened on the outer surface of the sealing cylinder, and the outer surface of the sealing cylinder is fixedly installed inside the driven gear.

[0011] Furthermore, a protective shell is fixedly connected to the inner wall of the tank, and a sealing plate is fixedly installed on the top of the protective shell.

[0012] This utility model has the following beneficial effects: 1. This utility model drives the transmission component installed at the output end of the start-up drive component to rotate, so that the transmission component drives the sampling component installed inside to rotate. When the sampling component rotates, it can open and close according to its rotation angle and the connection point of the tank's internal depth. Thus, the external extraction pump is fixedly installed with the sampling component, and the extraction pump is started to work with the sampling component to extract the culture at different depths inside the tank. The sampling component is in a closed state when not extracting, which can avoid the sampling component from being blocked by agglomerated and deposited culture. The stirring component is used to disperse the agglomerated and deposited culture, thereby improving the sampling efficiency of the culture.

[0013] 2. This utility model drives the output end of the second motor to rotate the active gear, which in turn drives the driven gear meshing with the surface to rotate. This drives the internally installed sealing cylinder to rotate, which in turn drives the through holes on the outer surface to rotate. This allows multiple sets of through holes to correspond sequentially with the inlets of multiple sampling tubes, thus enabling the sampling of cultures at different depths inside the tank.

[0014] Of course, any product implementing this utility model does not necessarily need to achieve all of the above advantages at the same time. Attached Figure Description

[0015] To more clearly illustrate the technical solutions of the utility model embodiments, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is a schematic diagram of the internal structure of the tank of this utility model; Figure 3 This is a schematic diagram of the internal structure of the protective shell of this utility model; Figure 4 For the present utility model Figure 3 Enlarged schematic diagram of the local structure at point A; Figure 5 This is an exploded view of the sampling component of this utility model; Figure 6 For the present utility model Figure 5 An enlarged schematic diagram of the local structure at point B.

[0017] The attached diagram lists the components represented by each number as follows: 1. Tank body; 2. Loading and unloading assembly; 201. Loading pipe; 202. Unloading pipe; 203. Solenoid valve; 3. Agitator assembly; 301. Mounting bracket; 302. First motor; 303. Rotating rod; 304. Agitating rod; 4. Drive assembly; 401. Mounting plate; 402. Second motor; 5. Transmission assembly; 501. Drive gear; 502. Driven gear; 6. Sampling assembly; 601. Mounting base; 602. Mounting cylinder; 603. Sampling tube; 604. Sealing cylinder; 605. Through hole; 7. Protective shell; 8. Sealing plate. Detailed Implementation

[0018] The technical solutions of the utility model embodiments will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the utility model, and not all embodiments. Based on the embodiments of the utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the utility model.

[0019] In the description of this utility model, it should be understood that the terms "opening", "upper", "lower", "top", "middle", "inner", etc., which indicate orientation or positional relationship, are only for the convenience of describing the utility model and simplifying the description, and do not indicate or imply that the components or elements referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the utility model.

[0020] Please see Figures 1-6 As shown, this utility model is a fermentation tank for pharmaceutical experiments that facilitates multi-level sampling, including a tank body 1: The tank body 1 is equipped with a loading and unloading assembly 2, a stirring assembly 3, a driving assembly 4, a transmission assembly 5, and a sampling assembly 6. The loading and unloading assembly 2 is internally connected to the interior of the tank 1, so that the loading and unloading assembly 2 can load or unload materials into the tank 1; The stirring assembly 3 is fixedly installed at its bottom end to the top end of the tank 1 so that the stirring assembly 3 can agitate the culture inside the tank 1. The drive assembly 4 is fixedly installed inside the transmission assembly 5 at its output end, so that the drive assembly 4 drives the transmission assembly 5 to rotate. The sampling component 6 is fixedly installed on its outer surface and inside the transmission component 5 so that the transmission component 5 drives the sampling component 6 to rotate, thereby opening and closing the sampling end of the sampling component 6.

[0021] In use, the loading and unloading assembly 2 is added into the tank 1, facilitating the removal of the cultured material inside the tank 1. When sampling the culture inside the tank 1, the stirring assembly 3 is activated to agitate the culture inside the tank 1, thereby breaking up any agglomerated or deposited culture. Then, the drive assembly 4 is activated to drive the transmission assembly 5 installed at the output end to rotate, which in turn drives the sampling assembly 6 installed inside the tank to rotate. When the sampling assembly 6 rotates, it can open and close at the connection point between its rotation angle and the depth inside the tank 1. An external extraction pump is fixedly installed with the sampling assembly 6, and the extraction pump is activated to work with the sampling assembly 6 to extract the culture at different depths inside the tank 1, which is quite convenient.

[0022] This invention uses a drive assembly 4 to drive the transmission assembly 5 installed at the output end to rotate, which in turn drives the sampling assembly 6 installed inside to rotate. When the sampling assembly 6 rotates, it can open and close at the connection point of the tank 1 according to its rotation angle. Thus, an external extraction pump is fixedly installed with the sampling assembly 6, and the extraction pump is started to work with the sampling assembly 6 to extract cultures at different depths inside the tank 1. The sampling assembly 6 is in a closed state when not extracting, which can prevent the sampling assembly 6 from being blocked by agglomerated and deposited cultures. In conjunction with the stirring assembly 3, agglomerated and deposited cultures are dispersed, thereby improving the sampling efficiency of cultures.

[0023] In one embodiment, the loading and unloading assembly 2 includes a loading pipe 201 and a unloading pipe 202. The bottom end of the loading pipe 201 is fixedly connected to the top end of the tank body 1, and the top end of the unloading pipe 202 is fixedly connected to the bottom end of the tank body 1. A solenoid valve 203 is fixedly installed inside the unloading pipe 202.

[0024] The culture is added into the tank 1 through the feeding pipe 201, which facilitates the culture to be cultured inside the tank 1. After culture, the culture can flow out from one end of the feeding pipe 202 through the tank 1 with the opening of the solenoid valve 203, which facilitates the discharge of the culture after culture is completed.

[0025] In one embodiment, the stirring assembly 3 includes a mounting frame 301. The bottom end of the mounting frame 301 is fixedly installed to the top end of the tank 1. A first motor 302 is fixedly installed at the top end of the mounting frame 301. A rotating rod 303 is fixedly installed at the output end of the first motor 302. A stirring rod 304 is fixedly installed on the outer surface of the rotating rod 303.

[0026] The first motor 302 is started to drive the rotating rod 303 installed at the output end to rotate, so that the rotating rod 303 drives the stirring rod 304 installed on the outer surface to rotate. Since the rotating rod 303 and the stirring rod 304 are both located inside the tank 1, when the stirring rod 304 rotates, it can stir the culture inside the tank 1.

[0027] In one embodiment, the drive assembly 4 includes a mounting plate 401, one side of which is fixedly connected to the inner wall of the tank 1, and a second motor 402 is fixedly mounted on the top of the mounting plate 401.

[0028] The mounting plate 401 is designed to support the second motor 402 mounted at the top, thereby ensuring the stability of the second motor 402 during operation.

[0029] In one embodiment, the transmission component 5 includes a drive gear 501, the interior of which is fixedly mounted to the output end of the second motor 402, and the surface of the drive gear 501 is meshed with a driven gear 502.

[0030] The second motor 402 drives the active gear 501 installed at the output end to rotate, so that the active gear 501 drives the driven gear 502 that is surface-meshing to rotate. Since the second motor 402 is a servo motor, it can work with the active gear 501 to drive the driven gear 502 to rotate at a precise angle, thereby improving the stability of the driven gear 502 during rotation.

[0031] In one embodiment, the sampling component 6 includes a mounting base 601. One side of the mounting base 601 is fixedly connected to the inner wall of the tank 1. An installation cylinder 602 is fixedly connected inside the mounting base 601. A sampling tube 603 is fixedly connected inside the installation cylinder 602. A sealing cylinder 604 is rotatably connected to the outer surface of the installation cylinder 602. A through hole 605 is opened on the outer surface of the sealing cylinder 604. The outer surface of the sealing cylinder 604 is fixedly installed inside the driven gear 502.

[0032] Four sets of through holes 605 are arranged in an upper and lower circumference, and each corresponds to one end of a sampling tube 603. When the driven gear 502 rotates with the rotation of the driving gear 501, the driven gear 502 drives the internally installed sealing cylinder 604 to rotate, which in turn drives the through holes 605 on the outer surface to rotate. This allows multiple sets of through holes 605 to correspond sequentially to the inlets of multiple sets of sampling tubes 603, thus enabling the sampling of cultures at different depths inside the tank 1.

[0033] In one embodiment, for the tank 1 described above, a protective shell 7 is fixedly connected to the inner wall of the tank 1, and a sealing plate 8 is fixedly installed on the top of the protective shell 7.

[0034] The protective shell 7 and the sealing plate 8 are both located on the outside of the second motor 402 to isolate the second motor 402 from the inner wall of the tank 1, thereby preventing the operation of the second motor 402 from affecting the culture inside the tank 1.

[0035] Through the above technical solution, 1. The drive component 4 drives the transmission component 5 installed at the output end to rotate, so that the transmission component 5 drives the sampling component 6 installed inside to rotate. When the sampling component 6 rotates, it can open and close according to its rotation angle and the communication point of the depth inside the tank 1. Thus, the external extraction pump is fixedly installed with the sampling component 6, and the extraction pump is started to cooperate with the sampling component 6 to extract the culture at different depths inside the tank 1. The sampling component 6 is in a closed state when it is not being extracted, which can avoid the clogging of the sampling component 6 by the agglomerated and deposited culture. In addition, the stirring component 3 is used to disperse the agglomerated and deposited culture, thereby improving the sampling efficiency of the culture. 2. By starting the second motor 402, the drive gear 501 installed at the output end is driven to rotate, so that the drive gear 501 drives the driven gear 502 that is meshed with the surface to rotate. This drives the internally installed sealing cylinder 604 to rotate, so that the sealing cylinder 604 drives the through hole 605 opened on the outer surface to rotate. This allows multiple sets of through holes 605 to correspond to the inlets of multiple sets of sampling tubes 603 in sequence, thereby enabling the sampling of cultures at different depths inside the tank 1.

[0036] In the description of this specification, references to terms such as "an embodiment," "example," "specific example," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the utility model. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0037] The preferred embodiments of the utility model disclosed above are merely illustrative of the utility model. These preferred embodiments do not exhaustively describe all details, nor do they limit the utility model to any specific implementation. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the utility model, thereby enabling those skilled in the art to better understand and utilize it. The utility model is limited only by the claims and their full scope and equivalents.

Claims

1. A fermenter for pharmaceutical trials, facilitating multi-level sampling, comprising a tank body (1), characterized in that: The tank body (1) is equipped with a loading and unloading assembly (2), a stirring assembly (3), a driving assembly (4), a transmission assembly (5), and a sampling assembly (6). The loading and unloading assembly (2) is connected to the interior of the tank (1) so that the loading and unloading assembly (2) can load or unload materials into the tank (1); The bottom end of the stirring assembly (3) is fixedly installed to the top end of the tank (1) so that the stirring assembly (3) can stir the culture inside the tank (1); The drive assembly (4) is fixedly installed inside the transmission assembly (5) at its output end, so that the drive assembly (4) drives the transmission assembly (5) to rotate; The sampling component (6) is fixedly installed on its outer surface and inside the transmission component (5) so that the transmission component (5) drives the sampling component (6) to rotate, so as to open and close the sampling end of the sampling component (6); The drive assembly (4) includes a mounting plate (401), one side of which is fixedly connected to the inner wall of the tank (1), and a second motor (402) is fixedly installed on the top of the mounting plate (401). The transmission assembly (5) includes a drive gear (501), the interior of which is fixedly installed with the output end of the second motor (402), and the surface of the drive gear (501) is meshed with a driven gear (502). The sampling assembly (6) includes a mounting base (601), one side of which is fixedly connected to the inner wall of the tank (1). An installation cylinder (602) is fixedly connected inside the mounting base (601), and a sampling tube (603) is fixedly connected inside the installation cylinder (602). A sealing cylinder (604) is rotatably connected to the outer surface of the installation cylinder (602). A through hole (605) is opened on the outer surface of the sealing cylinder (604), and the outer surface of the sealing cylinder (604) is fixedly installed inside the driven gear (502).

2. The fermenter for pharmaceutical testing facilitating multi-level sampling according to claim 1, characterized in that, The loading and unloading assembly (2) includes a loading pipe (201) and a unloading pipe (202). The bottom end of the loading pipe (201) is fixedly connected to the top end of the tank (1), and the top end of the unloading pipe (202) is fixedly connected to the bottom end of the tank (1). A solenoid valve (203) is fixedly installed inside the unloading pipe (202).

3. A fermenter for pharmaceutical testing that facilitates multi-level sampling according to claim 1, characterized in that, The stirring assembly (3) includes a mounting bracket (301), the bottom end of which is fixedly installed to the top end of the tank (1), a first motor (302) is fixedly installed at the top end of the mounting bracket (301), a rotating rod (303) is fixedly installed at the output end of the first motor (302), and a stirring rod (304) is fixedly installed on the outer surface of the rotating rod (303).

4. A fermenter for pharmaceutical testing that facilitates multi-level sampling according to claim 1, characterized in that, The inner wall of the tank (1) is fixedly connected to a protective shell (7), and a sealing plate (8) is fixedly installed on the top of the protective shell (7).

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