An isolated seal device

Abstract

The utility model provides a kind of isolation sealing device, it is related to mechanical equipment technical field, the isolation sealing device includes: rack, sealed box, air purification component, sealed box is fixedly installed on rack, production equipment is sealedly installed in sealed box, sealed box is sealedly welded with rack, air purification component is communicated with sealed box and is sealedly set in connecting place, air purification component is fixedly installed on rack. Form closed space by sealed box and rack sealed welding, cooperate air purification component to realize the efficient isolation and purification of toxic preparation production environment, with the advantages of improving production area sealing isolation, enhancing air purification effect, guaranteeing operating safety.

Description

Technical Field

[0001] This utility model relates to the field of mechanical equipment technology, and in particular to an isolation and sealing device. Background Technology

[0002] In the pharmaceutical packaging industry, especially in cases involving the production of toxic preparations, the requirements for a sealed and isolated production environment are extremely high.

[0003] Existing technologies, such as continuous blow-fill-seal machines, have significant drawbacks when producing toxic preparations, failing to effectively isolate and seal the production area. This not only risks product contamination but also poses a threat to the safety of operators. While aseptic isolation systems offer a degree of protection, they still suffer from insufficient sealing and inadequate air purification in practical applications. Particularly when handling highly allergenic and toxic drugs, existing systems struggle to simultaneously meet the multiple requirements of airtight isolation, air purification, and environmental parameter monitoring.

[0004] Furthermore, existing devices often lack real-time monitoring capabilities for the internal environmental parameters of the sealed enclosure, making it impossible to promptly grasp changes in key parameters such as air pressure, temperature, and humidity. These problems severely restrict the safety and reliability of toxic agent production, necessitating a solution that can achieve comprehensive sealing and isolation, efficient air purification, and real-time monitoring of multiple parameters. Utility Model Content

[0005] The purpose of this invention is to provide an isolation and sealing device that has the advantages of improving the sealing and isolation of the production area, enhancing the air purification effect, and ensuring operational safety.

[0006] To achieve the above objectives, the present invention adopts the following technical solution:

[0007] The isolation and sealing device according to an embodiment of the present utility model includes: a frame, a sealing box, and an air purification component. The sealing box is fixedly installed on the frame, and the production equipment is sealed and installed inside the sealing box. The sealing box is sealed and welded to the frame. The air purification component is connected to the sealing box and the connection is sealed. The air purification component is fixedly installed on the frame.

[0008] According to the embodiment of this utility model, the isolation and sealing device forms a closed space by sealing the box and the frame through sealing welding. Combined with the air purification component, it achieves efficient isolation and purification of the toxic agent production environment. It has the advantages of improving the sealing and isolation of the production area, enhancing the air purification effect, and ensuring operational safety.

[0009] In addition, the isolation and sealing device according to the above embodiments of this application may also have the following additional technical features:

[0010] In some embodiments of this utility model, the air purification component includes an air intake module, a first duct, and a purification module. The air intake module is installed on the sealed box and communicates with the sealed box. The first duct connects the sealed box module and the purification module, and the connection point of the first duct and the sealed box is located away from the connection point of the air intake module and the sealed box. The second duct connects the purification module and the external environment.

[0011] In some embodiments of this utility model, the purification module is provided with at least one air outlet, and the gas purified by the purification module is discharged to the external environment from the air outlet.

[0012] In some embodiments of this utility model, the air purification component further includes a second pipe, which is connected to the air outlet to direct the gas discharged by the purification module to a designated location.

[0013] In some embodiments of this utility model, the isolation and sealing device further includes a mounting box, which is fixedly installed on the frame and located close to the sealing box. The production equipment is sealed and installed inside the sealing box and the mounting box, and the sealing box is in communication with the mounting box.

[0014] In some embodiments of this utility model, the installation box is provided with the purification module, and the purification module is connected to the installation box.

[0015] In some embodiments of this utility model, the air intake module is provided with an air inlet, which connects the air intake module and the external environment. Air is drawn into the sealed box from the air inlet, flows out from the first pipe, is purified by the purification module, and is discharged through the second pipe.

[0016] In some embodiments of this utility model, multiple air purification components are provided, and multiple air purification components are connected to the sealed box.

[0017] In some embodiments of this utility model, the isolation sealing device further includes a detection component, the detection component comprising:

[0018] A pressure detection element is installed inside the sealed box to detect the air pressure inside the sealed box.

[0019] A temperature sensing element is installed inside the sealed box to detect the internal ambient temperature of the sealed box.

[0020] A humidity detection device, which is installed inside the sealed box to detect the humidity of the environment inside the sealed box;

[0021] An air velocity sensor is installed inside the sealed box to detect the flow rate of the gas input into the sealed box by the air intake module.

[0022] In some embodiments of this utility model, the isolation and sealing device further includes a control system, which is electrically or communicatively connected to the air purification component and the detection component.

[0023] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the isolation and sealing device structure according to an embodiment of the present utility model. Figure 1 ;

[0025] Figure 2 This is a schematic diagram of the isolation and sealing device structure according to an embodiment of the present utility model. Figure 2 ;

[0026] Figure 3 This is a schematic diagram of the isolation and sealing device structure according to an embodiment of the present utility model. Figure 3 .

[0027] Figure Labels

[0028] 100. Isolation and sealing device; 1. Frame; 2. Sealing box; 3. Air purification component; 4. Air inlet module; 5. First duct; 6. Purification module; 7. Air outlet; 8. Second duct; 9. Mounting box; 10. Air inlet; 11. Through passage. Detailed Implementation

[0029] The following is a more detailed description of an isolation and sealing device according to the present invention, with reference to the accompanying drawings, which illustrate preferred embodiments of the present invention. It should be understood that those skilled in the art can modify the present invention described herein while still achieving its advantageous effects. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit the present invention.

[0030] In the description of this specification, terms such as "one embodiment" or "some embodiments" mean that one or more embodiments of this specification include a particular feature, structure, or characteristic described in connection with that embodiment. Therefore, the phrases "in one embodiment," "in some embodiments," "in other embodiments," "in still other embodiments," etc., appearing in different parts of this specification do not necessarily refer to the same embodiment, but rather mean "one or more, but not all, embodiments," unless otherwise specifically emphasized.

[0031] The embodiments of this application are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0032] In existing technologies, aseptic isolation systems used in continuous blow-fill-seal machines have long suffered from insufficient protective capabilities. Traditional equipment lacks effective airtight isolation measures when producing toxic agents, resulting in a high risk of operator exposure to toxic substances. Existing technologies often employ partial shielding or simple negative pressure designs, which cannot achieve complete closed-loop control of the production area. This is especially prone to seal failure under equipment vibration, leading to cross-contamination and occupational health hazards.

[0033] To address these issues, a complete physical barrier must first be established to block the diffusion path of toxic substances. Considering the operational stability of the production equipment, the isolation structure must be rigidly connected to the equipment frame. Furthermore, a closed-loop air handling system needs to be designed to maintain cleanliness while preventing contaminant leakage. By fully integrating the production equipment and employing a sealed welding process, the integrity of the isolation space can be ensured. Directly fixing the air purification components to the frame reduces the impact of vibration transmission on sealing performance.

[0034] Therefore, this application proposes an isolation sealing device 100, and the isolation sealing device according to an embodiment of this application is described below with reference to the accompanying drawings.

[0035] According to the embodiment of the present utility model, the isolation and sealing device 100, such as Figure 1 As shown, it includes: a frame 1, a sealed box 2, and an air purification component 3. The sealed box 2 is fixedly installed on the frame 1, and the production equipment is sealed and installed inside the sealed box 2. The sealed box 2 is sealed and welded to the frame 1. The air purification component 3 is connected to the sealed box 2 and the connection is sealed. The air purification component 3 is fixedly installed on the frame 1.

[0036] The frame 1 refers to the supporting structure of the main body of the load-bearing device, which can be implemented using a steel frame structure to provide a stable installation foundation. The sealed box 2 refers to the enclosed space surrounding the production equipment, which can be implemented using a stainless steel welded box body, forming an airtight isolation environment through full-circumference welding. The air purification component 3 refers to the system that maintains the air quality inside the box, which can be implemented using a multi-stage filtration device, and its sealed connection with the sealed box 2 prevents gas leakage.

[0037] Specifically, the production equipment is completely enclosed within the sealed box 2 welded to the frame 1, forming a physical isolation layer. The rigid structure of the frame 1 effectively absorbs the vibration energy generated during equipment operation, preventing weld cracks due to long-term stress. The air purification component 3 is connected to the sealed box 2 through a sealed interface, forming an internal air circulation path. The purified air flows continuously in the closed-loop system, maintaining positive pressure inside the box to prevent the intrusion of external pollutants and promptly treating toxic aerosols generated during production. The air purification component 3 is directly fixed to the frame 1, reducing the impact of pipeline vibration on the connection points of the sealed box 2 and ensuring long-term operational reliability.

[0038] Compared to existing technologies, traditional solutions relying on localized negative pressure suction struggle to achieve comprehensive protection, while this solution completely isolates the production area through an integrated sealed structure. Existing air purification systems are often independently configured; compared to the purification components integrated with the frame 1 in this solution, there is a risk of vibration transmission causing interface loosening. Furthermore, traditional welding processes are only used for structural connections; this solution uses sealed welding as the core protection method, significantly improving isolation reliability.

[0039] Through the above technical solutions, this application achieves completely closed-loop operation in the production process of toxic agents, effectively blocking the diffusion path of toxic substances. The integrated installation of production equipment and purification system reduces the impact of vibration on sealing performance, ensuring long-term operational stability. The closed-loop air purification system maintains a clean environment while preventing the discharge of pollutants, thus balancing product protection and personnel safety requirements.

[0040] In some embodiments of this utility model, such as Figure 1 , Figure 2 As shown, the air purification component 3 includes an air intake module 4, a first duct 5, and a purification module 6. The air intake module 4 is installed on the sealed box 2 and communicates with the sealed box 2. The first duct 5 connects the sealed box 2 module and the purification module 6, and the connection point of the first duct 5 and the sealed box 2 is located away from the connection point of the air intake module 4 and the sealed box 2. The second duct 8 connects the purification module 6 and the external environment.

[0041] The air intake module 4 is a device that introduces outside air into the sealed box 2, specifically using an axial flow fan or a centrifugal fan, to create a positive pressure environment within the sealed box 2. The first pipe 5 is a flow guide component connecting the sealed box 2 and the purification module 6, specifically using a corrugated metal pipe or a PVC pipe; its connection point away from the air intake module 4 extends the flow path of polluted gas within the sealed box 2. The purification module 6 is a device that filters the polluted gas, specifically using a HEPA filter or an activated carbon adsorption layer, to remove harmful substances from the gas. The second pipe 8 is a channel for discharging the purified gas, specifically using a flanged metal pipe, to directionally deliver the clean gas to a designated area.

[0042] Specifically, external air enters the sealed box 2 through the air intake module 4, forming an airflow circulation. Polluted gas flows with the airflow within the sealed box 2 to the inlet of the first pipe 5. Due to the spatial separation between the first pipe 5 and the installation position of the air intake module 4, the polluted gas must travel a relatively long flow path within the sealed box 2 to enter the purification module 6. After the purification module 6 performs multi-stage filtration of the polluted gas, clean gas is discharged to the external environment through the second pipe 8. This spatial layout design forces the gas to form a unidirectional flow pattern, preventing unpurified gas from escaping directly due to the close proximity of the air inlet 10 and the exhaust vent, while also extending the residence time of the polluted gas in the purification module 6.

[0043] Compared to existing technologies, traditional sealing devices typically use adjacent gas inlets and outlets, which can easily lead to airflow short-circuiting and reduced purification efficiency. This solution separates the installation positions of the air inlet module 4 and the first pipe 5, ensuring that polluted gas must follow a complete flow path before being discharged. This effectively eliminates localized circulation dead zones and ensures that all gas undergoes thorough purification.

[0044] Through the above technical solutions, this application can avoid the short-circuiting phenomenon of airflow in the sealed box 2, ensure full contact between polluted gas and purification medium, and improve the removal efficiency of harmful substances; control the flow trajectory of purified gas through directional emission channels to prevent secondary pollution of clean gas; and use spatial separation pipeline layout to form forced circulating airflow to maintain the internal air pressure balance of the sealed box 2.

[0045] In some embodiments of this utility model, such as Figure 1 As shown, the purification module 6 is provided with at least one air outlet 7, and the gas purified by the purification module 6 is discharged to the external environment from the air outlet 7.

[0046] The air outlet 7 refers to the gas emission channel located at the end of the purification module 6. Specifically, it can be implemented using a louvered structure or a directional airflow hood, with its opening direction aligned with the gas flow path. This structure creates a directional airflow by defining the gas emission path, preventing the purified gas from spreading disorderly within the sealed box 2.

[0047] The purification module 6 refers to a gas treatment device containing a filtration unit, which can be implemented using a combination of multi-stage HEPA filters and activated carbon adsorption layers. This module establishes a connection with the external environment through the air outlet 7, allowing the treated gas to directly exit the production area.

[0048] Specifically, after filtration, the gas inside the purification module 6 is forcibly discharged to the external environment through the directional channel formed by the air outlet 7. The number of air outlets 7 can be adjusted according to the processing capacity of the purification module 6; for example, multiple air outlets 7 can be used to divert the gas flow when the gas flow rate is large. The gas flow path is limited to a unidirectional path from inside the purification module 6 through the air outlet 7 to the external environment, thereby preventing the mixing of treated and untreated gas. The internal pressure of the purification module 6 is dynamically balanced through the connection between the air outlet 7 and the external environment, preventing gas stagnation caused by pressure buildup.

[0049] Compared to existing technologies, traditional purification devices do not have a directional air outlet 7, relying solely on natural diffusion to emit gases, resulting in toxic substances remaining within the sealed chamber 2. This application constructs a forced emission channel through the air outlet 7, creating a closed loop between the gas flow path and the purification process, eliminating the risk of secondary pollution caused by disordered gas flow. Existing purification modules 6 typically employ an open emission design, which cannot adapt to emission requirements of different environmental standards. In contrast, the air outlet 7 structure of this application allows for adjustment of the airflow direction according to the target emission location.

[0050] Through the above technical solution, this application achieves directional emission control of purified gas, effectively preventing toxic substances from remaining in the sealed box 2. The forced constraint of the gas flow path ensures that the processing efficiency and emission efficiency of the purification module 6 are matched, avoiding a decrease in purification capacity due to poor emission. The outlet 7 structure provides an adjustable emission interface for emission requirements of different environmental standards; for example, by changing the angle of the outlet 7, the gas can be directed to the upper atmosphere or a specific collection device.

[0051] In some embodiments of this utility model, such as Figure 1 , Figure 2 As shown, the air purification component 3 also includes a second pipe 8, which is connected to the air outlet 7 to direct the gas discharged by the purification module 6 to a designated location.

[0052] The second pipe 8 refers to the channel used to guide the directional discharge of purified gas. It can be implemented using a corrosion-resistant metal pipe or a flexible hose. The pipe diameter can be adjusted according to the gas flow rate. The pipe connection is sealed and fixed by flanges or clamps to ensure no leakage during gas transportation.

[0053] The designated location refers to a pre-set emission area or recovery system, which can be achieved by setting directional valves or branch pipelines at the end of the pipeline. The gas is transported to specific treatment equipment or safe areas according to the needs of the production environment, avoiding direct discharge into the operating space.

[0054] Specifically, after the purification module 6 completes gas purification, the clean gas enters the second pipe 8 from the air outlet 7. The smooth structure of the pipe's inner wall reduces flow resistance, allowing the gas to be transported along a preset path to a designated location. For example, in a pharmaceutical production setting, the second pipe 8 can centrally discharge the purified gas to a dedicated external treatment device or sterile area, preventing the diffusion of gases containing trace amounts of residual substances in the operating environment. The connection between the pipe and the air outlet 7 uses a sealing ring or welding process to ensure airtightness meets GMP requirements.

[0055] Compared with existing technologies, traditional purification systems usually directly discharge gas into the surrounding environment, causing trace amounts of harmful components that may be carried by the purified gas to remain in the operating area. In contrast, this solution uses the directional delivery function of the second pipeline 8 to strictly control the gas within a preset path, eliminating the risk of cross-contamination caused by disorderly discharge.

[0056] Through the above technical solution, this application realizes a controllable emission path for purified gas, effectively preventing secondary pollution from affecting operators and the external environment, while meeting the strict control requirements for gas emissions in high-cleanliness production scenarios and improving the resource utilization efficiency of the purification system.

[0057] In some embodiments of this utility model, such as Figure 1 , Figure 2 As shown, the isolation sealing device 100 also includes a mounting box 9, which is fixedly installed on the frame 1 and located close to the sealing box 2. The production equipment is sealed and installed inside the sealing box 2 and the mounting box 9, and the sealing box 2 is connected to the mounting box 9.

[0058] The mounting box 9 refers to an independent box structure arranged parallel to the sealing box 2. It can be fixed to the frame 1 by welding or bolting, and its internal space is used to expand and accommodate production equipment. The frame 1 refers to the supporting frame that bears the sealing box 2 and the mounting box 9. It can be formed by welding steel structures to maintain the mechanical stability of the overall device. Figure 3As shown, the connection between the sealing box 2 and the mounting box 9 means that a through channel 11 is provided between the two. The through channel 11 is sealed and welded to the connection between the sealing box 2 and the mounting box 9. Specifically, the through channel 11 can be set as a through hole structure, and the mounting box 9 and the sealing box 2 are tightly welded to improve the degree of integration.

[0059] Specifically, the mounting box 9 is fixed to the frame 1, forming a layout adjacent to the sealing box 2, with the production equipment divided and installed in two independent boxes. The sealing box 2 and the mounting box 9 are connected by a through channel, creating a continuous sealed environment that allows the airflow of the air purification component 3 to circulate within the expanded space. This sealed installation method within the dual-box configuration avoids single-box seal failure due to excessive equipment size and maintains overall air pressure balance through the interconnected design. The addition of the mounting box 9 makes the equipment layout scalable, adapting to different production scales while maintaining welded seals.

[0060] Compared to existing technologies, traditional solutions using a single sealed box 2 structure result in limited equipment installation space. When the production equipment is large, a forced compression layout is required, which can easily lead to the risk of seal failure. This solution adds the installation box 9 to form a modular sealed space, achieving space expansion while maintaining the welded seal strength, thus avoiding a decrease in protective performance due to structural limitations. The interconnected design solves the air pressure imbalance problem that may occur when multiple boxes are independently sealed, ensuring the efficient coverage of the expanded space by the purification components.

[0061] Through the above technical solution, this application achieves flexible expansion of the original sealed space, allowing production equipment to be distributed and installed without compromising the sealing performance. The linkage design between the installation box 9 and the sealing box 2 effectively balances the internal air pressure, preventing the formation of purification dead zones due to spatial division. The double-box sealing structure enhances the physical barrier against the diffusion of toxic agents, while providing an adjustable isolation space layout for equipment operation.

[0062] In some embodiments of this utility model, such as Figure 1 As shown, the installation box 9 is equipped with the purification module 6, and the purification module 6 is connected to the installation box 9.

[0063] The mounting box 9 refers to a box structure fixedly installed on the frame 1 and located close to the sealing box 2. Specifically, it can be implemented by combining a welded metal frame and sealing plates, used to accommodate some production equipment and form a communicating space with the sealing box 2. This structure, by limiting the proximity of the mounting box 9 and the sealing box 2, provides a physical support basis for the integration of the purification module 6.

[0064] The purification module 6 refers to a functional component used to filter or decompose pollutants. Specifically, it can be implemented using a multi-stage filtration device or an activated carbon adsorption system. Its connection interface with the mounting box 9 is fixed via a flange or sealing ring, forming a directional airflow channel. This design allows the purification module 6 to directly process pollutants generated inside the mounting box 9, avoiding the risk of secondary pollution during gas transmission.

[0065] Specifically, when the production equipment operates within the sealed enclosure 2 and the mounting enclosure 9, toxic gases or particulate matter generated enter the purification module 6 through the connection interface between the mounting enclosure 9 and the purification module 6. The purification module 6 adsorbs or decomposes the pollutants and then discharges the clean gas into the external environment. Because the purification module 6 is directly mounted on the mounting enclosure 9, the pollutant treatment path is shortened, reducing the residence time of gas in the transmission pipeline and thus lowering the probability of leakage. Simultaneously, the physical integration of the mounting enclosure 9 and the purification module 6 simplifies the equipment layout, allowing maintenance operations to be concentrated in the same area, avoiding the inefficiency caused by dispersed installations.

[0066] Compared to existing technologies, traditional solutions typically place the purification module 6 independently, far from the production area, resulting in polluted gases needing to be transported through long-distance pipelines, which are prone to leakage due to pipeline seal failure or pressure fluctuations. This solution, however, integrates the purification module 6 directly into the mounting box 9, creating a closed-loop, short-path circulation between the pollution source and the treatment module. This eliminates the risk of leakage during long-distance transmission and reduces the equipment's footprint through modular layout. Furthermore, the connection interface between the mounting box 9 and the purification module 6 employs a directional airflow design, further enhancing the forced introduction of pollutants.

[0067] Through the above technical solution, this application achieves rapid and targeted treatment of pollutants inside the installation box 9, effectively blocking the diffusion of toxic substances inside the equipment; at the same time, by shortening the purification path and modular integration design, the complexity of equipment maintenance is reduced, and the operational safety and pollution control efficiency in the production process of toxic agents are improved.

[0068] In some embodiments of this utility model, such as Figure 1 , Figure 2 As shown, the air intake module 4 is provided with an air inlet 10, which connects the air intake module 4 and the external environment. Air is drawn into the sealed box 2 from the air inlet 10, flows out from the first pipe 5, is purified by the purification module 6, and is discharged through the second pipe 8.

[0069] The air intake module 4 is a component used to control the entry of external air into the sealed box 2. Specifically, it can be implemented using a ventilation device with a filter, which can intercept particulate matter in the air. The air inlet 10 is an opening structure provided on the air intake module 4, which can be implemented using a one-way valve or a louver structure to prevent backflow of gas. The first pipe 5 is a flow guide component connecting the sealed box 2 and the purification module 6, which can be implemented using a stainless steel corrugated pipe. The corrugated pipe is flexible to adapt to different installation positions. The purification module 6 is a device for treating polluted air, which can be implemented using a combination structure of an activated carbon adsorption layer and a high-efficiency air filter. The activated carbon adsorption layer is used to remove gaseous pollutants, and the high-efficiency air filter is used to intercept microorganisms. The second pipe 8 is an exhaust component that guides the purified gas to the outside, which can be implemented using a metal pipe with a directional guide plate, which is used to control the direction of gas exhaust.

[0070] Specifically, when outside air enters the air intake module 4 through the air inlet 10, it undergoes preliminary filtration before entering the sealed box 2. The sealed box 2 contains polluted air generated by the production equipment. Under the influence of air pressure difference, the polluted air flows along the first pipe 5 to the purification module 6. The purification module 6 performs graded treatment on the toxic substances in the polluted air, and the treated clean gas is directionally discharged to a designated area through the second pipe 8. The first pipe 5 and the air inlet 10 are installed diagonally on the sealed box 2, forming a unidirectional airflow path from the air inlet 10 to the first pipe 5, preventing the purified gas from flowing back. The end of the second pipe 8 is equipped with an anti-backflow structure to ensure that the discharged gas does not re-enter the sealed box 2.

[0071] Compared to existing technologies, traditional equipment lacks closed-loop control of the airflow path, allowing unfiltered pollutants to enter from outside air, and posing a risk of cross-contamination between the purified gas emission path and the intake path. This solution, through a spatially separated layout of the air inlet 10 and exhaust duct, combined with forced airflow direction control, achieves complete interception and directional treatment of polluted air.

[0072] Through the above technical solution, this application can effectively prevent external pollutants from entering the sealed box 2 with the incoming air, ensuring that the production environment meets the sterility requirements. The purified gas is discharged to a designated location through an independent pipeline, avoiding secondary pollution caused by the mixing of purified gas and untreated gas. The spatial isolation design between the air inlet module 4 and the exhaust pipeline eliminates the possibility of cross-contamination of airflow, ensuring the safety of operators during the production of toxic agents.

[0073] In some embodiments of this utility model, such as Figure 1 , Figure 2As shown, there are multiple air purification components 3, and the multiple air purification components 3 are connected to the sealed box 2.

[0074] The multiple air purification components 3 refer to two or more purification units with independent gas handling capabilities. Specifically, this can be achieved by using a parallel-installed filtration system or a split-type purifier array, thereby expanding the system's processing capacity by increasing the number of purification units. The connection between the sealed box 2 and the interior of the sealed box 2 means that each purification component forms a gas exchange channel. This can be achieved through flange interfaces or sealed sleeve connections, ensuring the airtightness of the gas transmission path.

[0075] Specifically, multiple air purification components 3 are configured to operate synchronously in different areas of the sealed enclosure 2, with each independently controlled purification unit handling the airflow in its corresponding area. When there are differences in pollutant concentrations within the sealed enclosure 2, each purification component can adjust its operating status based on detection data, for example, activating more purification units in areas with higher airflow. A redundant structure is formed among the purification components; if one unit fails, the remaining units can automatically increase their processing capacity to maintain system operation.

[0076] Compared to existing technologies, traditional isolation devices typically only have a single purification component, and their purification capacity is limited by the size and power of the equipment, making it difficult to cover the entire area of ​​the large sealed box 2. This solution overcomes the bottleneck of single-machine processing through modular design, achieving distributed purification processing within the same space, while reducing the overall system failure risk through multi-node control.

[0077] Through the above technical solution, this application achieves rapid, zoned purification of polluting gases within the sealed box 2, ensuring that environmental parameters in different operating areas remain stable within safe thresholds. The coordinated operation of multiple purification components effectively eliminates airflow dead zones, preventing the accumulation of pollutants in localized areas. The system's redundant design ensures that the purification function will not be interrupted due to the failure of a single component during continuous production of highly toxic substances.

[0078] In some embodiments of this utility model, the isolation sealing device 100 further includes a detection component (not shown in the figure), the detection component comprising:

[0079] A pressure detection element (not shown in the figure) is installed inside the sealed box 2 to detect the air pressure inside the sealed box 2;

[0080] A temperature sensing element (not shown in the figure) is installed inside the sealed box 2 to detect the internal ambient temperature of the sealed box 2;

[0081] A humidity detection device (not shown in the figure) is installed inside the sealed box 2 to detect the humidity of the environment inside the sealed box 2;

[0082] An air velocity sensor (not shown in the figure) is installed inside the sealed box 2 to detect the flow rate of the gas input into the sealed box 2 by the air intake module 4.

[0083] The pressure detection device refers to a sensor used to measure the gas pressure inside the sealed box 2, specifically a piezoelectric sensor or a capacitive sensor, which continuously monitors gas pressure changes to determine the integrity of the sealing system. The temperature detection device refers to a device used to collect ambient temperature data inside the sealed box 2, specifically a thermocouple or a thermistor, providing basic parameters for process stability. The humidity detection device refers to an instrument used to measure the humidity of the air inside the sealed box 2, specifically a capacitive humidity sensor or a resistive humidity sensor, ensuring that the humidity in the pharmaceutical production environment is within a controlled range. The wind speed detection device refers to a device used to measure the flow rate of the gas input to the air inlet module 4, specifically a hot-wire anemometer or an ultrasonic anemometer, verifying the air exchange efficiency of the air purification system.

[0084] Specifically, the pressure detection device monitors the air pressure changes inside the sealed chamber 2 in real time to determine if there is a risk of gas leakage; the temperature detection device continuously collects temperature data inside the chamber to provide feedback on the equipment's operating status; the humidity detection device dynamically monitors the humidity inside the chamber to prevent excessive humidity from causing microbial growth; and the wind speed detection device measures the airflow speed input to the air intake module 4 to ensure that the airflow exchange between the toxic environment and the external environment meets safety standards. These four types of detection data form a closed-loop monitoring network through a signal transmission system. When any parameter exceeds a preset threshold, an alarm mechanism is triggered, achieving multi-dimensional real-time control of the production environment.

[0085] In some specific embodiments, the pressure sensor can be arranged in the top area of ​​the sealed box 2 to avoid equipment vibration interfering with measurement accuracy; the temperature sensor can be located near the heat source of the production equipment; the humidity sensor can be installed near the ventilation opening on the side wall of the sealed box 2; and the wind speed sensor can be integrated into the air outlet 7 of the air inlet module 4. The detection data can be transmitted to the central control system via wired or wireless means to form a visual monitoring interface.

[0086] Compared to existing technologies, current isolation devices rely solely on single-dimensional air pressure monitoring, which fails to comprehensively assess the safety of the production environment for toxic agents. This solution integrates four types of detection units—pressure, temperature, humidity, and wind speed—to construct a composite monitoring system covering both physical parameters and airflow dynamics. This overcomes the technical limitations of traditional equipment in simultaneously monitoring multi-dimensional environmental parameters, enabling the isolation system to achieve the environmental control precision required by Good Manufacturing Practices (GMP) for pharmaceuticals.

[0087] Through the above technical solution, this application realizes synchronous real-time monitoring of the internal air pressure, temperature, humidity and airflow velocity of the sealed box 2, effectively identifying risks such as abnormal air pressure fluctuations, temperature and humidity deviations and insufficient airflow velocity, ensuring that the safety protection of operators and product quality control during the production of toxic preparations meet the mandatory standards of aseptic isolation systems, and meeting the dynamic monitoring requirements of closed environment parameters for the production of highly allergenic drugs.

[0088] In some embodiments of this utility model, the isolation sealing device 100 further includes a control system, which is electrically or communicatively connected to the air purification component 3 and the detection component.

[0089] The control system refers to an integrated module that can receive detection signals and output control commands. Specifically, it can be implemented using a programmable logic controller or an industrial computer to coordinate the logical relationship between environmental parameter acquisition and the operation of the purification equipment.

[0090] Electrical connection refers to physical circuit connection through cables or circuit boards, which can be achieved using RS485 bus or analog signal interface to ensure stable transmission of detection data and control commands.

[0091] Among them, communication connection refers to the data transmission channel established based on wireless or wired protocols, which can be implemented using Wi-Fi modules or industrial Ethernet modules, providing expansion possibilities for remote monitoring and multi-device networking.

[0092] Specifically, the pressure sensor, temperature sensor, humidity sensor, and wind speed sensor in the detection component continuously collect environmental data inside the sealed box 2 and transmit the measured values ​​to the control system. The control system controls the air intake volume by adjusting the speed of the air intake fan of the air purification component 3 according to a preset safety threshold range, while simultaneously adjusting the filtration power of the purification module 6. When an abnormal air pressure is detected, the control system can simultaneously control multiple air purification components 3 to work together to maintain the pressure difference balance inside and outside the box. The communication connection allows operators to view environmental parameter curves in real time in the control room and trigger an audible and visual alarm when parameters exceed limits.

[0093] Compared to existing technologies, traditional isolation devices rely on manual, periodic inspections of environmental parameters, resulting in response lag and insufficient adjustment precision. This solution utilizes a closed-loop control system to achieve coordinated control of environmental parameters and purification equipment, eliminating human error and automatically initiating enhanced purification procedures at the initial stage of toxic substance leakage, thus preventing the risk of pollutant spread.

[0094] Through the above technical solution, this application can monitor the air pressure fluctuations inside the sealed box 2 in real time, dynamically match the operating power of the purification equipment, and prevent the leakage of toxic gases from endangering operators. While maintaining a slightly positive pressure state in the box, it avoids energy waste caused by continuous maximum power operation, achieving a balance between safety protection and operating costs.

[0095] It should be understood that the specific embodiments described above are merely illustrative or explanatory of the principles of this utility model and do not constitute a limitation thereof. Therefore, any modifications, equivalent substitutions, improvements, etc., made without departing from the spirit and scope of this utility model should be included within its protection scope. Furthermore, the appended claims are intended to cover all variations and modifications falling within the scope and boundaries of the appended claims, or equivalent forms of such scope and boundaries.

Claims

1. An isolation and sealing device, characterized in that, include: The equipment includes a frame, a sealed box, and an air purification component. The sealed box is fixedly installed on the frame, and the production equipment is sealed inside the sealed box. The sealed box is sealed and welded to the frame. The air purification component is connected to the sealed box and the connection is sealed. The air purification component is fixedly installed on the frame.

2. The isolation and sealing device according to claim 1, characterized in that, The air purification component includes an air intake module, a first duct, and a purification module. The air intake module is installed on and connected to the sealed box. The first duct connects the sealed box module and the purification module, and the connection point between the first duct and the sealed box is located away from the connection point between the air intake module and the sealed box.

3. The isolation and sealing device according to claim 2, characterized in that, The purification module is provided with at least one air outlet, and the purified gas is discharged to the external environment from the air outlet.

4. The isolation and sealing device according to claim 3, characterized in that, The air purification component also includes a second pipe, which is connected to the air outlet to direct the gas discharged by the purification module to a designated location.

5. The isolation and sealing device according to claim 2, characterized in that, The isolation and sealing device also includes a mounting box, which is fixedly installed on the frame and located close to the sealing box. The production equipment is sealed and installed inside the sealing box and the mounting box, and the sealing box is in communication with the mounting box.

6. The isolation and sealing device according to claim 5, characterized in that, The purification module is installed on the installation box, and the purification module is connected to the installation box.

7. The isolation and sealing device according to claim 4, characterized in that, The air intake module is provided with an air inlet, which connects the air intake module and the external environment. Air is drawn into the sealed box from the air inlet, flows out from the first pipe, is purified by the purification module, and is discharged through the second pipe.

8. The isolation and sealing device according to claim 1, characterized in that, The air purification components are provided in multiple ways, and the multiple air purification components are connected to the sealed box.

9. The isolation and sealing device according to claim 1, characterized in that, The isolation sealing device further includes a detection component, which includes: A pressure detection element is installed inside the sealed box to detect the air pressure inside the sealed box. A temperature sensing element is installed inside the sealed box to detect the internal ambient temperature of the sealed box. A humidity detection device, which is installed inside the sealed box to detect the humidity of the environment inside the sealed box; An air velocity sensor is installed inside the sealed box to detect the flow rate of the gas input into the sealed box by the air intake module.

10. The isolation and sealing device according to claim 9, characterized in that, The isolation and sealing device also includes a control system, which is electrically or communicatively connected to the air purification component and the detection component.

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