Air tightness testing device

Abstract

The utility model relates to biological reactor technical field, concretely is air tightness detection device, including biological reactor, feed bottle, wide -mouth glass bottle and detection mechanism, and the detection mechanism sets up the surface at biological reactor, the detection mechanism includes gas multichannel adapter of air inlet end and tail gas end gas multichannel adapter, and the surface fixed connection of gas multichannel adapter of air inlet end has air inlet end silica gel pipe and air inlet end direct head, and the surface fixed connection of tail gas end gas multichannel adapter has tail gas end silica gel pipe and tail gas end direct head. The utility model discloses, through setting detection mechanism, can carry out air tightness detection to multiple biological reactor and feed bottle simultaneously, improves the detection efficiency, and distinguishes from the traditional mode of naked eye observation liquid level, utilizes spiral gas indicating tube and indicating ball more advantageously observes accurately, and effectively improves the convenience of equipment for this.

Description

Technical Field

[0001] This utility model relates to the field of bioreactor technology, and in particular to an airtightness detection device. Background Technology

[0002] After the bioreactor is assembled, the air inlet needs to be connected to the air outlet of the controller. After the air filter at the tail end is connected to the silicone tube, it is placed in a beaker filled with water. After the air displaces the water in the silicone tube and forms a stable rising bubble, use hemostatic forceps to clamp the air inlet. After 5 minutes, visually observe whether there is backflow in the liquid level in the silicone tube. The feed bottle and the corresponding silicone tubing are not tested for airtightness.

[0003] To address the issue of the difficulty in simultaneously and accurately testing the airtightness of multiple bioreactors and feed bottles, where a single airtightness test can only check one reactor, requiring individual testing of multiple reactors, is time-consuming and labor-intensive, and feed bottles cannot be tested, the liquid level changes in the silicone tubes of the beakers are not clearly indicated, and the liquid level position varies depending on the viewing angle, leading to subjective judgment, improvements are needed. Utility Model Content

[0004] The purpose of this invention is to solve the problem in the prior art that it is inconvenient to accurately test the airtightness of multiple bioreactors and feed bottles at the same time, and to propose an airtightness testing device.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: an airtightness detection device, comprising a bioreactor, a feeding bottle, a wide-mouth glass bottle, and a detection mechanism, wherein the detection mechanism is disposed on the surface of the bioreactor;

[0006] The detection mechanism includes an inlet gas multi-channel adapter and an exhaust gas multi-channel adapter. The surface of the inlet gas multi-channel adapter is fixedly connected to an inlet silicone tube and an inlet direct connector. The surface of the exhaust gas multi-channel adapter is fixedly connected to an exhaust silicone tube and an exhaust direct connector. Both the inlet silicone tube and the exhaust silicone tube are provided with Robert clips.

[0007] The surface of the wide-mouth glass bottle is threaded with a two-way screw cap, and the surface of the two-way screw cap is fixedly connected with a spiral gas indicator tube. The spiral gas indicator tube contains an indicator ball, and the inside of the wide-mouth glass bottle contains an indicator.

[0008] Furthermore, a needle air filter one and a needle air filter two are provided on the surface of the replenishment bottle.

[0009] Furthermore, an air inlet is provided on the surface of the bioreactor, and an exhaust gas filter port is provided on the surface of the bioreactor.

[0010] Furthermore, the exhaust gas end direct head is fixedly connected to the surface of the two-way screw cap, and the exhaust gas end direct head is connected to the spiral gas indicator tube.

[0011] Furthermore, the number of the inlet silicone tube, the exhaust silicone tube, and the Robert clamp are all multiple sets.

[0012] Furthermore, one set of the intake end silicone tubes is provided with an auxiliary direct head at its end, and the intake end silicone tubes are connected to the intake port through the auxiliary direct head; one set of the exhaust end silicone tubes is connected to the exhaust filter port.

[0013] Furthermore, the ends of the other set of inlet silicone tubes and exhaust silicone tubes are provided with male Luer connectors. The inlet silicone tube is connected to the first needle air filter through the male Luer connector, and the exhaust silicone tube is connected to the second needle air filter through the male Luer connector.

[0014] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0015] 1. In this utility model, a detection mechanism is set up. The inlet direct connector is connected to the controller outlet, and the outlet direct connector is connected to the spiral gas indicator tube through a two-way screw cap. Multiple sets of inlet silicone tubes are respectively connected to the inlet of the bioreactor through auxiliary direct connectors and to the needle air filter one of the feed bottle through a male Luer connector. Multiple sets of outlet silicone tubes are respectively directly connected to the outlet of the bioreactor's outlet gas filter and to the needle air filter two of the feed bottle through a male Luer connector. An indicator is placed inside the wide-mouth glass bottle. The Roborock... The special clamp is used to ventilate through the controller's outlet. After the indicator ball in the spiral gas indicator tube of the wide-mouth glass bottle rises to the indicator scale line, the Robert clamps at the gas supply end and the gas inlet end of the controller are closed. After standing for 5 minutes, observe the change in the position of the indicator ball. When the position of the indicator ball is lower than the scale line, it indicates that a gas leak has occurred. Close the Robert clamps at the gas inlet end and the gas outlet end, open one set of Robert clamps at the gas inlet end and the gas outlet end to ventilate, and then close the Robert clamp at the gas inlet end to observe whether the indicator ball in the spiral gas indicator tube is lower than the indicator scale line. Check each one one by one.

[0016] 2. In this utility model, by setting up a detection mechanism, the airtightness of multiple sets of bioreactors and feed bottles can be detected simultaneously, improving detection efficiency. Moreover, unlike the traditional method of observing the liquid level with the naked eye, the use of a spiral gas indicator tube and an indicator ball makes it easier to observe accurately, thus effectively improving the convenience of the equipment. Attached Figure Description

[0017] Figure 1 A three-dimensional structural schematic diagram of the airtightness testing device of this utility model is provided;

[0018] Figure 2 A side view of the detection mechanism in the airtightness testing device of this utility model is provided.

[0019] Figure 3 This invention provides a schematic diagram of another side view of the detection mechanism in the airtightness testing device.

[0020] Figure 4 A cross-sectional structural diagram of the detection mechanism in the airtightness testing device of this utility model is provided.

[0021] Figure 5 This invention presents another cross-sectional structural diagram of the detection mechanism in the airtightness detection device.

[0022] Legend:

[0023] 1. Bioreactor; 2. Feed bottle; 3. Wide-mouth glass bottle; 4. Detection mechanism; 401. Inlet gas multi-channel adapter; 402. Outlet gas multi-channel adapter; 403. Inlet silicone tube; 404. Inlet direct connector; 405. Outlet silicone tube; 406. Outlet direct connector; 407. Luer connector; 408. Robert clip; 409. Two-way screw cap; 410. Spiral gas indicator tube; 411. Indicator ball; 412. Needle air filter one; 413. Needle air filter two; 414. Inlet; 415. Outlet filter port; 416. Indicator; 417. Auxiliary direct connector. Detailed Implementation

[0024] Please see Figures 1-5 This utility model provides a technical solution: an airtightness detection device, including a bioreactor 1, a feeding bottle 2, a wide-mouth glass bottle 3, and a detection mechanism 4, wherein the detection mechanism 4 is disposed on the surface of the bioreactor 1.

[0025] The following section will explain the specific setup and function of its testing unit 4.

[0026] In this embodiment: the detection mechanism 4 includes an inlet gas multi-channel adapter 401 and an exhaust gas multi-channel adapter 402. The surface of the inlet gas multi-channel adapter 401 is fixedly connected to an inlet silicone tube 403 and an inlet direct connector 404. The surface of the exhaust gas multi-channel adapter 402 is fixedly connected to an exhaust silicone tube 405 and an exhaust direct connector 406. Robert clips 408 are provided on the surfaces of both the inlet silicone tube 403 and the exhaust silicone tube 405.

[0027] The surface of the wide-mouth glass bottle 3 is threaded with a two-way screw cap 409, and the surface of the two-way screw cap 409 is fixedly connected with a spiral gas indicator tube 410. The spiral gas indicator tube 410 is provided with an indicator ball 411 inside, and the wide-mouth glass bottle 3 is provided with an indicator 416 inside.

[0028] The effects achieved by the above components are as follows: The multi-channel gas adapter 401 at the inlet end and the multi-channel gas adapter 402 at the outlet end facilitate simultaneous airtightness testing of multiple bioreactors 1 and feed bottles 2, improving testing efficiency; the silicone tube 403 at the inlet end facilitates gas supply to bioreactors 1 and feed bottles 2; the direct connector 404 at the inlet end facilitates connection to the controller outlet; the silicone tube 405 at the outlet end facilitates exhaust from bioreactors 1 and feed bottles 2; and the direct connector 406 at the outlet end facilitates connection to a wide-mouth glass container. Bottle 3 is equipped with a Robert clamp 408 to facilitate the opening and closing of the inlet silicone tube 403 and the outlet silicone tube 405 to control the gas flow. A two-way screw cap 409 is provided to facilitate the connection of the outlet direct connector 406 to the spiral gas indicator tube 410 using one of the two ports, and to connect to the outside using the other port. An indicator 416, a spiral gas indicator tube 410, and an indicator ball 411 are provided to facilitate the use of the pressure difference between air pressure and water pressure to drive the position of the indicator ball 411 within the spiral gas indicator tube 410, thus visually indicating whether a gas leak has occurred.

[0029] Specifically, a needle air filter 412 is provided on the surface of the replenishment bottle 2, and a needle air filter 413 is provided on the surface of the replenishment bottle 2.

[0030] The effects achieved by the above components are as follows: the needle air filter 412 is provided to facilitate connection with the inlet silicone tube 403, and the needle air filter 413 is provided to facilitate connection with the exhaust silicone tube 405.

[0031] Specifically, an air inlet 414 is provided on the surface of the bioreactor 1, and an exhaust gas filter port 415 is provided on the surface of the bioreactor 1.

[0032] The effects achieved by the above components are as follows: the air inlet 414 is provided to facilitate connection with the air inlet silicone tube 403, and the exhaust filter port 415 is provided to facilitate connection with the exhaust silicone tube 405.

[0033] Specifically, the exhaust end direct connector 406 is fixedly connected to the surface of the two-way screw cap 409, and the exhaust end direct connector 406 is connected to the spiral gas indicator tube 410.

[0034] The effect achieved by the above components is as follows: the exhaust end direct head 406 and the spiral gas indicator tube 410 are set to make it easy to intuitively display whether there is a gas leak by using the position change of the indicator ball 411.

[0035] Specifically, there are multiple sets of the inlet silicone tube 403, the exhaust silicone tube 405, and the Robert clip 408.

[0036] The effect achieved by the above components is as follows: setting up multiple sets of inlet silicone tubes 403, outlet silicone tubes 405 and Robert clamps 408 is to facilitate the airtightness testing of multiple sets of bioreactors 1 and feed bottles 2, thereby improving the testing efficiency.

[0037] Specifically, one set of intake silicone tubes 403 is provided with an auxiliary direct connector 417 at its end. The intake silicone tubes 403 are connected to the intake port 414 through the auxiliary direct connector 417. One set of exhaust silicone tubes 405 is connected to the exhaust filter port 415.

[0038] The effect achieved by the above components is as follows: the auxiliary direct head 417 is set to facilitate the connection between the inlet silicone tube 403 and the inlet 414, and the inlet silicone tube 403, the auxiliary direct head 417 and the exhaust silicone tube 405 form a closed system between the bioreactor 1 and the detection mechanism 4.

[0039] Specifically, the ends of another set of inlet silicone tube 403 and exhaust silicone tube 405 are provided with male Luer connectors 407. The inlet silicone tube 403 is connected to the needle air filter 412 through the male Luer connector 407, and the exhaust silicone tube 405 is connected to the needle air filter 413 through the male Luer connector 407.

[0040] The effect achieved by the above components is as follows: the male Luer connector 407 is provided to facilitate the connection between the inlet silicone tube 403 and the needle air filter 412, and the outlet silicone tube 405 and the needle air filter 413, so that a closed system is formed between the replenishment bottle 2 and the detection mechanism 4.

[0041] Working principle: The system incorporates a detection mechanism 4. The inlet direct connector 404 connects to the controller outlet. The outlet direct connector 406 connects to the spiral gas indicator tube 410 via a two-way screw cap 409. Multiple inlet silicone tubes 403 connect to the inlet 414 of the bioreactor 1 via auxiliary direct connectors 417 and to the needle air filter 412 of the feed bottle 2 via a male Luer connector 407. Multiple outlet silicone tubes 405 connect directly to the outlet 415 of the bioreactor 1 and to the needle air filter 413 of the feed bottle 2 via a male Luer connector 407. An indicator 416 is placed inside the wide-mouth glass bottle 3. Open the Robert clamp 408 and ventilate using the controller's outlet. After the indicator ball 411 in the spiral gas indicator tube 410 of the wide-mouth glass bottle 3 rises to the indicator scale line, close the Robert clamp 408 at both the gas supply and inlet ends of the controller. Let it stand for 5 minutes and observe the position change of the indicator ball 411. When the position of the indicator ball 411 is lower than the scale line, it indicates that a gas leak has occurred. Close the Robert clamp 408 at both the inlet and outlet ends, and open one set of Robert clamp 408 at both the inlet and outlet ends to ventilate. Then close the Robert clamp 408 at the inlet end and observe whether the indicator ball 411 in the spiral gas indicator tube 410 is lower than the indicator scale line. Check each one one by one.

[0042] By setting up the detection mechanism 4, the airtightness of multiple sets of bioreactors 1 and feed bottles 2 can be detected simultaneously, improving detection efficiency. Moreover, unlike the traditional method of observing the liquid level with the naked eye, the spiral gas indicator tube 410 and indicator ball 411 are more conducive to accurate observation, which effectively improves the convenience of the equipment.

Claims

1. An airtightness testing device, comprising a bioreactor (1), a feed bottle (2), a wide-mouth glass bottle (3), and a testing mechanism (4), characterized in that: The detection mechanism (4) is disposed on the surface of the bioreactor (1); The detection mechanism (4) includes an inlet gas multi-channel adapter (401) and an exhaust gas multi-channel adapter (402). The surface of the inlet gas multi-channel adapter (401) is fixedly connected to an inlet silicone tube (403) and an inlet direct connector (404). The surface of the exhaust gas multi-channel adapter (402) is fixedly connected to an exhaust silicone tube (405) and an exhaust direct connector (406). The surfaces of the inlet silicone tube (403) and the exhaust silicone tube (405) are both provided with Robert clips (408). The surface of the wide-mouth glass bottle (3) is threaded with a two-way screw cap (409), and the surface of the two-way screw cap (409) is fixedly connected with a spiral gas indicator tube (410). The spiral gas indicator tube (410) is provided with an indicator ball (411) inside, and the wide-mouth glass bottle (3) is provided with an indicator (416).

2. The airtightness testing device according to claim 1, characterized in that: The surface of the replenishment bottle (2) is provided with a needle air filter one (412) and the surface of the replenishment bottle (2) is provided with a needle air filter two (413).

3. The airtightness testing device according to claim 1, characterized in that: The surface of the bioreactor (1) is provided with an air inlet (414) and an exhaust gas filter inlet (415).

4. The airtightness testing device according to claim 1, characterized in that: The exhaust gas end direct connector (406) is fixedly connected to the surface of the two-way screw cap (409), and the exhaust gas end direct connector (406) is connected to the spiral gas indicator tube (410).

5. The airtightness testing device according to claim 1, characterized in that: The number of the inlet silicone tube (403), the exhaust silicone tube (405), and the Robert clip (408) are all multiple sets.

6. The airtightness testing device according to claim 3, characterized in that: One of the sets of intake end silicone tubes (403) is provided with an auxiliary direct head (417) at its end. The intake end silicone tube (403) is connected to the intake port (414) through the auxiliary direct head (417). One of the sets of exhaust end silicone tubes (405) is connected to the exhaust filter port (415).

7. The airtightness testing device according to claim 2, characterized in that: Another set of inlet silicone tubes (403) and exhaust silicone tubes (405) are provided with male Luer connectors (407) at their ends. The inlet silicone tube (403) is connected to the first needle air filter (412) through the male Luer connector (407), and the exhaust silicone tube (405) is connected to the second needle air filter (413) through the male Luer connector (407).

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