An optical device for in-vitro diagnostic analyzers combining transmission and scattering

Abstract

The utility model relates to the field of medical detection discloses a kind of optical devices of in-vitro diagnostic analyzer transmission scattering combination, including reaction disc assembly, transmission component and scattering component, the reaction disc assembly includes carousel and several reaction cups, several the reaction cup is all installed on the carousel;The transmission component includes light source lamp and transmission light detector, the light source lamp is located the outside of the reaction cup, and the transmission light detector is located the inside of the reaction cup, to receive the transmission light ray formed by the light of light source lamp passing through sample in reaction cup;The scattering component includes laser and scattering light detector, the laser is located the inside of the reaction cup, and scattering light detector is located the outside of the reaction cup, to receive the scattering light ray formed by the light of laser passing through sample in reaction cup.The utility model has the beneficial effect that the versatility of detection device is widened, without transferring sample between different instruments, improves detection efficiency.

Description

Technical Field

[0001] This utility model relates to the field of medical testing, specifically to an optical device that combines transmission and scattering in an in vitro diagnostic analyzer. Background Technology

[0002] Transmission optical systems have high recognition accuracy when detecting high concentrations of immunoreaction complexes, but they have low sensitivity and poor anti-interference ability at low concentrations, making them insufficient for detecting low-concentration substances. Scattering optical systems exhibit high anti-interference and high sensitivity in the low-concentration detection region, but they are prone to the hook effect at high concentrations and have a narrow linear range.

[0003] Current in vitro diagnostic (IVD) instruments typically only have one optical system. Biochemical analyzers generally use transmission optical systems to accommodate most biochemical reactions and routine immunoassays. However, in immunoassay applications, biochemical analyzers often require special auxiliary testing in certain scenarios due to their low sensitivity. Some specific protein analyzers generally use scattering optical systems. Due to limitations in their detection channels and detection limits, these specific protein analyzers are often only applicable to certain items and require functions such as dilution and retesting to extend their linear range at high concentrations. This results in slow testing speed and low efficiency. Utility Model Content

[0004] The technical problem this invention aims to solve is that existing in vitro diagnostic instruments only have one optical system, requiring assistance from other testing instruments during the detection process, resulting in slow testing speed and low efficiency. The purpose is to provide an optical device that combines transmission and scattering in an in vitro diagnostic analyzer, enabling the device to meet both the high sensitivity requirements for low-concentration detection and the wide linear range requirements for high-concentration detection, thus broadening the versatility of the detection device, eliminating the need to transfer samples between different instruments, and improving detection efficiency.

[0005] This utility model is achieved through the following technical solution: An optical device combining transmission and scattering for an in vitro diagnostic analyzer includes a reaction disk assembly, a transmission assembly, and a scattering assembly. The reaction disk assembly includes a turntable and several reaction cups, all mounted on the turntable. The transmission assembly includes a light source and a transmission light detector. The light source is located outside the reaction cup, and the transmission light detector is located inside the reaction cup to receive transmitted light formed by light emitted from the light source passing through the sample inside the reaction cup. The scattering assembly includes a laser and a scattering light detector. The laser is located inside the reaction cup, and the scattering light detector is located outside the reaction cup to receive scattered light formed by light emitted from the laser passing through the sample inside the reaction cup.

[0006] The beneficial effects of this invention are that by setting a turntable, a transmission component, and a scattering component on the device, the sample to be tested in the reaction cup can be detected by both the transmission component and the scattering component in the same device during operation. This allows the same sample to be tested in two ways on the same device, enabling the device to meet both the high sensitivity requirements for low-concentration detection and the wide linear range requirements for high-concentration detection. This broadens the versatility of the detection device, eliminates the need for other testing instruments during the detection process, and eliminates the need to transfer samples between different instruments, thus improving detection efficiency.

[0007] In some embodiments, the reaction disk assembly further includes a drive motor and a rotating shaft. An output gear is mounted on the bottom of the rotating shaft. The output shaft of the drive motor is connected to a mounting shaft via a coupling. An input gear is mounted on the mounting shaft, and the input gear meshes with the output gear. The turntable is connected to the top of the rotating shaft. By setting the drive motor to drive the input gear connected to the mounting shaft to rotate, the input gear drives the output gear to rotate, thereby causing the rotating shaft to rotate. This facilitates the rotation of the reaction cups, enabling the detection of samples at different angles and improving detection accuracy. Furthermore, rotating the turntable allows the detection assembly to continuously detect samples in different reaction cups, improving detection efficiency.

[0008] In some embodiments, the reaction disk assembly further includes a base plate, the drive motor is mounted on the base plate, a fixed shaft is mounted on the base plate, and the rotating shaft is hollow and connected to the outside of the fixed shaft via a bearing. By setting the fixed shaft for support and positioning, and by using bearings to reduce frictional resistance during rotation, the rotational accuracy is ensured.

[0009] In some embodiments, a support member is further included, comprising a support disk and a plurality of support rods evenly distributed in a circle. The tops of the support rods are connected to the bottom of the support disk, and the bottoms are connected to a base. The support disk is supported on the outside of the turntable. The support rods provide support and positioning for the support disk, and the support disk also limits the turntable's position, ensuring the accuracy of the relative positions of the reaction cup with the transmission and scattering components, thereby ensuring the accuracy of the detection data.

[0010] In some embodiments, the turntable is a circular plate, and several loading disks are mounted on the edge of the turntable. The loading disks are evenly distributed in a circle on the turntable, and the reaction cups are mounted on the corresponding loading disks. By setting the loading disks to mount the reaction cups, the reaction cups are positioned, and the discrete samples are integrated into an ordered whole. This facilitates efficient sample flow within a limited space during detection through rotational movement.

[0011] In some embodiments, a lubrication ring is mounted on the support plate, and the lubrication ring is located between the turntable and the support plate. By providing a lubrication ring between the turntable and the support plate, the friction between them is reduced when the turntable rotates, thereby ensuring smooth rotation of the turntable.

[0012] In some embodiments, the transmission assembly further includes a front lens, and the transmission light detector includes a beam splitter and a rear lens. The front lens is mounted on the emitting end of the light source, and the rear lens is mounted on the light input end of the beam splitter. The beam splitter is electrically connected to the information processing board. By setting the front lens, the optics emitted by the light source are converted into parallel light, ensuring that the light passes through the reaction cup perpendicularly at a 90-degree angle. The rear lens collects and converges the weak and somewhat divergent transmitted light after absorption and attenuation by the sample, focusing it onto the entrance slit of the beam splitter to maximize the collection of valuable light carrying sample information, making it strong enough for the subsequent conversion of the optical signal into an electrical signal by the information processing board.

[0013] In some embodiments, the transmission assembly further includes a shielding cover connected to one side of the beam splitter. The shielding cover is typically made of metal (such as aluminum alloy or galvanized steel plate) and can form a closed electromagnetic shielding cavity to effectively block external electromagnetic radiation (such as high-frequency signals from surrounding circuits, electromagnetic noise from motors, and electrostatic induction from the equipment casing) from entering the beam splitter, thus ensuring the purity of the optical signal.

[0014] In some embodiments, a mounting bracket is further included, which is mounted on a base, and the beam splitter and the light source are both mounted on top of the mounting bracket. The mounting bracket provides support and positioning for the beam splitter and the light source.

[0015] In some embodiments, a scattering mounting plate is further included, the bottom of which is mounted on a base, and the scattering light detector is mounted on the upper end of the scattering mounting plate. The scattering mounting plate is used to support and position the scattering light detector.

[0016] Compared with the prior art, this utility model has the following advantages and beneficial effects: 1. During operation, the sample in the reaction vessel can be detected by both the transmission component and the scattering component in the same device. This allows the same sample to be detected by both components on the same device, enabling the device to meet both the high sensitivity requirements for low-concentration detection and the wide linear range requirements for high-concentration detection. This expands the versatility of the detection device. No other testing instruments are required during the detection process, and there is no need to transfer samples between different instruments, thus improving detection efficiency.

[0017] 2. By setting the front lens, the optics emitted by the light source are converted into parallel light, ensuring that the light passes through the reaction cup at a 90-degree angle. The rear lens collects and converges the light that has become weak and somewhat divergent after being absorbed and attenuated by the sample, and focuses it onto the entrance slit of the spectrometer to maximize the collection of valuable light carrying sample information.

[0018] 3. By setting a drive motor to drive the input gear connected to the mounting shaft to rotate, the input gear drives the output gear to rotate, which in turn makes the rotating shaft rotate, so as to drive the reaction cup to rotate, so as to detect the sample at different angles, improve the detection accuracy, and the rotating turntable also allows the detection component to continuously detect samples in different reaction cups, thereby improving the detection efficiency. Attached Figure Description

[0019] The accompanying drawings, which are included to provide a further understanding of the embodiments of the present invention and form part of this application, do not constitute a limitation thereof. In the drawings: Figure 1 This is a structural diagram of the present invention; Figure 2 This is a partial structural diagram of the present invention; Figure 3 This is a partial structural diagram of the present invention; Figure 4 This is a partial structural diagram of the present invention.

[0020] The attached diagram shows the markings and corresponding component names: The components include: reaction disk assembly 10, drive motor 11, output gear 12, input gear 13, base plate 14, rotating shaft 15, support component 151, loading disk 191, reaction cup 192, turntable 193, light source lamp 211, front lens 23, rear lens 24, beam splitter 25, shielding cover 251, information processing board 26, laser 32, scattering mounting plate 33, scattering light detector 35, and mounting bracket 39. Detailed Implementation Example

[0021] like Figures 1-4As shown, this embodiment 1 provides an optical device combining transmission and scattering for an in vitro diagnostic analyzer, including a reaction disk assembly 10, a transmission assembly, and a scattering assembly. The reaction disk assembly 10 includes a turntable 193 and several reaction cups 192, all of which are mounted on the turntable 193. The transmission assembly includes a light source 211 and a transmission light detector. The light source 211 is located outside the reaction cup 192, and the transmission light detector is located inside the reaction cup 192 to receive the transmitted light formed by the light emitted by the light source 211 passing through the sample of the object being examined in the reaction cup 192. The scattering assembly includes a laser 32 and a scattering light detector 35. The laser 32 is located inside the reaction cup 192, and the scattering light detector 35 is located outside the reaction cup 192 to receive the scattered light formed by the light emitted by the laser 32 passing through the sample of the object being examined in the reaction cup 192. This allows the device to meet both the high sensitivity requirements for low-concentration detection and the wide linear range requirements for high-concentration detection, thus broadening the versatility of the detection device. No other testing instruments are needed during the detection process, and there is no need to transfer samples between different instruments, thereby improving detection efficiency.

[0022] See Figure 1 and Figure 2 The reaction disk assembly 10 also includes a drive motor 11 and a rotating shaft 15. An output gear 12 is mounted on the bottom of the rotating shaft 15. The output shaft of the drive motor 11 is connected to a mounting shaft via a coupling. An input gear 13 is mounted on the mounting shaft, and the input gear 13 meshes with the output gear 12. The turntable 193 is connected to the top of the rotating shaft 15. By setting the drive motor 11 to drive the input gear 13 connected to the mounting shaft to rotate, the input gear 13 drives the output gear 12 to rotate, thereby causing the rotating shaft 15 to rotate. This allows the reaction cup 192 to rotate, enabling the detection of the sample at different angles, improving detection accuracy. Furthermore, rotating the turntable 193 allows the detection assembly to continuously detect the sample in different reaction cups 192, improving detection efficiency.

[0023] See Figure 2 The reaction disk assembly 10 also includes a base plate 14, on which the drive motor 11 is mounted. A fixed shaft is mounted on the base plate 14, and a hollow rotating shaft 15 is connected to the outside of the fixed shaft via a bearing. By setting the fixed shaft position, the rotating shaft 15 is supported and positioned, and the bearing is used to reduce the frictional resistance of the rotating shaft 15 during movement, thus ensuring rotational accuracy.

[0024] See Figures 1-4It also includes a support member 151, which comprises a support plate and several support rods evenly distributed in a circle. The top of each support rod is connected to the bottom of the support plate, and the bottom is connected to a base. The support plate is supported on the outside of the turntable 193. The support rods provide support and positioning for the support plate, and the support plate also limits the position of the turntable 193 to ensure the accuracy of the relative position of the reaction cup 192 with the transmission and scattering components, thereby ensuring the accuracy of the detection data.

[0025] See Figure 1 and Figure 2 The turntable 193 is a circular plate, and several loading trays 191 are installed on its edge. These loading trays 191 are evenly distributed in a circle on the turntable 193, and the reaction cups 192 are mounted on their corresponding loading trays 191. By setting the loading trays 191 to mount the reaction cups 192, the reaction cups 192 are positioned, integrating discrete samples into an ordered whole. This facilitates efficient sample flow within a limited space during detection through rotational movement.

[0026] See Figures 1-4 A lubrication ring is installed on the support plate, and the lubrication ring is located between the turntable 193 and the support plate. By setting the lubrication ring between the turntable 193 and the support plate, the friction between the two is reduced when the turntable 193 rotates, so that the turntable 193 rotates smoothly.

[0027] Specifically, the lubricating ring can be made of polytetrafluoroethylene, or it can be a bearing or bushing, etc.

[0028] See Figure 2 and Figure 3 The transmission assembly further includes a front lens 23, and the transmission light detector includes a beam splitter 25 and a rear lens 24. The front lens 23 is installed at the emitting end of the light source lamp 211, and the rear lens 24 is installed at the light input end of the beam splitter 25. The beam splitter 25 is electrically connected to the information processing board 26. By setting the front lens 23, the optical light emitted by the light source lamp 211 is converted into parallel light, ensuring that the light passes through the reaction cup 192 perpendicularly at a 90-degree angle. The rear lens 24 collects and converges the transmitted light, which has become weak and somewhat divergent after being absorbed and attenuated by the sample, and focuses it onto the entrance slit of the beam splitter 25 to maximize the collection of valuable light carrying sample information, making it strong enough so that the optical signal can be converted into an electrical signal by the information processing board 26.

[0029] See Figure 3 and Figure 4The transmission component also includes a shielding cover 251, which is connected to one side of the beam splitter 25. The shielding cover 251 is usually made of metal (such as aluminum alloy or galvanized steel plate) and can form a closed electromagnetic shielding cavity to effectively block external electromagnetic radiation (such as high-frequency signals from surrounding circuits, electromagnetic noise from motors, and electrostatic induction from the equipment casing) from entering the beam splitter, thus ensuring the purity of the optical signal.

[0030] See Figure 3 and Figure 4 It also includes a mounting bracket 39, which is mounted on a base. The beam splitter 25 and the light source 211 are both mounted on top of the mounting bracket 39. The mounting bracket 39 is used to support and position the beam splitter 25 and the light source 211.

[0031] See Figure 3 and Figure 4 It also includes a scattering mounting plate 33, the bottom of which is mounted on a base, and the scattering light detector 35 is mounted on the upper end of the scattering mounting plate 33. The scattering mounting plate 33 is used to support and position the scattering light detector 35.

[0032] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of this utility model. It should be understood that the above description is only a specific embodiment of this utility model and is not intended to limit the scope of protection of this utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the scope of protection of this utility model.

Claims

1. An optical device combining transmission and scattering in an in vitro diagnostic analyzer, characterized in that, include: A reaction disk assembly, comprising a turntable and several reaction cups, wherein the reaction cups are all mounted on the turntable; A transmission assembly, comprising a light source and a transmission light detector, wherein the light source is located outside the reaction cup and the transmission light detector is located inside the reaction cup to receive the transmitted light formed by the light emitted by the light source passing through the sample inside the reaction cup; The scattering assembly includes a laser and a scattered light detector. The laser is located inside the reaction cup, and the scattered light detector is located outside the reaction cup to receive the scattered light generated by the laser as it passes through the sample inside the reaction cup.

2. The optical device combining transmission and scattering in the in vitro diagnostic analyzer according to claim 1, characterized in that, The reaction disk assembly also includes a drive motor and a rotating shaft. An output gear is mounted on the bottom of the rotating shaft. The output shaft of the drive motor is connected to a mounting shaft via a coupling. An input gear is mounted on the mounting shaft. The input gear meshes with the output gear. The turntable is connected to the top of the rotating shaft.

3. The optical device combining transmission and scattering in the in vitro diagnostic analyzer according to claim 2, characterized in that, The reaction disk assembly also includes a base plate, the drive motor is mounted on the base plate, a fixed shaft is mounted on the base plate, the rotating shaft is hollow and connected to the outside of the fixed shaft through a bearing.

4. The optical device combining transmission and scattering in the in vitro diagnostic analyzer according to claim 2, characterized in that, It also includes a support component, which includes a support plate and several support rods. The support rods are evenly distributed in a circle. The top of each support rod is connected to the bottom of the support plate, and the bottom is connected to the base. The support plate is supported on the outside of the turntable.

5. The optical device combining transmission and scattering in the in vitro diagnostic analyzer according to claim 4, characterized in that, The turntable is in the shape of a circular plate, and several loading trays are installed on the edge of the turntable. The loading trays are evenly distributed in a circle on the turntable, and the reaction cup is installed on the corresponding loading tray.

6. The optical device combining transmission and scattering in the in vitro diagnostic analyzer according to claim 5, characterized in that, A lubrication ring is installed on the support plate, and the lubrication ring is located between the turntable and the support plate.

7. The optical device combining transmission and scattering in an in vitro diagnostic analyzer according to claim 1, characterized in that, The transmission component further includes a front lens, and the transmission light detector includes a beam splitter and a rear lens. The front lens is installed at the emitting end of the light source lamp, and the rear lens is installed at the light input end of the beam splitter. The beam splitter is electrically connected to the information processing board.

8. The optical device combining transmission and scattering in an in vitro diagnostic analyzer according to claim 7, characterized in that, The transmission assembly also includes a shielding cover, which is connected to one side of the beam splitter.

9. The optical device combining transmission and scattering in an in vitro diagnostic analyzer according to claim 7, characterized in that, It also includes a mounting bracket, which is mounted on a base, and the beam splitter and the light source are both mounted on top of the mounting bracket.

10. The optical device combining transmission and scattering in an in vitro diagnostic analyzer according to any one of claims 1-9, characterized in that, It also includes a scattering mounting plate, the bottom of which is mounted on a base, and the scattering light detector is mounted on the upper end of the scattering mounting plate.

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