A device for detecting components of fluralaner

Abstract

The utility model relates to a kind of flurazepam detection component devices, belong to the technical field of drug detection;The flurazepam detection component device includes: generating box, the generating box is separately equipped with distilling flask, condenser, collecting bottle and water vapor generator, distilling flask, condenser, collecting bottle and water vapor generator are sequentially distributed installation on generating box;The flurazepam detection component device can carry out purification operation to fluorine element in flurazepam complex matrix, reduce the interference of other components in later detection process, facilitate to realize high-precision detection to flurazepam complex matrix in later period.

Description

Technical Field

[0001] This utility model relates to a device for detecting components of sodium fluorella, belonging to the field of pharmaceutical testing technology. Background Technology

[0002] Fluranal is an innovative insecticide whose mechanism of action involves γ-aminobutyric acid (GABA) receptors. It exhibits excellent biological activity against arthropods such as ticks, fleas, lice, hemiptera, diptera, lepidoptera, and mites, with its main modes of action being stomach poison and contact. Fluranal sodium, an isoxazoline insecticide and acaricide, exerts its insecticidal effect by interfering with transmembrane signal transduction in the nervous system. It antagonizes γ-aminobutyric acid receptors and glutamate receptor-gated chloride ion channels, preventing chloride ions from penetrating into the postsynaptic membrane, thereby causing nervous system disorders in insects and ultimately leading to their death. In addition, in the field of health, compared with conventional agents such as doramectin, abamectin, and fipronil, fluranal sodium shows fewer side effects, faster onset of action, and longer duration of action. When analyzing the composition of sodium fluoride, the main focus is usually on determining the fluorine (F) content. The determination of the fluorine (F) content in sodium fluoride is typically performed using the ion-selective electrode method. The main steps of this ion-selective electrode method are: after dissolving or melting the sample, adjusting the pH, and directly measuring the fluorine ion concentration in the solution using a fluoride ion-selective electrode. The advantage of this component detection method is that it is simple to operate, fast and effective; however, the problem and defects are also obvious. This method is only suitable for the determination of sodium fluoride in a simple matrix. When determining sodium fluoride in a complex matrix (sodium fluoride is an inorganic compound, usually a mixture of sodium aluminum fluoride, such as Na3AlF6 or NaAlF4, which may contain impurities), it is obviously difficult to meet the high precision requirements. Utility Model Content To solve the above-mentioned technical problems, this utility model provides a device for detecting components of sodium fluorella, which enables high-precision detection of complex sodium fluorella matrices.

[0003] The technical solution adopted by this utility model to solve its technical problem is: A sodium fluorella detection device, the sodium fluorella detection device comprising: A generating chamber is provided with a distillation flask, a condenser, a collection bottle, and a steam generator, which are installed sequentially on the generating chamber. The top of the distillation flask is connected to the inside of the upper end of the condenser via a return pipe. The outside of the upper end of the condenser is connected to a cold water pipe and a hot water pipe, respectively. One end of the hot water pipe is connected to the inside of the steam generator. The bottom of the condenser is connected to the inlet pipe, and the outlet of the inlet pipe is directly opposite the bottom of the inside of the collection bottle. In addition, the top of the steam generator is connected to the inside of the distillation flask via a steam pipe, and a T-shaped safety tube is installed on the steam pipe.

[0004] Preferably, the upper side of the collection bottle is connected to the bottom of the steam generator via a backflush pipe.

[0005] Preferably, a closed door is movably installed on one side of the generating chamber, a first resistance heating tube is provided inside the generating chamber at the lower end of the distillation flask, and a second resistance heating tube is installed inside the generating chamber at the lower end of the steam generator.

[0006] Preferably, the upper end of the distillation flask is provided with a stone-feeding tube and a liquid-feeding tube on both sides respectively, and the stone-feeding tube is connected to the stone-feeding inlet on the part inside the distillation flask at one end; in addition, the end of the steam pipe that extends into the distillation flask is provided with a steam incline.

[0007] Preferably, a spiral heat exchange tube is installed inside the condenser tube, with the inlet at the bottom of the spiral heat exchange tube connected to one end of the cold water pipe and the outlet at the top of the spiral heat exchange tube connected to one end of the hot water pipe.

[0008] Compared with the prior art, the beneficial effects of this utility model are as follows: Compared with current methods for detecting sodium flurranel, the aforementioned device for detecting components has the following advantages: Instead of directly measuring the fluoride ion concentration in the solution using a fluoride ion selective electrode after dissolving or melting the sample and adjusting the pH, it uses a distillation flask, condenser, collection bottle, and steam generator. The distillation flask is used to heat and react the added sodium fluoride sample with concentrated sulfuric acid. The sodium fluoride sample decomposes in concentrated sulfuric acid (H2SO4) medium at high temperature (>135°C); fluoride (F⁻) reacts with sulfuric acid to generate volatile hydrogen fluoride (HF); 2F⁻ + H2SO4 → 2HF↑ + SO4²⁻. This process can purify the fluoride in the complex sodium fluoride matrix, reduce interference from other components in the later detection process, and facilitate high-precision detection of the complex sodium fluoride matrix. Meanwhile, the distillation flask, condenser, collection bottle, and steam generator are sealed and interconnected. For example, the water source used for heat exchange and cooling inside the condenser can be used as a supplementary water source for the steam generator. Moreover, the cold water is heated to become hot water before entering the steam generator, which reduces the heat required for the steam generator to evaporate water and generate steam, thus reducing energy consumption. At the same time, the water exhaust gas produced by the neutralization reaction inside the collection bottle can also be used as a supplementary water source for the steam generator, realizing resource recycling. Attached Figure Description

[0009] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0010] Figure 1 This is a schematic diagram of the structure of a sodium fluoride detection device according to the present invention.

[0011] Figure 2 This is a schematic diagram of the internal structure of a sodium fluoride detection device according to the present invention.

[0012] Figure 3 This is a schematic diagram of the internal structure of the distillation flask of a sodium fluoride detection device according to this utility model.

[0013] Figure 4 This is a schematic diagram of the condenser tube of a sodium fluoride detection device according to the present invention.

[0014] In the diagram: 1-Sealed door, 2-Generating box, 3-Distillation flask, 4-Stone-throwing tube, 5-Return pipe, 6-Injection pipe, 7-Condenser, 8-Hot water pipe, 9-Cold water pipe, 10-Steam generator, 11-Steam pipe, 12-First resistance heating tube, 13-Steam inclined tube, 14-T-shaped safety tube, 15-Second resistance heating tube, 16-Backflush tube, 17-Collection bottle, 18-Inlet pipe, 19-Stone-throwing inlet, 20-Boiling stone, 21-Spiral heat exchange tube. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figure 1-2 This utility model provides a technical solution: A sodium fluorella detection device, the sodium fluorella detection device comprising: The generating chamber 2 is equipped with a distillation flask 3, a condenser 7, a collection bottle 17, and a steam generator 10, which are arranged sequentially on the generating chamber 2. The top of the distillation flask 3 is connected to the inside of the upper end of the condenser tube 7 via the return pipe 5. The outside of the upper end of the condenser tube 7 is connected to the cold water pipe 9 and the hot water pipe 8 respectively. One end of the hot water pipe 8 is connected to the inside of the steam generator 10. The bottom end of the condenser tube 7 is connected to the inlet pipe 18, and the outlet of the inlet pipe 18 is directly opposite the bottom of the inside of the collection bottle 17. At the same time, one side of the upper end of the collection bottle 17 is connected to the bottom of the inside of the steam generator 10 via the backflush pipe 16. In addition, the top of the steam generator 10 is connected to the inside of the distillation flask 3 through the steam pipe 11, and a T-shaped safety pipe 14 is installed on the steam pipe 11. In an embodiment of this invention, a distillation flask 3 is used to heat and react the added sodium fluoride sample with concentrated sulfuric acid. The distillation flask 3 is typically a long-necked, heat-resistant hard glass bottle or quartz bottle (resistant to sulfuric acid corrosion and high temperature). The sodium fluoride sample decomposes in concentrated sulfuric acid (H2SO4) medium at high temperature (>135°C); fluoride (F⁻) reacts with sulfuric acid to generate volatile hydrogen fluoride (HF); 2F⁻ + H2SO4 → 2HF↑ + SO4²⁻; During the heating process, the steam generator 10 generates high-temperature steam, which is then transported to the bottom of the distillation flask 3 through the steam pipe 11. The sodium fluoride sample and concentrated sulfuric acid inside the distillation flask 3 are then steam distilled. The continuous introduction of steam helps to maintain a relatively constant temperature inside the distillation flask 3 (usually around 140°C in the return pipe 13), preventing local overheating inside the distillation flask 3 from causing sulfuric acid decomposition or sample carbonization. At the same time, the steam dilutes and carries away the volatilized HF or H2SiF6 from the distillation flask 3. Water vapor dilutes the volatilized HF or H2SiF6 and carries it out of the distillation flask 3, then through the return pipe 5 to the condenser 7, where it flows from top to bottom. Meanwhile, cold water is introduced through the cold water pipe 9. Upon entering the condenser 7, the cold water exchanges heat with the high-temperature vapor mixed with HF or H2SiF6, causing the HF-containing vapor to... High-temperature vapor from H2SiF6 condenses into droplets and flows through inlet pipe 18 into collection bottle 17, which is filled with dilute NaOH solution. This ensures effective absorption of volatile fluorides. Meanwhile, cold water is heated by heat exchange and then transported to steam generator 10 via hot water pipe 8 for use as a source of high-temperature steam. In addition, during the absorption of volatile fluorides with alkaline solution inside collection bottle 17, the exhaust gas discharged from collection bottle 17 enters steam generator 10 through backflushing pipe 16. This not only replenishes the water source inside steam generator 10 but also pressurizes the steam generator 10, accelerating the discharge of steam generated inside. This allows for a sealed connection between the distillation flask 3, condenser 7, collection bottle 17, and steam generator 10. For example, the water source used for heat exchange and cooling inside the condenser 7 can serve as a supplementary water source for the steam generator 10. Moreover, the cold water is heated to become hot water before entering the steam generator 10, which reduces the heat required for the steam generator 10 to evaporate water and generate steam, thus reducing energy consumption. At the same time, the water vapor that escapes from the neutralization reaction inside the collection bottle 17 can also serve as a supplementary water source for the steam generator 10, achieving resource recycling. Please see Figure 1 and Figure 2 In one embodiment of this utility model, a movably installed sealing door 1 is provided on one side of the generating chamber 2. The movably installed sealing door 1 facilitates opening the generating chamber 2, taking out the absorbent liquid inside the collection bottle 17, and performing final component analysis on the absorbent liquid. At the same time, a first resistance heating tube 12 is provided inside the generating chamber 2 at the lower end of the distillation flask 3, and a second resistance heating tube 15 is installed inside the generating chamber 2 at the lower end of the steam generator 10. The first resistance heating tube 12 and the second resistance heating tube 15 have the same function, which is to provide a heating source for the distillation flask 3 or the steam generator 10. Please see Figure 3 In one embodiment of the present invention, the upper ends of the distillation flask 3 are respectively provided with a stone-throwing tube 4 and a liquid-throwing tube 6. One end of the stone-throwing tube 4 is connected to the stone-throwing oblique opening 19 on the part inside the distillation flask 3. In addition, the end of the steam pipe 11 that extends into the interior of the distillation flask 3 is provided with a steam oblique tube 13. The catapult tube 4 and the catapult angled opening 19 are used to add boiling stones 20 into the distillation flask 3. Adding boiling stones 20 into the distillation flask 3 can prevent bumping when heating and evaporating the sample and concentrated sulfuric acid mixture. The catapult angled opening 19 can shorten the descent distance and change the falling direction when adding boiling stones 20 through the catapult tube 4, so as to prevent the added boiling stones 20 from falling directly into the inner wall of the distillation flask 3 by gravity and causing damage to the inner wall of the distillation flask 3. The steam inclined tube 13 and the T-shaped safety tube 14 work together to prevent the high-temperature concentrated acid inside the distillation flask 3 from being drawn back into the steam generator 10 when the distillation is finished, thus preventing an accident. Please see Figure 4 In one embodiment of the present invention, a spiral heat exchange tube 21 is installed inside the condenser tube 7. The bottom inlet of the spiral heat exchange tube 21 is connected to one end of the cold water pipe 9, and the top outlet of the spiral heat exchange tube 21 is connected to one end of the hot water pipe 8. In an embodiment of this utility model, cold water is transported to the spiral heat exchange tube 21 through the cold water pipe 9, and then flows from bottom to top inside the condenser tube 7. During the flow, it exchanges heat with the HF or H2SiF6 dilution vapor entering the condenser tube 7 and is heated to become hot water, which is then discharged from the hot water pipe 8. The HF or H2SiF6 dilution vapor condenses into droplets after heat exchange and flows from top to bottom inside the condenser tube 7, and finally exits from the liquid inlet tube 18. The workflow of this embodiment is as follows: The sodium fluorella sample reacts with concentrated sulfuric acid inside distillation flask 3 by heating; distillation flask 3 is heated by the first resistance heating tube 12. During the heating process, the steam generator 10 generates high-temperature steam, which is delivered to the bottom of the distillation flask 3 through the steam pipe 11 to perform steam distillation on the sodium fluoride sample and concentrated sulfuric acid inside the distillation flask 3; the steam generator 10 is heated through the second resistance heating tube 15. Water vapor dilutes the volatilized HF or H2SiF6 and carries it out of the distillation flask 3, then through the return pipe 5 to the condenser 7, where it flows from top to bottom. Meanwhile, cold water is introduced through the cold water pipe 9. The cold water enters the condenser 7 and exchanges heat with the high-temperature vapor mixed with HF or H2SiF6, causing the vapor to condense into droplets. These droplets are then guided through the inlet pipe 18 to the collection bottle 17, which is filled with dilute NaOH solution. This ensures effective absorption of volatile fluorides. Finally, the absorbed fluoride was analyzed for its components. High-performance liquid chromatography (HPLC) can be used to detect fluoride, but a special column is required. Ordinary C18 columns do not retain fluorinated compounds well, so it is recommended to use a pentafluorophenyl column. Ammonium acetate should also be added to the mobile phase to help with ionization. Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A device for detecting components using sodium fluorella, characterized in that... include: The generating chamber (2) is provided with a distillation flask (3), a condenser (7), a collection bottle (17) and a steam generator (10), which are installed in sequence on the generating chamber (2). Among them, the top of the distillation flask (3) is connected to the inside of the upper end of the condenser (7) through the return pipe (5), and the outside of the upper end of the condenser (7) is connected to the cold water pipe (9) and the hot water pipe (8) respectively. One end of the hot water pipe (8) is connected to the inside of the steam generator (10). The bottom end of the condenser (7) is connected to the liquid inlet pipe (18), and the outlet of the liquid inlet pipe (18) is directly opposite the bottom of the inside of the collection bottle (17); in addition, the top of the steam generator (10) is connected to the inside of the distillation flask (3) through the steam pipe (11), and a T-shaped safety pipe (14) is installed on the steam pipe (11).

2. The sodium fluorella detection device according to claim 1, characterized in that: The upper side of the collection bottle (17) is connected to the bottom of the steam generator (10) through the backflush pipe (16).

3. The sodium fluorella detection device according to claim 1, characterized in that: A closed door (1) is movably installed on one side of the generating box (2). Inside the generating box (2), a first resistance heating tube (12) is provided at the lower end of the distillation flask (3). Inside the generating box (2), a second resistance heating tube (15) is installed at the lower end of the steam generator (10).

4. The sodium fluorella detection device according to claim 3, characterized in that: The upper end of the distillation flask (3) is provided with a stone-throwing tube (4) and a liquid-throwing tube (6) respectively. One end of the stone-throwing tube (4) is connected to the stone-throwing inlet (19) on the part inside the distillation flask (3). In addition, the end of the steam pipe (11) that extends into the distillation flask (3) is provided with a steam inlet (13).

5. The sodium fluorella detection device according to claim 1, characterized in that: The condenser tube (7) is equipped with a spiral heat exchange tube (21). The bottom inlet of the spiral heat exchange tube (21) is connected to one end of the cold water pipe (9), and the top outlet of the spiral heat exchange tube (21) is connected to one end of the hot water pipe (8).

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