Liquid disturbance resistant suspension positioning disintegration apparatus

Abstract

The utility model relates to a kind of drug detection instruments, disclose a kind of liquid disturbance prevention's suspension positioning disintegration appearance, including disintegration box (1), simulation device (2), heating device (3), disintegration capsule (4), acid-base display meter (5), the simulation device (2) including support (21), motor (22), output shaft (23), crossbeam (24);The one end of support (21) is fixed with the top of disintegration box (1), the other end of support (21) is fixed with motor (22), the output shaft (23) of motor (22) is fixed with the middle part of crossbeam (24), the end of crossbeam (24) is fixed with disintegration capsule (4).The utility model one side says, compared with linear reciprocating motion, disintegration capsule (4) inside will not produce excessive liquid disturbance;On the other hand, avoid the problem that the detection drug disintegration time is not accurate due to temperature inhomogeneity.

Description

Technical Field

[0001] This utility model relates to a drug testing instrument, and more particularly to a suspension positioning disintegration device for preventing liquid disturbance. Background Technology

[0002] Liquid disturbance refers to uncontrolled flow (such as turbulence and eddies) in a liquid medium (such as simulated gastric / intestinal fluid) during a disintegration test due to longitudinal mechanical motion, temperature inhomogeneity, etc. Its hazards are mainly manifested in:

[0003] 1. The realism of the simulation of the destructive disintegration process

[0004] Traditional disintegration devices simulate the regular peristalsis of the human gastrointestinal tract through basket lifting and lowering (typically at a frequency of 5-40 times / minute, with a lifting distance of 55mm). If additional turbulence is generated in the liquid at the reversal position, the tablet will be subjected to impact forces from directions other than those designed for it, leading to:

[0005] Uneven stress: The tablet breaks prematurely or dissolves locally, and the disintegration time is shorter than the actual value;

[0006] Positional deviation: The tablet detaches from the center area of ​​the basket screen, or even floats on the liquid surface, and cannot pass through the standard screen (such as 710μm pore size), and is misjudged as "not completely disintegrated".

[0007] 2. Affects the reproducibility of test results

[0008] Experiments show that traditional water baths, due to deficiencies in heater placement or stirrer design, can exhibit temperature differences of ±2℃ between different zones, inducing natural convection. This irregular flow can increase the standard deviation of disintegration time for the same batch of tablets by more than 30%, reducing the reliability of quality inspection.

[0009] Patent document CN205720195U discloses a drug disintegration device that uses a container shaped like a stomach bag to hold the drug and its dissolving solution. The device promotes drug disintegration by repeatedly striking the bottom of the stomach-shaped container. However, in real drug disintegration in the stomach, the drug only experiences lateral forces and not significant longitudinal forces. That is, people move laterally and do not jump up and down. Therefore, the simulated disintegration scenario of longitudinal reciprocating motion differs from the actual drug disintegration scenario.

[0010] Therefore, there is a need for a suspension positioning disintegration device that is resistant to liquid disturbance and simulates drug disintegration scenarios through lateral reciprocating motion. Utility Model Content

[0011] The technical problem to be solved by this utility model is to provide a suspension positioning disintegration device that is resistant to liquid disturbance and simulates drug disintegration scenarios through lateral reciprocating motion.

[0012] This utility model discloses a suspension positioning disintegration device that is resistant to liquid disturbance, comprising a disintegration chamber, a simulation device, a heating device, a disintegration capsule, and a pH display. The simulation device includes a support, a motor, an output shaft, and a crossbeam. One end of the support is fixed to the top of the disintegration chamber, and the other end of the support is fixed to the motor. The output shaft of the motor is fixed to the middle of the crossbeam, and a disintegration capsule is fixed to the end of the crossbeam.

[0013] This utility model relates to a suspension positioning disintegrator that prevents liquid disturbance. The disintegration sac has the same shape as the stomach. A conduit is provided at the top of the disintegration sac, and a first permanent magnet is fixed at the bottom. The first permanent magnet can repel a second magnet. The second magnet is coaxially arranged with the output shaft of the motor. The top of the conduit is fixed to the crossbeam.

[0014] The present invention relates to a suspension positioning disintegration device for preventing liquid disturbance, wherein the axis of the conduit does not coincide with the center of mass and / or geometric center of the first permanent magnet.

[0015] The present invention relates to a suspension positioning disintegrator that prevents liquid disturbance, wherein the second magnet is disposed within the heating device.

[0016] This utility model relates to a suspension positioning disintegration device that prevents liquid disturbance, wherein both ends of the crossbeam are fixed with disintegration bladders.

[0017] The present invention relates to a suspension positioning disintegration device for preventing liquid disturbance, wherein the side of the disintegration chamber is fixed with an obstacle block that can contact the disintegration bladder.

[0018] The present invention relates to a suspension positioning disintegration device for preventing liquid disturbance, wherein the surface of the obstacle block that impacts the disintegration bladder is provided with a wavy surface.

[0019] This utility model relates to a suspension positioning disintegration device that is resistant to liquid disturbance, wherein the crossbeam is fixed to the output shaft of the motor by bolts.

[0020] This invention relates to a suspension positioning disintegrator that is resistant to liquid disturbance, wherein the disintegration capsule is made of rubber.

[0021] This invention relates to a suspension positioning disintegrator that prevents liquid disturbance, wherein the disintegration capsule is made of plastic.

[0022] The difference between this novel liquid-disturbance-resistant suspension-positioning disintegrator and existing technologies lies in that this novel disintegrator constructs a crank structure using the output shaft of the aforementioned motor, a crossbeam, and a disintegration bladder. This crank structure is suspended within the disintegration chamber. Firstly, through centrifugal circular motion, the drug within the disintegration bladder undergoes lateral reciprocating motion. Furthermore, due to this lateral reciprocating motion, compared to linear reciprocating motion, excessive liquid disturbance is avoided within the disintegration bladder. Secondly, the crank structure replaces the function of a stirring rod, facilitating the uniform temperature of the dissolved liquid heated by the heating device within the disintegration chamber, thus preventing inaccurate drug disintegration time detection caused by uneven temperature distribution.

[0023] The following description, in conjunction with the accompanying drawings, further illustrates the liquid-resistant suspension positioning disintegration device of this invention. Attached Figure Description

[0024] Figure 1 This is the front view of the first state of the suspension positioning disintegrator, which is resistant to liquid disturbance;

[0025] Figure 2 This is the front view of the second state of the liquid-resistant suspension positioning disintegrator;

[0026] Figure 3 This is the main view of the third state of the suspension positioning disintegrator that is resistant to liquid disturbance;

[0027] Figure 4 yes Figure 1 The top view of the first form;

[0028] Figure 5 yes Figure 1 The top view of the second form. Detailed Implementation

[0029] like Figures 1-5 As shown, see Figure 1 , 2 3. This utility model discloses a suspension positioning disintegration device for preventing liquid disturbance, comprising a disintegration chamber 1, a simulation device 2, a heating device 3, a disintegration capsule 4, and a pH display 5. The simulation device 2 includes a support 21, a motor 22, an output shaft 23, and a crossbeam 24. One end of the support 21 is fixed to the top of the disintegration chamber 1, and the other end of the support 21 is fixed to the motor 22. The output shaft 23 of the motor 22 is fixed to the middle of the crossbeam 24, and the disintegration capsule 4 is fixed to the end of the crossbeam 24.

[0030] This invention constructs a crank structure using the output shaft 23 of the motor 22, the crossbeam 24, and the disintegration capsule 4, and suspends this crank structure in the disintegration chamber 1. On the one hand, through centrifugal circular motion, the drug in the disintegration capsule 4 undergoes lateral reciprocating motion, and because of the lateral reciprocating motion in the direction of its circular motion, compared with linear reciprocating motion, there will be less liquid disturbance inside the disintegration capsule 4. On the other hand, the crank structure replaces the function of the stirring rod, which facilitates the uniform temperature of the solution heated by the heating device 3 in the disintegration chamber 1, avoiding the problem of inaccurate drug disintegration time detection caused by uneven temperature.

[0031] The disintegration capsule 4 can be a completely sealed transparent rubber bag, transparent plastic bag, or transparent silicone bag, facilitating direct observation of the drug disintegration within the capsule and enabling the statistical analysis of disintegration time and rate. In this scenario, the disintegration capsule 4 is filled or nearly filled with a dissolving solution. The disintegration chamber 1 is filled or nearly filled with the same dissolving solution or water. Filling with a dissolving solution allows for better adaptation to temperature changes. Filling with water utilizes water's high specific heat capacity to stabilize the temperature within the disintegration chamber 1.

[0032] Of course, the disintegration capsule 4 can also be a transparent rubber bag, transparent plastic bag, or transparent silicone bag with mesh openings. This avoids the drug being subjected to excessive water flow impact and disintegrating too quickly due to the high water flow velocity when the motor 22 rotates too fast, thus adapting to a more realistic drug disintegration simulation. In this scenario, since the mesh-opening disintegration capsule 4 allows the interior of the disintegration capsule 4 to communicate with the interior of the disintegration chamber 1, both the disintegration chamber 1 and the disintegration capsule 4 should be filled with the same dissolving solution.

[0033] In some embodiments, see Figure 1 , 2 3. The shape of the disintegration sac 4 is the same as that of the stomach. The top of the disintegration sac 4 is provided with a conduit 41 and the bottom is fixed with a first permanent magnet 42. The first permanent magnet 42 can repel the second magnet 43. The second magnet 43 is coaxially arranged with the output shaft 23 of the motor 22. The top of the conduit 41 is fixed with the crossbeam 24.

[0034] This invention utilizes a second magnet 43 located at the rotation center of the disintegration capsule 4 to continuously repel the first permanent magnet 42. Firstly, this increases the left-right reciprocating motion stroke of the disintegration capsule 4 during rotation. Secondly, due to its repulsive force, it can also provide a certain degree of support for the disintegration capsule 4, thereby increasing the service life of the soft material disintegration capsule 4. Thirdly, it magnetizes the dissolving liquid to a certain extent, thereby avoiding the influence of excessive contaminants and impurities on disintegration, or in other words, promoting the reaction between the drug and the disintegration liquid.

[0035] The above solution is based on the patent document CN205720195U in the background art, and is only the same or substantially the same design as it.

[0036] In some embodiments, see Figure 1 The axis of the conduit 41 does not coincide with the center of mass and / or geometric center of the first permanent magnet 42.

[0037] This invention, through the eccentrically positioned first permanent magnet 42 and conduit 41 configuration, allows the disintegration capsule 4 to swing at a different angle when rotated to the leftmost side of the disintegration chamber 1 compared to when it is at the rightmost side. That is, the movement trajectory of the disintegration capsule 4 within the disintegration chamber 1 is not a perfect circle but rather an elliptical trajectory, or a trajectory resembling the outline of the moon near the Mid-Autumn Festival. Thus, this invention, by using a non-circular disintegration capsule 4, allows the drug inside the disintegration capsule 4 to generate a certain relative movement, rather than remaining stationary relative to the disintegration capsule 4 and undergoing complete centrifugal motion. This eliminates most of the liquid disturbance while allowing the drug to have a certain amount of movement, thereby increasing the contact between the dissolving solution and the drug, and achieving a better simulation of drug disintegration under real-world conditions.

[0038] The above non-overlap can be understood as such Figure 1 The geometric center or centroid of the first permanent magnet 42 shown is a distance a from the axis of the conduit 41, where a is greater than 0.

[0039] It should be noted that, in order to achieve the purpose of the above solution, the catheter 41 and the disintegration capsule 4 can be integrally molded. For example, the catheter 41 and the disintegration capsule 4 are both integrally made of rubber or silicone.

[0040] Preferably, the catheter 41 is fixed to the crossbeam 24 by welding or adhesive bonding; in the absence of any medication, such as Figure 1 As shown, the conduit 41 of the disintegration capsule 4 can be vertically downwardly positioned using the aforementioned welding or adhesive bonding force. However, the repulsive force of the magnet is not as... Figure 1 Configuration scheme.

[0041] In some embodiments, see Figure 1 , 4 5. The second magnet 43 is disposed within the heating device 3.

[0042] This invention uses a heating device 3 to simultaneously configure a second magnet 43, which can protect the second magnet 43 solely through the waterproof function of the heating device, thus saving the cost of configuring the second magnet 43 with waterproofing.

[0043] The second magnet 43 can be a permanent magnet, which facilitates configuration. That is, a second permanent magnet 43 is embedded inside a heating device 3 with a waterproof shell.

[0044] As a variation, since most heating devices 3 are caused by energizing a coil, and an electromagnet is made by adding an iron core to an energized coil, the original heating device 3 can be transformed into a device that can both heat and act as a second magnet 43 simply by adding an iron core to the center of the original heating device 3.

[0045] As a further variation of this invention, the power supply module of the heating device 3 is connected to the power supply module of the motor 22, and both can be connected to a control circuit. The control circuit can adjust the current direction of the coil of the heating device 3 according to the rotation angle of the motor 22, so that the second magnet 43 is always repelled by the first permanent magnet 42.

[0046] However, the control circuit described above can also be implemented in a way that allows the second magnet 43 and the first permanent magnet 42 to attract and repel each other at different times, so that the disintegration capsule 4 does not move in a circular motion, thereby increasing the movement of the drug within the disintegration capsule 4 and achieving a better drug disintegration effect. Similarly, even if the second magnet 43 is made of a permanent magnet, it can attract the first permanent magnet 42 when rotating to one side and repel it on the other side, thus facilitating the non-circular motion of the disintegration capsule 4.

[0047] The conduit 41 can also be fixed to the crossbeam 24 by clamps or clips.

[0048] In some embodiments, see Figure 1 , 4 5. Both ends of the crossbeam 24 are fixed with disintegration bags 4.

[0049] The presence of disintegration cysts on both sides of the crossbeam can improve experimental efficiency.

[0050] In some embodiments, see Figure 1 , 4 5. An obstacle block 6 that can contact the disintegration bladder 4 is fixed on the side of the disintegration box 1.

[0051] This invention uses the obstacle block 6 to impact the disintegration bladder 4 to a certain extent when it moves to this point. Although the impact may increase the influence of liquid disturbance on drug disintegration, when the motor 22 rotates at a relatively slow speed, it will still promote the non-circular motion of the disintegration bladder 4, so that the drug can increase the drug disintegration speed under acceptable small-amplitude liquid disturbance through acceptable small turbulence, thereby improving experimental efficiency.

[0052] The obstacle block 6 is configured in four parts, located on the four sides of the inner surface of the disintegration chamber 1. The four obstacle blocks 6 have different thicknesses to increase the randomness of the impact. The obstacle block 6 can be a rectangular planar block.

[0053] Of course, obstacle block 6 can be omitted to reduce liquid disturbance. That is, to increase experimental efficiency, the speed of motor 22 can be increased without obstacle block 6.

[0054] In some embodiments, see Figure 5 The surface of the obstacle block 6 that impacts the disintegration capsule 4 is provided with a wavy surface.

[0055] This invention can further increase the drug disintegration rate and improve experimental efficiency through the aforementioned wavy surface.

[0056] The barrier block 6 can be made of the same material as the disintegration bladder 4 to reduce liquid disturbance.

[0057] In some embodiments, see Figure 1 , 2 3. The crossbeam 24 is fixed to the output shaft 23 of the motor 22 by bolts.

[0058] The present invention, through the aforementioned detachable crossbeam 24 and output shaft 23, allows for easy removal and reuse of the disintegration capsule 4 after the experiment is completed.

[0059] In some embodiments, see Figure 1 , 2 3. The disintegration capsule 4 is made of rubber.

[0060] It should be noted that rubber or plastic are both soft materials, with a hardness similar to that of the human stomach.

[0061] In some embodiments, see Figure 1 , 2 3. The disintegration capsule 4 is made of plastic.

[0062] It should be noted that rubber or plastic are both soft materials, with a hardness similar to that of the human stomach.

[0063] The embodiments described above are merely preferred embodiments of the present utility model and are not intended to limit the scope of the present utility model. Various modifications and improvements made to the technical solutions of the present utility model by those skilled in the art without departing from the spirit of the present utility model should fall within the protection scope defined by the claims of the present utility model.

Claims

1. A suspension-positioning disintegration device resistant to liquid disturbance, comprising a disintegration chamber (1), a simulation device (2), a heating device (3), a disintegration capsule (4), and a pH display (5), characterized in that: The simulation device (2) includes a bracket (21), a motor (22), an output shaft (23), and a crossbeam (24); one end of the bracket (21) is fixed to the top of the disintegration box (1), the other end of the bracket (21) is fixed to the motor (22), the output shaft (23) of the motor (22) is fixed to the middle of the crossbeam (24), and a disintegration bladder (4) is fixed to the end of the crossbeam (24). The shape of the disintegration sac (4) is the same as that of the stomach. The top of the disintegration sac (4) is provided with a conduit (41) and the bottom is fixed with a first permanent magnet (42). The first permanent magnet (42) can repel the second magnet (43). The second magnet (43) is coaxially arranged with the output shaft (23) of the motor (22). The top of the conduit (41) is fixed with the crossbeam (24). The axis of the conduit (41) does not coincide with the centroid and / or geometric center of the first permanent magnet (42).

2. The suspension positioning disintegrator with anti-liquid disturbance according to claim 1, characterized in that: The second magnet (43) is disposed within the heating device (3).

3. The suspension positioning disintegrator with anti-liquid disturbance according to claim 1, characterized in that: Both ends of the crossbeam (24) are fixed with disintegration bladders (4).

4. The suspension positioning disintegrator with anti-liquid disturbance according to claim 1, characterized in that: The side of the disintegration box (1) is fixed with an obstacle block (6) that can contact the disintegration bladder (4).

5. The liquid-resistant suspension positioning disintegrator according to claim 4, characterized in that: The surface of the obstacle block (6) that impacts the disintegration capsule (4) is provided with a wavy surface.

6. The liquid-resistant suspension positioning disintegrator according to claim 1, characterized in that: The crossbeam (24) is fixed to the output shaft (23) of the motor (22) by bolts.

7. The liquid-resistant suspension positioning disintegrator according to claim 1, characterized in that: The disintegration capsule (4) is made of rubber.

8. The suspension positioning disintegrator with anti-liquid disturbance according to claim 1, characterized in that: The disintegration capsule (4) is made of plastic.

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