A multifunction pre-temperature control module for liquid chromatography

Abstract

This utility model relates to the field of liquid chromatography technology, specifically a multifunctional pre-temperature control module for liquid chromatography, including a base plate, a fixed partition, and a display screen. A control circuit board is slidably connected to the rear of the display screen. The control circuit board has four slots, each containing a locking block. A mounting plate is slidably connected to the outside of each locking block. A heat dissipation patch is attached to the rear end of the mounting plate, and a Peltier temperature control element is attached to the rear end of the heat dissipation patch. Grooves are provided on both the front and rear sides of the fixed partition. This device does not rely on the chromatographic column for heating and can be applied to analyses involving heating or cooling of the chromatographic column. It achieves precise control of the mobile phase temperature, reducing the influence of the mobile phase temperature on the column temperature, improving the stability and efficiency of the liquid chromatography system, and reducing customer operating costs, resulting in good economic efficiency.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, and more specifically, to a multifunctional pre-temperature control module for liquid chromatography. Background Technology

[0002] Liquid chromatography (LC) is a chromatographic technique that uses a liquid as the mobile phase to separate and detect different substances based on the difference in their partition coefficients between the stationary and mobile phases. It is widely used in pharmaceutical research, food analysis, biomedicine, environmental chemistry, and industrial production. It is primarily used to separate, analyze, and identify components in complex mixtures, with the separation achieved through a chromatographic column.

[0003] In liquid chromatography, temperature affects the separation performance of the chromatographic column and reduces the viscosity of the mobile phase, thus influencing the analytical results. To improve the reproducibility of the analytical results, a column oven is usually used to heat or cool the chromatographic column and provide a constant temperature environment to ensure the reproducibility of the analytical results. However, even if the chromatographic column is in a constant temperature state, environmental fluctuations will affect the temperature of the mobile phase, and the mixing of different components of the mobile phase will also cause temperature changes. This will cause the temperature balance of the chromatographic column to be disrupted when the mobile phase enters the chromatographic column, affecting the parameters of the chromatographic peaks and the reproducibility of the analytical results.

[0004] However, in actual use, when the chromatographic column is heated to the same temperature, although the temperature can be increased when the mobile phase passes through it, due to the limitations of the pipeline volume and heat exchange efficiency, there is still a certain temperature difference between the heated mobile phase and the chromatographic column, so the improvement effect is very limited. Utility Model Content

[0005] In order to overcome the above-mentioned defects of the prior art, this utility model provides a multifunctional pre-temperature control module for liquid chromatography, so as to solve the problem that in the prior art, due to the limitation of pipeline volume and heat exchange efficiency, there is still a certain temperature difference between the heated mobile phase and the chromatographic column, resulting in very limited improvement effect.

[0006] To solve the above technical problems, this utility model provides the following technical solution: a multifunctional pre-temperature control module for liquid chromatography, including a base plate, a fixed partition, and a display screen. A control circuit board is slidably connected to the rear side of the display screen. The control circuit board has four slots inside, and a locking block is locked inside each slot. A mounting plate is slidably connected to the outside of each locking block. A heat dissipation patch is attached to the rear end of the mounting plate, and a Peltier temperature control element is attached to the rear end of the heat dissipation patch. Grooves are provided on both the front and rear sides of the fixed partition. The Peltier temperature control element is slidably connected inside the front groove, and a stainless steel tube is slidably connected inside the rear groove.

[0007] The card slot has two fixedly connected internal limit rings, and the card block has two limit grooves on its outside. The limit rings slide against the outside of the card block and fit against the inside of the limit grooves.

[0008] The mounting plate has four mounting slots inside. A compression plate is fixedly connected to the rear end of the card block. A pull rope is fixedly connected to the rear end of the compression plate. A rotating rod is fixedly connected to the end of the pull rope away from the compression plate. An elastic element is sleeved on the outside of the pull rope.

[0009] The base plate is attached to the stainless steel pipe, and the display screen is attached to the mounting plate.

[0010] The card block is slidably connected inside the mounting groove, and the extrusion plate is slidably connected inside the mounting groove.

[0011] The pull rope is slidably connected inside the mounting groove, and the rotating rod is rotatably connected inside the mounting plate.

[0012] One end of the elastic element is fixedly connected to the inner wall of the mounting groove, and the other end of the elastic element is fixedly connected to the extrusion plate.

[0013] Compared with the prior art, the beneficial effects of this utility model are:

[0014] In the above solution, the device does not rely on the chromatographic column for heating and can be applied to the analysis of heating or cooling the chromatographic column. It also achieves precise control of the mobile phase temperature, reduces the influence of the mobile phase temperature on the chromatographic column temperature, improves the stability and efficiency of the liquid chromatography system, reduces the customer's operating costs, and makes it more economical to use. Attached Figure Description

[0015] Figure 1 This is a perspective view of the present utility model;

[0016] Figure 2 This is an exploded view of the present invention;

[0017] Figure 3 This is a front view of the control circuit board of this utility model;

[0018] Figure 4 For the present utility model Figure 3 Cross-sectional view of the structure at point AA;

[0019] Figure 5 For the present utility model Figure 4 Enlarged view of the structure at point A in the middle.

[0020] [Figure Labels]

[0021] 1. Base plate; 2. Stainless steel pipe; 3. Fixed partition; 4. Peltier temperature control element; 5. Heat sink; 6. Mounting plate; 7. Control circuit board; 8. Display screen; 9. Slot; 10. Block; 11. Mounting groove; 12. Extrusion plate; 13. Pull rope; 14. Elastic element; 15. Rotating rod; 16. Limiting groove; 17. Limiting ring. Detailed Implementation

[0022] To make the technical problems, technical solutions and advantages of this utility model clearer, a detailed description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0023] Example 1: Please refer to Figures 1 to 5 This utility model provides a technical solution: a multifunctional pre-temperature control module for liquid chromatography, including a base plate 1, a fixed partition plate 3, and a display screen 8. A control circuit board 7 is slidably connected to the rear interior of the display screen 8. The display screen 8 is an automated screen used in conjunction with the control circuit board 7, capable of independent operation and real-time temperature monitoring and control. The control circuit board 7 has four slots 9 inside, with locking blocks 10 inside each slot. A mounting plate 6 is slidably connected to the outside of the locking blocks 10, allowing the control circuit board 7 to be conveniently mounted on the mounting plate 6. The display screen 8 fits snugly against the mounting plate 6, resulting in high installation stability for the control circuit board 7. A heat dissipation patch 5 is attached to the rear end of the mounting plate 6, and a Peltier temperature control element 4 is attached to the rear end of the heat dissipation patch 5. The heat dissipation patch 5 uses a material with high thermal conductivity, ensuring the Peltier temperature control element 4 operates smoothly. The heat or cold generated on the surface is transferred out to ensure the normal operation of the Peltier temperature control element 4. The Peltier temperature control element 4 has the characteristics of both heating and cooling, and it is small in size, high in power and long in life. The front and rear sides of the fixed partition 3 are provided with grooves. The Peltier temperature control element 4 is slidably connected in the front groove, and the stainless steel tube 2 is slidably connected in the rear groove. The stainless steel tube 2 serves as a channel for the mobile phase. Thermal grease is applied to its surface to increase the heat transfer efficiency. Different inner diameter pipes or pipes of different lengths can be replaced according to different application scenarios to achieve pre-temperature control of mobile phases of different volumes. The base plate 1 is attached to the stainless steel tube 2, so that the stainless steel tube 2 can be easily installed. The base plate 1, stainless steel tube 2, fixed partition 3, Peltier temperature control element 4, heat sink 5, mounting plate 6 and display screen 8 are assembled together with fixing screws.

[0024] The multifunctional mobile phase pre-temperature control module can actively heat or cool without relying on the chromatographic column for temperature supply, and can be applied to analytical methods that require heating or cooling of the chromatographic column, improving efficiency and reducing customer operating costs.

[0025] The multifunctional mobile phase pre-temperature control module can set the column temperature to be high or low, so that after the mobile phase undergoes temperature exchange within the module, the temperature when it enters the column is closer to the column temperature. This achieves precise control of the mobile phase temperature, reduces the influence of the mobile phase temperature on the column temperature, and improves the stability of the liquid chromatography system and the reproducibility of experimental results.

[0026] Display 8 can be programmed with corresponding functions as needed, and has great scalability. It can monitor the current temperature of the module in real time and make settings, without relying on the monitoring and control of liquid chromatography software, making it more flexible to use.

[0027] The multifunctional mobile phase pre-temperature control module is not only used for pre-temperature control of the mobile phase before it enters the chromatographic column, but also for pre-temperature control of the mobile phase before it enters the liquid chromatography detector module. It can lower or raise the mobile phase temperature to bring it closer to the detector cell temperature, thereby reducing the impact of temperature on the baseline noise and drift of the detector signal and improving experimental results.

[0028] Example 2: Based on Example 1, in order to improve the installation stability of the control circuit board 7, two limiting rings 17 are fixedly connected inside the slot 9, and two limiting grooves 16 are opened on the outside of the block 10. The limiting rings 17 slide against the outside of the block 10, so that the limiting rings 17 can be squeezed and deformed, and fit against the inside of the limiting grooves 16, so that the locking stability between the slot 9 and the block 10 is high.

[0029] When the control circuit board 7 needs to be installed, the control circuit board 7 is attached to the mounting plate 6, and the locking block 10 is moved forward so that the locking block 10 can slide into the inside of the slot 9 and squeeze the limiting ring 17 to deform. After the locking block 10 is engaged with the slot 9, the limiting ring 17 can perform a reset movement and thus fit into the inside of the limiting groove 16, so that the installation stability of the control circuit board 7 is high.

[0030] Example 3: Based on Example 2, to facilitate the pulling of the locking block 10, the mounting plate 6 has four mounting slots 11 inside. The locking block 10 is slidably connected inside the mounting slots 11, which provide movement space for the locking block 10. A pressing plate 12 is fixedly connected to the rear end of the locking block 10. The pressing plate 12 is slidably connected inside the mounting slots 11, which limit the pressing plate 12, preventing it from shifting during sliding. A pull rope 13 is fixedly connected to the rear end of the pressing plate 12. The pull rope 13 is slidably connected inside the mounting groove 11, which limits the pull rope 13 and allows it to slide smoothly. The end of the pull rope 13 away from the extrusion plate 12 is fixedly connected to a rotating rod 15. The rotating rod 15 is rotatably connected inside the mounting plate 6, which limits the rotating rod 15 and prevents it from deviating when rotating. An elastic element 14 is sleeved on the outside of the pull rope 13. One end of the elastic element 14 is fixedly connected to the inner wall of the mounting groove 11, and the other end of the elastic element 14 is fixedly connected to the extrusion plate 12.

[0031] When the locking block 10 needs to be pulled, the rotating rod 15 is rotated so that one end of the pull rope 13 is wound around it, and the other end of the pull rope 13 pulls the compression plate 12 inward, thereby causing the compression plate 12 to compress the elastic element 14 and deform it, and pull the locking block 10 into the interior of the mounting groove 11. Conversely, by releasing the rotating rod 15, the elastic element 14 is reset, thereby causing the elastic element 14 to push the compression plate 12 forward, and causing the compression plate 12 to push the locking block 10 into the interior of the groove 9.

[0032] The working process of this utility model is as follows:

[0033] When the control circuit board 7 needs to be installed, the rotating rod 15 is rotated to wind one end of the pull rope 13, causing the other end of the pull rope 13 to pull the extrusion plate 12 inward. This causes the extrusion plate 12 to compress the elastic element 14, causing it to deform and pull the locking block 10 into the mounting groove 11, thus bringing the control circuit board 7 into contact with the mounting plate 6. By releasing the rotating rod 15, the elastic element 14 is reset, causing it to push the extrusion plate 12 forward. This pushes the locking block 10 into the slot 9, causing the slot 9 to compress the limiting ring 17, causing it to deform. Once the locking block 10 is engaged with the slot 9, the limiting ring 17 is reset and fits into the inside of the limiting groove 16, resulting in high installation stability of the control circuit board 7.

[0034] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0035] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.

[0036] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A multifunctional pre-temperature control module for liquid chromatography, characterized in that, The device includes a base plate (1), a fixed partition plate (3), and a display screen (8). A control circuit board (7) is slidably connected to the rear side of the display screen (8). The control circuit board (7) has four slots (9) inside. A card block (10) is snapped into the slot (9). A mounting plate (6) is slidably connected to the outside of the card block (10). A heat dissipation patch (5) is attached to the rear end of the mounting plate (6). A Peltier temperature control element (4) is attached to the rear end of the heat dissipation patch (5). Grooves are provided on both the front and rear sides of the fixed partition plate (3). The Peltier temperature control element (4) is slidably connected inside the front groove. A stainless steel tube (2) is slidably connected inside the rear groove.

2. The multifunctional pre-temperature control module for liquid chromatography according to claim 1, characterized in that, The card slot (9) has two fixedly connected limiting rings (17) inside, and the card block (10) has two limiting grooves (16) on the outside. The limiting rings (17) slide against the outside of the card block (10) and fit against the inside of the limiting grooves (16).

3. The multifunctional pre-temperature control module for liquid chromatography according to claim 2, characterized in that, The mounting plate (6) has four mounting slots (11) inside. The back end of the card block (10) is fixedly connected to a compression plate (12). The back end of the compression plate (12) is fixedly connected to a pull rope (13). The end of the pull rope (13) away from the compression plate (12) is fixedly connected to a rotating rod (15). An elastic element (14) is sleeved on the outside of the pull rope (13).

4. The multifunctional pre-temperature control module for liquid chromatography according to claim 1, characterized in that, The base plate (1) is attached to the stainless steel pipe (2), and the display screen (8) is attached to the mounting plate (6).

5. The multifunctional pre-temperature control module for liquid chromatography according to claim 3, characterized in that, The card block (10) is slidably connected inside the mounting groove (11), and the extrusion piece (12) is slidably connected inside the mounting groove (11).

6. The multifunctional pre-temperature control module for liquid chromatography according to claim 3, characterized in that, The pull rope (13) is slidably connected inside the mounting groove (11), and the rotating rod (15) is rotatably connected inside the mounting plate (6).

7. The multifunctional pre-temperature control module for liquid chromatography according to claim 3, characterized in that, One end of the elastic element (14) is fixedly connected to the inner wall of the mounting groove (11), and the other end of the elastic element (14) is fixedly connected to the extrusion plate (12).

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