A reconstitution device

Abstract

The application discloses a reconstitution device, comprising: a rotating heating assembly, comprising a reconstitution station for placing a sample container, a rotating driving device for driving the sample container to rotate, and a heating device for heating the sample container; and a liquid adding assembly, comprising a sample adding needle for injecting a reconstitution solution into the sample container. When reconstituting a freeze-dried sample, the sample container containing the freeze-dried sample is placed on the reconstitution station. The reconstitution device is provided with the rotating driving device for driving the sample container on the reconstitution station to rotate and the heating device for heating the sample container. While the sample adding needle of the liquid adding assembly injects the reconstitution solution into the sample container, the heating device heats the sample container, and the rotating driving device drives the sample container to rotate, so that the mixing of the reconstitution solution and the freeze-dried sample can be accelerated, and the dissolution of the freeze-dried sample can be accelerated by high temperature. The reconstitution of the freeze-dried sample is realized artificially, and the labor intensity of the operator is reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of freeze-dried sample dissolving, and more particularly to a reconstitution device. BACKGROUND

[0002] In some scenarios, freeze-dried powder or frost sample (hereinafter referred to as freeze-dried sample) needs to be reconstituted before use. At present, when reconstituting the freeze-dried sample, the operator pours the reconstitution solution into the sample container containing the freeze-dried sample, and then heats the solution in the sample container to speed up the dissolution of the freeze-dried sample. However, the current reconstitution of the freeze-dried sample needs to be completed manually by the operator, which consumes manpower and increases the labor intensity of the operator.

[0003] Therefore, how to reduce the labor intensity of the operator is a problem to be solved by those skilled in the art. CONTENT OF THE UTILITY MODEL

[0004] Therefore, the purpose of the present application is to provide a reconstitution device to reduce the labor intensity of the operator.

[0005] To achieve the above-mentioned purpose, the present application provides the following technical solutions:

[0006] The first aspect of the present application provides a reconstitution device, comprising:

[0007] A rotating heating assembly, comprising a reconstitution station for placing a sample container, a rotating drive device for driving the sample container to rotate, and a heating device for heating the sample container;

[0008] A liquid adding assembly, comprising a sample adding needle, a reconstitution solution storage container, a reconstitution solution pump, a lifting drive device, and a displacement drive device, the sample adding needle being used to inject reconstitution solution into the sample container, the reconstitution solution storage container being used to store reconstitution solution, an inlet of the reconstitution solution pump being in communication with the reconstitution solution storage container through a liquid inlet pipeline, an outlet of the reconstitution solution pump being in communication with the sample adding needle through a liquid outlet pipeline, the displacement drive device being arranged at an output end of the lifting drive device, the sample adding needle being installed at an output end of the displacement drive device, and the displacement drive device being used to drive the sample adding needle to move in a direction close to and away from the sample container.

[0009] In a possible implementation manner, the sample adding needle is arranged at an angle greater than 0° with respect to the axis of the sample container.

[0010] In a possible implementation manner, the reconstitution device further comprises an oscillation device arranged at the oscillation station, and the oscillation device is used to perform oscillation processing on the sample container into which the reconstitution solution is added.

[0011] In a possible implementation, the reconstitution station is provided with a rotating table for supporting the sample container, and the output end of the rotating drive device is in transmission connection with the rotating table.

[0012] The heating device is in a ring structure, and when the sample container is located at the reconstitution station, the heating device is sleeved outside the sample container.

[0013] In a possible implementation, the sample adding needle is installed on the output end of the displacement drive device through a mounting assembly, the mounting assembly includes a first mounting block and a second mounting block, the first mounting block is installed on the output end of the displacement drive device, the sample adding needle is installed on the second mounting block, and the second mounting block is rotatably locked on the first mounting block to adjust the angle of the sample adding needle.

[0014] In a possible implementation, the reconstitution device further includes a pipeline clamp assembly for clamping the liquid inlet pipeline and / or the liquid outlet pipeline, the pipeline clamp assembly includes a support rod and a pipeline clamp arranged on the support rod.

[0015] The pipeline clamp includes a first clamp body and a second clamp body, a pipeline slot for clamping the liquid inlet pipeline and / or the liquid outlet pipeline is formed between the first clamp body and the second clamp body, and the first clamp body and the second clamp body are adjusted in spacing through a threaded member.

[0016] In a possible implementation, the liquid adding assembly further includes a container bracket for supporting the reconstitution solution storage container, the container bracket includes a support plate, a limiting plate and a connecting rod connecting the support plate and the limiting plate, the limiting plate is located on the upper side of the support plate, and is provided with an insertion opening for inserting the reconstitution solution storage container to limit the movement of the reconstitution solution storage container.

[0017] In a possible implementation, the liquid adding assembly further includes a liquid receiving groove located at the standby station, and when the sample adding needle is in an idle state, the sample adding needle is located above the liquid receiving groove.

[0018] And / or,

[0019] The rotating heating assembly includes a housing, the housing is formed with a detection notch, and the reconstitution device further includes a code scanning device for identifying the identification code information of the sample container through the detection notch.

[0020] The reconstitution device provided by the application is used to reconstitute the freeze-dried sample. When the freeze-dried sample needs to be reconstituted, the sample container containing the freeze-dried sample is placed in the reconstitution station. The reconstitution device is provided with a rotating driving device for driving the sample container on the reconstitution station to rotate and a heating device for heating the sample container. The sample needle of the liquid adding assembly injects the reconstitution solution into the sample container, and at the same time, the heating device heats the sample container, and the rotating driving device drives the sample container to rotate, so that the mixing of the reconstitution solution and the freeze-dried sample can be accelerated, and the dissolution of the freeze-dried sample can be accelerated by high temperature. The reconstitution of the freeze-dried sample can be realized by the reconstitution device instead of manual operation, and the labor intensity of the operator is reduced. BRIEF DESCRIPTION OF DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or the prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0022] Figure 1 The structure schematic diagram of the reconstitution device disclosed by the embodiments of the present application is shown in the figure.

[0023] Figure 2 The partial structure schematic diagram of the reconstitution solution storage container and the container bracket disclosed by the embodiments of the present application is shown in the figure.

[0024] Figure 3 The structure schematic diagram of the rotating heating assembly disclosed by the embodiments of the present application is shown in the figure.

[0025] Figure 4 The partial structure schematic diagram of the sample needle and the pipeline clamp assembly disclosed by the embodiments of the present application is shown in the figure.

[0026] The meanings of the various reference signs in the figure are as follows:

[0027] 100-rotating heating assembly; 110-heating device; 120-rotating driving device; 130-housing; 131-detection notch;

[0028] 200-displacement driving device;

[0029] 300-sample needle; 310-liquid receiving groove; 320-first mounting block; 330-second mounting block; 340-quick release part;

[0030] 400-sample container;

[0031] 500-container bracket; 510-supporting plate; 520-limiting plate; 521-insertion port; 530-linkage;

[0032] 600-reconstitution solution storage container;

[0033] 700-pipe clamp assembly; 710-supporting rod; 720-pipe clamp; 721-first clamp body; 722-second clamp body; 723-threaded fastener; 724-pipe slot; 725-gripping block;

[0034] 800-lifting driving device;

[0035] 900-code scanning device. DETAILED DESCRIPTION

[0036] The embodiment of the application discloses a re-dissolving device to reduce the labor intensity of the operator.

[0037] Hereinafter, the embodiments will be described with reference to the accompanying drawings. In addition, the embodiments shown below do not have any limiting effect on the application content recited in the claims. In addition, the entire content of the configuration represented in the following embodiments is not limited to what is necessary as a solution to the application recited in the claims. It should be noted that only the parts related to the application are shown in the drawings for ease of description. In the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined with each other.

[0038] After the extraction of effective components of traditional Chinese medicinal materials is completed, the separation of compounds is carried out in a chromatographic device, and the components of traditional Chinese medicinal materials after the separation of compounds are collected in a fraction tube (an open test tube) to prepare for the subsequent test of specific components. In order to purify the compounds of the components of traditional Chinese medicinal materials in the fraction tube, freeze-drying treatment is usually required to evaporate the internal water and alcohol substances, etc., to form a freeze-dried sample. When the compounds in the fraction tube are needed, the freeze-dried sample needs to be re-dissolved.

[0039] At present, when the freeze-dried sample is re-dissolved, the operator pours a re-dissolving solution (re-dissolving solution) into a sample container containing the freeze-dried sample, and then heats the solution in the sample container to accelerate the dissolution of the freeze-dried sample. The re-dissolving solution can be dimethyl sulfoxide (Dimethyl sulfoxide, DMSO), which is a sulfur-containing organic compound and an organic solvent with high polarity and water solubility. It is well known that DMSO can dissolve a variety of compounds, including many water-soluble compounds and fat-soluble compounds, so DMSO is also known as a universal solvent.

[0040] However, the current freeze-dried sample re-dissolving work needs to be completed manually, which consumes manpower and increases the labor intensity of the operator. Based on this, the embodiment of the present application discloses a re-dissolving device to reduce the labor intensity of the operator.

[0041] As Figure 1 and Figure 3As shown, the reconstitution apparatus disclosed in this application includes a rotary heating assembly 100 and a liquid addition assembly. The rotary heating assembly 100 includes a reconstitution station for placing a sample container 400, a rotary drive device 120 for rotating the sample container 400, and a heating device 110 for heating the sample container 400.

[0042] The remelting station is used to position the sample container 400. After being placed in the remelting station, the sample container 400 must remain stable to prevent it from falling off the station when it rotates. Specifically, a necessary placement slot can be provided in the remelting station. The sample container 400 is placed in the slot, and the side wall of the slot limits its position, thus keeping it in place on the remelting station.

[0043] Furthermore, the heating device 110 can heat the sample container 400, transferring heat to the reconstituted solution within the sample container 400 through the side wall of the sample container 400, thereby accelerating the dissolution of the lyophilized sample by the reconstituted solution. This application does not limit the specific heating method of the heating device 110; for example, it may include a heating wire to heat the sample container 400 through electrical heating.

[0044] The liquid dispensing assembly includes a dispensing needle 300 for injecting the reconstituted solution into the sample container 400. While the dispensing needle 300 injects the reconstituted solution into the sample container 400, the rotary drive device 120 can simultaneously drive the sample container 400 to rotate, so that the reconstituted solution injected by the dispensing needle 300 can come into contact with the lyophilized sample in the sample container 400 over a wider range, thereby improving the mixing efficiency.

[0045] The reconstitution apparatus disclosed in this application, when reconstitution of lyophilized samples is required, places a sample container 400 containing the lyophilized sample at the reconstitution station. The reconstitution apparatus is equipped with a rotary drive device 120 for driving the sample container 400 to rotate at the reconstitution station and a heating device 110 for heating the sample container 400. While the dispensing needle of the dispensing assembly injects the reconstitution solution into the sample container 400, the heating device 110 heats the sample container 400, and the rotary drive device 120 drives the sample container 400 to rotate, thereby accelerating the mixing of the reconstitution solution and the lyophilized sample. The high temperature accelerates the dissolution of the lyophilized sample. This application can replace manual reconstitution of lyophilized samples with a reconstitution apparatus, reducing the labor intensity of operators.

[0046] Some of the lyophilized samples inside the sample container 400 are usually attached to the inner wall of the sample container 400. Some of them are attached at a higher position, so a higher level of reconstitution solution needs to be injected in order to soak all the lyophilized samples. This will inevitably affect the reconstitution efficiency and reconstitution effect.

[0047] Based on this, in one specific embodiment of this application, the sampling needle 300 and the axis of the sample container 400 are arranged at an angle greater than 0°. This arrangement ensures that when the sampling needle 300 is inserted into the sample container 400, the outlet of the sampling needle 300 can closely adhere to the inner wall of the sample container 400. When the reconstitution solution is ejected, it forms a directional liquid flow that directly washes away the lyophilized sample adhering to the inner wall, allowing the reconstitution solution to remove the lyophilized sample adhering to the inner wall and flow towards the bottom of the sample container 400. Combined with the rotation of the sample container 400, the entire inner wall can be washed away, ensuring that all the lyophilized sample on the side walls of the sample container 400 is washed away by the reconstitution solution.

[0048] Furthermore, the inclined flow of liquid from the sampling needle 300 generates a tangential mechanical impact force on lyophilized sample clumps, helping to break up and dissolve the lyophilized sample blocks, accelerating their disintegration and dissolution process, especially effective for tightly packed samples. It also effectively rinses corners where sample tends to accumulate, such as the junction of the bottom and side walls of the sample container 400. Combined with the rotation of the sample container 400, it ensures complete coverage of all corners with the rehydration solution, avoiding the problem of the rehydration solution failing to wet the edges of the lyophilized sample when applied vertically.

[0049] Furthermore, when adding the reconstitution solution vertically, the droplets falling from a certain height may impact the liquid surface or the bottom of the container, causing tiny droplet splashes. These splashed droplets may carry sample components, contaminating the exterior of the sampling needle 300 or the opening of the sample container 400. In this embodiment, however, the sampling needle 300 is tilted and placed against the wall, allowing the reconstitution solution to flow smoothly down the inner wall of the sample container 400, greatly reducing the risk of splashing.

[0050] In one specific embodiment of this application, the reconstitution apparatus may further include an oscillation device (not shown in the figure) disposed at the oscillation station. The oscillation device is used to oscillate the sample container 400 to which the reconstitution solution is added. The oscillation device may be a vortex oscillation device or other types of oscillation devices. This embodiment does not limit the specific type of oscillation device.

[0051] The vibration of the oscillation process greatly accelerates the thermal and relative motion of the reconstituted solution and the lyophilized sample, allowing the molecules of the reconstituted solution to penetrate into every pore of the lyophilized sample more quickly, while simultaneously carrying away the dissolved molecules from the powder surface, creating space for subsequent dissolution.

[0052] Oscillation (especially vortex oscillation) generates strong eddies, shear forces, and convection within the liquid. This is highly effective in breaking up any remaining tiny lyophilized sample particles or aggregates, eliminating potential dead zones after the initial flushing with the syringe needle 300, and ensuring that no undissolved particles remain.

[0053] After standing dissolution or gentle shaking, there may be concentration differences between the bottom and top of the reconstituted solution and the lyophilized sample solution. Shaking ensures that the solution reaches a high degree of molecular homogeneity in a short time, resulting in a completely consistent concentration in any fraction drawn from the solution. This is crucial for the accuracy of subsequent quantitative analysis results. Shaking can achieve the dissolution effect that would require tens of minutes of gentle shaking manually in tens of seconds to minutes, significantly shortening the entire reconstitution process time, making it particularly suitable for high-throughput screening.

[0054] In one specific embodiment of this application, a rotating platform supporting a sample container 400 is provided at the reconstitution station, and the output end of the rotation drive device 120 is connected to the rotating platform for transmission. The rotating platform is used to support the sample container 400. Since the purpose of rotating the sample container 400 is mainly to ensure that the reconstitution solution can be uniformly injected into the sample container 400, when the sampling needle 300 is tilted, the rotation of the sample container 400 can ensure that the reconstitution solution can flow uniformly downwards along the inner wall of the sample container 400. Therefore, the rotation speed of the sample container 400 does not need to be too fast. So even if the rotating platform does not need to fix the sample container 400, the gravity of the sample container 400 can still ensure that the sample container 400 can be driven to rotate when the rotating platform rotates.

[0055] To ensure that the sample container 400 does not shake when it rotates, a corresponding receiving groove can be set on the rotating platform. The bottom of the sample container 400 is placed in the receiving groove of the rotating platform to support the outer wall of the sample container 400.

[0056] In this embodiment, the heating device 110 can be a ring structure, and when the sample container 400 is located at the remelting station, the heating device 110 is sleeved on the outside of the sample container 400. The heating device 110 can be fixed to the shell structure around the remelting station. When a receiving groove is provided on the rotating platform, the heating device 110 is located above the rotating platform, and the central hole of the heating device 110 corresponds vertically to the receiving groove on the rotating platform. The sample container 400 can be inserted into the central hole of the heating device 110 and the receiving groove of the rotating platform from top to bottom. The heating device 110 above the rotating platform can also position the sample container 400 to prevent the sample container 400 from shaking during rotation.

[0057] In this embodiment, the heating device 110 is designed as a ring structure, which can uniformly conduct heat to the sample container 400 along the outer periphery of the sample container 400, ensuring that the solution in the sample container 400 is heated evenly.

[0058] like Figure 2 and Figure 4 As shown in a specific embodiment of this application, the liquid addition assembly further includes a reconstitution storage container 600 and a reconstitution pump (not shown in the figure).

[0059] The reconstitution solution storage container 600 is used to store the reconstitution solution. The inlet of the reconstitution solution pump is connected to the storage container 600 via an inlet line, and the outlet of the pump is connected to the sampling needle 300 via an outlet line. After the reconstitution solution pump is turned on, the reconstitution solution stored in the storage container 600 can be injected into the sample container 400 through the sampling needle 300. The flow rate of the reconstitution solution pump can be adjusted. It should be noted that a corresponding flow valve can also be installed on the outlet line to adjust the flow rate of the reconstitution solution.

[0060] like Figure 4 As shown in the figure, in this embodiment, the liquid addition assembly may further include a lifting drive device 800 and a displacement drive device 200.

[0061] The displacement drive device 200 is located at the output end of the lifting drive device 800, so that when the lifting drive device 800 outputs an action, it can drive the displacement drive device 200 to perform a lifting action through its output end. Specifically, based on the action requirements, the displacement drive device 200 can be driven to rise or fall.

[0062] The sampling needle 300 is mounted at the output end of the displacement drive device 200, which drives the sampling needle 300 to move closer to and further away from the sample container 400. Through the combined action of the lifting drive device 800 and the displacement drive device 200, movement of the sampling needle 300 within space can be achieved. Specifically, the lifting drive device 800 can be used to achieve vertical movement, and the displacement drive device 200 can be used to achieve horizontal movement along the direction closer to and further away from the sample container 400.

[0063] When the sampling needle 300 needs to inject the reconstituted solution into the sample container 400, the lifting drive device 800 first raises the displacement drive device 200 and the sampling needle 300, making the sampling needle 300 higher than the opening of the sample container 400. Then, the displacement drive device 200 actuates, moving the sampling needle 300 closer to the sample container 400 until it is above the opening of the sample container 400. Next, the lifting drive device 800 lowers the displacement drive device 200 and the sampling needle 300, so that the outlet of the sampling needle 300 is below the opening of the sample container 400, i.e., the outlet of the sampling needle 300 extends into the sample container 400. Finally, the displacement drive device 200 actuates, moving the sampling needle 300 until the outlet of the sampling needle 300 is against the inner wall of the sample container 400.

[0064] After the injection of liquid into the sampling needle 300 is completed, the displacement drive device 200 can be activated to move the sampling needle 300 until its outlet is no longer in contact with the inner wall of the sample container 400. Then, the lifting drive device 800 raises the displacement drive device 200 and the sampling needle 300, positioning the outlet of the sampling needle 300 above the opening of the sample container 400, thus removing the sampling needle 300 from the sample container 400. Finally, the displacement drive device 200 activates, moving the sampling needle 300 away from the sample container 400 to the desired position.

[0065] The lifting drive device 800 lowers the sampling needle 300 to a suitable height within the sample container 400. Subsequently, the displacement drive device 200 fine-tunes the position of the sampling needle 300, ensuring its outlet is precisely positioned at the target location on the inner wall of the sample container 400 (typically the area where the lyophilized sample adheres) with the optimal tilt angle. This complex, multi-step standardized operation completely eliminates reliance on manual operation, guaranteeing a high degree of consistency and repeatability in each action.

[0066] Precise motion control ensures that the sampling needle 300, during its tilted entry and exit, only contacts the pre-defined inner wall of the sample container 400, avoiding contact with the rim or other parts of the container, thus fundamentally preventing cross-contamination. For lyophilized samples adhering to different heights within the sample container 400, the program can also control the sampling needle 300 to slowly rise during injection, allowing the reconstitution solution to flow along a path from bottom to top, ensuring full contact with all powder.

[0067] In one specific embodiment of this application, the sampling needle 300 is mounted to the output end of the displacement driving device 200 via a mounting assembly. The mounting assembly includes a first mounting block 320 and a second mounting block 330. The first mounting block 320 is mounted to the output end of the displacement driving device 200, and the sampling needle 300 is mounted on the second mounting block 330. Specifically, the sampling needle 300 can be fixed to the second mounting block 330 via a quick-release piece 340.

[0068] The quick-release component 340 may include an insert block fixed to the second mounting block 330. The insert block has an insertion hole into which the sampling needle 300 is inserted. The insert block has a locking element that abuts against the sampling needle 300 to fix the sampling needle 300 to the insert block, and subsequently to the second mounting block 330. The locking element may be a spring-loaded locking element, specifically including a locking rod and a spring sleeved on the locking rod that pushes the locking rod towards the sampling needle 300. Under the action of the spring, the locking rod presses against the outer wall of the sampling needle 300, using friction to hold the sampling needle 300 within the insertion hole of the insert block. When it is necessary to disassemble the sampling needle 300 or adjust the position of the sampling needle 300 in the insertion hole, simply pull the locking rod away from the sampling needle 300 so that the end face of the locking rod is disengaged from the outer wall of the sampling needle 300. Then the sampling needle 300 can be removed or its position adjusted. After the operation is completed, release the locking rod, and the locking rod will continue to tighten the sampling needle 300 under the action of the spring.

[0069] The second mounting block 330 is rotatably locked onto the first mounting block 320 to adjust the angle of the sampling needle 300. Specifically, the first mounting block 320 and the second mounting block 330 are rotatably connected via a pivot, meaning the second mounting block 330 can rotate relative to the pivot. During the rotation of the second mounting block 330, the sampling needle 300 can be driven to swing, thereby adjusting the tilt angle of the sampling needle 300. After the tilt angle of the sampling needle 300 is adjusted, the first mounting block 320 and the second mounting block 330 can be locked together by a locking device to hold the sampling needle 300 at the corresponding tilt angle.

[0070] The locking element used to lock the first mounting block 320 and the second mounting block 330 can be a locking screw. Specifically, a threaded hole is provided on the second mounting block 330, and the locking screw mates with the threaded hole. When it is necessary to rotate the second mounting block 330, the locking screw is loosened, so that the end of the locking screw disengages from the first mounting block 320. When the second mounting block 330 is rotated to the appropriate position (i.e., when the tilt angle of the sample needle 300 is adjusted to the appropriate position), the locking screw is tightened, so that the end of the locking screw abuts against the first mounting block 320. Under the action of friction, the first mounting block 320 and the second mounting block 330 are locked together.

[0071] It should be noted that a threaded hole can also be provided on the first mounting block 320, and the end of the locking screw can be pressed against the second mounting block 330. The locking mechanism is the same as described above, and will not be repeated here.

[0072] In one specific embodiment of this application, the reconstitution device may further include a pipe clamp assembly 700 for clamping the inlet pipe and / or outlet pipe. Those skilled in the art can select the number of pipe clamp assemblies 700 according to requirements. The pipe clamp assembly 700 can organize and store the inlet pipe, outlet pipe, and other pipes, ensuring that the corresponding pipes are held in their respective positions, preventing them from being randomly placed and affecting the movement of surrounding moving parts (such as the output ends of the lifting drive device 800 and the displacement drive device 200), or from being squeezed by moving parts and causing damage and leakage.

[0073] The pipe clamp assembly 700 may include a support rod 710 and a pipe clamp 720 disposed on the support rod 710. The pipe clamp 720 can be detachably fixed to the support rod 710. The support rod 710 has a certain height, and the position of the pipe clamp 720 on the support rod 710 can be adjusted, so that the pipe clamp 720 can be arranged at a corresponding height position according to the space requirements, so as to facilitate the arrangement of pipes.

[0074] In this embodiment, the pipe clamp 720 includes a first clamping body 721 and a second clamping body 722, with a pipe groove 724 formed between the first clamping body 721 and the second clamping body 722 to clamp the inlet pipe and / or outlet pipe. One of the first clamping body 721 and the second clamping body 722 can be detachably fixed to the support rod 710 by fasteners and clamping blocks 725. Taking the first clamping body 721 and the clamping block 725 clamping the support rod 710 by fasteners as an example, both the first clamping body 721 and the clamping block 725 have grooves that match the outer surface of the support rod 710. Typically, the support rod 710 has a cylindrical structure, so the grooves on the first clamping body 721 and the clamping block 725 are arc-shaped grooves. The first clamping body 721 and the clamping block 725 clamp the support rod 710 between them, ensuring that the grooves of the first clamping body 721 and the clamping block 725 cooperate with the support rod 710. Fasteners are used to secure the first clamping body 721 and the clamping block 725, thereby fixing the first clamping body 721 and the clamping block 725 on the support rod 710. After the fasteners are loosened, the clamping force of the first clamping body 721 and the clamping block 725 on the support rod 710 is reduced, and the first clamping body 721 and the clamping block 725 can be moved to adjust the height of the first clamping body 721 and the second clamping body 722 on the support rod 710. After adjustment, the fasteners can be tightened.

[0075] The first clamp 721 and the second clamp 722 are spaced apart by a threaded part 723. Both the first clamp 721 and the second clamp 722 are provided with pipe half-grooves. When the first clamp 721 and the second clamp 722 are connected, the pipe half-grooves on the two are aligned to form a pipe groove 724.

[0076] One of the first clamping body 721 and the second clamping body 722 may be provided with a smooth hole, and the other with a threaded hole. A threaded component 723 passes through the smooth hole and engages with the threaded hole, thereby achieving clamping of the pipeline by the first clamping body 721 and the second clamping body 722. To ensure the stability of the clamping, threaded components 723 need to be provided on both sides of the pipeline groove 724.

[0077] like Figure 2 As shown in a specific embodiment of this application, the liquid addition assembly further includes a container bracket 500 supporting the reconstituted solution storage container 600. The container bracket 500 includes a support plate 510, a limiting plate 520, and a connecting rod 530 connecting the support plate 510 and the limiting plate 520. There are typically multiple connecting rods 530, which connect the support plate 510 and the limiting plate 520 at multiple locations, thus providing support for the support plate 510 from multiple positions.

[0078] The limiting plate 520 is located above the support plate 510. The two can be arranged in parallel, and the distance between them in the height direction can be designed according to the height of the reconstituted solution storage container 600. For example, a part of the reconstituted solution storage container 600 can be located above the limiting plate 520, and the center of gravity of the reconstituted solution storage container 600 can be located below the limiting plate 520, which can ensure the stability of the container bracket 500 in placing the reconstituted solution storage container 600.

[0079] The limiting plate 520 is provided with an insertion port 521 for inserting the reconstituted solution storage container 600 to restrict its movement. The reconstituted solution storage container 600 is inserted through the insertion port 521 and supported on the support plate 510. The inner wall of the insertion port 521 serves as a limiting boundary for the reconstituted solution storage container 600, preventing it from moving on the support plate 510, thereby improving the stability of the reconstituted solution storage container 600 and preventing it from tipping over.

[0080] The number of insertion ports 521 of the limiting plate 520 can be determined according to the number of reconstituted solution storage containers 600 that need to be placed, so as to satisfy the placement of each reconstituted solution storage container 600.

[0081] like Figure 4 As shown in a specific embodiment of this application, the liquid dispensing assembly also includes a liquid receiving tank 310 located at the waiting station. When the sampling needle 300 is idle, it needs to be moved to the waiting station. When the sampling needle 300 is at the waiting station, it is located above the liquid receiving tank 310 so that the reconstituted solution dripped from the sampling needle 300 can be received by the liquid receiving tank 310, preventing contamination of other surrounding components.

[0082] In one specific embodiment of this application, the rotary heating assembly 100 further includes a housing 130, the rotary table and the heating device 110 may be disposed inside the housing 130, and the rotary drive device 120 may be disposed inside the housing 130 or outside the housing 130.

[0083] A detection notch 131 is formed on the housing 130 so that the sample container 400 can be exposed at the detection notch 131. The reconstitution apparatus also includes a barcode scanner 900 that collects the identification code information of the sample container 400 through the detection notch 131. For example, a QR code with identification code information can be affixed to the sample container 400. The barcode scanner 900 can scan the QR code to identify the identification code information and track process records. The identification code information may include information such as the drug number and the current process flow of the drug.

[0084] As indicated in this application and claims, unless the context clearly indicates otherwise, the words "a," "an," "a," and / or "the" are not specifically singular and may include the plural. Generally, the terms "comprising" and "including" only indicate the inclusion of expressly identified steps and elements, which do not constitute an exclusive list, and the method or apparatus may also include other steps or elements. An element defined by the phrase "comprising an..." does not exclude the presence of other identical elements in the process, method, product, or apparatus that includes the element.

[0085] In the description of this application, unless otherwise expressly defined, terms such as "setup," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this application in conjunction with the specific content of the technical solution.

[0086] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0087] This document uses specific examples to illustrate the principles and implementation methods of this application. The descriptions of the embodiments above are only for the purpose of helping to understand the method and core ideas of this application. It should be noted that those skilled in the art can make several improvements and modifications to this application without departing from the principles of this application, and these improvements and modifications also fall within the protection scope of the claims of this application.

Claims

1. A reconstitution apparatus, characterized in that, include: The rotary heating assembly (100) includes a remelting station for placing a sample container (400), a rotary drive device (120) for rotating the sample container (400), and a heating device (110) for heating the sample container (400). The liquid dispensing assembly includes a dispensing needle (300), a reconstitution solution storage container (600), a reconstitution solution pump, a lifting drive device (800), and a displacement drive device (200). The dispensing needle (300) is used to inject the reconstitution solution into the sample container (400). The reconstitution solution storage container (600) is used to store the reconstitution solution. The inlet of the reconstitution solution pump is connected to the reconstitution solution storage container (600) through an inlet pipe, and the outlet of the reconstitution solution pump is connected to the dispensing needle (300) through an outlet pipe. The displacement drive device (200) is located at the output end of the lifting drive device (800), and the dispensing needle (300) is installed at the output end of the displacement drive device (200). The displacement drive device (200) is used to drive the dispensing needle (300) to move towards and away from the sample container (400).

2. The resolution apparatus as described in claim 1, characterized in that, The sample dispensing needle (300) is arranged at an angle greater than 0° with the axis of the sample container (400).

3. The resolution apparatus as described in claim 1, characterized in that, It also includes an oscillation device located at the oscillation station, which is used to oscillate the sample container (400) to which the reconstitution solution has been added.

4. The resolution apparatus as described in claim 1, characterized in that, The reconstitution station is equipped with a rotating platform that supports the sample container (400), and the output end of the rotation drive device (120) is connected to the rotating platform for transmission. The heating device (110) has a ring structure, and when the sample container (400) is located at the reconstitution station, the heating device (110) is sleeved on the outside of the sample container (400).

5. The resolution apparatus as described in claim 1, characterized in that, The sampling needle (300) is mounted on the output end of the displacement drive device (200) via a mounting assembly. The mounting assembly includes a first mounting block (320) and a second mounting block (330). The first mounting block (320) is mounted on the output end of the displacement drive device (200), and the sampling needle (300) is mounted on the second mounting block (330). The second mounting block (330) is rotatably locked onto the first mounting block (320) to adjust the angle of the sampling needle (300).

6. The resolution apparatus as described in claim 1, characterized in that, It also includes a pipe clamp assembly (700) for clamping the inlet pipe and / or the outlet pipe, the pipe clamp assembly (700) including a support rod (710) and a pipe clamp (720) disposed on the support rod (710). The pipe clamp (720) includes a first clamp body (721) and a second clamp body (722), and a pipe groove (724) for clamping the liquid inlet pipe and / or the liquid outlet pipe is formed between the first clamp body (721) and the second clamp body (722). The distance between the first clamp body (721) and the second clamp body (722) is adjusted by a threaded part (723).

7. The resolution apparatus as described in claim 1, characterized in that, The liquid addition assembly also includes a container bracket (500) supporting the reconstituted solution storage container (600). The container bracket (500) includes a support plate (510), a limiting plate (520), and a connecting rod (530) connecting the support plate (510) and the limiting plate (520). The limiting plate (520) is located on the upper side of the support plate (510) and has an insertion port (521) for inserting the reconstituted solution storage container (600) to restrict the movement of the reconstituted solution storage container (600).

8. The resolution apparatus according to any one of claims 1-7, characterized in that, The liquid dispensing assembly also includes a liquid receiving tank (310) located at the waiting station, and the sampling needle (300) is located above the liquid receiving tank (310) when it is idle.

9. The resolution apparatus according to any one of claims 1-7, characterized in that, The rotary heating assembly (100) includes a housing (130) on which a detection notch (131) is formed. The remelting device also includes a barcode scanner (900) that identifies the identification code information of the sample container (400) through the detection notch (131).

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