A reagent bottle dispensing liquid adding device

Abstract

The application relates to a reagent bottle sub-packaging liquid adding device and relates to the technical field of laboratory automation equipment, which comprises a rack, a liquid filling mechanism is arranged on the upper surface of the rack, and the liquid filling mechanism comprises a supporting shell, a controller, a liquid containing groove and a liquid supplementing tank. An outer surface of the supporting shell is provided with the controller. The liquid level in the liquid containing groove is monitored in real time through a high-low liquid level meter. When the liquid level is lower than a set value, the controller automatically controls a solution pump to start and pump liquid from the liquid supplementing tank to the liquid containing groove, so that automatic liquid supplementing is realized, manual intervention is avoided, continuous and uninterrupted automatic sub-packaging process is ensured, and the overall sub-packaging efficiency is improved. When the water inlet pipe is inserted into the liquid containing groove, a sealing cover plate is lifted to open a liquid channel. When the water inlet pipe is pulled out, a spring supporting rod automatically resets the sealing cover plate to close the channel, prevents liquid leakage, facilitates quick dismounting and thorough cleaning of the liquid containing groove, and reduces dead angle residues and cross contamination.

Description

Technical Field

[0001] This application relates to the technical field of laboratory automation equipment, and in particular to a reagent bottle dispensing and liquid adding device. Background Technology

[0002] A reagent bottle dispensing and filling device is an automated device used in laboratory or production environments. Its main function is to accurately and efficiently dispense liquid reagents into multiple reagent bottles. The device typically consists of a pipetting system, a bottle conveying and positioning mechanism, and a control system. It can quickly complete the filling operation according to a preset volume while avoiding liquid splashing or cross-contamination. It is widely used in biopharmaceutical, chemical analysis and other fields, significantly improving the accuracy and efficiency of the dispensing process and reducing the risks of manual operation. However, existing reagent bottle dispensing and liquid adding devices have the following shortcomings: the solution supply process lacks automatic monitoring and replenishment functions. When the liquid level in the container drops, manual operation is required to pause and replenish the liquid, making it difficult to achieve a continuous and uninterrupted automated production process, which affects the overall dispensing efficiency. Furthermore, fixed container tanks and pipette tips may have blind spots during cleaning. If cleaning is not thorough, it can easily lead to residues and cross-contamination of reagents from different batches or with different components, affecting the purity of the reagents and the accuracy of the experimental results. Summary of the Invention

[0003] The purpose of this application is to provide a reagent bottle dispensing and adding device to solve the above-mentioned problems.

[0004] In a first aspect, the reagent bottle dispensing and liquid adding device provided in this application adopts the following technical solution: it includes a frame, a liquid filling mechanism is installed on the upper surface of the frame, the liquid filling mechanism includes a support shell, a controller, a liquid tank, and a replenishment tank, the controller is provided on the outer surface of the support shell, and the controller is electrically connected to the high and low liquid level gauges provided inside the liquid tank, a positioning plate is provided at the upper end of the inside of the support shell to support and fix the liquid tank, the replenishment tank is installed at the lower end of the inside of the support shell, a solution pump is provided on the replenishment tank, the solution pump is electrically connected to the controller, and the controller controls the solution pump to pump the liquid in the replenishment tank into the liquid tank based on the signal from the high and low liquid level gauges; By adopting the above technical solution, the liquid level in the liquid tank is monitored in real time by high and low liquid level gauges. When the liquid level is lower than the set value, the controller automatically controls the solution pump to start and pump liquid from the replenishment tank to the liquid tank, realizing automatic liquid replenishment, avoiding manual intervention, ensuring a continuous and uninterrupted automated dispensing process, and improving the overall dispensing efficiency.

[0005] Preferably, the lower end of the solution pump is connected to a hose, and a gravity ball is provided at the lower end of the hose. The lower end of the hose is located inside the lower end of the replenishment tank. The upper end of the solution pump is connected to a water inlet pipe, and the upper end of the water inlet pipe is inserted into the lower end of the liquid container. By adopting the above technical solution, the design of the hose and gravity ball ensures that the gravity ball will always be submerged at the bottom of the liquid regardless of changes in the liquid level in the replenishment tank, ensuring that the solution pump can effectively draw liquid and avoid dry suction. In addition, the water inlet pipe is inserted into the liquid tank, which facilitates liquid transportation and maintains a sealed connection, reducing the risk of leakage.

[0006] Preferably, a sealing cover is provided at the bottom of the inner side of the liquid tank, and when the upper end of the water inlet pipe is inserted into the liquid tank, the sealing cover is pushed upward. A spring support rod is provided on the bottom surface of the sealing cover, and the lower end of the spring support rod is installed inside the lower end of the liquid tank with clearance fit. By adopting the above technical solution, when the water inlet pipe is inserted into the liquid tank, the sealing cover is lifted to open the liquid channel. When the water inlet pipe is pulled out, the spring support rod causes the sealing cover to automatically reset and close the channel to prevent liquid leakage. At the same time, it facilitates the quick disassembly and thorough cleaning of the liquid tank, reducing dead corner residue and cross-contamination.

[0007] Secondly, the reagent bottle dispensing and liquid adding device provided in this application adopts the following technical solution: a support rod is welded to the upper surface of the frame, and a driving mechanism is provided at the upper end of the support rod. The driving mechanism includes a horizontal linear module and a vertical linear module. A vertical linear module is installed on the front surface of the horizontal linear module, and the horizontal linear module drives the vertical linear module to move horizontally. A pipette is installed on the front surface of the vertical linear module, and the vertical linear module drives the pipette to move vertically. By adopting the above technical solution, both the horizontal and vertical linear modules are existing technologies and will not be described in detail here. The coordinated operation of the horizontal and vertical linear modules enables the pipette to move precisely in both horizontal and vertical directions, covering multiple reagent bottle positions, achieving fast and accurate dispensing operations, and improving dispensing efficiency and positioning accuracy.

[0008] Preferably, a stepper motor is fixedly installed on the top of the pipette, and a lead screw is connected to the output end of the stepper motor and drives it to rotate. A slider is slidably installed on the lead screw, and a pusher bracket is connected to the outer end of the slider. A suction mechanism is connected to the lower end of the pusher bracket. By adopting the above technical solution, the stepper motor drives the slider to move through the lead screw, thereby driving the propulsion support and the liquid suction mechanism to move up and down, realizing precise control of liquid suction and discharge; the stepper motor provides high-precision displacement control, ensuring the accuracy and repeatability of liquid transfer volume, and meeting the laboratory's requirements for dispensing accuracy.

[0009] Preferably, the liquid aspiration mechanism includes a connecting support plate, a liquid aspiration chamber, and a ceramic pipette rod. The upper surface of the connecting support plate is welded to the lower end of the propulsion bracket, and the lower surface of the connecting support plate is fixed to the top of the ceramic pipette rod. The lower end of the ceramic pipette rod is installed inside the liquid aspiration chamber with a clearance fit. The liquid aspiration chamber is located at the lower end of the pipette. A pipette tip is provided at the lower end of the pipette, and the liquid aspiration chamber is connected to the inside of the pipette tip through a built-in channel. By adopting the above technical solution, the connecting support plate transmits the movement of the propulsion bracket to the ceramic suction rod. The ceramic suction rod moves in the suction chamber, generating negative or positive pressure, thereby achieving liquid suction or discharge through the pipette tip. The ceramic material used in the ceramic suction rod has the characteristics of corrosion resistance and easy cleaning, avoiding reagent residue and cross-contamination, and ensuring the purity of the reagents and the accuracy of the experimental results.

[0010] Preferably, a positioning rod is also provided at the lower end of the pipette interior, and the positioning rod is engaged with the positioning of the pipette tip; By adopting the above technical solution, the positioning rod ensures accurate positioning and firm fixation of the pipette tip during installation, preventing the pipette tip from loosening or falling off during pipetting, thus ensuring the stability and reliability of operation. At the same time, it facilitates quick replacement of the pipette tip and improves maintenance efficiency.

[0011] In summary, this application includes at least one of the following beneficial technical effects of reagent bottle dispensing and adding devices: 1. The liquid level in the liquid tank is monitored in real time by high and low level gauges. When the liquid level is lower than the set value, the controller automatically controls the solution pump to start and pump liquid from the replenishment tank to the liquid tank, realizing automatic liquid replenishment, avoiding manual intervention, ensuring a continuous and uninterrupted automated dispensing process, and improving the overall dispensing efficiency. 2. When the water inlet pipe is inserted into the liquid tank, it lifts the sealing cover and opens the liquid passage. When the water inlet pipe is pulled out, the spring support rod automatically resets the sealing cover and closes the passage to prevent liquid leakage. At the same time, it facilitates the quick disassembly and thorough cleaning of the liquid tank, reducing dead corner residue and cross-contamination. 3. By using a stepper motor to drive the lead screw to control the liquid suction mechanism, combined with a ceramic suction rod and positioning structure, high-precision liquid dispensing and reliable nozzle positioning are achieved, which not only ensures the accuracy of the dispensing volume, but also improves the durability and operational stability of the equipment. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the overall structure of Embodiment 1 of this application; Figure 2 This is a three-dimensional structural diagram of the liquid filling mechanism of this application; Figure 3 This is a schematic diagram of the internal structure of the liquid tank in this application; Figure 4 This application Figure 3 A magnified structural diagram of part A in the middle; Figure 5 This is a schematic diagram of the internal structure of the pipette in this application; Explanation of reference numerals in the attached drawings: 1. Frame; 2. Liquid filling mechanism; 21. Support shell; 211. Positioning plate; 22. Controller; 23. Liquid tank; 231. High and low level gauges; 232. Sealing cover plate; 2321. Spring support rod; 24. Replenishment tank; 241. Hoses; 242. Gravity ball; 243. Solution pump; 244. Water inlet pipe; 3. Pipette; 31. Stepper motor; 32. Lead screw; 33. Slider; 34. Propulsion bracket; 35. Connecting support plate; 36. Suction chamber; 37. Ceramic suction rod; 38. Positioning rod; 39. Pipette tip; 4. Support rod; 5. Horizontal linear module; 6. Vertical linear module. Detailed Implementation

[0013] The following is in conjunction with the appendix Figure 1 - Appendix Figure 5 This application will be described in further detail below.

[0014] Example 1: A reagent bottle dispensing and adding device, referring to... Figure 1-4 The system includes a frame 1, on the upper surface of which a liquid filling mechanism 2 is mounted. The liquid filling mechanism 2 includes a support shell 21, a controller 22, a liquid tank 23, and a replenishment tank 24. The controller 22 is mounted on the outer surface of the support shell 21 and is electrically connected to a high / low level gauge 231 inside the liquid tank 23. A positioning plate 211 is mounted on the upper part of the support shell 21 to support and fix the liquid tank 23. The replenishment tank 24 is mounted on the lower part of the support shell 21 and is equipped with a solution pump 243. The solution pump 243 is electrically connected to the controller 22. The controller 22 controls the solution pump 243 to pump the liquid in the replenishment tank 24 into the liquid tank 23 based on the signal from the high / low level gauge 231. The liquid level in the liquid tank 23 is monitored in real time by the high and low liquid level gauges 231. When the liquid level is lower than the set value, the controller 22 automatically controls the solution pump 243 to start, pumping liquid from the replenishment tank 24 to the liquid tank 23, realizing automatic liquid replenishment, avoiding manual intervention, ensuring a continuous and uninterrupted automated dispensing process, and improving the overall dispensing efficiency.

[0015] The lower end of the solution pump 243 is connected to a hose 241, and a gravity ball 242 is installed at the lower end of the hose 241. The lower end of the hose 241 is located inside the lower end of the replenishment tank 24. The upper end of the solution pump 243 is connected to a water inlet pipe 244, and the upper end of the water inlet pipe 244 is inserted into the lower end of the liquid container 23. The design of the hose 241 and the gravity ball 242 ensures that the gravity ball 242 remains submerged at the bottom of the liquid regardless of changes in the liquid level in the replenishment tank 24, ensuring that the solution pump 243 can effectively draw liquid and avoid dry suction. In addition, the water inlet pipe 244 is inserted into the liquid container 23 to facilitate liquid delivery and maintain a sealed connection, reducing the risk of leakage.

[0016] A sealing cover plate 232 is provided at the bottom of the inner side of the liquid tank 23. When the upper end of the water inlet pipe 244 is inserted into the liquid tank 23, the sealing cover plate 232 is pushed up. A spring support rod 2321 is provided on the bottom surface of the sealing cover plate 232. The lower end of the spring support rod 2321 is installed inside the lower end of the liquid tank 23 with clearance fit. When the inlet pipe 244 is inserted into the liquid tank 23, it lifts the sealing cover 232 and opens the liquid passage. When the inlet pipe 244 is pulled out, the spring support rod 2321 causes the sealing cover 232 to automatically reset and close the passage to prevent liquid leakage. At the same time, it facilitates the quick disassembly and thorough cleaning of the liquid tank 23, reducing dead corner residue and cross-contamination.

[0017] The implementation principle of this application embodiment is as follows: When the liquid tank 23 is installed on the upper end of the support shell 21, when the water inlet pipe 244 is inserted into the liquid tank 23, the sealing cover plate 232 is lifted and the liquid channel is opened. When the liquid tank 23 needs to be cleaned later, the liquid tank 23 is moved upward and the spring support rod 2321 causes the sealing cover plate 232 to automatically move downward and reset, sealing the bottom of the liquid tank 23 and preventing leakage when the liquid tank 23 is disassembled. After installation, the liquid tank 23 stores the liquid to be dispensed. The high and low level gauges 231 monitor the liquid level inside the liquid tank 23 in real time. When the liquid level is lower than the set value, the high and low level gauges 231 send a signal to the controller 22. The controller 22 then starts the solution pump 243. The solution pump 243 draws liquid from the bottom of the replenishment tank 24 through the hose 241 and the gravity ball 242, and pumps it into the liquid tank 23 through the water inlet pipe 244 to achieve automatic liquid replenishment.

[0018] Example 2: A reagent bottle dispensing and adding device, referring to... Figure 5 A support rod 4 is welded to the upper surface of the frame 1. A drive mechanism is provided at the upper end of the support rod 4. The drive mechanism includes a horizontal linear module 5 and a vertical linear module 6. The vertical linear module 6 is installed on the front surface of the horizontal linear module 5, and the horizontal linear module 5 drives the vertical linear module 6 to move horizontally. A pipette 3 is installed on the front surface of the vertical linear module 6, and the vertical linear module 6 drives the pipette 3 to move vertically. Both the horizontal linear module 5 and the vertical linear module 6 are existing technologies and will not be described in detail here. The coordinated operation of the horizontal linear module 5 and the vertical linear module 6 enables the pipette 3 to move precisely in both horizontal and vertical directions, covering multiple reagent bottle positions, achieving fast and accurate dispensing operations, and improving dispensing efficiency and positioning accuracy.

[0019] A stepper motor 31 is fixedly installed on the top of the pipette 3, and the output end of the stepper motor 31 is connected to a lead screw 32 and drives it to rotate. A slider 33 is slidably installed on the lead screw 32, and a pusher bracket 34 is connected to the outer end of the slider 33. A suction mechanism is connected to the lower end of the pusher bracket 34. The stepper motor 31 drives the slider 33 to move through the lead screw 32, thereby driving the propulsion support 34 and the liquid suction mechanism to move up and down, achieving precise control of liquid suction and discharge; the stepper motor 31 provides high-precision displacement control, ensuring the accuracy and repeatability of liquid transfer volume, and meeting the laboratory's requirements for dispensing accuracy.

[0020] The liquid aspiration mechanism includes a connecting support plate 35, a liquid aspiration chamber 36, and a ceramic suction rod 37. The upper surface of the connecting support plate 35 is welded to the lower end of the pusher bracket 34, and the lower surface of the connecting support plate 35 is fixed to the top of the ceramic suction rod 37. The lower end of the ceramic suction rod 37 is installed inside the liquid aspiration chamber 36 with a clearance fit. The liquid aspiration chamber 36 is located at the lower end of the pipette 3. A pipette tip 39 is provided at the lower end of the pipette 3, and the liquid aspiration chamber 36 is connected to the inside of the pipette tip 39 through an internal channel. The connecting plate 35 transmits the movement of the pusher 34 to the ceramic pipette 37. The ceramic pipette 37 moves within the suction chamber 36, generating negative or positive pressure, thereby achieving liquid suction or discharge through the pipette tip 39. The ceramic material used in the ceramic pipette 37 has the characteristics of corrosion resistance and easy cleaning, avoiding reagent residue and cross-contamination, and ensuring the purity of the reagents and the accuracy of the experimental results.

[0021] The lower end of the pipette 3 is also provided with a positioning rod 38, and the positioning rod 38 is engaged with the pipette tip 39. The positioning rod 38 ensures the precise positioning and secure fixation of the pipette tip 39 during installation, preventing the pipette tip 39 from loosening or falling off during pipetting, thus ensuring the stability and reliability of operation. At the same time, it facilitates quick replacement of the pipette tip 39, improving maintenance efficiency.

[0022] The implementation principle of this application embodiment is as follows: Based on embodiment 1, the horizontal linear module 5 and the vertical linear module 6 drive the pipette 3 to move above the liquid container 23. The vertical linear module 6 drives the pipette 3 to descend, immersing the pipette tip 39 in the liquid. The stepper motor 31 drives the slider 33 to move downward through the lead screw 32, driving the pusher bracket 34 and the connecting support plate 35 to move the ceramic suction rod 37 upward in the suction chamber 36, generating negative pressure, thereby drawing liquid through the pipette tip 39. Subsequently, the horizontal linear module 5 and the vertical linear module 6 drive the pipette 3 to move above the reagent bottle. The stepper motor 31 reverses, driving the ceramic suction rod 37 to move downward, generating positive pressure, and discharging the liquid into the reagent bottle, realizing dispensing and adding liquid.

[0023] The embodiments described in this specific implementation are preferred embodiments of this application and are not intended to limit the scope of protection of this application. Identical components are represented by the same reference numerals. Therefore, all equivalent changes made to the structure, shape, and principle of this application should be covered within the scope of protection of this application.

Claims

1. A reagent bottle dispensing and adding device, comprising a frame (1), wherein a filling mechanism (2) is mounted on the upper surface of the frame (1), characterized in that, The liquid filling mechanism (2) includes a support shell (21), a controller (22), a liquid tank (23), and a replenishment tank (24). The controller (22) is provided on the outer surface of the support shell (21), and the controller (22) is electrically connected to the high and low liquid level gauges (231) provided inside the liquid tank (23). A positioning plate (211) is provided at the upper end of the inside of the support shell (21) to support and fix the liquid tank (23). The replenishment tank (24) is installed at the lower end of the inside of the support shell (21). A solution pump (243) is provided on the replenishment tank (24). The solution pump (243) is electrically connected to the controller (22). The controller (22) controls the solution pump (243) to pump the liquid in the replenishment tank (24) into the liquid tank (23) based on the signal from the high and low liquid level gauges (231).

2. The reagent bottle dispensing and adding device according to claim 1, characterized in that, The solution pump (243) is connected to a hose (241) at its lower end, and a gravity ball (242) is provided at the lower end of the hose (241). The lower end of the hose (241) is located inside the lower end of the replenishment tank (24). The solution pump (243) is connected to a water inlet pipe (244) at its upper end, and the upper end of the water inlet pipe (244) is inserted into the lower end of the liquid container (23).

3. The reagent bottle dispensing and adding device according to claim 2, characterized in that, A sealing cover plate (232) is provided at the bottom of the inner side of the liquid tank (23), and when the upper end of the water inlet pipe (244) is inserted into the liquid tank (23), the sealing cover plate (232) is pushed up. A spring support rod (2321) is provided on the bottom surface of the sealing cover plate (232), and the lower end of the spring support rod (2321) is installed inside the lower end of the liquid tank (23) with clearance fit.

4. The reagent bottle dispensing and adding device according to claim 1, characterized in that, The upper surface of the frame (1) is welded with a support rod (4), and the upper end of the support rod (4) is provided with a driving mechanism. The driving mechanism includes a horizontal linear module (5) and a vertical linear module (6). The front surface of the horizontal linear module (5) is equipped with the vertical linear module (6), and the horizontal linear module (5) drives the vertical linear module (6) to move horizontally. The front surface of the vertical linear module (6) is equipped with a pipette (3), and the vertical linear module (6) drives the pipette (3) to move vertically.

5. A reagent bottle dispensing and adding device according to claim 4, characterized in that, A stepper motor (31) is fixedly installed on the top of the pipette (3), and a lead screw (32) is connected to the output end of the stepper motor (31) and drives it to rotate. A slider (33) is slidably installed on the lead screw (32), and a pusher bracket (34) is connected to the outer end of the slider (33), and a suction mechanism is connected to the lower end of the pusher bracket (34).

6. The reagent bottle dispensing and adding device according to claim 5, characterized in that, The liquid aspiration mechanism includes a connecting support plate (35), a liquid aspiration chamber (36), and a ceramic suction rod (37). The upper surface of the connecting support plate (35) is welded to the lower end of the propulsion bracket (34), and the lower surface of the connecting support plate (35) is fixed to the top of the ceramic suction rod (37). The lower end of the ceramic suction rod (37) is installed inside the liquid aspiration chamber (36) with a clearance fit. The liquid aspiration chamber (36) is located at the lower end of the pipette (3). The lower end of the pipette (3) is provided with a pipette tip (39), and the liquid aspiration chamber (36) is connected to the inside of the pipette tip (39) through a built-in channel.

7. A reagent bottle dispensing and adding device according to claim 6, characterized in that, The lower end of the pipette (3) is also provided with a positioning rod (38), and the positioning rod (38) is engaged with the pipette tip (39).

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