Long distance portable live cell transport device
Patent Information
- Application Number
- CN202521385145.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-02
- Publication Date
- 2026-10-13
- Estimated Expiration
- 2035-07-02
AI Technical Summary
细胞的生长除需要营养环境(培养基)外，对于温度和气氛的要求也很严格，高温、低温、气氛浓度不合适(如二氧化碳浓度)都会影响细胞的形态及活性，导致无法正常观察细胞形态以及辨别药物处理后细胞的变化
[0015]本申请实施例提供了一种远途便携式活细胞运输装置，该远途便携式活细胞运输装置在进行远途活细胞运输时，可以通过加热器使气氛箱中的细胞培养器皿保持一定温度，通过二氧化碳产气袋输出的二氧化碳为细胞培养器皿提供一定的二氧化碳浓度，且当二氧化碳监测器显示二氧化碳浓度不足时，可及时更换新的二氧化碳产气袋，从而可以实现远距离活细胞运输中对温度、气氛等的有效控制，能够维持活细胞正常生理状态，确保移送后能够正常观察细胞形态以及辨别药物处理后细胞的变化，且本实用新型远途便携式活细胞运输装置体积小、可手提或肩背，使用方便便携，一方面给予有远距离携带活细胞需求的实验室提供了活细胞运输条件，另一方面给予缺乏细胞培养箱的实验室提供了数小时内活细胞保存条件。
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Figure CN224849058U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of medical device technology, and in particular to a long-distance portable live cell transport device. Background Technology
[0002] Cell culture and transport are indispensable parts of life science experiments, applicable to research in biology, medicine, chemistry, physics, and many other disciplines. With the continuous development and construction of large-scale, high-end instruments and life science-related facilities, more angles and detailed characterization of cells are possible. However, these high-end instruments and facilities are scarce resources. As the government promotes the sharing and opening of these facilities to the public, they are often located far from laboratories in need, requiring long-distance, long-duration (e.g., more than 30 minutes) transport of live cells, while ensuring that the cells maintain their normal physiological state for a certain period after transport (e.g., more than 1 hour). Besides requiring a nutrient environment (culture medium), cell growth also has strict requirements for temperature and atmosphere. High temperatures, low temperatures, and unsuitable atmospheric concentrations (e.g., carbon dioxide concentration) can all affect cell morphology and activity, making it impossible to observe cell morphology normally and identify changes in cells after drug treatment. Current cell transport devices generally consist of culture flasks placed in foam boxes, lacking a 37-degree constant temperature system and failing to meet the suitable atmospheric environment for live cell survival (e.g., carbon dioxide concentration), making them unsuitable for long-distance transport of live cells. Utility Model Content
[0003] In view of the problems existing in the background technology, this application provides a long-distance portable live cell transport device, which can effectively control temperature, atmosphere and other factors during long-distance live cell transport, effectively maintain the normal physiological state of live cells, and ensure that cell morphology can be observed normally after transfer and changes in cells after drug treatment can be identified.
[0004] According to one aspect of the present invention, a long-distance portable live cell transport device is provided, comprising a thermostatic chamber and a thermostatic chamber cover covering the top opening of the thermostatic chamber, a heater being provided on the thermostatic chamber, an atmosphere chamber being provided inside the thermostatic chamber, and a sealing cover being provided at the top opening of the atmosphere chamber; the atmosphere chamber is used to contain cell culture vessels, and the atmosphere chamber is provided with a carbon dioxide gas generating bag and a carbon dioxide monitor.
[0005] In some embodiments of this utility model, the space inside the atmosphere chamber is divided into a first region for accommodating the carbon dioxide gas generating bag, a second region for accommodating the cell culture vessel, and a third region for accommodating the carbon dioxide monitor, with the second region located between the first region and the third region.
[0006] In some embodiments of this utility model, a partition plate is provided between the second region and the first region, and between the second region and the third region.
[0007] In some embodiments of this utility model, a petri dish rack and / or a test tube rack are provided in the second region.
[0008] In some embodiments of this utility model, the heater is an electric heater, and the constant temperature chamber is provided with a power socket connected to the electric heater.
[0009] In some embodiments of this utility model, the electric heater is disposed around the perimeter and bottom of the constant temperature chamber.
[0010] In some embodiments of this utility model, the constant temperature chamber is provided with heat dissipation holes.
[0011] In some embodiments of this utility model, the constant temperature chamber is equipped with a temperature control display.
[0012] In some embodiments of this utility model, the lid of the constant temperature chamber is provided with a handle.
[0013] In some embodiments of this utility model, the constant temperature chamber is provided with shoulder straps on both sides.
[0014] Compared with the prior art, the present invention achieves the following technical effects:
[0015] This application provides a portable live cell transport device for long-distance transport. During long-distance live cell transport, the device uses a heater to maintain a certain temperature in the cell culture vessel within the atmosphere chamber. Carbon dioxide is output from a carbon dioxide generator bag to provide a specific carbon dioxide concentration to the cell culture vessel. When the carbon dioxide monitor indicates insufficient carbon dioxide concentration, a new carbon dioxide generator bag can be promptly replaced. This allows for effective control of temperature and atmosphere during long-distance live cell transport, maintaining the normal physiological state of the live cells and ensuring that cell morphology can be observed normally after transfer, as well as identifying changes in cells after drug treatment. Furthermore, this portable live cell transport device is small in size, can be carried by hand or on the shoulder, and is convenient to use. It provides live cell transport conditions for laboratories requiring long-distance transport and offers conditions for preserving live cells for several hours for laboratories lacking cell culture chambers. Attached Figure Description
[0016] Various other advantages and benefits will become apparent to those skilled in the art upon reading the following detailed description of preferred embodiments. The accompanying drawings are for illustrative purposes only and are not intended to limit the scope of this application. Furthermore, the same reference numerals denote the same parts throughout the drawings. In the drawings:
[0017] Figure 1 This is a front sectional view of the portable live cell transport device for long-distance transport according to this utility model;
[0018] Figure 2 This is a top view of an atmosphere chamber according to an embodiment of this utility model;
[0019] Figure 3 This is a top view of an atmosphere chamber according to another embodiment of the present invention.
[0020] The labels in the attached diagram represent the following: 1. Thermostatic chamber; 2. Thermostatic chamber lid; 3. Handle; 4. Ventilation vent; 5. Heater; 6. Atmosphere chamber; 7. First zone; 8. Second zone; 9. Third zone; 10. Carbon dioxide gas generating bag; 11. Petri dish rack; 12. Petri dish hole; 13. Carbon dioxide monitor; 14. Temperature control display; 15. Sealing cap; 16. Power socket; 17. Test tube rack; 18. Test tube hole; 19. Divider. Detailed Implementation
[0021] It should be understood that the described embodiments are merely some, not all, of the embodiments in this application. All other embodiments obtained by those skilled in the art based on the embodiments in this application without inventive effort are within the scope of protection of this application.
[0022] In the following description, when referring to the accompanying drawings, the same numbers in different drawings denote the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with this application. Rather, they are merely examples of apparatuses and methods consistent with some aspects of this application as detailed in the appended claims.
[0023] In the description of this application, it should be understood that the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances. Furthermore, in the description of this application, unless otherwise stated, "multiple" refers to two or more. "And / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. The character " / " generally indicates that the preceding and following related objects are in an "or" relationship.
[0024] The portable live cell transport device provided in the embodiments of this application will now be described with reference to the accompanying drawings.
[0025] This application discloses a long-distance portable live cell transport device. For example... Figure 1 As shown, the long-distance portable live cell transport device includes a thermostatic chamber 1 and a thermostatic chamber cover 2 covering the top opening of the thermostatic chamber 1. The thermostatic chamber 1 is equipped with a heater 5 and an atmosphere chamber 6 is provided inside the thermostatic chamber 1. The top opening of the atmosphere chamber 6 is equipped with a sealing cover 15. The atmosphere chamber 6 is used to hold cell culture vessels and is equipped with a carbon dioxide gas generating bag 10 and a carbon dioxide monitor 13.
[0026] By using the portable live cell transport device of this technical solution, during long-distance live cell transport, the heater 5 can be used to heat and maintain the temperature of the constant temperature chamber 1. Then, the cell culture vessel containing live cells is placed in the atmosphere chamber 6, and the carbon dioxide generator bag 10 is opened and placed in the atmosphere chamber 6. The atmosphere chamber 6 is then placed inside the constant temperature chamber 1. During transport, the heater 5 maintains a certain temperature in the atmosphere chamber 6, and the carbon dioxide output from the carbon dioxide generator bag 10 provides a certain carbon dioxide concentration to the cell culture vessel. Furthermore, when the carbon dioxide monitor 13 displays... When the carbon dioxide concentration is insufficient, a new carbon dioxide gas generating bag 10 can be replaced in time, which can provide the required carbon dioxide within a few hours. It is suitable for the survival of conventional live cells, thus enabling effective control of temperature, atmosphere, etc. during long-distance live cell transportation. It can maintain the normal physiological state of live cells, ensure that cell morphology can be observed normally after transfer, and identify changes in cells after drug treatment. After transportation to the destination, the cell culture vessels to be used can be taken out for experimental observation as needed, adopting the "one-for-one" principle. Other cell culture vessels to be tested can still be kept in the atmosphere chamber 6, and the atmosphere chamber 6 should be kept sealed.
[0027] In some embodiments of this utility model, cell culture vessels include, but are not limited to, cell culture dishes, test tubes, and cell culture flasks. Those skilled in the art can choose according to their needs, and no limitation is made here.
[0028] In some embodiments of this utility model, such as Figure 1 As shown, the space inside the atmosphere chamber 6 is divided into a first region 7 for containing the carbon dioxide gas generating bag 10, a second region 8 for containing the cell culture vessel, and a third region 9 for containing the carbon dioxide monitor 13. The second region 8 is located between the first region 7 and the third region 9.
[0029] In this embodiment, by dividing the space inside the atmosphere chamber 6 into zones, the clutter in the space inside the atmosphere chamber 6 can be avoided. Furthermore, by placing the cell culture vessel between the carbon dioxide gas generating bag 10 and the carbon dioxide monitor 13, and using the far end of the cell culture vessel away from the carbon dioxide gas generating bag 10 as the detection point, the reliability and accuracy of the carbon dioxide concentration detection can be ensured, and the detection results can be avoided if the carbon dioxide monitor 13 is too close to the carbon dioxide gas generating bag 10, which would result in unreliable detection results.
[0030] In some embodiments of this utility model, the atmosphere chamber 6 is rectangular in plan view. The first region 7, the second region 8, and the third region 9 are divided sequentially from one end of the rectangular atmosphere chamber 6 to the other end. The area of the second region 8 is larger than that of the first region 7 or the third region 9 to ensure that there is enough space to store a certain number of cell culture vessels.
[0031] In some embodiments of this utility model, such as Figure 1 As shown, partition plates 19 are respectively provided between the second region 8 and the first region 7, and between the second region 8 and the third region 9.
[0032] In this embodiment, the separation of each functional area by the partition plate 19 can ensure the independence of each functional area and prevent objects in each functional area from moving around during transportation.
[0033] It should be noted that although the partition plate 19 is used to separate the functional areas, the functional areas are still connected after the sealing cover 15 is closed on the opening of the atmosphere chamber 6, so as to ensure that the carbon dioxide output by the carbon dioxide gas generating bag 10 can be dispersed in the functional areas of the atmosphere chamber 6, especially the second area 8. For example, the sealing cover 15 can adopt a bowl-shaped structure, so that the inner top of the sealing cover 15 leaves a certain space with the opening of the atmosphere chamber 6.
[0034] Furthermore, the partition plate 19 can be a perforated partition plate 19, which ensures that it plays a role in partitioning, while ensuring the uniformity of carbon dioxide dispersion in the second region 8 of the partition plate 19 and ensuring the accuracy of carbon dioxide detection by the carbon dioxide monitor 13 in the third region 9.
[0035] In some embodiments of this utility model, a petri dish rack 11 and / or a test tube rack 17 are provided in the second region 8.
[0036] It should be understood that the present invention can simultaneously provide a petri dish rack 11 and a test tube rack 17 in the second region 8, or provide only a petri dish rack 11 or a test tube rack 17 at the same time.
[0037] In one embodiment of this utility model, such as Figure 1 and Figure 2 As shown, four petri dish racks 11 are arranged in an array in the second region 8 of the atmosphere chamber 6.
[0038] In one embodiment of this utility model, such as Figure 3 As shown, two petri dish racks 11 and two test tube racks 17 are placed in the second area 8 of the atmosphere chamber 6.
[0039] In this embodiment, by placing a petri dish rack 11 and / or a test tube rack 17 in the second region 8, the stability of the petri dishes and test tubes placed in the atmosphere chamber 6 can be further improved, reducing the possibility of leakage due to shaking.
[0040] Furthermore, the culture dish rack 11 is provided with multiple culture dish holes 12, which are arranged sequentially from top to bottom on the culture dish rack 11; the test tube rack 17 has multiple vertical test tube holes 18 arranged in an array on the same plane so that test tubes can be placed separately. In this embodiment, multiple cell culture dishes or test tubes can be placed at the same time, realizing the synchronous transportation of multiple cell culture dishes or test tubes. When the culture dish rack 11 and the test tube rack 17 are used together, the synchronous transportation of test tubes and cell culture dishes can be realized.
[0041] Preferably, both the petri dish rack 11 and the test tube rack 17 are placed in the second area 8 in a removable manner, so that the petri dishes or test tubes can be placed securely outside the atmosphere chamber 6 before being placed into the atmosphere chamber 6 as a whole.
[0042] In other embodiments of this utility model, some movable culture dish racks 11 or test tube racks 17 may be removed as needed to leave space for placing cell culture flasks.
[0043] In some embodiments of this utility model, such as Figure 1 As shown, heater 5 is an electric heater 5, and the constant temperature chamber 1 is provided with a power socket 16 for connecting to the electric heater 5.
[0044] Furthermore, the power socket 16 can be connected to an AC cable to be plugged into an outdoor power bank or a 220V household socket, or it can be connected to a DC cable to be plugged into a car cigarette lighter socket for power supply.
[0045] In some embodiments of this utility model, such as Figure 1 As shown, the electric heater 5 is installed around the perimeter and bottom of the constant temperature chamber 1.
[0046] Specifically, in this embodiment, the electric heater 5 can be a flat plate type electric heater 5. Multiple electric heaters 5 are embedded in the thickness of the four side walls and the bottom wall of the constant temperature chamber 1 and connected in series, so as to achieve uniform heating and heat preservation of the space inside the constant temperature chamber 1.
[0047] In some embodiments of this utility model, such as Figure 1 As shown, the constant temperature chamber 1 is provided with heat dissipation holes 4.
[0048] In this embodiment, by setting heat dissipation holes 4 on the constant temperature chamber 1, such as on the side wall of the constant temperature chamber 1, active or passive heat dissipation can be achieved by working in conjunction with the electric heater 5 to balance the temperature inside the constant temperature chamber 1, avoid overheating, and protect the electric heater 5, thereby making the temperature inside the constant temperature chamber 1 more controllable and precise.
[0049] In some embodiments of this utility model, such as Figure 1 As shown, the constant temperature chamber 1 is equipped with a temperature control display 14.
[0050] Furthermore, the temperature control display 14 has a switch for the thermostat chamber 1, a temperature adjustment button, and a temperature display screen.
[0051] It should be understood that the constant temperature chamber 1 is equipped with a temperature sensor, and the temperature control display 14 is connected to the temperature sensor and the electric heater 5. It can be powered by an external power supply through the power socket 16. After the power socket 16 is connected to the power supply, the temperature of the constant temperature chamber 1 can be set to the required temperature, such as 37°C, through the temperature control display 14. When the real-time temperature display screen of the constant temperature chamber 1 shows a stable temperature of 37°C, it will automatically maintain the temperature and can then preserve live cells in cell culture dishes.
[0052] In some embodiments of this utility model, such as Figure 1 As shown, the lid 2 of the constant temperature chamber is equipped with a handle 3.
[0053] In this embodiment, by providing a handle 3 on the constant temperature chamber lid 2, the user can easily and smoothly move the long-distance portable live cell transport device of this utility model.
[0054] Furthermore, the constant temperature chamber 1 is also equipped with shoulder straps on both sides to provide users with more ways to handle it.
[0055] In some embodiments of this utility model, the carbon dioxide monitor 13 may be a carbon dioxide sensor with a display screen, which can measure and display the carbon dioxide concentration in real time.
[0056] To improve the timeliness of carbon dioxide concentration feedback, the carbon dioxide monitor 13 can also be set with a carbon dioxide concentration monitoring threshold and an audible alarm, so that when the carbon dioxide concentration in the atmosphere chamber 6 is lower than the set value, the accompanying personnel will be promptly alerted by the audible alarm.
[0057] In some embodiments of this utility model, such as Figure 1As shown, the constant temperature chamber cover 2 can be connected to the constant temperature chamber body 1 by hinge, and the constant temperature chamber cover 2 is fixed to the constant temperature chamber body 1 by a latch (not shown) so that when in use, the constant temperature chamber cover 2 can be rotated to one side of the constant temperature chamber body 1 after the latch is opened, and during movement and transportation, the constant temperature chamber cover 2 can be closed on the constant temperature chamber body 1 and locked with the latch.
[0058] The above description is merely a preferred embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model. Therefore, the protection scope of this utility model should be determined by the scope of the claims.
Claims
1. A long-distance portable live cell transport device, characterized in that, The device includes a constant temperature chamber and a constant temperature chamber cover with an opening at the top of the constant temperature chamber. The constant temperature chamber is equipped with a heater and an atmosphere chamber is provided inside the constant temperature chamber. The opening at the top of the atmosphere chamber is equipped with a sealing cover. The atmosphere chamber is used to hold cell culture vessels and is equipped with a carbon dioxide gas generating bag and a carbon dioxide monitor.
2. The long-distance portable live cell transport device according to claim 1, characterized in that, The atmosphere chamber is divided into a first region for accommodating the carbon dioxide gas generating bag, a second region for accommodating the cell culture vessel, and a third region for accommodating the carbon dioxide monitor, with the second region located between the first and third regions.
3. The long-distance portable live cell transport device according to claim 2, characterized in that, A partition plate is provided between the second region and the first region, and between the second region and the third region.
4. The long-distance portable live cell transport device according to claim 3, characterized in that, The second area is equipped with a petri dish rack and / or a test tube rack.
5. The long-distance portable live cell transport device according to claim 1, characterized in that, The heater is an electric heater, and the constant temperature chamber is equipped with a power socket for connecting the electric heater.
6. The long-distance portable live cell transport device according to claim 5, characterized in that, The electric heaters are located around the perimeter and bottom of the constant temperature chamber.
7. The long-distance portable live cell transport device according to claim 5, characterized in that, The constant temperature chamber is equipped with heat dissipation holes.
8. The long-distance portable live cell transport device according to claim 5, characterized in that, The constant temperature chamber is equipped with a temperature control display.
9. The long-distance portable live cell transport device according to claim 1, characterized in that, The constant temperature chamber lid is equipped with a handle.
10. The long-distance portable live cell transport device according to claim 1, characterized in that, The constant temperature chamber is equipped with shoulder straps on both sides.