A chromatographic column for capsule inspection

Abstract

The utility model provides a kind of chromatographic column for capsule inspection, including column pipe, column pipe is hollow structure, the side wall of the end of column pipe is equipped with clamping hole, locking member is inserted in clamping hole, the hollow structure end of column pipe is inserted with filter assembly, filter assembly includes snap ring with the hollow side wall of column pipe, locking hole is equipped with locking member on snap ring, the inside of snap ring is provided with filter plate, the utility model can be detachably fixed and firm locking operation to filter assembly by locking member, greatly improve the efficiency of disassembly maintenance replacement of filter assembly, operation is more safe and convenient.

Description

Technical Field

[0001] This utility model relates to the field of chromatographic column technology for detection, and specifically to a chromatographic column for testing capsules. Background Technology

[0002] A chromatographic column consists of a column tube, pressure cap, ferrule (sealing ring), sieve plate (filter), connectors, screws, etc. The column tube is mostly made of stainless steel, but thick-walled glass or quartz tubes can also be used; the inner wall of the tube requires a very high degree of smoothness. To improve column efficiency and reduce tube wall effects, the inner wall of stainless steel columns is often polished. Some people also coat the inner wall of stainless steel columns with fluoroplastics to improve the smoothness of the inner wall, achieving the same effect as polishing. Molten silicon or glass linings are also used for thin-tube columns. The column connectors at both ends of the chromatographic column are equipped with sieve plates, made of sintered stainless steel or titanium alloy; the sieve mesh size depends on the packing particle size, and its purpose is to prevent packing leakage.

[0003] In the quality inspection of capsules (such as antibiotic capsules and vitamin capsules), high-performance liquid chromatography (HPLC) is the core analytical method. The chromatographic column, as a key separation component, directly affects the accuracy of the test results. Traditionally, chromatographic columns used for capsule testing often use threads or glue to fix the filter components and packing rings. Disassembly requires special tools, and components are easily damaged due to thread corrosion or glue adhesion. Replacing filter plates or packing rings significantly increases the time required per transaction, severely impacting testing efficiency. This is especially true in batch capsule testing scenarios, resulting in high maintenance costs and numerous inconveniences during operation. Utility Model Content

[0004] In view of this, the present invention provides a chromatographic column for capsule testing. By designing a chromatographic column with quick assembly and disassembly, secure fixation, and convenient grip, it solves the problems of filter components and packing rings being fixed by threads or glue, requiring special tools for disassembly, and being prone to damage due to thread corrosion and glue adhesion; the replacement of filter plates or packing rings takes a lot of time, seriously affecting testing efficiency, especially in batch capsule testing scenarios, where maintenance costs are high and there are many inconveniences in operation. This invention greatly improves testing efficiency, accuracy, and operational safety.

[0005] To solve the above-mentioned technical problems, this utility model provides a chromatographic column for capsule testing, including a column tube with a hollow structure. A locking hole is provided on the side wall of the end of the column tube, and a locking element is inserted into the locking hole. A filter assembly is inserted into the hollow end of the column tube. The filter assembly includes a retaining ring adapted to the hollow side wall of the column tube, and a locking hole adapted to the locking element is provided on the retaining ring. A filter plate is provided inside the retaining ring. This utility model can achieve detachable fixing and secure locking of the filter assembly through the locking element, greatly improving the efficiency of disassembly, maintenance, and replacement of the filter assembly, and making operation safer and more convenient.

[0006] A packing ring is provided on the inner wall of the column tube. The packing ring fits into the inner wall of the column tube, which facilitates full contact and reaction with the reactants.

[0007] An installation ring is inserted into the hollow structure at the other end of the column tube. The installation ring is fixed together with the end of the packing ring, which facilitates a firm and stable connection between the installation ring and the packing ring and the column tube, making operation more convenient.

[0008] At least two lugs are provided on the outer wall of the mounting ring. The lugs are evenly distributed on the mounting ring, and the lugs facilitate easy disassembly and removal of the mounting ring and the packing ring. A limiting hole is provided on the side wall of the other end of the column tube, and a positioning hole adapted to the limiting hole is provided on the mounting ring. The other end of the locking member can be inserted into the coaxial limiting hole and positioning hole. This makes it easy to fix the filter assembly and the packing ring at the same time. Moreover, the locking member can also act as a lifting handle to facilitate the removal of the column tube.

[0009] The locking component includes a connecting rod, with locking inserts at both ends of the connecting rod that are adapted to the locking hole and the positioning hole, respectively.

[0010] A handle is provided on the outside of the connecting rod, which makes it easy for the operator to grip and operate.

[0011] The filter plate has multiple filter holes, which facilitate efficient filtration.

[0012] The outside of the handle is equipped with an anti-slip sleeve, which serves to prevent slipping and provide protection.

[0013] In summary, compared with the prior art, this application includes at least one of the following beneficial technical effects: 1. Solves the problem of inconvenient disassembly and assembly and improves maintenance efficiency: This utility model can complete the disassembly and assembly of the filter assembly and the packing ring without special tools through the threaded fit of the locking part and the ear plate design. The time for a single replacement is greatly shortened and the maintenance efficiency is greatly improved, which is suitable for the high-efficiency requirements of batch capsule testing.

[0014] 2. Solving the problem of loose fixation and ensuring inspection accuracy: The locking component in this utility model simultaneously fixes the filter assembly and the packing ring. The threaded fit and gap sealing design prevent displacement and loosening during high-pressure washing, improve the uniformity of the packing layer, greatly reduce the separation deviation of the effective ingredients in the capsule, and significantly improve the accuracy of the inspection results.

[0015] 3. Solve the problem of inconvenient handling and improve operational safety: This utility model provides a reliable grip structure through the combination design of handle and anti-slip sleeve. The anti-slip texture enhances friction and prevents the hand from slipping and falling. The anti-slip sleeve isolates the solvent and low temperature stimulation, greatly reducing the risk of skin contact for operators and significantly improving operational safety.

[0016] 4. Solve the problem of insufficient contact and improve separation effect: This utility model uses a packing ring to fit the inner wall of the column tube and a spiral guide groove to guide the sample solution to flow evenly, avoiding the "channeling effect". The contact area between the packing and the sample is greatly increased, the separation degree between effective components and impurities is greatly improved, and the reliability of the test results is ensured. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of the chromatographic column used for capsule testing according to this utility model; Figure 2 This is a front view of the chromatographic column used in the testing of capsules according to this utility model; Figure 3 This is a top view of the chromatographic column used in the testing of capsules according to this utility model; Figure 4 This utility model Figure 3 Sectional view at point AA.

[0018] Explanation of reference numerals in the attached drawings: 100, column tube; 101, locking hole; 102, limiting hole; 200, locking element; 210, connecting rod; 220, locking rod; 300, filter assembly; 310, retaining ring; 311, locking hole; 320, filter plate; 321, filter hole; 400, packing ring; 500, mounting ring; 501, positioning hole; 600, handle. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the following will be described in conjunction with the accompanying drawings of the embodiments of this utility model. Figure 1-4 The technical solutions of the embodiments of this utility model are clearly and completely described herein. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model are within the protection scope of this utility model.

[0020] like Figure 1-4As shown: This embodiment provides a chromatographic column for capsule testing, including a column tube 100. Material and manufacturing process: It is made of stainless steel, CNC machined, and the inner wall is polished. Stainless steel possesses excellent corrosion resistance and structural stability, preventing chemical reactions with capsule samples. Polishing the inner wall reduces liquid flow resistance, prevents sample residue adsorption, and ensures test repeatability. Structural design: The openings at both ends of the column tube 100 are rounded to avoid scratching the filter assembly 300 and the mounting ring 500. The inner walls of the retaining hole 101 and the limiting hole 102 are machined with internal threads, and the end of the locking rod 220 is machined with external threads. The threaded fit enhances the fixing stability and prevents loosening. The column tube 100 has a hollow structure. A locking hole 101 is provided on the side wall of the end of the column tube 100. A locking element 200 is inserted into the locking hole 101. A filter assembly 300 is inserted into the hollow end of the column tube 100. The filter assembly 300 includes a retaining ring 310 that is adapted to the hollow side wall of the column tube 100. The retaining ring 310 is made of polytetrafluoroethylene by molding. Its outer circumference is in good fit with the inner wall of the column tube 100. Polytetrafluoroethylene is solvent resistant and has low adhesion, which avoids adsorbing the components of the capsule sample. At the same time, it has a certain degree of elasticity and can fit tightly against the inner wall of the column tube 100 to prevent liquid leakage. The retaining ring 310 has a locking hole 311 that matches the locking member 200. A filter plate 320 is installed inside the retaining ring 310. The filter plate 320 is made of 316L stainless steel sintered filter mesh, suitable for separating the active ingredients of capsules from impurities and intercepting impurity particles. The filter plate 320 is fixed to the inside of the retaining ring 310 by ultrasonic welding to ensure it does not fall off during high-pressure washing. This invention allows for the detachable fixing and secure locking of the filter assembly 300 through the locking member 200, greatly improving the efficiency of disassembly, maintenance, and replacement of the filter assembly 300, and making operation safer and more convenient.

[0021] According to one embodiment of the present invention, such as Figure 1-4 As shown, a packing ring 400 is provided on the inner wall of the column tube 100. The packing ring 400 fits into the inner wall of the column tube 100, which facilitates full contact and reaction with the substitute reactants.

[0022] According to another embodiment of the present invention, such as Figure 1 and Figure 2 As shown, an installation ring 500 is inserted into the hollow structure at the other end of the column tube 100. The installation ring 500 is fixed together with the end of the packing ring 400. This facilitates a firm and stable connection between the installation ring 500, the packing ring 400 and the column tube 100, making operation more convenient.

[0023] According to another embodiment of the present invention, such as Figure 1 and Figure 3As shown, at least two ear plates are provided on the outer wall of the mounting ring 500. The ear plates are evenly distributed on the mounting ring 500 and are made of 304 stainless steel, bent and formed, and fixed to the outer wall of the mounting ring 500 by argon arc welding. They are symmetrically distributed. The ends of the ear plates have arc grooves to facilitate hooking with fingers or tools, enabling quick disassembly of the mounting ring 500 and the packing ring 400. The ear plates facilitate easy disassembly of the mounting ring 500 and the packing ring 400.

[0024] According to another embodiment of the present invention, such as Figure 3 and Figure 4 As shown, a limiting hole 102 is provided on the side wall of the other end of the column tube 100, and a positioning hole 501 adapted to the limiting hole 102 is provided on the mounting ring 500. The other end of the locking member 200 can be inserted into the coaxial limiting hole 102 and positioning hole 501. This facilitates the locking member 200 to fix the filter assembly 300 and the packing ring 400 at the same time. Moreover, the locking member 200 can also function as a lifting handle, which facilitates the removal of the column tube 100.

[0025] According to another embodiment of the present invention, such as Figure 1 and Figure 3 As shown, the locking component 200 includes a connecting rod 210. Both ends of the connecting rod 210 are respectively provided with locking inserts 220 that are adapted to the locking hole 311 and the positioning hole 501. A handle 600 is provided on the outer side of the connecting rod 210, which facilitates the operator's gripping operation. Both the connecting rod 210 and the locking insert 220 are made of 304 stainless steel and machined. The connecting rod 210 and the locking insert 220 are integrally formed to ensure structural strength. The handle 600 is cylindrical and welded perpendicularly to the connecting rod 210. A silicone anti-slip sleeve is fitted on the outer side, with anti-slip textured surfaces to enhance grip friction and isolate low temperature or solvent irritation. The locking insert 220's outer diameter is clearance-fitted with the inner diameter of the locking hole 311 and the positioning hole 501, and its external thread engages with the internal thread on the inner wall of the hole. After tightening, it can simultaneously lock the filter assembly 300 and the packing ring 400, preventing relative displacement.

[0026] The filter plate 320 has multiple filter holes 321, which facilitates efficient filtration.

[0027] The outer side of the handle 600 is equipped with an anti-slip sleeve, which serves to prevent slipping and provide protection.

[0028] Working principle and usage of this utility model: First, it should be clarified that the chromatographic column involved in this utility model is mainly used for quality testing of reagents. This utility model takes the assembly and use of the chromatographic column in the quality testing process of capsules as an example to explain its working principle and usage method in detail. The working principle is as follows: Component fixing and sealing: Insert the filter assembly 300 into one end of the column tube 100, making the locking hole 311 of the retaining ring 310 coaxial with the retaining hole 101 of the column tube 100; insert the packing ring 400 and the mounting ring 500 fixing body into the other end of the column tube 100, making the positioning hole 501 of the mounting ring 500 coaxial with the limiting hole 102 of the column tube 100; insert the locking rods 220 at both ends of the locking member 200 into the retaining hole 101-locking hole 311 and the limiting hole 102-positioning hole 501 respectively, and rotate the handle 600 to tighten the threads, so as to realize the synchronous and firm fixing of the filter assembly 300, the packing ring 400 and the column tube 100. The retaining ring 310 and the mounting ring 500 respectively fit against the inner walls of both ends of the column tube 100 to form a seal and prevent the sample solution from leaking.

[0029] Sample separation and filtration: The capsule sample solution flows into one end of the column tube 100 and first passes through the filter plate 320 to intercept impurity particles and avoid contaminating the packing material. The filtered sample solution flows through the packing ring 400, and the spiral guide groove guides the solution to be evenly distributed and fully contact the packing material to achieve separation of the active ingredient and impurities. The separated solution flows out from the other end of the column tube 100 and enters the detector for testing.

[0030] Convenient operation and maintenance: When picking up the chromatographic column, hold the anti-slip sleeve of the handle 600 to prevent it from slipping and falling; when disassembling, rotate the handle 600 in the opposite direction to loosen the locking part 200, pull out the locking rod 220, and pull out the packing ring 400 and the mounting ring 500 by hooking the ear plate of the mounting ring 500. Then, pull out the filter assembly 300 directly to complete the replacement or cleaning without special tools.

[0031] The usage method is as follows: Equipment preparation and installation Check the integrity of each component: confirm that the filter plate 320 is undamaged, the packing ring 400 is not deformed, the threads of the locking piece 200 are undamaged, and the anti-slip sleeve is not detached; Install the filter assembly 300: Insert the filter assembly 300 along one end of the column tube 100, ensuring that the retaining ring 310 fits tightly against the inner wall of the column tube 100, and that the locking hole 311 is aligned with the retaining hole 101; Install packing ring 400 and mounting ring 500: Insert the packing ring 400 and mounting ring 500 fixing body along the other end of the column tube 100, ensuring that the positioning hole 501 is aligned with the limiting hole 102 and the ear plate faces outward; Locking and fixing: Insert the locking rods 220 at both ends of the locking part 200 into the locking hole 101-locking hole 311 and the limiting hole 102-positioning hole 501 respectively, and rotate the handle 600 clockwise to tighten until the resistance is uniform and the fixing is secure.

[0032] Sample inspection procedures Connecting the equipment: Connect both ends of the chromatographic column to the chromatograph's injection port and detector respectively through compression fittings, and tighten the fittings to ensure a seal; Parameter settings: Based on the capsule testing standards, set parameters such as elution solvent flow rate and column temperature; Sample injection test: Inject the capsule sample solution, start the chromatograph, and after filtration and separation, the sample solution enters the detector. Record the test data.

[0033] Disassembly and maintenance Shutdown and depressurization: After the test is completed, turn off the chromatograph and wait for the pressure inside the column tube to drop to atmospheric pressure before disconnecting the connectors at both ends; Loosen locking part 200: Turn the handle counterclockwise 600 to pull out locking part 200; Disassembly of components: Use your fingers to hook the ear plate, remove the mounting ring 500 and the packing ring 400, and pull out the filter assembly 300 directly; Cleaning and replacement: Rinse the inner wall of column tube 100, filter plate 320 and packing ring 400 with rinsing solvent. If filter plate 320 is clogged or packing is ineffective, replace with new components and reassemble according to the installation steps.

[0034] This invention addresses the challenges of using threads or glue to fix filter components and packing rings 400, which require specialized tools for disassembly and are prone to damage due to thread corrosion and glue adhesion. Furthermore, replacing filter plates 320 or packing rings 400 significantly increases the time required, severely impacting testing efficiency, especially in batch capsule testing scenarios where maintenance costs are high and operations are inconvenient. This invention significantly improves testing efficiency, accuracy, and operational safety by designing a chromatographic column with quick assembly / disassembly, secure fixation, and easy gripping.

[0035] Furthermore, it should be noted that, in the description of this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0036] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this utility model, and these improvements and modifications should also be considered within the protection scope of this utility model.

Claims

1. A chromatographic column for testing capsules, comprising a column tube (100), characterized in that: The column tube (100) has a hollow structure. A locking hole (101) is provided on the side wall of the end of the column tube (100). A locking member (200) is inserted into the locking hole (101). A filter assembly (300) is inserted into the hollow end of the column tube (100). The filter assembly (300) includes a retaining ring (310) that is adapted to the hollow side wall of the column tube (100). A locking hole (311) that is adapted to the locking member (200) is provided on the retaining ring (310). A filter plate (320) is provided on the inner side of the retaining ring (310).

2. The chromatographic column for capsule testing as described in claim 1, characterized in that: A packing ring (400) is provided on the inner wall of the column tube (100), and the packing ring (400) fits against the inner wall of the column tube (100).

3. The chromatographic column for capsule testing as described in claim 2, characterized in that: An installation ring (500) is inserted inside the hollow structure at the other end of the column tube (100), and the installation ring (500) is fixed together with the end of the packing ring (400).

4. The chromatographic column for capsule testing as described in claim 3, characterized in that: A limiting hole (102) is provided on the side wall of the other end of the column tube (100), and a positioning hole (501) adapted to the limiting hole (102) is provided on the mounting ring (500). The other end of the locking member (200) can be inserted into the coaxial limiting hole (102) and positioning hole (501).

5. The chromatographic column for capsule testing as described in claim 4, characterized in that: The locking component (200) includes a connecting rod (210), and the two ends of the connecting rod (210) are respectively provided with locking inserts (220) that are adapted to the locking hole (311) and the positioning hole (501).

6. The chromatographic column for capsule testing as described in claim 5, characterized in that: A handle (600) is provided on the outside of the connecting rod (210).

7. The chromatographic column for capsule testing as described in claim 1, characterized in that: The filter plate (320) has multiple filter holes (321).

8. The chromatographic column for capsule testing as described in claim 6, characterized in that: The handle (600) is provided with an anti-slip sleeve on the outside.

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