An animal modeling experiment cage

Abstract

The utility model discloses an animal modeling experiment cage belongs to animal experiment cage technical field, including experiment cage body still includes: the cage door of rotation installation in the one side of experiment cage body, through the cooperation of above -mentioned each device, through the setting of detection mechanism, removes transparent baffle, and lets two mice fight 15 minutes, and then reinserts transparent baffle, and when non -fighting period is through visual stimulation and lets small mouse face enemy, induces psychological fear, and both sides space is equipped with clean water basin and feed basin, and supplies mouse drinking water and eats, and the sugar water basin is additionally set up to one side of small mouse, is used for daily detection its sugar water drinking amount, and simultaneously starts monitoring camera record fight frequency, and daily fight frequency needs to exceed 15 times, as the core index of modeling, and the sugar water drinking amount detects once every 5 days, if there is statistical difference with control group, then determines modeling success, and determines modeling cycle, does not need artificial observation fight frequency, and effectively improves experimental efficiency.

Description

Technical Field

[0001] This utility model relates to the field of animal experimental cage technology, specifically an animal modeling experimental cage. Background Technology

[0002] The social defeat model cage is an experimental device specifically designed for this model. It typically consists of two parts: one part is used to house aggressive "resident" animals, and the other part is used to house "intruder" animals that need to experience social defeat. This cage induces depressive-like behaviors in "intruders" by simulating aggression and sensory stimulation in social hierarchy conflicts. It is an important tool for studying the mechanisms of affective disorders.

[0003] At the start of the experiment, the "intruder" was placed in the cage of the "resident" to induce aggressive behavior. After a period of time, the two mice were separated by a partition, so that they maintained visual and olfactory contact for the next day, but without direct physical contact, thereby increasing psychological stress. However, the experiment required recording the number of fights between the "intruder" and the "resident", which previously required manual observation, which not only reduced the efficiency of the experiment, but also meant that each person could only observe one group of "intruders" and "residents".

[0004] Therefore, this utility model provides an animal modeling experimental cage to solve the above problems. Utility Model Content

[0005] This invention provides an animal modeling experimental cage, which aims to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: an animal modeling experimental cage, comprising an experimental cage body, and further comprising: a cage door rotatably mounted on one side of the experimental cage body, a top cover disposed above the experimental cage body, a sliding top plate disposed on the top of the top cover, a transparent partition slidably mounted inside the sliding top plate for dividing the space of the experimental cage body, a handle fixedly mounted on the top of the transparent partition, and a detection mechanism disposed inside the experimental cage body for detecting experimental data.

[0007] The detection mechanism includes two clean water basins, two feed basins, and a sugar water basin located inside the experimental cage body, as well as a monitoring camera fixedly installed on the top cover.

[0008] Preferably, the two water purification basins are symmetrically distributed inside the experimental cage body, and the two feed basins are symmetrically distributed inside the experimental cage body.

[0009] Preferably, a top frame is fixedly connected to the top of the top cover, the sliding top plate is slidably connected inside the top frame, and a pressure plate is provided inside the top frame.

[0010] Preferably, the bottom of the pressure plate is in contact with the top of the sliding top plate, and a sliding rod is slidably connected inside the top frame, with the bottom end of the sliding rod fixedly connected to the top of the pressure plate.

[0011] Preferably, a pull plate is fixedly connected to the top of the slide rod, and a tension spring is provided on the top of the top frame. The pull plate is elastically connected to the top of the top frame through the tension spring.

[0012] Preferably, a mounting plate is fixedly connected to the side of the experimental cage body near the cage door, a limit pin is fixedly connected to one side of the mounting plate, and a handle is fixedly connected to one side of the cage door.

[0013] Preferably, a pull rod is slidably connected inside the handle, the pull rod passes through the handle, and an annular groove for inserting the pull rod is provided on the side surface of the limiting post.

[0014] Preferably, a retaining ring is fixedly connected to the side surface of the pull rod, and a spring is sleeved on the side surface of the pull rod. The retaining ring is elastically connected to the inner wall of one side of the handle through the spring.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] This invention features a simple structure and convenient operation. Through the setup of the detection mechanism, a transparent partition is removed, allowing two mice to fight for 15 minutes. The partition is then reinserted. During non-fighting periods, visual stimulation induces fear in the mice by exposing them to their opponent. Both sides are equipped with water and food bowls for the mice to drink and eat. An additional sugar water bowl is provided on one side of the mice to monitor their daily sugar water intake. A monitoring camera simultaneously records the number of fights, with more than 15 fights per day serving as the core indicator for model establishment. Sugar water intake is measured every 5 days. If a statistically significant difference is found compared to the control group, the model is considered successfully established, and the modeling period is determined. This eliminates the need for manual observation of fights, effectively improving experimental efficiency. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model;

[0018] Figure 2 This is a cross-sectional schematic diagram of the experimental cage body in this utility model;

[0019] Figure 3 This is a cross-sectional schematic diagram of the top frame in this utility model;

[0020] Figure 4 for Figure 3 Enlarged view of point A in the middle;

[0021] Figure 5This is a schematic diagram of the installation of the top frame in this utility model;

[0022] Figure 6 This is a schematic diagram of the installation of the tie rod in this utility model.

[0023] In the picture:

[0024] 1. Experimental cage body; 2. Cage door; 3. Top cover; 4. Sliding top plate; 5. Transparent partition; 6. Clean water basin; 7. Feed basin; 8. Sugar water basin; 9. Monitoring camera; 10. Handle; 11. Top frame; 12. Pressure plate; 13. Slide rod; 14. Pull plate; 15. Tension spring; 16. Mounting plate; 17. Limiting pin; 18. Handle; 19. Pull rod; 20. Retaining ring; 21. Spring; 22. Detection mechanism. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0026] like Figures 1 to 6 As shown, this utility model provides an animal modeling experimental cage, which includes an experimental cage body 1, and further includes: a cage door 2 rotatably installed on one side of the experimental cage body 1, a top cover 3 located above the experimental cage body 1, a sliding top plate 4 located on the top of the top cover 3, a transparent partition 5 slidably installed inside the sliding top plate 4 for dividing the experimental cage body 1 into spaces, a handle 10 fixedly installed on the top of the transparent partition 5, and a detection mechanism 22 located inside the experimental cage body 1 for detecting experimental data.

[0027] The testing unit 22 includes two clean water basins 6, two feed basins 7, a sugar water basin 8, and a monitoring camera 9 fixedly installed on the top cover 3, all located inside the experimental cage body 1.

[0028] Two clean water basins 6 are symmetrically distributed inside the experimental cage body 1, and two feed basins 7 are symmetrically distributed inside the experimental cage body 1.

[0029] Using the above scheme: When using this animal modeling experimental cage, according to the experimental design requirements, the transparent partition 5 can be pulled along the internal track of the sliding top plate 4 by holding the handle 10, dividing the experimental cage body 1 into two independent experimental spaces, each accommodating one mouse. Then, the cage door 2 is rotated to place the two mice into the two spaces respectively, one side for the larger mouse and the other side for the smaller black mouse. During modeling, the transparent partition 5 is removed, allowing the two mice to fight for 15 minutes; then the transparent partition 5 is reinserted, and during the non-fighting period, visual stimulation is used to make the black mouse face the "enemy" directly, causing it to develop psychological fear. Both spaces are equipped with a water bowl 6 and a food bowl 7 for the mice to drink and eat. An additional sugar water bowl 8 is placed on the side of the black mouse to monitor its daily sugar water consumption. At the same time, a monitoring camera 9 fixed on the top cover 3 is activated to monitor the number of fights between the mice. The number of limb contact between the two mice is identified through video signals and used as an indicator of the number of fights in the social defeat model. This data is one of the core indicators of successful modeling. During the modeling period, the mice need to fight for 15 minutes every day, and each fight should involve more than 15 fights. The consumption data of the sugar water bowl 8 on the black mouse's side can be used to explore the modeling cycle: for example, the sugar water consumption is monitored every 5 days. If there is a statistically significant difference compared with the control group, it indicates that the modeling is successful, and the modeling cycle can be determined at this time.

[0030] like Figure 1 , Figure 2 , Figure 3 , Figure 4 and Figure 5 As shown, in order to adapt to the activity needs of different experimental animals, the top cover 3 is fixedly connected to the top frame 11, the sliding top plate 4 is slidably connected to the inside of the top frame 11, and the inside of the top frame 11 is provided with a pressure plate 12.

[0031] The bottom of the pressure plate 12 is in contact with the top of the sliding top plate 4, and the top frame 11 is slidably connected to the slide rod 13, the bottom end of the slide rod 13 is fixedly connected to the top of the pressure plate 12.

[0032] A pull plate 14 is fixedly connected to the top of the slide rod 13, and a tension spring 15 is provided on the top of the top frame 11. The pull plate 14 is elastically connected to the top of the top frame 11 through the tension spring 15.

[0033] Using the above scheme: When using this animal modeling experimental cage, the pull plate 14 can be pulled upwards according to the size of the experimental animal or its activity needs. This causes the sliding rod 13 to slide upwards along the inside of the top frame 11, thereby lifting the pressure plate 12 and separating it from the sliding top plate 4. At this time, the sliding top plate 4 can be pushed to slide left and right within the top frame 11. When the sliding top plate 4 is adjusted to a suitable position, the pull plate 14 is released, and the tension spring 15 will pull the pull plate 14 downwards to reset it. This causes the sliding rod 13 and the pressure plate 12 to press back onto the top of the sliding top plate 4. The friction between the pressure plate 12 and the sliding top plate 4 is used to fix the sliding top plate 4, thereby changing the space inside the experimental cage.

[0034] like Figure 1 , Figure 2 and Figure 6 As shown, in order to facilitate opening and closing the cage door 2, an installation plate 16 is fixedly connected to the side of the experimental cage body 1 near the cage door 2, a limit pin 17 is fixedly connected to one side of the installation plate 16, and a handle 18 is fixedly connected to one side of the cage door 2.

[0035] A pull rod 19 is slidably connected inside the handle 18. The pull rod 19 passes through the handle 18, and an annular groove for the pull rod 19 to be inserted is provided on the side surface of the limiting post 17.

[0036] A retaining ring 20 is fixedly connected to the side surface of the pull rod 19, and a spring 21 is sleeved on the side surface of the pull rod 19. The retaining ring 20 is elastically connected to the inner wall of one side of the handle 18 through the spring 21.

[0037] Using the above scheme: When using this animal modeling experimental cage, if it is necessary to open the cage door 2, the pull rod 19 can be pulled inward. The pull rod 19 drives the retaining ring 20 to slide along the inside of the handle 18 and compress the spring 21, so that the end of the pull rod 19 completely exits from the annular groove on the side surface of the limiting post 17. At this time, by holding the handle 18, the cage door 2 can be flipped outward around the connection axis with the experimental cage body 1. When it is necessary to close the cage door 2, push the cage door 2 to a position that is completely in contact with the opening of the experimental cage body 1. During this process, the inclined surface of the pull rod 19 will contact the inclined surface of the limiting post 17 and squeeze the pull rod 19 outward. Then the spring 21 will release elastic potential energy to push the retaining ring 20 and the pull rod 19 to return to the position closer to the limiting post 17. The end of the pull rod 19 is inserted into the annular groove of the limiting post 17, thereby firmly fixing the cage door 2 in the closed state. The operation is simple and convenient, and effectively avoids the situation where the cage door 2 is accidentally opened during the experiment, causing the animal to escape.

[0038] Working principle and usage process of this utility model:

[0039] When using this animal modeling experimental cage, first place the cage body 1 in a suitable position. Next, adjust the position of the sliding top plate 4 according to the size of the experimental animal: pull the pull plate 14 at the top of the top frame 11 upward, causing the slide rod 13 to slide upward along the sliding groove inside the top frame 11, thereby lifting the pressure plate 12 so that the bottom of the pressure plate 12 is completely separated from the top of the sliding top plate 4. Then push the sliding top plate 4 to slide left and right in the top frame 11 until the size of the partition area below meets the activity needs of the experimental animal. Release the pull plate 14, and the tension spring 15 pulls the pull plate 14 downward to reset due to the elastic restoring force. The slide rod 13 causes the pressure plate 12 to press back onto the top of the sliding top plate 4. The friction between the pressure plate 12 and the sliding top plate 4 is used to firmly fix the sliding top plate 4, ensuring the stability of the partition space size.

[0040] Then, grasp the handle 10 at the top of the transparent partition 5 and insert the transparent partition 5 along the track inside the sliding top plate 4 until its bottom contacts the bottom surface of the experimental cage body 1, dividing the experimental cage body 1 into two independent and completely enclosed experimental spaces on the left and right.

[0041] Next, open the cage door 2: pull the lever 19 into the handle 18. The lever 19 drives the retaining ring 20 to slide along the slide inside the handle 18 and compress the spring 21, so that the end of the lever 19 completely exits from the annular groove on the side surface of the limiting post 17. At this time, hold the handle 18 and flip the cage door 2 outward around the connection axis with the experimental cage body 1. Then, put the two experimental mice that have been prepared in advance into the two separate spaces on the sides: put the larger aggressive mouse in one side and the smaller black stress mouse in the other side. After putting them in, close the cage door 2 and push the cage door 2 to a position where it is completely in contact with the opening of the experimental cage body 1.

[0042] During this process, the inclined surface of the pull rod 19 will contact the inclined surface of the limiting post 17 and be squeezed outward. After the cage door 2 is completely closed, the spring 21 releases elastic potential energy, pushing the retaining ring 20 and the pull rod 19 to return to the direction close to the limiting post 17. The end of the pull rod 19 is accurately inserted into the annular groove on the side surface of the limiting post 17, which firmly fixes the cage door 2 in the closed state, preventing the cage door 2 from being accidentally opened during the experiment and causing the mouse to escape. Next, a clean water basin 6 and a feed basin 7 are symmetrically placed in the experimental spaces on both sides to ensure that both mice can easily obtain water and food. In the experimental space on the side where the black mouse is located, an additional sugar water basin 8 is placed to monitor its sugar water consumption daily.

[0043] Subsequently, the monitoring camera 9 fixed on the top cover 3 is activated, and the angle of the camera is adjusted so that its lens covers the entire interior of the experimental cage 1. It is then connected to the experimental data acquisition system to record the fighting behavior of the mice. During the experiment, the handle 10 is held, and the transparent partition 5 is pulled out along the track inside the sliding top plate 4, so that the two mice are in the same open space and they fight for 15 minutes. During the fight, the monitoring camera 9 records the behavior of the two mice in real time, automatically identifies the number of limb contact through the video signal, and transmits the data synchronously to the data acquisition system. After the fight ends, the transparent partition 5 is immediately reinserted to separate the two mice into independent spaces again. At this time, the black mice can directly face the "enemy" through the transparent partition 5, and maintain their psychological fear state through visual stimulation. During the modeling period, the above procedure is repeated every day. At the same time, the amount of sugar water consumed in the sugar water bowl 8 on the side where the black mice are located is measured every day and compared with the amount of sugar water consumed by the control group. If the amount of sugar water consumed in three consecutive tests is statistically different from that of the control group, and the number of fights per day exceeds 15, it indicates that the modeling is successful. At this time, the modeling experiment can be stopped and the subsequent testing stage can be entered.

[0044] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0045] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An animal modeling experimental cage, comprising an experimental cage body (1), characterized in that: Also includes: The cage door (2) is rotated and installed on one side of the experimental cage body (1), the top cover (3) is set above the experimental cage body (1), the sliding top plate (4) is set on the top of the top cover (3), the transparent partition (5) is slidably installed inside the sliding top plate (4) to divide the space of the experimental cage body (1), the handle (10) is fixedly installed on the top of the transparent partition (5), and the detection mechanism (22) is set inside the experimental cage body (1) to detect experimental data. The detection mechanism (22) includes two clean water basins (6) set inside the experimental cage body (1), two feed basins (7) set inside the experimental cage body (1), a sugar water basin (8) set inside the experimental cage body (1), and a monitoring camera (9) fixedly installed on the top cover (3).

2. The animal modeling experimental cage according to claim 1, characterized in that: The two water purification basins (6) are symmetrically distributed inside the experimental cage body (1), and the two feed basins (7) are symmetrically distributed inside the experimental cage body (1).

3. The animal modeling experimental cage according to claim 1, characterized in that: The top of the top cover (3) is fixedly connected to the top frame (11), the sliding top plate (4) is slidably connected inside the top frame (11), and the top frame (11) is provided with a pressure plate (12).

4. The animal modeling experimental cage according to claim 3, characterized in that: The bottom of the pressure plate (12) is in contact with the top of the sliding top plate (4), and the top frame (11) is slidably connected to a slide rod (13), the bottom end of the slide rod (13) being fixedly connected to the top of the pressure plate (12).

5. The animal modeling experimental cage according to claim 4, characterized in that: The top of the slide bar (13) is fixedly connected to a pull plate (14), and the top of the top frame (11) is provided with a tension spring (15). The pull plate (14) is elastically connected to the top of the top frame (11) through the tension spring (15).

6. The animal modeling experimental cage according to claim 1, characterized in that: The experimental cage body (1) is fixedly connected to a mounting plate (16) on the side near the cage door (2), and a limit pin (17) is fixedly connected to one side of the mounting plate (16), and a handle (18) is fixedly connected to one side of the cage door (2).

7. The animal modeling experimental cage according to claim 6, characterized in that: The handle (18) is slidably connected to a pull rod (19), which passes through the handle (18). The side surface of the limiting post (17) is provided with an annular groove for the pull rod (19) to be inserted.

8. The animal modeling experimental cage according to claim 7, characterized in that: A retaining ring (20) is fixedly connected to the side surface of the pull rod (19), and a spring (21) is sleeved on the side surface of the pull rod (19). The retaining ring (20) is elastically connected to the inner wall of one side of the handle (18) through the spring (21).

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