A purification device for chemical synthetic drug production

Abstract

The utility model discloses a kind of purification devices for chemical synthetic drug production, including purification tank body, further include: flow guide pipe and the joint of being connected in the lower end of ceramic membrane unit, flow guide pipe is located between ceramic membrane unit and recrystallization unit, and the upper end of flow guide pipe is connected with joint;The shunt component of shunting of purifying drug, including the sleeve pipe of being connected in the upper end of flow guide pipe, sleeve pipe upper end is set to the outside of joint, sleeve pipe lateral wall is respectively connected with a group of coarse shunt pipe and a group of thin shunt pipe, for the drug of different viscosity is guided respectively, a group of through holes are set up in the lateral wall of joint;Driving part, for driving sleeve pipe to rotate, the utility model is structured by flow guide pipe and shunt component, cooperate with the spiral groove of shunt pipe inner wall and the shunt plate in joint, high viscosity drug can be shunted and form turbulence state, avoid drug stratified flow and local retention, when drug enters recrystallization unit, mixed uniformity is promoted, guarantee crystal growth uniformity.

Description

Technical Field

[0001] This utility model relates to the technical field of chemical synthesis drug purification, and in particular to a purification device for the production of chemical synthesis drugs. Background Technology

[0002] Purification of chemically synthesized drugs is a crucial step in drug production, directly affecting the purity, efficacy, and safety of the drug. Purification equipment requires the coordinated action of multiple units, such as filtration, distillation, membrane separation, and recrystallization, to remove impurities, unreacted monomers, catalyst residues, and other harmful substances from the raw materials, ultimately obtaining a high-purity finished drug product. Especially for high-viscosity drug intermediates such as oils and polymer complexes, uniform transport and efficient separation of the drug during the purification process are the core to ensuring product quality.

[0003] In existing purification devices for chemically synthesized drugs, a straight-tube or simple diverter tube is usually used to transfer drugs between the ceramic membrane unit and the recrystallization unit. However, the viscosity of the drug after membrane separation may increase due to the increased concentration. When the drug after membrane separation flows directly into the recrystallization unit through a single channel, the high-viscosity drug is prone to stratification and local retention in the channel, resulting in uneven drug mixing. This, in turn, affects the uniformity of crystal growth in the subsequent recrystallization process and reduces the purity of the product.

[0004] To address these issues, we propose a purification device for the production of chemically synthesized drugs. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a purification device for the production of chemically synthesized drugs.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: A purification apparatus for the production of chemically synthesized drugs includes a purification tank body, which contains, from top to bottom, a filtration unit, a distillation unit, a ceramic membrane unit, and a recrystallization unit. The apparatus also includes: A flow guide tube and a connector connected to the lower end of the ceramic membrane unit, wherein the flow guide tube is located between the ceramic membrane unit and the recrystallization unit, and the upper end of the flow guide tube is connected to the connector; A diversion assembly for diverting purified drugs includes a sleeve connected to the upper end of a guide tube, the upper end of the sleeve being fitted onto the outside of a connector. A set of coarse diversion tubes and a set of fine diversion tubes are respectively connected to the side wall of the sleeve for diverting drugs of different viscosities. A set of through holes is provided on the side wall of the connector, and the through holes are selectively connected to the coarse diversion tubes or the fine diversion tubes. The driving component is used to drive the sleeve to rotate, so as to achieve selective connection between the through hole and the coarse or fine flow tube.

[0007] Preferably, the connector is provided with a rotating diverter plate, the position of which corresponds to the through hole, for diverting the drug through the through hole.

[0008] Preferably, the outer wall of the connector is provided with an annular groove, and the side wall of the sleeve corresponding to the position of the annular groove is designed with a protrusion, which extends into the annular groove for limiting and fitting.

[0009] Preferably, both the coarse and fine diffusing tubes have spiral grooves on their inner walls to create a spiral turbulent flow of the drug.

[0010] Preferably, the coarse and fine flow tubes are arranged alternately along the side wall of the sleeve, and the spacing between adjacent coarse and fine flow tubes is the same.

[0011] Preferably, a magnetic block is provided on the outside of the through hole, and a magnetic block is also provided on the side wall of the pipe opening where the coarse and fine diverter pipes connect with the through hole. The magnetic properties of the two magnetic blocks are opposite, which is used for docking and positioning.

[0012] Preferably, the driving component includes a drive motor and a half gear. The drive motor is mounted on the outer wall of the connector, and the power output end of the drive motor is connected to the shaft of the half gear. The sleeve sidewall is provided with a tooth groove, and the half gear meshes with the tooth groove to drive the sleeve to rotate.

[0013] Compared with the prior art, the beneficial effects of this utility model are as follows: This invention, through the structural design of the guide tube and the flow-dividing assembly, prevents drugs from entering the recrystallization unit directly through a single channel, thereby achieving uniform distribution of materials within the recrystallization unit. Simultaneously, the flow-dividing plate within the connector and the spiral grooves on the inner wall of the flow-dividing tube can divert high-viscosity drugs and create a turbulent flow state, preventing drug stratification and localized retention. This improves the mixing uniformity of the drug entering the recrystallization unit, ensuring uniform crystal growth. The varying coarseness of the flow-dividing assembly allows for adjustment of the use of coarse or fine flow-dividing tubes according to the characteristics of different chemical drugs, expanding the overall applicability of the device. For high-viscosity drugs, a coarse flow-dividing tube reduces flow resistance; for low-viscosity drugs, a fine flow-dividing tube increases flow rate and mass transfer efficiency, preventing drug retention and significantly improving the overall purification efficiency of the drug. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a cross-sectional structural diagram of the present invention; Figure 3 This is a schematic diagram of the connection structure between the connector and the guide tube of this utility model; Figure 4 This is a schematic diagram of the exploded structure of the connector and guide tube of this utility model; Figure 5 This is a schematic diagram of the guide tube and its auxiliary structures of this utility model.

[0015] In the diagram: 1-purification tank body, 2-guide pipe, 3-connector, 31-diverter plate, 4-diverter assembly, 5-sleeve, 6-coarse diverter pipe, 61-spiral groove, 7-fine diverter pipe, 8-through hole, 81-magnetic block, 9-driving component, 91-drive motor, 92-half gear, 93-tooth groove. Detailed Implementation

[0016] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0017] In the description of this utility model, "multiple" means two or more, unless otherwise explicitly specified. Combined with the given innovation of "bionic leaf vein-type mass transfer channel: improving the mixing uniformity of high-viscosity drugs," In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "sleeved / connected," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0019] Reference Figure 1-2A purification device for the production of chemically synthesized drugs includes a purification tank body 1. The purification tank body 1 is provided with a filtration unit, a distillation unit, a ceramic membrane unit and a recrystallization unit arranged from top to bottom, so that the drug undergoes a step-by-step process of pretreatment → distillation → membrane separation → recrystallization. The filtration unit is a filter tank with a small pore size. The distillation unit is filled with corrugated packing to increase the gas-liquid contact area and improve the distillation efficiency. The ceramic membrane unit is a three-stage series structure of coarse filtration membrane, fine filtration membrane and specific adsorption membrane to avoid clogging of a single membrane module or incomplete purification. The recrystallization unit is a small evaporator crystallizer with multiple sets of inclined guide plates inside to accelerate drug-liquid mixing. It also includes a guide pipe 2 and a connector 3 connected to the lower end of the ceramic membrane unit. The guide pipe 2 is located between the ceramic membrane unit and the recrystallization unit, and the upper end of the guide pipe 2 is connected to the connector 3. The two are only connected by butt joint. Reference Figure 3-5 The diversion assembly 4 for diverting purified drugs includes a sleeve 5 connected to the upper end of the guide tube 2. The upper end of the sleeve 5 is fitted onto the outside of the connector 3, and a rubber gasket is provided between the two to increase sealing. An annular groove is provided on the outer wall of the connector 3. The side wall of the sleeve 5 corresponding to the position of the annular groove is designed with a protrusion. The protrusion extends into the annular groove for limiting engagement. The two engage to restrict the sleeve 5 to the outside of the connector 3 to prevent detachment and will not affect its rotation. A set of coarse diversion tubes 6 and a set of fine diversion tubes 7 are respectively connected to the side wall of the sleeve 5 for diverting drugs of different viscosities. For high-viscosity drugs, the coarse diversion tubes 6 are used to reduce flow resistance. For low-viscosity drugs, the fine diversion tubes 7 are used to increase flow rate and mass transfer efficiency and avoid drug retention. The inner walls of the coarse diversion tubes 6 and the fine diversion tubes 7 are provided with spiral grooves 61 to make the drug form a spiral turbulent state, break the concentration boundary layer of high-viscosity drugs, reduce drug flow resistance, and the inner walls are lined with a polytetrafluoroethylene anti-sticking layer. The coarse diverter tubes 6 and fine diverter tubes 7 are arranged alternately along the side wall of the sleeve 5, with the same spacing between adjacent coarse diverter tubes 6 and adjacent fine diverter tubes 7. A set of through holes 8 are provided on the side wall of the connector 3, with the spacing between adjacent through holes 8 also being the same as the spacing between adjacent coarse diverter tubes 6 and adjacent fine diverter tubes 7. The through holes 8 selectively communicate with either the coarse diverter tube 6 or the fine diverter tube 7. The through holes 8 only connect with one type of diverter tube at a time. When connecting one type of diverter tube, the side wall of the connector 3 at the unopened position closes the other type of diverter tube. A rotating diverter plate 3 is provided inside the connector 3. 1. The position of the diverter plate 31 corresponds to that of the through hole 8. The diverter plate 31 is designed with an inclination. Under the force generated by the drug falling from the top, the diverter plate 9 is rotated by the lateral force to assist the drug in diverting towards the through hole 8. A magnetic block 81 is provided on the outside of the through hole 8. A magnetic block 81 is also provided on the side wall of the pipe opening where the coarse diverter pipe 6 and the fine diverter pipe 7 connect with the through hole 8. The magnetic blocks 81 on the side wall of the coarse diverter pipe 6 and the fine diverter pipe 7 have opposite magnetic properties to the magnetic blocks 81 on the side wall of the through hole 8. The magnetic force is used to connect and position the pipes to prevent the relative position of the two pipes from shifting and affecting the diversion effect. Reference Figure 5 The driving component 9 is used to drive the sleeve 5 to rotate, so as to selectively connect the through hole 8 with the coarse diverter 6 or the fine diverter 7. The driving component 9 includes a driving motor 91 and a half gear 92. The driving motor 91 is installed on the outer wall of the connector 3. The power output end of the driving motor 91 is connected to the shaft of the half gear 92. The sleeve 5 has a toothed groove 93 on its side wall. The number of teeth in the toothed groove 93 matches the number of teeth on the half gear 92. The half gear 92 meshes with the toothed groove 93 to drive the sleeve 5 to rotate. When the driving component 9 is running, the driving force is greater than the magnetic force of the magnetic block 81, so it can drive the sleeve 5 to rotate. The through hole 8 can be switched to connect with the coarse diverter 6 or the fine diverter 7 according to the actual drug usage requirements.

[0020] The above embodiments are preferred embodiments of the present utility model, but the embodiments of the present utility model are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present utility model shall be considered equivalent substitutions and shall be included within the protection scope of the present utility model.

[0021] In the description of this utility model, it should be understood that the terms indicating orientation or positional relationship are based on the orientation or positional relationship shown in the drawings and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

Claims

1. A purification apparatus for the production of chemically synthesized drugs, comprising a purification tank body (1), wherein a filtration unit, a distillation unit, a ceramic membrane unit, and a recrystallization unit are respectively arranged from top to bottom inside the purification tank body (1), characterized in that, Also includes: The guide tube (2) and the connector (3) connected to the lower end of the ceramic membrane unit, the guide tube (2) being located between the ceramic membrane unit and the recrystallization unit, and the upper end of the guide tube (2) being connected to the connector (3); The diversion assembly (4) for diverting purified drugs includes a sleeve (5) connected to the upper end of the guide tube (2). The upper end of the sleeve (5) is sleeved on the outside of the connector (3). A set of coarse diversion tubes (6) and a set of fine diversion tubes (7) are respectively connected to the side wall of the sleeve (5) for diverting drugs of different viscosities. A set of through holes (8) is opened on the side wall of the connector (3). The through holes (8) are selectively connected to the coarse diversion tubes (6) or the fine diversion tubes (7). The driving component (9) is used to drive the sleeve (5) to rotate, so as to achieve selective connection between the through hole (8) and the coarse diverter (6) or the fine diverter (7).

2. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, The connector (3) is provided with a rotating diverter plate (31), which is positioned corresponding to the through hole (8) to divert the drug through the through hole (8).

3. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, The outer wall of the connector (3) is provided with an annular groove, and the side wall of the sleeve (5) corresponding to the position of the annular groove is designed with a protrusion, which extends into the annular groove for limiting and fitting.

4. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, Both the coarse diverter (6) and the fine diverter (7) have spiral grooves (61) on their inner walls to create a spiral turbulent flow of the drug.

5. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, The coarse diverter tube (6) and the fine diverter tube (7) are arranged alternately along the side wall of the sleeve (5), and the spacing between adjacent coarse diverter tubes (6) and adjacent fine diverter tubes (7) is the same.

6. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, A magnetic block (81) is provided on the outside of the through hole (8). A magnetic block (81) is also provided on the side wall of the pipe opening where the coarse diverter (6) and the fine diverter (7) meet the through hole (8). The magnetic properties of the two magnetic blocks (81) are opposite and are used for docking and positioning.

7. The purification apparatus for the production of chemically synthesized drugs according to claim 1, characterized in that, The driving component (9) includes a drive motor (91) and a half gear (92). The drive motor (91) is installed on the outer wall of the connector (3). The power output end of the drive motor (91) is connected to the shaft of the half gear (92). The sleeve (5) has a toothed groove (93) on its side wall. The half gear (92) meshes with the toothed groove (93) to drive the sleeve (5) to rotate.

Images