Plug-like collagen sponge filling defoaming device

Abstract

The utility model discloses a kind of plug-like collagen sponge filling defoaming devices, including freeze-drying mould and smearing cover, the freeze-drying mould and smearing cover are all rectangular, the top of freeze-drying mould is uniformly provided with several cylindrical holes, the bottom of the cylindrical hole is hemispherical structure, the bottom of the smearing cover is uniformly provided with several cylindrical bodies that are embedded with the cylindrical hole, the bottom of the cylindrical body is hemispherical structure, the cylindrical body quantity, distribution, pitch of the smearing cover are identical with the cylindrical hole of freeze-drying mould, the utility model structure is simple, convenient to operate, can quickly solve the bubble problem of high concentration collagen material liquid in filling process in filling process, realize that dozens of hundreds of plug-like collagen sponge defoaming high-efficiency operation can be completed in one "dipping+smearing", to improve product quality stability, reduce the rate of defective products, promote the further application of high concentration plug-like collagen sponge in stomatology field.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a plug-shaped collagen sponge filling and defoaming device. Background Technology

[0002] Collagen plugs, as a biocompatible restorative material, have been widely used in the field of oral medicine, such as for tooth extraction wound protection, bone defect filling, and soft tissue regeneration. Their core advantage lies in the natural bioactivity of collagen, which promotes tissue healing, while the high density of the collagen plug significantly enhances its structural support, strengthens the mechanical protection of the wound, prolongs the material's retention time in the oral cavity, and thus optimizes the restorative effect.

[0003] However, high-concentration collagen solutions, due to their high viscosity, easily trap air and form bubbles during the filling process before freeze-drying. These bubbles create irregular pores after the sponge solidifies, particularly on the surface and inside plug-like products, leading to a series of problems: First, surface pores prevent the sponge from adhering properly to oral tissues, easily causing food residue accumulation and increasing the risk of infection; second, compromised appearance affects the product's clinical acceptability; third, the randomness of the pores causes a significant deviation between the actual product volume and the design value, resulting in inaccurate dosage control; fourth, the uncontrollable nature of these pore defects increases the difficulty of quality inspection, making it difficult to achieve strict quality control standards, ultimately leading to a high defect rate and severely restricting the large-scale production and clinical application of high-concentration plug-like collagen sponges. Currently, the industry's main defoaming methods for high-concentration collagen raw materials are vacuum defoaming and ultrasonic defoaming. However, vacuum defoaming requires specialized vacuum equipment, is costly, and results in uneven solution concentration; ultrasonic defoaming easily leads to collagen denaturation, affecting bioactivity. The above methods cannot remove air bubbles from the mold sidewalls and bottom of the holes, nor can they balance defoaming effect, production efficiency and material stability. Therefore, there is an urgent need for a low-cost and high-efficiency defoaming device.

[0004] In view of the above, this utility model is hereby proposed. Utility Model Content

[0005] The purpose of this invention is to provide a defoaming device for filling plug-shaped collagen sponges. It has a simple structure and is easy to operate. During the filling process, it can quickly solve the problem of air bubbles in high-concentration collagen solution, achieving efficient defoaming of dozens or even hundreds of plug-shaped collagen sponges with a single "dipping + spreading" operation. This improves product quality stability, reduces the defect rate, and promotes the further application of high-concentration plug-shaped collagen sponges in the field of oral medicine. It has broad application prospects and is conducive to widespread application.

[0006] To achieve the above objectives, this utility model provides a plug-shaped collagen sponge filling and defoaming device, comprising a freeze-drying mold and an application cap. Both the freeze-drying mold and the application cap are rectangular. The top of the freeze-drying mold is evenly distributed with a plurality of cylindrical holes, the bottom of which has a hemispherical structure. The bottom of the application cap is evenly distributed with a plurality of cylindrical bodies that fit into the cylindrical holes, the bottom of which has a hemispherical structure. The number, distribution, and spacing of the cylindrical bodies on the application cap are the same as those of the cylindrical holes on the freeze-drying mold.

[0007] Preferably, the number of the cylindrical holes is 20-300, the inner diameter is 0.5-5cm, the depth is 0.5-4cm, and the distance between adjacent centers is 1-15cm.

[0008] Preferably, the diameter of the cylindrical part of the coating cap is 0.5-5 mm smaller than the inner diameter of the cylindrical hole of the freeze-drying mold, and the height of the cylindrical part of the coating cap is 0.5-3 cm higher than the depth of the cylindrical hole of the freeze-drying mold.

[0009] Preferably, the freeze-drying mold is an integrally molded structure made of stainless steel, titanium alloy, Hastelloy, nickel-based alloy, cobalt-chromium alloy, aluminum alloy, polytetrafluoroethylene, polyethylene, resin, PET, or silicone rubber.

[0010] Preferably, the coating cap is a molded structure made of one or a combination of two of the following materials: stainless steel, titanium alloy, Hastelloy, nickel-based alloy, cobalt-chromium alloy, aluminum alloy, polytetrafluoroethylene, polyethylene, resin, PET, and silicone rubber.

[0011] The present invention provides a plug-shaped collagen sponge filling and defoaming device, which has the following beneficial effects.

[0012] 1. This utility model has a simple structure and is easy to operate. It can quickly solve the problem of air bubbles in high-concentration collagen liquid during the filling process, and can efficiently remove bubbles from dozens or hundreds of plug-shaped collagen sponges with a single "dipping + spreading" operation. This improves product quality stability, reduces the defect rate, and promotes the further application of high-concentration plug-shaped collagen sponges in the field of oral medicine.

[0013] 2. This invention involves applying a liquid material before filling. After application, the liquid material forms a uniform thin film on the inner wall of the quasi-cylindrical hole. This film breaks down the air interface between the liquid material and the inner wall of the mold, thereby eliminating air bubbles formed due to surface tension during direct filling. Simultaneously, the hemispherical structure at the bottom of the quasi-cylindrical body conforms to the hemispherical area at the bottom of the quasi-cylindrical hole, ensuring no air bubbles remain at the bottom. The operation is simple and effective, requiring no complex liquid material treatment process or modification of the freeze-drying mold, saving time, effort, and costs, with significant results.

[0014] 3. This utility model is equipped with a coating cap, the cylindrical part of which corresponds one-to-one with the cylindrical holes of the freeze-drying mold, realizing one-time processing of the entire mold, saving time, improving efficiency, reducing the risk of contamination during personnel operation, and facilitating its application in cleanrooms to solve practical problems. Attached Figure Description

[0015] Figure 1 A three-dimensional view showing the separation of the freeze-drying mold and the coating cap of a plug-shaped collagen sponge filling and defoaming device provided by this utility model; Figure 2 A front view showing the separation of the freeze-drying mold and the coating cap in a plug-shaped collagen sponge filling and defoaming device provided by this utility model; Figure 3 A perspective view of the freeze-drying mold and coating cap fitting together in a plug-shaped collagen sponge filling and defoaming device provided by this utility model; Figure 4 A front view of the freeze-drying mold and coating cap fitting together in a plug-shaped collagen sponge filling and defoaming device provided by this utility model; Figure 5 The images show actual photos of plug-shaped collagen sponges, where A is a plug-shaped collagen sponge obtained without using this invention for filling, and B is a plug-shaped collagen sponge obtained using this invention for filling.

[0016] In the picture: 1. Freeze-drying mold 2. Coating cap 3. Cylindrical hole 4. Cylindrical body. Detailed Implementation

[0017] The present invention will be further described below with reference to specific embodiments and accompanying drawings to help to understand the content of the present invention.

[0018] Figures 1-4The figures shown are a three-dimensional view and a front view showing the separation of the freeze-drying mold and the application cap, as well as a three-dimensional view and a front view showing their assembly, of a plug-shaped collagen sponge filling and defoaming device provided by this utility model. The plug-shaped collagen sponge filling and defoaming device includes a freeze-drying mold 1 and an application cap 2. Both the freeze-drying mold 1 and the application cap 2 are rectangular. The top of the freeze-drying mold 1 has a plurality of cylindrical holes 3 evenly distributed, and the bottom of each cylindrical hole 3 has a hemispherical structure. The bottom of the application cap 2 has a plurality of cylindrical bodies 4 evenly distributed, which engage with the cylindrical holes 3. The bottom of each cylindrical body 4 also has a hemispherical structure. The number, distribution, and spacing of the cylindrical bodies 4 on the application cap 2 are the same as those of the cylindrical holes 3 on the freeze-drying mold 1. The number of cylindrical holes 3 is 20-300, the inner diameter is 0.5-5 cm, the depth is 0.5-4 cm, and the distance between adjacent centers is 1-15 cm. The diameter of the cylindrical part 4 of the coating cap 2 is 0.5-5 mm smaller than the inner diameter of the cylindrical hole 3 of the freeze-drying mold 1, and the height of the cylindrical part 4 of the coating cap 2 is 0.5-3 cm higher than the depth of the cylindrical hole 3 of the freeze-drying mold 1. The freeze-drying mold is an integrally molded structure made of stainless steel, titanium alloy, Hastelloy, nickel-based alloy, cobalt-chromium alloy, aluminum alloy, polytetrafluoroethylene, polyethylene, resin, PET, or silicone rubber. The coating cap is a molded structure made of one or a combination of two of the following materials: stainless steel, titanium alloy, Hastelloy, nickel-based alloy, cobalt-chromium alloy, aluminum alloy, polytetrafluoroethylene, polyethylene, resin, PET, and silicone rubber.

[0019] The working principle of this utility model is as follows: During operation, first, use the cylindrical part 4 of the coating cap 2 to dip into the collagen liquid, insert it into the freeze-drying mold 1, and shake the coating cap 2 horizontally in a circular motion for 5-10 turns to fully coat the inside of the cylindrical hole 3 of the freeze-drying mold 1 with some liquid. Then, remove the coating cap 2. Squeeze the collagen liquid into the cylindrical hole 3 until it overflows 0.1-0.3cm from the top of the cylindrical hole 3 (ensuring there are no gaps in the hole). Finally, scrape off the excess liquid and proceed to the next freeze-drying process.

[0020] like Figure 5 The image shown is a photograph of a plug-shaped collagen sponge. Image A shows a plug-shaped collagen sponge obtained without using this invention for filling; irregular pores are visible on the sponge surface, affecting its clinical application. Image B shows a plug-shaped collagen sponge obtained using this invention for filling; the sponge has a complete shape and a smooth, delicate surface.

[0021] Comparative experiment: 1000 plug-shaped collagen sponge samples were prepared, of which 500 were prepared using this device (experimental group) and the other 500 were not prepared using this device (control group). The samples were observed and the number was counted. The experimental results are shown in Table 1.

[0022] As shown in Table 1, the porosity of samples not treated with this device was significantly higher than that of samples treated with this device, thus proving that this invention has a significant effect on reducing pores on the surface of plug-like collagen sponges. Furthermore, weighing and statistical analysis of the samples revealed that the average weight of samples with pores was lower than that of qualified products, fully demonstrating that pores affect sample weight and thus the quality stability of the samples.

[0023] Table 1. Test Results

[0024] This invention features a simple structure and convenient operation. It quickly resolves the air bubble problem in high-concentration collagen solution during filling, achieving efficient defoaming of dozens or even hundreds of plug-shaped collagen sponges with a single "dipping + coating" process. This improves product quality stability, reduces the defect rate, and promotes the further application of high-concentration plug-shaped collagen sponges in the field of oral medicine. Before filling, the solution is coated, forming a uniform film on the inner wall of the quasi-cylindrical hole 3. This film breaks down the air interface between the solution and the mold's inner wall, eliminating air bubbles formed due to surface tension during direct filling. Simultaneously, the hemispherical structure at the bottom of the quasi-cylindrical body 4 conforms to the hemispherical area at the bottom of the quasi-cylindrical hole 3, ensuring no air bubbles remain at the bottom of the hole. The operation is simple and effective, requiring no complex solution processing or modification of the freeze-drying mold, saving time, effort, and costs, with significant results. This utility model is equipped with a coating cover 2, and the cylindrical body 4 of the coating cover 2 corresponds one-to-one with the cylindrical hole 3 of the freeze-drying mold 1, realizing one-time processing of the entire mold, which can save time, improve efficiency, reduce the risk of contamination by personnel, facilitate application in cleanrooms, and solve practical problems.

[0025] This article uses specific examples to illustrate the inventive concept in detail. The description of the above embodiments is only for the purpose of helping to understand the core idea of ​​this utility model. It should be noted that any obvious modifications, equivalent substitutions or other improvements made by those skilled in the art without departing from the inventive concept should be included within the protection scope of this utility model.

Claims

1. A plug-shaped collagen sponge filling and defoaming device, characterized in that, The device includes a freeze-drying mold and an application cap. Both the freeze-drying mold and the application cap are rectangular. The top of the freeze-drying mold has several cylindrical holes, and the bottom of each cylindrical hole has a hemispherical structure. The bottom of the application cap has several cylindrical bodies that fit into the cylindrical holes. The bottom of each cylindrical body also has a hemispherical structure. The number, distribution, and spacing of the cylindrical bodies on the application cap are the same as those on the cylindrical holes of the freeze-drying mold.

2. The plug-shaped collagen sponge filling and defoaming device according to claim 1, characterized in that, The number of the cylindrical holes is 20-300, the inner diameter is 0.5-5cm, the depth is 0.5-4cm, and the distance between adjacent centers is 1-15cm.

3. The plug-shaped collagen sponge filling and defoaming device according to claim 2, characterized in that, The diameter of the cylindrical part of the coating cap is 0.5-5mm smaller than the inner diameter of the cylindrical hole of the freeze-drying mold, and the height of the cylindrical part of the coating cap is 0.5-3cm higher than the depth of the cylindrical hole of the freeze-drying mold.

4. The plug-shaped collagen sponge filling and defoaming device according to claim 3, characterized in that, The freeze-drying mold is an integrally molded structure made of stainless steel, titanium alloy, Hastelloy, nickel-based alloy, cobalt-chromium alloy, aluminum alloy, polytetrafluoroethylene, polyethylene, resin, PET, or silicone rubber.

Images