A gene sequencing device

Abstract

The utility model relates to gene sequencing equipment technical field provides a kind of gene sequencing equipment, including rack, working platform is arranged thereon;Shell, including door, rack and working platform form opening, door is installed in opening;Between door and rack, and between door and working platform, first sealing gasket is arranged;Shell, rack and working platform can be collectively enclosed to form first working space;The top of shell is provided with first air inlet and first air filter assembly, and the position of first air filter assembly and first air inlet is opposite and is set;First air outlet is opened in working platform, and the position of second air filter assembly opposite with first air outlet is set in the below of working platform;Second air outlet and second air inlet are also respectively opened in working platform, and the air inlet of dehumidification component is communicated second air outlet, and dehumidification component is set in the below of working platform.

Description

Technical Field

[0001] This utility model belongs to the field of gene sequencing equipment technology, and in particular relates to a gene sequencing device. Background Technology

[0002] Current gene sequencing equipment typically involves steps such as sampling, sample separation, nucleic acid extraction, sample spotting, and interpretation to obtain nucleic acid test results when sequencing samples.

[0003] This gene sequencing equipment is typically placed in a standard cleanroom, but the working environment within the laboratory, such as humidity and cleanliness, can be affected by human factors and may not meet the requirements of some clients. Furthermore, using this equipment requires modifying the laboratory environment, resulting in significant costs. Utility Model Content

[0004] In view of the shortcomings of the existing technology, the purpose of this utility model is to provide a gene sequencing device with a clean environment that can meet customer requirements at low cost.

[0005] To achieve this objective, the present invention adopts the following technical solution: A gene sequencing device, comprising: A frame on which a work platform is mounted; A housing, the housing being mounted on the frame, the housing including a door, the frame and the work platform forming an opening, the door being mounted on the opening; A first sealing gasket is provided between the door and the frame, and between the door and the work platform; The housing, the frame, and the work platform can together enclose and form a first workspace; The top of the housing is provided with a first air inlet and a first air filter assembly. The first air filter assembly is positioned directly opposite the first air inlet and is used to introduce filtered clean air into the first working space. The working platform is provided with a first air outlet, and a second air filter component is provided below the working platform, which is directly opposite the position of the first air outlet. The second air filter component can draw in the air in the first working space, filter the air and discharge it to the outside of the gene sequencing device. The working platform is also provided with a second air outlet and a second air inlet. A dehumidification component is provided below the working platform, and the air inlet of the dehumidification component is connected to the second air outlet.

[0006] Preferably, a first magnetic attraction component is provided between the work platform and the door, and the first magnetic attraction component is configured to press the door and the work platform together to press the first sealing gasket. And / or, a second magnetic attraction assembly is provided between the door and the frame, the second magnetic attraction assembly being configured to press the door and the work platform against the first sealing gasket.

[0007] Preferably, the material of the first sealing gasket is any one of foamed cotton, rubber gasket, silicone foam strip, or flexible magnet.

[0008] Preferably, a third air filter assembly is also provided at the second air outlet, the third air filter assembly being directly opposite the second air outlet and positioned below the working platform.

[0009] Preferably, the second air inlet is provided with a fourth air filter assembly, which is positioned directly opposite the second air inlet and is located below the working platform.

[0010] Preferably, the horizontal distance L3 between the center of the second air inlet and the center of the second air outlet is in the range of 500mm-1000mm, and / or the vertical distance L4 between the center of the second air inlet and the center of the second air outlet is in the range of 500mm-800mm.

[0011] Preferably, the first air filter assembly, the second air filter assembly, the third air filter assembly, and the fourth air filter assembly all include a mounting frame and a high-efficiency air filter or an ultra-high-efficiency air filter installed inside the mounting frame.

[0012] Preferably, the gene sequencing device further includes an air cooling component. A third air inlet is provided on the working platform. The air cooling component is installed below the working platform and is directly opposite the third air inlet. The air cooling component can blow cooling air within a preset temperature range into the first working space through the third air inlet.

[0013] Preferably, the air cooling assembly includes: a mounting housing, a water-cooling radiator, a mounting plate, and a fan. The mounting housing is mounted on the lower surface of the work platform, the water-cooling radiator is mounted inside the mounting housing, and a preset gap L5 is provided between at least one inner wall of the mounting housing and the water-cooling radiator. The mounting plate is disposed above the water-cooling radiator, and the fan is mounted on the mounting plate and located inside the mounting housing. The fan blows air into the first workspace through the third air inlet. The water-cooled radiator is equipped with an inlet and an outlet, both of which are connected to an external cooling circulation system.

[0014] Preferably, the gene sequencing device further includes a control component and a first temperature detection component, the first temperature detection component being configured to detect the temperature within the first workspace in real time, and both the first temperature detection component and the air cooling component being electrically connected to the control component.

[0015] Compared with the prior art, the present invention has the following beneficial effects: In the present invention, a door is installed on the frame, and a first sealing gasket is provided between the door and the frame to ensure that the air in the first working space between the casing, the frame and the working platform can only enter from the first air inlet, and will not enter the first working space from the gap between the frame and the door, or between the door and the working platform, thereby ensuring that the cleanliness of the air in the first working space meets the preset requirements.

[0016] In addition, the aforementioned second air filter assembly can draw in and filter the air within the first working space, thereby expelling the air from the first inlet to the outside of the gene sequencing equipment. That is, air enters the first working space from the first inlet and flows out from the first outlet, thus forming an air loop to maintain the air within the first working space at a preset required cleanliness level.

[0017] The aforementioned work platform is also equipped with a second air outlet and a second air inlet. A dehumidification component is installed below the work platform to draw in air from the first working space, remove moisture from the air, and maintain the air in the first working space at a preset humidity level, thereby meeting the requirements of the sequencing equipment.

[0018] The aforementioned integrated environmental control system combines cleanliness control and humidity control loops within the first working space of the same device. These two systems can operate independently or collaboratively, providing a highly stable, clean, and humidity-controlled operating environment for gene sequencing. This not only significantly improves the accuracy and reliability of the sequencing data but also effectively prevents external environmental fluctuations from interfering with the biochemical reactions occurring within the sequencing equipment. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the gene sequencing device in this utility model.

[0020] Figure 2 This is a structural schematic diagram of the gene sequencing device of this utility model from a first angle (excluding part of the casing). Figure 3 This is a cross-sectional view of the gene sequencing device of this utility model; Figure 4This is a second-angle structural diagram of the gene sequencing device of this utility model (excluding part of the casing). Figure 5 This is a structural schematic diagram of the gene sequencing device in this utility model from a third angle (excluding part of the casing). Figure 6 This is a schematic diagram of the air cooling component in this utility model; Figure 7 This is a top view of the air cooling component in this utility model; Figure 8 This is a cross-sectional view of the air cooling component in this utility model.

[0021] The components are as follows: 1. Frame; 2. Housing; 3. First air inlet; 4. First air outlet; 41. First vent hole; 42. Second vent hole; 5. Second air inlet; 6. Second air outlet; 7. Third air inlet; 8. First magnetic suction assembly; 9. First sealing groove; 10. Dehumidification assembly; 11. Air cooling assembly; 111. Mounting housing; 112. Water cooling radiator; 113. Mounting plate; 12. Second magnetic suction assembly; 13. Door; 15. Movable plate; 16. Opening door; 17. Handle; 18. Working platform; 19. Second air filter assembly; 192. Second air outlet; 20. First partition; 21. Second partition; 211. Third through hole. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0023] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0024] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0025] In the description of this utility model, it should be noted that the terms "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this utility model is in use. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," and "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0026] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0027] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0028] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0029] like Figures 1-8As shown, this embodiment provides a gene sequencing device, primarily designed to provide a highly clean, temperature- and humidity-controlled, stable working environment for gene testing. Specifically, the gene sequencing device includes a rack 1 and a housing 2. The rack 1 has a working platform 18, which is a flat plate used to install various functional modules required in the nucleic acid detection process, including sampling, sample separation, nucleic acid extraction, sample spotting, and interpretation. The housing 2 is mounted on the rack 1 and includes a door 13. The rack 1 and the working platform 18 form an opening, and the door 13 is installed in the opening. Specifically, the door 13 is connected to the rack 1 via a hinge. This hinge connection method is simple in structure, enables smooth opening and closing of the door 13, and ensures precise alignment of the door 13 with the first sealing gasket when closed.

[0030] A first sealing gasket is installed around the opening. After the door 13 is closed, the upper and side parts of the door 13 are in contact with the frame 2, and the lower part of the door 13 is in contact with the side of the work platform 18. Therefore, a first sealing gasket is installed between the door 13 and the frame 2. Since the door 13 is in contact with the side of the work platform 18, a first sealing ring is installed on the side of the door 13 and the work platform 18.

[0031] To ensure the airtightness of the first working space, first sealing gaskets are installed between door 13 and rack 1, and between door 13 and the side wall of work platform 18. When door 13 is closed and the equipment is not in operation, door 13, rack 1, and work platform 18 together enclose and form a sealed first working space. This first working space is located above work platform 18. Specifically, when door 13 is closed and the equipment is not in operation, it means that the equipment is stopped, and the first working space is in a state of isolation and sealing from the external environment. When the gene sequencing equipment starts working, the aforementioned first air filter assembly, second air filter assembly 19, and dehumidification assembly 10 start working, and the gas in the first working space begins to circulate.

[0032] To meet the cleanliness requirements in the first working space, a first air inlet 3 and a first air filter assembly are provided on the top of the casing 2. The first air filter assembly is positioned opposite the first air inlet 3 and is used to introduce filtered clean air into the first working space.

[0033] The working platform 18 is provided with a first air outlet 4, and a second air filter assembly 19 is provided below the working platform 18, which is directly opposite the position of the first air outlet 4. The second air filter assembly 19 can draw in the air in the first working space, filter it and then discharge it to the outside of the equipment.

[0034] Specifically, the second air inlet of the second air filter assembly 19 is connected to the first air outlet 4, and the second air outlet 192 is connected to the external environment.

[0035] More specifically, the first air outlet 4 includes a first vent 41 and a second vent 42 opened on the working platform 18. A first protective net is provided on the first vent 41, and a gas containing space is provided below the second vent 42. A third through hole 211 is opened in the gas containing space, and the third through hole 211 is connected to the second air inlet of the second air filter assembly 19. In this embodiment, the third through hole 211 is directly connected to the second air inlet. A first partition 20 and a second partition 21 are provided below the working platform 18. The third through hole 211 is opened in the second partition 21. The first partition 20, the second partition 21, the housing 2, and the frame 1 located below the working platform 18 enclose the gas containing space. Sealing gaskets are provided between the first partition 20 and the frame 1, between the second partition 21 and the frame 1, and between the housing 2 and the frame 1. Gas can only be discharged to the external environment through the third through hole 211 via the second air filter assembly 19.

[0036] By circulating air through the first air inlet 3 and the first air outlet 4, a directional airflow is formed inside the equipment, which can continuously remove aerosol pollutants that may be generated inside, thereby keeping the gas in the first working space at the preset cleanliness level.

[0037] To achieve humidity control within the first working space, the working platform 18 is also equipped with a second air outlet 6 and a second air inlet 5. A dehumidification component 10 is installed below the working platform 18. The air inlet of the dehumidification component 10 is connected to the second air outlet 6, and the air outlet of the dehumidification component 10 is connected to the second air inlet 5. The dehumidification component 10 is configured to draw in air from the first working space, dehumidify it, and then return the dry air to the first working space, thereby maintaining the air humidity within the first working space within a preset range to meet the strict humidity requirements of gene sequencing reagents and reaction processes.

[0038] In this embodiment, a door 13 is installed on the frame 1, and a first sealing gasket is provided between the door 13 and the frame 1 to ensure that the air in the first working space between the housing 2, the frame 1 and the working platform 18 can only enter from the first air inlet 3, and will not enter the first working space from the gap between the frame 1 and the door 13, or between the door 13 and the working platform 18, thereby ensuring that the cleanliness of the air in the first working space meets the preset requirements.

[0039] In addition, the second air filter assembly 19 can draw in and filter the air in the first working space, so as to exhaust the air in the first inlet to the outside of the gene sequencing equipment. That is, air enters the first working space from the first air inlet 3 and flows out from the first air outlet 4, thereby forming an air loop to keep the air in the first working space at a preset required cleanliness level.

[0040] The aforementioned working platform 18 is also provided with a second air outlet 6 and a second air inlet 5. The dehumidification component 10 is installed below the working platform 18 to draw air from the first working space, remove moisture from the air, and keep the air in the first working space at a preset humidity, thereby meeting the requirements of the sequencing equipment.

[0041] The aforementioned integrated environmental control system combines cleanliness control and humidity control loops within the first working space of the same device. These two systems can operate independently or collaboratively, providing a highly stable, clean, and humidity-controlled operating environment for gene sequencing. This not only significantly improves the accuracy and reliability of the sequencing data but also effectively prevents external environmental fluctuations from interfering with the biochemical reactions occurring within the sequencing equipment.

[0042] Preferably, a first sealing groove 9 is provided on the frame 1, and a first sealing gasket is installed in the first sealing groove 9.

[0043] Preferably, there are two sets of first air inlets 3, with two sets of first air inlets 3 provided on the top surface of the housing 2. The positions of the first air inlets 3 are both within the coverage area of ​​the first air filter assembly, that is, they share a large first air filter assembly. Compared with a single centralized air inlet, the symmetrically distributed two sets of air inlets can form a more uniform and stable laminar or quasi-laminar downward airflow across the cross-section of the entire working space, effectively avoiding eddies, dead zones, or areas with excessively high local airflow velocities that may be caused by a single air inlet. This ensures that samples or reagents at all positions on the working platform 18 are uniformly covered, eliminating local cleanliness differences caused by uneven airflow distribution, and providing a high-cleanliness environment for gene sequencing within the entire first working space. By sharing a single first air filter assembly to filter the air from both air inlets simultaneously, this design effectively increases the total effective air intake area without increasing the number of filters or significantly increasing costs. This satisfies the high air exchange rate required for large air volume inside the equipment, while avoiding the problems of complex structure, complicated installation, increased cost, and increased sealing positions caused by using multiple independent filters. It can improve performance without significantly increasing production costs.

[0044] By using only a single primary air filter assembly, the number of filters requiring monitoring and replacement in the system is reduced. This lowers the complexity, time, and cost of later maintenance, as operators only need to replace one filter to maintain the entire intake system. It also reduces systemic risks arising from inconsistent performance degradation across multiple filters, thus improving the long-term operational reliability of the equipment.

[0045] Preferably, two sets of first air inlets 3 are symmetrically opened on the top surface of the housing 2.

[0046] Preferably, the first air outlet 4 includes a first vent 41 and a second vent 42, the distance L1 between the center of the first vent 41 and the center of the second vent 42 along the horizontal direction W is 1000mm-1500mm, and / or the distance L2 between the center of the first vent 41 and the center of the second vent 42 along the vertical direction H is 500mm-700mm.

[0047] The spacing between the first vent 41 and the second vent 42, designed with symmetrical air intake at the top, and horizontally separated by 1000mm-1500mm, ensures that these two vents collectively cover most of the width of the work platform 18. This allows clean air supplied from the top to be evenly and efficiently drawn out after flowing downwards across the entire work area. The arrangement of the first vent 41 and the second vent 42 creates a stable and uniform downward airflow field. This ensures that any aerosol contaminants generated in the workspace, such as sample droplets and dust, are quickly carried away from the first workspace and discharged through the nearest first vent 4, preventing accumulation and back-and-forth movement in corners or the center of the equipment. This significantly improves contaminant removal efficiency and fundamentally eliminates the formation of cleanroom dead zones.

[0048] Furthermore, if the first vent 41 and the second vent 42 are too close together, they will compete for airflow, resulting in a smaller combined suction area. Areas far from the first outlet 4 may form weak airflow zones or even vortex zones due to insufficient suction. By setting the horizontal distance L1 within the aforementioned range and the vertical distance L2 to 500mm-700mm, and combining this with a staggered layout of the first outlet 4 in the vertical direction corresponding to the height of the working space, sufficient spatial independence is ensured for the two sets of first outlets 4. Both the first vent 41 and the second vent 42 effectively form a relatively independent exhaust area, jointly constructing a complete and dynamically balanced airflow organization, avoiding internal airflow turbulence, and ensuring that the clean airflow can descend smoothly.

[0049] The selection of the size ranges of L1 and L2, taking into account the overall size of the work platform 18, achieves the best airflow control effect by optimizing the layout of the two first air outlets 4 without adding additional complex air ducts or more air outlets.

[0050] Regarding the specific structure of the dehumidification component 10, where the air inlet is connected to the second air outlet 6 and the air outlet is connected to the second air inlet 5, the air inlet of the dehumidification component 10 is connected to the second air outlet 6 through a first pipe, and the air outlet of the dehumidification component 10 is connected to the second air inlet 5 through a second pipe.

[0051] Preferably, a first magnetic attraction component 8 is provided between the work platform 18 and the door 13, and / or a second magnetic attraction component 12 is provided between the door 13 and the frame 1. The first magnetic attraction component 8 and the second magnetic attraction component 12 are configured to press the first sealing gasket tightly. The magnetic attraction force of the first magnetic attraction component 8 and the second magnetic attraction component 12 is not less than 280KG, so as to ensure that the first sealing gasket between the door 13 and the work platform 18, and between the door 13 and the frame 1 is pressed tightly, thereby ensuring the sealing between the door 13 and the work platform 18, and between the door 13 and the frame 1.

[0052] In this embodiment, a portion of the frame 1 is located above the work platform 18. The housing 2 surrounding the frame 1 above the work platform 18, the frame 1, and the work platform 18 form the aforementioned first working space. After the door 13 is closed, the door 13 presses against the first sealing gasket installed on the side of the work platform 18.

[0053] Preferably, a first magnetic attraction component 8 is provided between the bottom of each door 13 and the working platform 18, and a second magnetic attraction component 12 is provided between the top of each door 13 and the frame 1. Magnetic attraction components are provided both above and below the door 13 to ensure the pressing force of the door 13 on the first sealing gasket. At the same time, the first sealing gasket around the door 13 is subjected to relatively uniform force to ensure sealing performance.

[0054] Specifically, the first magnetic attraction component 8 and the second magnetic attraction component 12 are all of the following: permanent magnet attraction type magnetic attraction component, electromagnetic lock type magnetic attraction component, and permanent magnet-electrically unlocked type magnetic attraction component.

[0055] Specifically, the aforementioned permanent magnet attraction-type magnetic closure assembly includes a high-strength permanent magnet, such as a neodymium iron boron (NdFeB) magnet, installed on the door 13, and another permanent magnet or a piece of highly magnetic soft iron or low-carbon steel, i.e., an armature, installed at a corresponding position on the frame 1 and / or the work platform 18. When the door 13 is closed to its nearest position, the two permanent magnets attract each other, or a strong attraction is generated between the permanent magnet and the armature, firmly closing the door 13. The aforementioned electromagnetic lock type magnetic closure assembly includes an electromagnetic lock body installed on the frame 1, which contains a coil, and an armature plate installed at a corresponding position on the door 13. When the equipment is powered on and the door 13 needs to be closed, the control component energizes the electromagnetic lock, causing it to generate a magnetic field that attracts the armature plate on the door 13. After power is cut off, the magnetic field disappears, and the door 13 can be opened. Alternatively, a spring can be provided, causing the door 13 to open automatically.

[0056] The aforementioned permanent magnet-electrically controlled unlocking magnetic attraction assembly is based on the permanent magnet attraction structure, with the addition of a mechanical or electrical structure to overcome the magnetic force and thus achieve unlocking. Specifically, the permanent magnet provides a continuous closing force; when door 13 needs to be opened, a button or switch triggers a small electromagnet or motor to briefly apply a force to separate or move the permanent magnet, thereby opening door 13.

[0057] Preferably, the first sealing gasket is made of any one of the following: foamed cotton, rubber gasket, silicone foam strip, or flexible magnet. More preferably, the first sealing gasket is made of foamed cotton, typically PE, EVA, or PU foam.

[0058] Because the interior of the foam is filled with tiny, independent or interconnected air bubbles, it can deform significantly under the pressure of door 13, easily filling the tiny gaps between two contact surfaces caused by unevenness. Furthermore, the raw material and manufacturing costs of foam, especially PE and EVA, are relatively low. Foam can be easily cut into various complex two-dimensional shapes, and it has pressure-sensitive adhesive on the back. During installation, simply peel off the release paper to adhere it to the sheet metal, greatly improving assembly efficiency and saving labor costs.

[0059] To prevent small items or reagents from accidentally falling into the pipe, preferably, a second protective net is installed at the second air outlet 6. The second protective net can effectively prevent items from falling from the second air outlet 6 into the space below the work platform 18 without affecting air circulation.

[0060] Preferably, a third air filter assembly is also provided at the second air outlet 6. The third air filter assembly is positioned directly opposite the second air outlet 6 and is located below the working platform 18. The third air filter assembly can filter the air before it enters the dehumidification assembly 10, intercept dust and particulate matter, protect the internal components of the dehumidification assembly 10, extend its service life, and ensure the cleanliness of the circulating gas.

[0061] Preferably, a third protective net is provided at the second air inlet 5, which also serves to prevent items from falling.

[0062] Preferably, the second air inlet 5 is also equipped with a fourth air filter assembly. The fourth air filter assembly is positioned directly opposite the second air inlet 5 and is located below the working platform 18. The fourth air filter assembly can filter the air that is about to be blown back into the first working space after being processed by the dehumidification assembly 10, ensuring the cleanliness of the gas sent into the first working space and preventing the dehumidification assembly 10 itself from becoming a source of pollution in the first working space.

[0063] As another important design feature of this embodiment, preferably, the horizontal distance L3 between the center of the second air inlet 5 and the center of the second air outlet 6 is in the range of 500mm-1000mm, and / or the vertical distance L4 between the center of the second air inlet 5 and the center of the second air outlet 6 is in the range of 500mm-800mm. This arrangement ensures that the second air outlet 6 and the second air inlet 5 are spatially separated, effectively preventing airflow short-circuiting. That is, it prevents the dry air just introduced from the second air inlet 5 from being directly drawn back into the second air outlet 6 without fully participating in the internal gas circulation, thereby significantly improving dehumidification efficiency, reducing equipment energy consumption, and ensuring the uniformity of the humidity field within the first working space.

[0064] Preferably, the first air filter assembly, the second air filter assembly 19, the third air filter assembly, and the fourth air filter assembly all include a mounting frame and a high-efficiency particulate air (HEPA) or ultra-high-efficiency particulate air (ULPA) filter installed inside the mounting frame. These filters can be selected according to the required cleanliness level, and are commonly used structures in the art; their detailed structures will not be described in detail here.

[0065] In order to accurately control the temperature in the first working space, the gene sequencing device preferably includes an air cooling component 11. A third air inlet 7 is provided on the working platform 18. The air cooling component 11 is installed below the working platform 18 and is directly opposite the third air inlet 7. The air cooling component 11 can blow cooling air within a preset temperature range into the first working space through the third air inlet 7.

[0066] Preferably, a fourth protective net is provided at the third air inlet 7. The fourth protective net can prevent items on the work platform 18 from falling from the third air inlet 7 into the air cooling assembly 11.

[0067] Specifically, the air cooling assembly 11 includes: a mounting housing 111, a water-cooled radiator 112, a mounting plate 113, and a fan. The mounting housing 111 is mounted on the lower surface of the work platform 18. The water-cooled radiator 112 is mounted inside the mounting housing 111, and a preset gap L5 is provided between at least one inner wall of the mounting housing 111 and the water-cooled radiator 112. The mounting plate 113 is positioned above the water-cooled radiator 112. The fan is mounted on the mounting plate 113 and located inside the mounting housing 111. The fan blows air towards the work platform 18 and into the first working space through a third air inlet 7. In this embodiment, three fans are arranged in the same column.

[0068] The water-cooled radiator 112 is equipped with an inlet and an outlet, both of which are connected to an external cooling circulation system. Cooling water is introduced into the water-cooled radiator 112 through the external cooling circulation system, and the air flowing through it is cooled after heat exchange with the cold water.

[0069] When the fan starts, it draws the hotter air in the first working space downwards, forcing the hot air through the cooler water-cooled fins 112. After heat exchange, it forms cold air, which is then blown back into the first working space through the third air inlet 7. This achieves active and efficient cooling, ensuring that temperature-sensitive biochemical reagents, samples, and reaction processes can be carried out at the preset temperature.

[0070] Furthermore, the gene sequencing device also includes a control component (not shown) and a first temperature detection component (not shown). The first temperature detection component is configured to detect the temperature within the first working space in real time. Both the first temperature detection component and the air cooling component 11 are electrically connected to the control component. The control component receives the temperature signal and compares it with a preset temperature threshold. When the temperature within the first working space exceeds the preset value, it controls the air cooling component 11 to start moving, forming a closed-loop temperature control system to stabilize the temperature within the first working space within a preset range.

[0071] As a preferred heat dissipation airflow design, a preset gap is provided between the water-cooling radiator 112 and the side wall of the mounting housing 111, the position of which corresponds to a portion of the third air inlet 7. At the same time, a vent is provided on the mounting plate 113 that is directly opposite the position of the preset gap. The above arrangement forms a cooling circulation airflow. The fan blows air into the first working space for cooling through the third air inlet 7. Part of the hot air in the first working space is directly drawn downward by the fan, while the other part can enter the interior of the mounting housing 111 from other areas of the third air inlet 7 through the vent and the preset gap, and then be drawn in by the fan to participate in the next cycle. This design increases the internal airflow disturbance and heat exchange efficiency, and avoids local overheating.

[0072] In this embodiment, the ventilation opening is rectangular.

[0073] Preferably, the first temperature detection component includes a temperature sensor, a mounting structure for fixing the temperature sensor, and a signal line connecting the temperature sensor and the control component. The temperature sensor includes any one of a digital temperature sensor, a thermistor, or a platinum resistance thermometer.

[0074] In a preferred embodiment of the present invention, a digital temperature sensor encapsulated in a housing may be used, which is fixed to the side wall of the working platform 18 by a mounting bracket to accurately sense the ambient temperature in the first working space.

[0075] Both the first temperature detection component and the air cooling component 11 are electrically connected to the control component.

[0076] The first temperature detection component transmits the detected temperature signal, such as a digital temperature value or an analog voltage signal, to the control component in real time. The control component has a preset temperature range pre-stored within it, which is required for the gene sequencing process. The control component compares and determines the received real-time temperature value with the preset range.

[0077] When the real-time temperature exceeds the preset upper threshold, the control component generates a control command to start the air cooling component 11, which blows cooling air into the workspace. When the temperature is cooled to below the preset lower threshold, the control component generates a command to shut down the air cooling component 11. Through the above closed-loop feedback control, the temperature in the workspace is automatically and accurately stabilized within the preset temperature range.

[0078] Biochemical reactions in gene sequencing, such as PCR amplification, are extremely sensitive to temperature. Even minute temperature fluctuations can lead to decreased reaction efficiency, non-specific primer binding, or even experimental failure. This component's real-time monitoring and feedback provide a highly stable temperature environment for the reaction, a fundamental prerequisite for obtaining accurate and reproducible sequencing data. Furthermore, this gene sequencing equipment operates without manual intervention, automatically maintaining the optimal operating temperature. This reduces the skill requirements and workload for operators, while avoiding human error and ensuring standardized and consistent equipment operation. In particular, the preferred digital temperature sensor outputs a digital signal with strong resistance to electromagnetic interference, and the signal is less prone to attenuation or distortion during transmission, ensuring data accuracy even after long-distance transmission.

[0079] Preferably, an air vent is provided on the housing 2 located below the working platform 18, and the gas in the first working space is discharged outside the equipment through the first air outlet 4 and then through the air vent.

[0080] Specifically, the frame 1 includes an upper frame 1 and a lower frame 1, and the housing 2 includes an upper housing 2 and a lower housing 2. The upper frame 1 is located above the work platform 18, and a first workspace is formed between the upper housing 2, the upper frame 1, and the work platform 18.

[0081] The lower frame 1 is located below the working platform 18, and a second working space is formed between the lower frame 1, the lower housing 2, and the working platform 18. The second air filter assembly 19, the third air filter assembly, the fourth air filter assembly, the dehumidification assembly 10, and the air cooling assembly 11 are all located in the second working space.

[0082] The air outlet of the second air filter assembly 19 is connected to the second working space, and the lower housing 2 is provided with the aforementioned air outlet.

[0083] In addition, the gene sequencing equipment also includes an industrial control computer, which is located in the second workspace.

[0084] Preferably, the top plate of the housing 2 includes a movable plate 15, which is installed on the frame 1 and is sealed and fixedly connected to the frame 1. When it is necessary to maintain the equipment, the movable plate 15 can be disassembled to facilitate the maintenance of the internal structure of the frame 1.

[0085] Preferably, the movable plate 15 is provided with a handle 17 to facilitate disassembly of the movable plate 15.

[0086] Preferably, the movable plate 15 has a movable opening, and an opening / closing door 16 is installed at the movable opening. A second sealing gasket is provided between the opening / closing door 16 and the movable plate 15. When the gene sequencing device is working, the opening / closing door 16 is in the closed state. Specifically, the opening / closing door 16 closes by its own weight. In other embodiments, a third magnetic attraction assembly is provided between the movable plate 15 and the opening / closing door 16, ensuring a seal between the opening / closing door 16 and the movable plate 15 through its own weight and magnetic attraction. When the gene sequencing device is shut down, the internal structure will lift and open the opening / closing door 16 for maintenance of that part of the structure.

[0087] Specifically, the second sealing gasket is made of the same material as the first sealing gasket.

[0088] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating the present utility model, and are not intended to limit the implementation of the present utility model. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.

Claims

1. A gene sequencing device, characterized in that, include: A frame (1) on which a work platform (18) is provided; A housing (2) is mounted on the frame (1). The housing (2) includes a door (13). The frame (1) and the work platform (18) form an opening, and the door (13) is mounted on the opening. A first sealing gasket is provided between the door (13) and the frame (1), and between the door (13) and the work platform (18); The housing (2), the frame (1), and the work platform (18) can together enclose and form a first workspace; The top of the housing (2) is provided with a first air inlet (3) and a first air filter assembly. The first air filter assembly is directly opposite the first air inlet and is used to introduce filtered clean air into the first working space. The working platform (18) is provided with a first air outlet (4), and a second air filter assembly (19) is provided below the working platform (18) and is directly opposite to the first air outlet (4). The second air filter assembly (19) can draw in the air in the first working space, filter the air and discharge it to the outside of the gene sequencing device. The working platform (18) is also provided with a second air outlet (6) and a second air inlet (5). A dehumidification component (10) is provided below the working platform (18), and the air inlet of the dehumidification component (10) is connected to the second air outlet (6).

2. The gene sequencing device according to claim 1, characterized in that, A first magnetic suction assembly (8) is provided between the work platform (18) and the door (13), and the first magnetic suction assembly (8) is configured to press the door (13) and the work platform (18) together to press the first sealing gasket. And / or, a second magnetic assembly (12) is provided between the door (13) and the frame (1), the second magnetic assembly (12) being configured to press the door (13) and the work platform (18) against the first sealing gasket.

3. The gene sequencing device according to claim 1 or 2, characterized in that, The first sealing gasket is made of any one of the following: foamed cotton, rubber gasket, silicone foam strip, or flexible magnet.

4. The gene sequencing device according to claim 1 or 2, characterized in that, A third air filter assembly is also provided at the second air outlet (6). The third air filter assembly is positioned directly opposite the second air outlet (6) and is located below the working platform (18).

5. The gene sequencing device according to claim 4, characterized in that, The second air inlet (5) is provided with a fourth air filter assembly, which is positioned directly opposite the second air inlet (5) and is located below the working platform (18).

6. The gene sequencing device according to claim 1 or 2, characterized in that, The horizontal distance L3 between the center of the second air inlet (5) and the center of the second air outlet (6) is 500mm-1000mm, and / or the vertical distance L4 between the center of the second air inlet (5) and the center of the second air outlet (6) is 500mm-800mm.

7. The gene sequencing device according to claim 5, characterized in that, The first air filter assembly, the second air filter assembly (19), the third air filter assembly and the fourth air filter assembly each include a mounting frame and a high-efficiency air filter or an ultra-high-efficiency air filter installed inside the mounting frame.

8. The gene sequencing device according to claim 1 or 2, characterized in that, The gene sequencing device also includes an air cooling component (11). A third air inlet (7) is provided on the working platform (18). The air cooling component (11) is installed below the working platform (18) and is directly opposite the third air inlet (7). The air cooling component (11) can blow cooling air within a preset temperature range into the first working space through the third air inlet (7).

9. The gene sequencing device according to claim 8, characterized in that, The air cooling assembly (11) includes: a mounting housing (111), a water cooling radiator (112), a mounting plate (113), and a fan. The mounting housing (111) is mounted on the lower surface of the work platform (18). The water cooling radiator (112) is mounted inside the mounting housing (111), and a preset gap L5 is provided between at least one inner wall of the mounting housing (111) and the water cooling radiator (112). The mounting plate (113) is located above the water cooling radiator (112). The fan is mounted on the mounting plate (113) and located inside the mounting housing (111). The fan blows air into the first workspace through the third air inlet (7). The water-cooled radiator (112) is provided with an inlet and an outlet, both of which are connected to an external cooling circulation system.

10. The gene sequencing device according to claim 8, characterized in that, The gene sequencing device further includes a control component and a first temperature detection component, the first temperature detection component being configured to detect the temperature in the first workspace in real time, and both the first temperature detection component and the air cooling component (11) being electrically connected to the control component.

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