Nucleic acid extractor

Abstract

The utility model discloses a nucleic acid extraction appearance, including host computer, reagent box tray, limit block and magnetic bead transfer subassembly. Host computer is provided with experiment cavity, and the lower extreme of experiment cavity is provided with the mounting groove, reagent box tray can be dismantled and installed in the mounting groove, and the profiling hole is set up on reagent box tray, and the profiling hole is used for placing reagent box in cooperation, limit block can be dismantled and connected in the edge of mounting groove, and limit block is used for blocking reagent box tray to separate from mounting groove, and magnetic bead transfer subassembly is along vertical sliding and is arranged in experiment cavity, and magnetic bead transfer subassembly is used for transferring the magnetic bead in reagent box. The detachable installation design of reagent box tray and the detachable connection design of limit block make reagent box tray can carry out quick replacement, utilize limit block to limit reagent box tray to separate from mounting groove, make reagent box tray can be stably installed in mounting groove, and the profiling hole on reagent box tray can adaptively install reagent box, and achieve one machine multi -use.

Description

Technical Field

[0001] This utility model relates to medical equipment, and in particular to a nucleic acid extractor. Background Technology

[0002] Nucleic acid extractors are common medical devices, such as those shown in patent document CN114381367A.

[0003] However, existing nucleic acid extractors have a fixed connection between the reagent tray at the bottom and the main unit. If a replacement is needed, the main unit must be completely disassembled. Therefore, existing nucleic acid extractors can often only hold one type of reagent kit. When faced with reagent kits of different shapes or different processing requirements, existing nucleic acid extractors cannot adapt to the usage needs. Utility Model Content

[0004] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a nucleic acid extractor that allows for easy replacement of reagent kit trays.

[0005] A nucleic acid extractor according to an embodiment of the present invention includes a main unit, a reagent tray, a limiting block, and a magnetic bead transfer assembly. The main unit has an experimental chamber with a mounting groove at its lower end. The reagent tray is detachably mounted in the mounting groove and has a contoured hole for placing the reagent kit. The limiting block is detachably connected to the edge of the mounting groove to prevent the reagent tray from detaching from the groove. The magnetic bead transfer assembly is vertically slidable within the experimental chamber and is used to transfer magnetic beads from the reagent kit.

[0006] It has at least the following beneficial effects: The detachable installation design of the reagent tray and the detachable connection design of the limiting block enable quick replacement of the reagent tray. The limiting block prevents the reagent tray from detaching from the mounting slot, ensuring stable installation of the reagent tray within the mounting slot. The contoured holes on the reagent tray allow for adaptable installation of reagents. If different reagents are used, the corresponding reagent tray can be replaced accordingly, truly achieving multi-purpose functionality. It can accommodate reagent trays of different volumes, shapes, and quantities, such as 1ml, 2ml, 5ml, 10ml, or 20ml reagents, eliminating the cost and operational inconvenience of disassembling the machine or using multiple machines, making it convenient to use.

[0007] According to some embodiments of the present invention, the magnetic bead transfer assembly includes a first mounting bracket and a second mounting bracket. The first mounting bracket is disposed above the reagent kit tray, and the second mounting bracket is disposed above the first mounting bracket. Both the first mounting bracket and the second mounting bracket are capable of sliding vertically. The first mounting bracket is used to mount a magnetic rod sleeve, which can extend into the well of the reagent kit. The second mounting bracket is used to mount a magnetic rod, which can extend into the magnetic rod sleeve. The magnetic rod is used to adsorb magnetic beads in the well of the reagent kit through the magnetic rod sleeve.

[0008] According to some embodiments of the present invention, a plurality of mounting slots are provided, and the plurality of mounting slots are arranged side by side, with each mounting slot having a reagent kit tray installed.

[0009] According to some embodiments of the present invention, the reagent kit tray includes a main body and a support part, the support part is disposed on the main body, the contour hole is disposed on the support part, and the support part is provided with a plurality of holes.

[0010] According to some embodiments of the present invention, a positioning bead is provided on the side of the limiting block near the support portion, and the positioning bead is used to hold the reagent kit.

[0011] According to some embodiments of the present invention, the lower end of the first mounting bracket is provided with a T-shaped slot, the T-shaped slot is used to engage the magnetic rod sleeve, and the upper end of the T-shaped slot is provided with an avoidance opening.

[0012] According to some embodiments of the present invention, the magnetic rod is connected to the second mounting bracket via an adapter, the magnetic rod extends vertically, and the magnetic rod can pass through the clearance opening to be inserted into the magnetic rod sleeve.

[0013] According to some embodiments of the present invention, the host is provided with at least two cooling fans, which are used to exhaust heat and volatile alcohols in the experimental chamber.

[0014] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0015] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein: Figure 1 This is a schematic diagram of the structure of the nucleic acid extractor according to an embodiment of the present invention; Figure 2 for Figure 1 An exploded view of the nucleic acid extractor is shown. Figure 3 for Figure 1The diagram shown is a schematic representation of the reagent tray of a nucleic acid extractor. Figure 4 for Figure 1 An exploded view of the reagent tray of the nucleic acid extractor is shown. Figure 5 for Figure 1 A perspective view of the reagent tray of the nucleic acid extractor from a bottom angle; Figure 6 for Figure 1 An exploded view of the reagent tray of the nucleic acid extractor from a bottom angle.

[0016] Figure label: Main unit 100, experimental chamber 110, mounting slot 120, heating plate 130, guide column 140; The reagent tray 200, the main body 210, the support part 220, the contour hole 221, the insert groove 222, and the insertion block 230; Limiting block 300, positioning bead 310; Magnetic bead transfer assembly 400, first mounting bracket 410, T-shaped slot 411, clearance opening 412, second mounting bracket 420, magnetic rod 421; Cooling fan 500. Detailed Implementation

[0017] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0018] In the description of this utility model, the use of "first" and "second" is only for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance or implicitly indicating the number of technical features or the order of the technical features.

[0019] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.

[0020] Reference Figures 1 to 6This utility model discloses a nucleic acid extractor, including a main unit 100, a reagent tray 200, a limiting block 300, and a magnetic bead transfer assembly 400. The main unit 100 is provided with an experimental chamber 110, and the lower end of the experimental chamber 110 is provided with a mounting groove 120; the reagent tray 200 is detachably installed in the mounting groove 120, and the reagent tray 200 is provided with a contoured hole 221 for placing the reagent kit; the limiting block 300 is detachably connected to the edge of the mounting groove 120, and the limiting block 300 is used to prevent the reagent tray 200 from detaching from the mounting groove 120; the magnetic bead transfer assembly 400 is slidably disposed vertically in the experimental chamber 110, and the magnetic bead transfer assembly 400 is used to transfer magnetic beads in the reagent kit.

[0021] It should be noted that the detachable installation design of the reagent tray 200 and the detachable connection design of the limiting block 300 enable the reagent tray 200 to be quickly replaced. The limiting block 300 is used to prevent the reagent tray 200 from detaching from the mounting slot 120, so that the reagent tray 200 can be stably installed in the mounting slot 120. The contour hole 221 on the reagent tray 200 can be adapted to install reagents. If the reagents are different, the reagent tray 200 corresponding to the reagent can also be replaced accordingly, truly achieving multi-purpose use. It can meet the use of reagent trays of different volumes, shapes and quantities, such as 1ml, 2ml, 5ml, 10ml or 20ml reagents, eliminating the cost and operation trouble of disassembling the machine or using multiple machines, and making it convenient to use.

[0022] Reference Figure 1 and Figure 2 The magnetic bead transfer assembly 400 includes a first mounting bracket 410 and a second mounting bracket 420. The first mounting bracket 410 is positioned above the reagent kit tray 200, and the second mounting bracket 420 is positioned above the first mounting bracket 410. Both the first and second mounting brackets 410 and 420 are vertically slidable. The first mounting bracket 410 is used to mount a magnetic rod sleeve, which can extend into the wells of the reagent kit. The second mounting bracket 420 is used to mount a magnetic rod 421, which can extend into the magnetic rod sleeve. The magnetic rod 421 is used to adsorb magnetic beads in the wells of the reagent kit through the magnetic rod sleeve. The first mounting bracket 410 achieves uniform mixing of the reagent magnetic beads through reciprocating up and down movement. The first mounting bracket 410, together with the second mounting bracket 420, adsorbs and transfers magnetic beads in the wells of the reagent kit.

[0023] In some embodiments, a plurality of mounting slots 120 are provided, arranged side by side, and each mounting slot 120 is equipped with a reagent kit tray 200. It is understood that the plurality of mounting slots 120 are arranged side by side in the left-right direction, and there are partitions between adjacent mounting slots 120.

[0024] In some embodiments, the reagent kit tray 200 includes a main body 210 and a support portion 220. The support portion 220 is disposed on the main body 210, and a contoured hole 221 is disposed on the support portion 220. The support portion 220 is provided with a plurality of such holes. It is understood that the main body 210 is provided with an installation opening, the support portion 220 is installed in the installation opening from bottom to top, and the upper end of the support portion 220 protrudes out of the main body 210, and the protruding portion of the support portion 220 is provided with the contoured hole 221.

[0025] Reference Figures 3 to 6 The support portion 220 has an embedding groove 222 at its bottom. The support portion 220 is made of a thermally conductive metal material, including copper, aluminum, or aluminum alloy. The support portion 220 is mounted on the base plate 600, forming a single mounting unit. The base plate 600 has a heating plate 130 and a guide post 140. After the support portion 220 is installed onto the main body 210, the heating plate 130 can be inserted into the embedding groove 222. The lower end of the main body 210 has a guide hole (not shown in the figure) corresponding to the guide post 140, into which the guide post can be inserted. The lower end of the base plate 600 has a plug block 230, which is essentially a plug used to connect to a socket on a circuit board located inside the experimental chamber 110.

[0026] In some embodiments, a positioning bead 310 is provided on the side of the limiting block 300 near the support portion 220. The positioning bead 310 is used to hold the reagent kit in place. It is understood that the positioning bead 310 provides a locking function for the reagent kit. The reagent kit is a consumable, mainly used to load detection substances, and is a common consumable. Generally, reagent kits are made of plastic and have a certain degree of deformation and elasticity. The positioning bead 310 allows the reagent kit to be more stably locked within the mounting slot 120.

[0027] Reference Figure 1 and Figure 2 The lower end of the first mounting bracket 410 is provided with a T-shaped slot 411, which is used to hold the magnetic rod sleeve. The upper end of the T-shaped slot 411 is provided with a clearance opening 412.

[0028] In some embodiments, the magnetic rod 421 is connected to the second mounting bracket 420 via an adapter. The magnetic rod 421 extends vertically and can pass through the clearance opening 412 to be inserted into the magnetic rod sleeve.

[0029] In some embodiments, the host 100 is provided with at least two cooling fans 500, which are used to remove heat and volatile alcohols from the experimental chamber 110.

[0030] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0031] Of course, this utility model is not limited to the above-described embodiments. Those skilled in the art can make equivalent modifications or substitutions without departing from the spirit of this utility model. All such equivalent modifications or substitutions are included within the scope defined by the claims of this application.

Claims

1. A nucleic acid extractor, characterized in that, include: The host (100) is provided with an experimental chamber (110), and the lower end of the experimental chamber (110) is provided with an installation groove (120). The reagent kit tray (200) is detachably installed in the mounting slot (120). The reagent kit tray (200) is provided with a contour hole (221) for placing the reagent kit. A limiting block (300) is detachably connected to the edge of the mounting groove (120), and the limiting block (300) is used to prevent the reagent tray (200) from disengaging from the mounting groove (120). A magnetic bead transfer assembly (400) is vertically slidably disposed within the experimental chamber (110), and the magnetic bead transfer assembly (400) is used to transfer magnetic beads in the reagent kit.

2. The nucleic acid extractor according to claim 1, characterized in that, The magnetic bead transfer assembly (400) includes a first mounting bracket (410) and a second mounting bracket (420). The first mounting bracket (410) is disposed above the reagent kit tray (200), and the second mounting bracket (420) is disposed above the first mounting bracket (410). Both the first mounting bracket (410) and the second mounting bracket (420) are capable of sliding vertically. The first mounting bracket (410) is used to install a magnetic rod sleeve, which can extend into the well of the reagent kit. The second mounting bracket (420) is used to install a magnetic rod (421), which can extend into the magnetic rod sleeve. The magnetic rod (421) is used to adsorb magnetic beads in the well of the reagent kit through the magnetic rod sleeve.

3. The nucleic acid extractor according to claim 2, characterized in that, The mounting slots (120) are provided in a plurality of manner, and the plurality of mounting slots (120) are arranged side by side, and each mounting slot (120) is equipped with the reagent kit tray (200).

4. The nucleic acid extractor according to claim 3, characterized in that, The reagent kit tray (200) includes a main body (210) and a support (220). The support (220) is disposed on the main body (210), and the contour hole (221) is disposed on the support (220). The support (220) is provided with a plurality of holes.

5. The nucleic acid extractor according to claim 4, characterized in that, The limiting block (300) is provided with a positioning bead (310) on the side near the support part (220), and the positioning bead (310) is used to hold the reagent kit.

6. The nucleic acid extractor according to claim 5, characterized in that, The lower end of the first mounting bracket (410) is provided with a T-shaped slot (411), which is used to hold the magnetic rod sleeve, and the upper end of the T-shaped slot (411) is provided with a clearance opening (412).

7. The nucleic acid extractor according to claim 6, characterized in that, The magnetic rod (421) is connected to the second mounting bracket (420) via an adapter. The magnetic rod (421) extends vertically and can pass through the clearance opening (412) to be inserted into the magnetic rod sleeve.

8. The nucleic acid extractor according to claim 1, characterized in that, The host (100) is equipped with at least two cooling fans (500), which are used to remove heat and volatile alcohols from the experimental chamber (110).

Images