Multi-channel transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for rats and mice

Abstract

The utility model discloses a multi -channel percutaneous transabdominal sympathetic nerve electric stimulation device suitable for big and small mice, including organism, the current delivery end of organism is connected with electrode cable subassembly, the end of electrode cable subassembly is connected with a plurality of electrode piece subassembly, the organism includes impulse generator, the controller of fixed surface on impulse generator and the joint of fixed connection in the front end of impulse generator. This technical scheme realizes electric stimulation through the cooperative work of organism, electrode cable subassembly and electrode piece subassembly. Among them, the electrically conductive microneedle of electrode piece subassembly sends current to the sympathetic nerve area. The conductive gel sleeve and the insulating sleeve form an electric field trap to avoid interference, and the adhesive tape and the adhesive tape make the electrode piece more firm. The design of conductive gel sleeve and insulating sleeve effectively prevents electrode piece from interfering with each other, ensures stimulation accuracy; firm fixing mode avoids electrode piece displacement, can guarantee experiment stability.

Description

Technical Field

[0001] This utility model relates to the technical field of sympathetic nerve electrical stimulation equipment, specifically to a multi-channel transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for rats and mice. Background Technology

[0002] In the field of neuroscience research, sympathetic nerve electrical stimulation studies on laboratory animals such as mice and rats are crucial for a deeper understanding of nervous system function, exploration of disease mechanisms, and development of treatments. Currently, existing sympathetic nerve electrical stimulation devices have several limitations when applied to mice and rats. Regarding electrode fixation, current techniques often suffer from insecure fixation, leading to electrode displacement during experiments, affecting the accuracy and stability of stimulation, and consequently interfering with experimental results. Furthermore, when multiple electrode pads are densely attached to the same location on the animal's body, electric field interference can easily occur between the electrodes, making it difficult for the stimulation signal to accurately target the nerve region, thus reducing the reliability of experimental data. Therefore, there is an urgent practical need to develop a multi-path transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for mice and rats that can solve the above problems. Utility Model Content

[0003] The purpose of this invention is to provide a technical solution for a multi-channel transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for rats and mice, thereby overcoming the shortcomings mentioned in the background art. To address the drawbacks and defects described in the background art, this technical solution includes the following: The invention includes an organism, wherein the current transmission end of the organism is connected to an electrode cable assembly, and the end of the electrode cable assembly is connected to a plurality of electrode sheet assemblies. The machine body includes a pulse generator, a controller fixed on the upper surface of the pulse generator, and a connector fixedly connected to the front end of the pulse generator. The electrode cable assembly includes a plug that is inserted into the connector, and several electrode cables that are connected to the front end of the plug. The electrode assembly includes an electrode tip connected to an electrode cable and a conductive post inserted into the lower port of the electrode tip. A layer of adhesive tape is fixedly connected to the outer surface of the conductive post, and a conductive microneedle is fixed to the bottom end of the conductive post. The upper surface of the adhesive tape is provided with a conductive gel sleeve and an insulating sleeve that cover the electrode tip and the conductive post.

[0004] As a preferred embodiment of this utility model: the inner cavity sidewall of the conductive gel sleeve is in contact with the outer surface of the electrode tip, and the inner cavity sidewall of the insulating sleeve is in contact with the outer surface sidewall of the conductive gel sleeve, so as to form an electric field trap for the conductive post and the electrode tip, thereby avoiding mutual interference when the electrode sheets are densely attached to the same position.

[0005] As a preferred embodiment of this utility model: the side walls of the conductive gel sleeve and the insulating sleeve are provided with openings through which the wiring terminals of the power supply end head pass.

[0006] As a preferred embodiment of this utility model: 6-8 adhesive strips are attached to the top surface of the insulating sleeve in a circular array, and each adhesive strip is fixedly connected to the end of an adhesive strip.

[0007] As a preferred embodiment of this utility model: the bottom surface of the tape at the end away from the adhesive tape has adhesive material, and the bottom surface of the tape is connected to the skin of the experimental mouse and the top surface of the adhesive tape.

[0008] As a preferred embodiment of this utility model: multiple notches arranged in a ring array are provided on the outer side wall surface of the adhesive tape for the adhesive tape and adhesive strip to pass through, and to apply a pulling and pressing force to the adhesive tape.

[0009] As a preferred embodiment of this invention, the tip of the conductive microneedle is inserted into the subcutaneous tissue of the experimental mouse to achieve deep stimulation.

[0010] The technical effects and advantages provided by this utility model in the above technical solution are as follows: This technical solution achieves electrical stimulation through the coordinated operation of the body, electrode cable assembly, and electrode pad assembly. The conductive microneedles of the electrode pad assembly deliver current to the sympathetic nerve region. The conductive gel sleeve and insulating sleeve form an electric field trap to prevent interference, while adhesive tape and adhesive strips ensure a more secure fixation of the electrode pads. The design of the conductive gel sleeve and insulating sleeve effectively prevents mutual interference between the electrode pads, ensuring stimulation accuracy; the secure fixation method prevents electrode pad displacement, guaranteeing experimental stability. Attached Figure Description

[0011] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0012] Figure 1 This is a schematic diagram of the overall structure of the electrical stimulation device. Figure 2 This is a schematic diagram of a pulse generator and its controller; Figure 3 This is a schematic diagram of the electrode cable; Figure 4 This is a schematic diagram of the electrode sheet.

[0013] Explanation of reference numerals in the attached figures: 1. Body; 11. Pulse generator; 12. Connector; 13. Controller; 2. Electrode cable assembly; 21. Plug; 22. Electrode cable; 3. Electrode plate assembly; 31. Electrode end tip; 32. Conductive terminal; 33. Adhesive tape; 34. Conductive microneedle; 35. Conductive gel sleeve; 36. Insulating sleeve; 37. Adhesive tape; 38. Adhesive tape. Detailed Implementation

[0014] To provide a clearer explanation and description of the technical solution and implementation of this utility model, several preferred specific embodiments for implementing the technical solution of this utility model are introduced below.

[0015] The following description is exemplary in nature and is not intended to limit the scope, application, or use of this disclosure. It should be understood that in all these figures, the same or similar reference numerals indicate the same or similar parts and features. The figures are merely schematic representations of the concept and principles of embodiments of this disclosure and do not necessarily show the specific dimensions and scale of each embodiment. Specific details or structures of embodiments of this disclosure may be exaggerated in particular portions of certain figures. The disclosures of various publications, patents, and published patent specifications cited herein are incorporated herein by reference in their entirety. The technical solutions of this utility model will be clearly and completely described below in conjunction with embodiments of this utility model. Obviously, the described embodiments are only a part of the embodiments of this utility model.

[0016] Example 1: A multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device suitable for rats and mice, comprising an organism 1, wherein the current delivery end of the organism 1 is connected to an electrode cable assembly 2, and the end of the electrode cable assembly 2 is connected to multiple electrode pad assemblies 3. Specifically, the organism 1 includes a pulse generator 11, a controller 13, and a connector 12. The pulse generator 11 provides the required pulse current to the device. The controller 13 is fixed to the upper surface of the pulse generator 11 and is used to adjust the current parameters generated by the pulse generator 11, such as pulse frequency and amplitude. The connector 12 is fixedly connected to the front end of the pulse generator 11 for connection with the electrode cable assembly 2. The electrode cable assembly 2 includes a plug 21 and several electrode cables 22. The plug 21 is inserted into the connector 12 to achieve electrical connection with the organism 1, and the several electrode cables 22 are connected to the front end of the plug 21 for current transmission.

[0017] The electrode assembly 3 includes an electrode tip 31, a conductive terminal 32, an adhesive tape 33, a conductive microneedle 34, a conductive gel sleeve 35, and an insulating sleeve 36. The electrode tip 31 is connected to the electrode cable 22. The conductive terminal 32 is inserted into the lower port of the electrode tip 31. The adhesive tape 33 is fixedly connected to the outer surface of the conductive terminal 32. The conductive microneedle 34 is fixed to the bottom end of the conductive terminal 32. The inner cavity sidewall of the conductive gel sleeve 35 is in contact with the outer surface of the electrode tip 31. The inner cavity sidewall of the insulating sleeve 36 is in contact with the outer surface sidewall of the conductive gel sleeve 35, forming an electric field trap for the conductive terminal 32 and the electrode tip 31, thus preventing mutual interference when the electrode sheets are densely attached to the same position. In actual operation, the experimental mice are first fixed on the experimental table. According to the experimental requirements, an appropriate number of electrode pad assemblies 3 are selected. The conductive microneedles 34 of the electrode pad assembly 3 are aligned with the sympathetic nerve area in the abdomen of the experimental mouse that needs to be stimulated. The conductive microneedles 34 are gently pressed to pierce the subcutaneous tissue. At the same time, the adhesive tape 33 is ensured to adhere to the mouse's skin. Then, the appropriate current parameters are set through the controller 13, and the pulse generator 11 is started. The current is transmitted to the electrode pad assembly 3 through the electrode cable assembly 2 to electrically stimulate the sympathetic nerves of the experimental mice.

[0018] Example 2: This example, based on Example 1, details the fixing method of the electrode assembly 3. In the electrode assembly 3, 6-8 adhesive strips 37 are attached in a circular array to the top surface of the insulating sleeve 36. Each adhesive strip 37 has an attached adhesive tape 38 at its end. Multiple notches arranged in a circular array are provided on the outer side wall of the adhesive tape 33 for the adhesive strips 37 and 38 to pass through. During the experiment, the conductive microneedle 34 is inserted into the subcutaneous tissue of the experimental mouse as described in Example 1. After the adhesive tape 33 initially adheres to the mouse's skin, the adhesive strips 37 and 38 are passed through the notches on the adhesive tape 33. Then, the bottom surface of the adhesive tape 38, away from the adhesive strip 37, is connected to the mouse's skin and the top surface of the adhesive tape 33 with adhesive material. The adhesive strips 37 and 38 apply a pulling and pressing force to the adhesive tape 33, making the electrode assembly 3 more firmly fixed to the experimental mouse and preventing displacement of the electrode assembly 3 during the experiment, which would affect the electrical stimulation effect. For example, when it is necessary to conduct sympathetic nerve electrical stimulation experiments on laboratory mice for a long time, this fixation method can ensure the stability of electrode assembly 3 and ensure that the current can continuously and accurately stimulate the target nerve area.

[0019] Example 3: This example, based on the structures of Examples 1 and 2, illustrates the implementation of the device under different stimulation parameters. During the experiment, the current parameters generated by the pulse generator 11 are adjusted via the controller 13 according to the experimental objective and individual differences among the experimental mice. For example, when studying the sympathetic nervous system's response to current stimulation at different frequencies, different pulse frequencies can be set, such as 5Hz, 10Hz, and 20Hz. After setting the frequency, the pulse generator 11 is activated, and the current is transmitted through the electrode cable assembly 2 to the electrode pad assembly 3. The conductive microneedles 34 transmit the current to the sympathetic nervous system region of the experimental mice, while simultaneously observing the physiological responses of the experimental mice, such as changes in heart rate and blood pressure. When studying the effects of current stimulation at different amplitudes, the current amplitude of the pulse generator 11 is also adjusted via the controller 13, such as 0.5mA, 1mA, and 2mA, and the physiological responses of the experimental mice under different amplitude current stimulation are recorded. Furthermore, different stimulation durations, such as continuous stimulation for 5 minutes, 10 minutes, and 15 minutes, can be combined to comprehensively analyze the sympathetic nervous system's response to different stimulation parameters.

[0020] Based on the above-described preferred technical solution, the workflow of this technical solution is explained as follows: First, experimental preparation is carried out by placing the body 1 of the multi-channel transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for rats and mice in a suitable position. The body 1 includes a pulse generator 11, a controller 13, and a connector 12. The pulse generator 11 is used to generate pulse current. The controller 13 is fixed on the upper surface of the pulse generator 11 to adjust the current parameters generated by the pulse generator 11, such as pulse frequency and amplitude. The connector 12 is fixedly connected to the front end of the pulse generator 11 for connection with the electrode cable assembly 2. Then, the electrode cable assembly 2 is taken out, which includes a plug 21 and several electrode cables 22. The plug 21 is inserted into the connector 12 to achieve electrical connection.

[0021] Next, prepare multiple electrode assembly 3, which includes electrode tip 31, conductive terminal 32, adhesive tape 33, conductive microneedles 34, conductive gel sleeve 35, and insulating sleeve 36. Connect the electrode tip 31 of the electrode assembly 3 to the electrode cable 22. Fix the experimental mouse on the experimental table, select an appropriate number of electrode assembly 3 according to the experimental requirements, and align the conductive microneedles 34 of the electrode assembly 3 with the sympathetic nerve area in the abdomen of the experimental mouse that needs to be stimulated. Gently press to allow the conductive microneedles 34 to pierce the subcutaneous tissue, while ensuring that the adhesive tape 33 adheres to the mouse's skin. At this time, the inner sidewall of the conductive gel sleeve 35 is in contact with the outer surface of the electrode tip 31, and the inner sidewall of the insulating sleeve 36 is in contact with the outer surface of the conductive gel sleeve 35, forming an electric field trap for the conductive terminal 32 and electrode tip 31, thus avoiding mutual interference when the electrode pieces are densely attached to the same position.

[0022] If the fixing method in Example 2 is adopted, after the adhesive tape 33 is initially attached to the mouse skin, 6-8 adhesive strips 37 and adhesive strips 38 fixedly connected at their ends, which are attached in a ring array to the top surface of the insulating sleeve 36, are passed through multiple notches arranged in a ring array on the outer wall surface of the adhesive tape 33. Then, the bottom surface of the adhesive strip 38 away from the adhesive strip 37 is connected to the skin of the experimental mouse and the top surface of the adhesive tape 33 with adhesive material. The adhesive strips 37 and 38 apply a pulling and pressing force to the adhesive tape 33, so that the electrode assembly 3 is more firmly fixed to the experimental mouse. The controller 13 sets appropriate current parameters. For example, according to the experimental purpose and individual differences of the experimental mice, if studying the response of the sympathetic nerve to current stimulation of different frequencies, different pulse frequencies such as 5Hz, 10Hz, 20Hz, etc. can be set; if studying the effect of current stimulation of different amplitudes, the current amplitude of the pulse generator 11 can be adjusted, such as 0.5mA, 1mA, 2mA, etc.; different stimulation times can also be combined, such as continuous stimulation for 5 minutes, 10 minutes, 15 minutes, etc. After setting the current parameters, the pulse generator 11 is activated. The pulse generator 11 generates a pulse current with the set parameters. The current is transmitted through the electrode cable 22 of the electrode cable assembly 2 to the electrode terminal 31 of the electrode plate assembly 3, and then through the conductive terminal 32 and conductive microneedle 34 to the sympathetic nerve area of ​​the experimental mouse, thus electrically stimulating the sympathetic nerve of the experimental mouse. During the electrical stimulation, the physiological responses of the experimental mouse are observed, such as changes in heart rate, blood pressure, limb movement, and respiratory rate, and the relevant data are recorded.

[0023] The foregoing description only illustrates certain exemplary embodiments of the present invention. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the above drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A multi-channel transcutaneous transventricular sympathetic electrical stimulation device suitable for rats and mice, comprising an organism (1), characterized in that: The current transmission end of the body (1) is connected to an electrode cable assembly (2), and the end of the electrode cable assembly (2) is connected to a plurality of electrode sheet assemblies (3). The body (1) includes a pulse generator (11), a controller (13) fixed on the upper surface of the pulse generator (11), and a connector (12) fixedly connected to the front end of the pulse generator (11). The electrode cable assembly (2) includes a plug (21) inserted into the connector (12) and a plurality of electrode cables (22) connected to the front end of the plug (21). The electrode assembly (3) includes an electrode tip (31) connected to an electrode cable (22) and a conductive terminal (32) inserted into the lower port of the electrode tip (31). A layer of adhesive tape (33) is fixedly connected to the outer surface of the conductive terminal (32), and a conductive microneedle (34) is fixed to the bottom end of the conductive terminal (32). The upper surface of the adhesive tape (33) is provided with a conductive gel sleeve (35) and an insulating sleeve (36) covering the electrode tip (31) and the conductive terminal (32).

2. The multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device suitable for rats and mice according to claim 1, characterized in that: The inner cavity sidewall of the conductive gel sleeve (35) is in contact with the outer surface of the electrode tip (31), and the inner cavity sidewall of the insulating sleeve (36) is in contact with the outer surface sidewall of the conductive gel sleeve (35), which is used to form an electric field trap for the conductive terminal (32) and the electrode tip (31), so as to avoid mutual interference when the electrode sheets are densely attached to the same position.

3. The multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device suitable for rats and mice according to claim 1, characterized in that: The conductive gel sleeve (35) and the insulating sleeve (36) have openings on their side walls through which the wiring terminals of the power supply end head (31) pass.

4. The multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device suitable for rats and mice according to claim 1, characterized in that: The top surface of the insulating sleeve (36) is covered with 6-8 adhesive tapes (37) in a ring array, and each end of the adhesive tapes (37) is fixedly connected with tape (38).

5. The multi-channel transcutaneous transabdominal sympathetic nerve electrical stimulation device suitable for rats and mice according to claim 4, characterized in that: The bottom surface of the tape (38) away from the adhesive tape (37) has adhesive material, and the bottom surface of the tape (38) is connected to the skin of the experimental mouse and the top surface of the adhesive tape (33).

6. The multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device suitable for rats and mice according to claim 1, characterized in that: The outer wall surface of the adhesive tape (33) has multiple notches arranged in a ring array for the adhesive tape (37) and adhesive tape (38) to pass through and apply a pulling and pressing force to the adhesive tape (33).

7. The multi-channel transcutaneous transventricular sympathetic nerve electrical stimulation device for rats and mice according to claim 1, characterized in that: The tip of the conductive microneedle (34) is inserted into the subcutaneous tissue of the experimental mouse to achieve deep stimulation.

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