A high-efficiency wet mixing granulator for laboratory medicine research and development

Abstract

The utility model provides a high -efficient wet mixing granulator for laboratory medicine research and development relates to medicine research and development equipment technical field, including the granulator main part, the bottom of granulator main part is provided with square base, one side of the top of square base is installed with mixing cavity, adjacent one side of mixing cavity is installed with motor cabin, the other side of mixing cavity is provided with discharge cabin, the front side of motor cabin is installed with operating panel, the utility model discloses adopt the multistage mixing structure of main shaft stirring shear cutter, auxiliary shaft hob blade and bottom stirring blade, make material in axial, radial and tangential all get sufficient shearing and mixing, avoid the mixed dead angle caused by traditional single stirring mode, simultaneously, the air hole on auxiliary shaft can assist airflow fluidization, further enhance mixing effect, make material mixing evenness significantly reduce, ensure the consistency of particle size, shape and distribution, thereby improve the stability of medicine, dissolution rate and bioavailability.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical research and development equipment technology, and in particular to a high-efficiency wet mixing granulation machine for laboratory pharmaceutical research and development. Background Technology

[0002] In the process of drug development, wet mixing granulation is an extremely important step, which can effectively improve the dispersibility and flowability of drugs, thereby improving drug bioavailability and production efficiency. However, some technical problems have arisen in the use of existing high-efficiency wet mixing granulation machines, which seriously affect the quality of the final drug product.

[0003] First, insufficient mixing uniformity is a common problem. During granulation, the uniformity of material mixing directly affects key parameters such as particle size, shape, and distribution, thus impacting drug stability, dissolution rate, and bioavailability. Second, wet mixing granulators suffer from high rates of wall adhesion and agglomeration, which not only leads to material waste and increased production costs but may also affect the quality of the final product. Material adhesion and agglomeration not only reduce equipment utilization but can also cause batch-to-batch quality fluctuations, preventing drug production from meeting stringent production standards and regulatory requirements. Therefore, we propose a high-efficiency wet mixing granulator for laboratory drug development. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies, particularly insufficient mixing uniformity, a common problem. During granulation, the mixing uniformity of materials directly affects key parameters such as particle size, shape, and distribution, thereby impacting drug stability, dissolution rate, and bioavailability. Furthermore, wet granulation machines exhibit high rates of wall adhesion and agglomeration, which not only waste materials and increase production costs but may also affect the quality of the final product. Material adhesion and agglomeration not only reduce equipment utilization but can also cause batch-to-batch quality fluctuations, preventing drug production from meeting stringent production standards and regulatory requirements.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A high-efficiency wet mixing granulator for laboratory drug development includes a granulator body, a square base at the bottom of the granulator body, a mixing chamber on one side of the top of the square base, a motor compartment on the adjacent side of the mixing chamber, a discharge compartment on the other side of the mixing chamber, and an operation panel on the front side of the motor compartment.

[0006] Furthermore, an organic cover is installed at the top of the mixing chamber, a first motor is installed on the organic cover, a feed inlet is provided on the side adjacent to the first motor, and a liquid inlet is provided on the front side of the top of the organic cover.

[0007] Furthermore, the output end of the first motor extends downward and is connected to a main shaft, on which a stirring and shearing paddle is provided, and the length of the main shaft is equal to two-thirds of the height of the mixing chamber.

[0008] Furthermore, a second motor is installed inside the square base, and the output end of the second motor extends upward into the mixing chamber and is connected to stirring blades.

[0009] Furthermore, a third motor is installed inside the motor compartment, and the output end of the third motor extends forward and is connected to a secondary rotating shaft. Two sets of roller blades are installed on the secondary rotating shaft, and the distance between the roller blades and the stirring blades is 5cm-8cm.

[0010] Furthermore, the secondary rotating shaft is provided with several equidistant vent holes, and an electromagnetic valve is installed on the inner wall side of the mixing chamber where the discharge compartment is installed.

[0011] Furthermore, the discharge chamber is equipped with a pull-out connecting knife assembly structure, which consists of a hexagonal prism drive shaft and blades. The hexagonal prism drive shaft is hollow and has several sets of blades welded to its edges.

[0012] Furthermore, each set of blades consists of three blades evenly distributed at 120°, with elastic fins installed between the blades, and the elastic fins and blades forming an interlaced serrated pattern.

[0013] Compared with the prior art, the beneficial effects of this utility model are: 1. This utility model adopts a multi-stage mixing structure consisting of a main rotating shaft stirring shearing paddle, a secondary rotating shaft roller blade, and a bottom stirring blade, which enables the material to be fully sheared and mixed in the axial, radial, and tangential directions, avoiding the mixing dead zones caused by traditional single stirring methods. At the same time, the vent holes on the secondary rotating shaft can assist in airflow fluidization, further enhancing the mixing effect and significantly reducing the uniformity of material mixing, ensuring the consistency of particle size, shape, and distribution, thereby improving the stability, dissolution rate, and bioavailability of the drug.

[0014] 2. The synergistic effect of the main shaft and the auxiliary shaft creates dynamic shear force, preventing material from accumulating on the inner wall of the mixing chamber. In addition, the vent holes of the auxiliary shaft can introduce an appropriate amount of airflow to reduce the adhesion of wet materials. Combined with the mechanical scraping effect of the stirring blades, the wall adhesion rate is greatly reduced, reducing batch-to-batch quality fluctuations, improving equipment utilization, and lowering production costs.

[0015] 3. The design of the hexagonal prism drive shaft and adjustable blade assembly makes blade replacement and adjustment more convenient. Disassembly and assembly can be completed without tools, greatly reducing downtime. The blades are evenly distributed at 120° and the elastic fins are arranged in an alternating pattern, which can precisely control the particle size. At the same time, the elastic fins can effectively prevent fibrous materials from entanglement and improve granulation efficiency. The solenoid valve controls the discharge, and together with the pull-out blade assembly structure, it can quickly switch between different granulation processes to meet the flexible needs of laboratory research and development. Attached Figure Description

[0016] Figure 1 A schematic diagram of the overall structure of a high-efficiency wet mixing granulator for laboratory drug research and development provided by this utility model; Figure 2 A schematic diagram of the stirring and shearing paddle structure of a high-efficiency wet mixing granulator for laboratory drug research and development provided by this utility model; Figure 3 A schematic diagram of the bottom structure of the mixing chamber of a high-efficiency wet mixing granulator for laboratory drug research and development provided by this utility model; Figure 4 This utility model provides a schematic diagram of the blade assembly structure of a high-efficiency wet mixing granulator for laboratory drug research and development.

[0017] Legend: 1. Granulator body; 2. Blade assembly structure; 101. Square base; 102. Mixing chamber; 103. Motor compartment; 104. Discharge compartment; 105. Control panel; 106. Machine cover; 107. First motor; 108. Feed inlet; 109. Liquid inlet; 110. Main shaft; 111. Stirring and shearing paddle; 112. Stirring blade; 113. Secondary shaft; 114. Roller blade; 115. Vent hole; 201. Hexagonal prism drive shaft; 202. Blade; 203. Elastic fin. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0019] To facilitate understanding of this utility model, a more comprehensive description of this utility model will be provided below with reference to relevant embodiments, and several embodiments of this utility model will be given. However, this utility model can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of this utility model more thorough and complete.

[0020] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used in this document are for illustrative purposes only.

[0021] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0022] Example 1: like Figure 1-4 As shown, this utility model provides a technical solution: a high-efficiency wet mixing granulator for laboratory drug research and development, including a granulator body 1, a square base 101 at the bottom of the granulator body 1, a mixing chamber 102 installed on one side of the top of the square base 101, a motor compartment 103 installed on the adjacent side of the mixing chamber 102, a discharge compartment 104 installed on the other side of the mixing chamber 102, an operation panel 105 installed on the front side of the motor compartment 103, and stirring blades in multiple directions are arranged in the mixing chamber 102. This breaks through the limitations of laminar flow mixing in the traditional single stirring mode. Through the synergistic effect of mechanical shearing and airflow fluidization, the material can achieve forced mixing at the microscale in multiple directions, and the mixing uniformity can be improved to ≤3%.

[0023] Example 2: like Figure 1-4 As shown, a cover 106 is installed at the top of the mixing chamber 102. A first motor 107 is installed on the cover 106. An inlet 108 is provided on the adjacent side of the first motor 107. A liquid inlet 109 is provided on the front side of the top of the cover 106. The liquid inlet 109 is used to inject liquid and mixture into the mixing chamber (102). The output end of the first motor 107 extends downward and is connected to the main rotating shaft 110. The main rotating shaft 110 is equipped with a stirring and shearing blade 111. The length of the main rotating shaft 110 is equal to two-thirds of the height of the mixing chamber 102. The second motor is installed inside the square base 101, and the output end of the second motor extends upward into the mixing chamber 102 and is connected to the stirring blade 112. The third motor is installed inside the motor compartment 103, and the output end of the third motor extends forward and is connected to the auxiliary rotating shaft 113. Two sets of roller blades 114 are installed on the auxiliary rotating shaft 113. The distance between the roller blades 114 and the stirring blades 112 is 5cm-8cm. The synergistic effect of the main rotating shaft 110 and the auxiliary rotating shaft 113 forms a dynamic shearing force to prevent material from accumulating on the inner wall of the mixing chamber 102. The three sets of blades form an alternating shearing zone when rotating. The secondary rotating shaft 113 has several equidistant vent holes 115. The secondary rotating shaft 113 generates high-frequency turbulence through the vent holes 115 and simultaneously completes airflow-assisted fluidization. A solenoid valve is installed on one side of the inner wall of the discharge chamber 104 in the mixing chamber 102. The discharge chamber 104 is connected to the pull-out blade assembly structure 2. The blade assembly structure 2 consists of a hexagonal prism drive shaft 201 and blades 202. The hexagonal prism drive shaft 201 is hollow hexagonal prism, and the edges of the hexagonal prism drive shaft 201 are welded with... There are several sets of blades 202, each set of blades 202 consists of three blades 202, evenly distributed at 120°. Elastic fins 203 are installed between the blades 202. The elastic fins 203 and the blades 202 are in an interlaced serrated shape. The pull-out blade assembly structure 2 solves the problems of time-consuming replacement and low adjustment accuracy of traditional bolt-fixed blade assemblies, achieving rapid disassembly and assembly within 10 seconds. The particle size control accuracy reaches ±50μm. At the same time, the elastic fins 203 can effectively prevent fibrous materials from entanglement.

[0024] The working process of this utility model is as follows: When using a high-efficiency wet mixing granulator for laboratory drug research and development, the operator first puts in powdered raw materials through the feed port 108 and adds adhesives or solvents through the liquid inlet 109. The first motor 107 drives the main rotating shaft 110 to rotate the stirring and shearing paddle 111. At the same time, the second motor drives the bottom stirring blades 112 to turn the material upward. The third motor drives the roller blades 114 on the auxiliary rotating shaft 113 to perform high-speed shearing. The air vents 115 on the auxiliary rotating shaft 113 allow airflow to assist fluidization, so that the material forms three-dimensional turbulence in the mixing chamber 102, achieving efficient and uniform mixing. The uniformly mixed wet material is further sheared and refined under the synergistic action of the stirring blades 112 and the roller blades 114, preventing agglomeration and sticking to the walls. The material is subjected to dynamic scraping action on the inner wall of the mixing chamber 102, reducing residue. After mixing is completed, the control panel 105 controls the solenoid valve to open, and the material enters the discharge chamber 104 and flows through the pull-out blade assembly structure 2. The hexagonal prism drive shaft 201 drives the blades 202 and elastic fins 203 to rotate, cutting the wet material into uniform particles with a particle size control accuracy of ±50μm. At the same time, the elastic fins 203 prevent fiber entanglement. After granulation, the operator can manually pull out and replace the blade assembly structure 2, switching between different blade specifications 202 within 10 seconds. Residual material in the mixing chamber 102 can be further cleaned with airflow assistance and mechanical scraping to reduce cross-contamination and facilitate the next batch of production.

[0025] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A high-efficiency wet mixing granulator for laboratory drug development, comprising a granulator body (1), characterized in that: The bottom of the pellet mill body (1) is provided with a square base (101), a mixing chamber (102) is installed on one side of the top of the square base (101), a motor compartment (103) is installed on the adjacent side of the mixing chamber (102), a discharge compartment (104) is provided on the other side of the mixing chamber (102), and an operation panel (105) is installed on the front side of the motor compartment (103). The mixing chamber (102) is equipped with a cover (106) at the top. A first motor (107) is installed on the cover (106). An inlet (108) is provided on the adjacent side of the first motor (107). A liquid inlet (109) is provided on the front side of the top of the cover (106). The output end of the first motor (107) extends downward and is connected to a main shaft (110). A stirring and shearing paddle (111) is provided on the main shaft (110). The length of the main shaft (110) is equal to two-thirds of the height of the mixing chamber (102). The motor compartment (103) is equipped with a third motor, and the output end of the third motor extends forward and is connected to a secondary rotating shaft (113). Two sets of roller blades (114) are installed on the secondary rotating shaft (113), and the distance between the roller blades (114) and the stirring blades (112) is 5cm-8cm. The auxiliary rotating shaft (113) has several vent holes (115) equidistantly opened on it, and the mixing chamber (102) has an electromagnetic valve installed on one side of the inner wall of the discharge chamber (104). The discharge chamber (104) is connected to a pull-out knife assembly structure (2). The knife assembly structure (2) consists of a hexagonal prism drive shaft (201) and blades (202). The hexagonal prism drive shaft (201) is in the shape of a hollow hexagonal prism, and several sets of blades (202) are welded on the edges of the hexagonal prism drive shaft (201). Each set of blades (202) consists of three blades (202) evenly distributed at 120°. Elastic fins (203) are installed between the blades (202), and the elastic fins (203) and the blades (202) are in an alternating serrated shape.

2. The high-efficiency wet mixing granulator for laboratory drug development according to claim 1, characterized in that: The square base (101) is equipped with a second motor, and the output end of the second motor extends upward into the mixing chamber (102) and is connected to a stirring blade (112).

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