A pre-reaction device for mixing ingredients for preparing ibuprofen ester

Abstract

The utility model relates to chemical equipment technical field, concretely relates to a kind of Ibuprofen ester preparation with batching mixing pre-reaction device, including base, the side mounting of base has support;Pre-reaction component, pre-reaction component is installed in the side of base, pre-reaction component is used to mix pre-reaction for Ibuprofen ester preparation with batching;Buffering component, buffering component is installed in the upper portion of pre-reaction component, buffering component is used to buffer and dispersed flow guide for the material entering.Compared with prior art, the application is by circulating pump and buffering component, pre-reaction component cooperation, realize material forced external circulation and grading homogenization, avoid flow field disorder and local anomaly, pre-reaction component lets material multilevel mixing, combined with external circulation to improve mixing uniformity and reaction efficiency;Buffering component makes material evenly enter pre-reaction cavity, and enhances stability.

Description

Technical Field

[0001] This utility model relates to the field of chemical equipment technology, and in particular to a pre-reaction device for mixing ingredients for the preparation of ibuprofen ester. Background Technology

[0002] Ibuprofen ester, a compound with significant applications in the pharmaceutical field, relies heavily on the pre-reaction stage of ingredient mixing during its preparation process, which plays a crucial role in the quality and performance of the final product. In the industrial production of ibuprofen ester, the design and performance of the pre-reaction mixing equipment directly affect various aspects, including the uniformity of material mixing, reaction contact efficiency, pre-reaction time, and reaction quality, thereby determining the product yield and purity.

[0003] In traditional pre-reaction apparatuses for ibuprofen ester preparation, the material mixing method is relatively simple. Most apparatuses rely solely on the stirring action of a stirring paddle to achieve material mixing. However, this single macroscopic stirring method is insufficient to meet the needs of multi-level mixing. Localized uneven mixing easily occurs within the pre-reaction chamber, with some areas having excessively high material concentrations while others have excessively low concentrations. This leads to insufficient reaction contact and inconsistent reaction rates, thus affecting product quality and performance. In traditional apparatuses, the material often enters the pre-reaction chamber instantaneously, resulting in the immediate formation of localized high-concentration areas. Due to delayed stirring and mixing, these localized high-concentration areas cannot quickly diffuse throughout the pre-reaction chamber, thus affecting the reaction. Uniformity is also a concern. In the reaction process, traditional equipment struggles to effectively control and uniformly distribute the temperature within the pre-reaction chamber. Due to the lack of effective circulation and heat transfer mechanisms, dead zones easily form inside the tank, i.e., areas where material flow is slow or stagnant. The temperature in these areas differs significantly from other areas, leading to localized high or low temperatures. Localized high temperatures accelerate side reactions and reduce product purity, while localized low temperatures slow down the reaction rate, prolong the pre-reaction time, and affect production efficiency. Furthermore, existing linear guide or planar baffle structures can only achieve unidirectional flow splitting and cannot simultaneously achieve buffering and uniform introduction. Especially in high-viscosity or exothermic systems, turbulence and localized temperature anomalies still occur. Utility Model Content

[0004] In view of this, the purpose of this utility model is to propose a pre-reaction device for mixing ingredients in the preparation of ibuprofen ester, so as to solve the problem of uneven material mixing in existing ibuprofen ester preparation devices.

[0005] To achieve the above objectives, this utility model provides a pre-reaction apparatus for mixing ingredients in the preparation of ibuprofen ester, comprising: a base, wherein a support is mounted on one side of the base; A pre-reaction assembly is installed on one side of the base. The pre-reaction assembly is used to mix and pre-react the ingredients for the preparation of ibuprofen ester. The pre-reaction assembly includes a pre-reaction tank with an inspection cover on one side. The interior of the pre-reaction tank is formed from top to bottom as a buffer chamber and a pre-reaction chamber. A feed pipe is connected to one side of the pre-reaction tank, and a discharge port is provided at the bottom of the pre-reaction tank. A buffer assembly is installed on the upper part of the pre-reaction assembly. The buffer assembly is used to buffer and disperse the incoming material. The buffer assembly includes a guide plate horizontally arranged in the pre-reaction tank. A sleeve is installed at the center of the guide plate. The sleeve is connected to the inner side of the inspection cover. Several guide blades are installed on the guide plate circumferentially.

[0006] Preferably, a maintenance cover is provided on one side of the pre-reaction tank, and the maintenance cover is detachably connected to the opening on the side wall of the pre-reaction tank via a flange.

[0007] Preferably, a motor is installed on one side of the bracket, the output end of the motor is connected to a power shaft, the power shaft passes through the pre-reaction tank and extends into the pre-reaction chamber, and an agitator and a dispersion disc are sequentially installed on the power shaft along the axial direction.

[0008] Preferably, the stirring paddle is arranged in the upper middle part of the pre-reaction chamber; the dispersion disk is arranged in the bottom region of the pre-reaction chamber.

[0009] Preferably, the base is equipped with a circulation pump, the suction port of the circulation pump is connected to the bottom of the pre-reaction chamber via a return pipe, the outlet of the circulation pump is connected to the buffer chamber via a reflux pipe, and the reflux pipe is equipped with a thermometer and a one-way valve.

[0010] Preferably, the guide plate is used to separate the buffer chamber from the pre-reaction chamber.

[0011] Preferably, the guide vanes are evenly distributed along the circumference of the sleeve and arranged at an inclined angle relative to the guide plate.

[0012] Preferably, the buffer cavity is provided with a baffle along its inner wall, and the baffle is arranged in a spiral upward shape.

[0013] Preferably, the outer circumference of the guide plate is provided with a plurality of evenly arranged guide ports.

[0014] The beneficial effects of this utility model are: This pre-reaction device for preparing ibuprofen esters, by combining a circulating pump with a buffer assembly and a pre-reaction assembly, enables the device to extract materials from the bottom of the pre-reaction chamber and directionally return them to the buffer chamber. This achieves forced external circulation and graded homogenization of the materials. After the reflux enters the buffer chamber through the reflux pipe, it first forms tangential and circumferential redistribution and retention under the action of the guide plate, inclined guide vanes and spiral baffles in the chamber. This allows the refluxed materials to be uniformly distributed in a ring and then re-enter the pre-reaction chamber. This avoids the flow field disturbance and local high concentration or high temperature areas caused by the direct impact of the stirring shaft or local direct discharge of traditional reflux.

[0015] This pre-reaction device for preparing ibuprofen esters, by setting up a pre-reaction component, enables multi-level mixing of materials in the pre-reaction chamber through macroscopic circulation mixing by the stirring paddle and microscopic shear dispersion by the dispersion disc. Combined with the external circulation reflux driven by the circulation pump, it effectively avoids the problem of uneven local mixing, significantly improves the mixing uniformity and reaction contact efficiency of the materials, thereby shortening the pre-reaction time and improving the reaction quality.

[0016] This pre-reaction device for preparing ibuprofen esters incorporates a buffer assembly. Spiral baffles guide the material to spiral down the buffer chamber, while inclined guide vanes generate tangential dispersion as the material descends. The combined effect of these two components creates a stable three-dimensional flow field, allowing the material to be fully homogenized before entering the pre-reaction chamber. Compared to a single guiding method, this device improves mixing uniformity, reduces temperature fluctuations, significantly shortens the pre-reaction time, and suppresses side reactions.

[0017] This pre-reaction mixing device for ibuprofen ester preparation is equipped with a one-way valve and a thermometer. The circulation pump, in conjunction with the one-way valve, ensures stable unidirectional flow of the medium and prevents backflow when the pump stops or operating conditions fluctuate. This external circulation path can significantly eliminate dead zones in the tank, improve the material exchange rate, and accelerate heat and mass transfer. With the real-time monitoring of the circulation temperature by the thermometer on the reflux pipe, the heating, heat release, and equilibrium stages can be optimized by adjusting the pump speed or heat exchange load: in the early stage, the circulation can be increased to quickly and evenly distribute the heat release; during the period of intense heat release, the circulation can be used to disperse the heat along the cavity to prevent local overheating; and in the later stage, the circulation intensity can be appropriately reduced to maintain temperature stability. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only for this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1This is a three-dimensional structural diagram of the present invention; Figure 2 This is a three-dimensional structural diagram of the reflux tube, temperature measuring instrument, and pre-reaction tank of this utility model; Figure 3 This is a first-view schematic diagram of the internal structure of the pre-reaction tank of this utility model; Figure 4 This is a second-view schematic diagram of the internal structure of the pre-reaction tank of this utility model.

[0020] The diagram is marked as follows: 1. Base; 2. Bracket; 3. Circulating pump; 4. Motor; 5. Power shaft; 6. Return pipe; 7. Discharge port; 8. Backflow pipe; 9. Thermometer; 10. Pre-reaction tank; 11. Feed pipe; 12. Baffle; 13. Buffer chamber; 14. Pre-reaction chamber; 15. Stirring paddle; 16. Dispersion disc; 17. Sleeve; 18. Guide disc; 19. Guide port; 20. Guide vane; 22. Check valve; 23. Inspection cover. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to specific embodiments.

[0022] It should be noted that, unless otherwise defined, the technical or scientific terms used in this utility model should have the ordinary meaning understood by one of ordinary skill in the art to which this utility model pertains. The terms "first," "second," and similar terms used in this utility model do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. Terms such as "connected" or "linked" are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. Terms such as "upper," "lower," "left," and "right" are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0023] like Figures 1 to 4 As shown, the pre-reaction device for mixing ingredients for ibuprofen ester preparation includes: a base 1, with a support 2 mounted on one side of the base 1; a pre-reaction component, mounted on one side of the base 1, used for mixing and pre-reacting the ingredients for ibuprofen ester preparation; a buffer component, mounted on top of the pre-reaction component, used for buffering and dispersing the incoming materials; and a maintenance cover 23 on one side of the pre-reaction tank 10, which is detachably connected to an opening in the side wall of the pre-reaction tank 10 via a flange. In use, the pre-reaction mixing device for ibuprofen ester preparation is supported and stably installed by the base 1 and the bracket 2. After the material enters the buffer component, it is first damped by the flow guiding structure in the buffer chamber 13 to prevent the material from directly impacting the pre-reaction chamber 14, thus playing a role in buffering and initial dispersion. At the same time, a certain rotation or dispersion flow is formed in the buffer component, so that the material is evenly distributed before entering the pre-reaction component. The material entering the pre-reaction component is mixed and circulated axially and radially in the pre-reaction chamber 14 through synergistic stirring, thereby ensuring that the ingredients for ibuprofen ester preparation are fully mixed and uniformly pre-reacted, and finally a pre-reaction material with good flowability and high uniformity is obtained.

[0024] like Figure 1 , Figure 3 As shown, the pre-reaction assembly includes a pre-reaction tank 10, with an inspection cover 23 on one side. Inside the pre-reaction tank 10, a buffer chamber 13 and a pre-reaction chamber 14 are formed sequentially from top to bottom. A feed pipe 11 is connected to one side of the pre-reaction tank 10, and a discharge port 7 is located at its bottom. A motor 4 is installed on one side of the support 2, with its output end connected to a power shaft 5. The power shaft 5 passes through the pre-reaction tank 10 and extends into the pre-reaction chamber 14. An agitator 15 and a dispersion disc 16 are sequentially installed along the axial direction on the power shaft 5. The agitator 15 is located in the upper middle part of the pre-reaction chamber 14. The dispersion disc 16 is located in the bottom area of ​​the pre-reaction chamber 14. A circulation pump 3 is installed on the base 1. The suction port of the circulation pump 3 is connected to the bottom of the pre-reaction chamber 14 via a return pipe 6, and the outlet of the circulation pump 3 is connected to the buffer chamber 13 via a reflux pipe 8. A thermometer 9 and a one-way valve 22 are installed on the reflux pipe 8. When the pre-reaction component is in operation, after the material enters the pre-reaction tank 10 through the feed pipe 11, it is first initially buffered and dispersed in the buffer chamber 13, and then enters the pre-reaction chamber 14 located below. In the pre-reaction chamber 14, the stirring paddle 15 mounted on the power shaft 5 rotates at high speed under the drive of the motor 4, generating axial and radial circulating flow, so that the material forms a large-scale tumbling and circulation in the tank, thereby achieving macroscopic uniform mixing; the dispersion disk 16 located at the bottom of the pre-reaction chamber 14 further applies strong local dispersion and shearing to the material. The process involves refining larger particles or droplets, enhancing the micro-mixing effect of the materials. Simultaneously, the circulating pump 3 located on the base 1 continuously draws a portion of the material from the bottom of the pre-reaction chamber 14, which then enters the circulating pump 3 through the return pipe 6 and is then transported back to the buffer chamber 13 through the reflux pipe 8, achieving external circulation mixing. During this process, the one-way valve 22 on the reflux pipe 8 ensures unidirectional flow of the material, and the thermometer 9 monitors the material temperature in real time. The entire pre-reaction process effectively improves the mixing uniformity and pre-reaction efficiency of ibuprofen ester formulations through a combination of stirring, dispersion, and external circulation.

[0025] like Figure 3 , Figure 4As shown, the buffer assembly includes a guide plate 18 horizontally disposed within the pre-reaction tank 10. The guide plate 18 separates the buffer chamber 13 from the pre-reaction chamber 14. A sleeve 17 is installed at the center of the guide plate 18, and the sleeve 17 is connected to the inner side of the inspection cover 23. Several guide vanes 20 are installed circumferentially on the guide plate 18. The guide vanes 20 are evenly distributed along the circumference of the sleeve 17 and are arranged at an inclined angle relative to the guide plate 18. The buffer chamber 13 is provided with baffles 12 along its inner wall, and the baffles 12 are arranged in a spiral upward manner. Several evenly arranged guide ports 19 are opened on the outer circumference of the guide plate 18. When the buffer assembly is in operation, the material enters the pre-reaction tank 10 through the feed pipe 11 and first enters the buffer chamber 13. The baffles 12 inside the buffer chamber 13 are arranged in a spiral upward pattern, causing the incoming material to rotate and flow along the tank wall within the chamber, thus avoiding concentrated impact caused by the material falling straight down. When the material flows to the bottom of the buffer chamber 13, it comes into contact with the horizontally arranged guide plate 18. The guide vanes 20 installed on the guide plate 18 are evenly distributed and inclined along the circumference of the sleeve 17, tangentially guiding the material during its downward flow. The material is evenly dispersed around the guide plate 18; subsequently, the material flows into the pre-reaction chamber 14 below in a ring-shaped distribution through multiple guide ports 19 opened on the outer circumference of the guide plate 18, thereby achieving buffering, uniform flow and dispersion of the material. This avoids the impact of instantaneous impact on the stirring shaft and the stirring flow field, and also helps the material to achieve uniform distribution before entering the pre-reaction chamber 14, improving the stability and efficiency of subsequent mixing and reaction. The number of guide blades 20 can be 6 to 12, evenly distributed on the guide plate 18, similar to fan blades. The blades are arranged radially; each blade is inclined, with an inclination angle ranging from 20° to 60°, and its leading edge is higher than its trailing edge, which allows the fluid to generate a tangential component during its descent, changing the fluid direction; the blades have an arc or trapezoidal cross-section, and the contact surface with the liquid flow is a smooth curved surface to reduce fluid resistance; furthermore, in the preferred embodiment of this invention: the relationship between the number and inclination angle of the guide blades 20 and the orifice 19 (opening ratio): number of guide blades 20: 6–12; inclination angle of the guide blades 20: 20°–60° °; the opening ratio of the guide port 19 (the ratio of the total opening area of ​​the outer periphery of the guide plate 18 to the outer periphery cross-sectional area): 8%–20%, and the guide vanes 20 are arranged circumferentially at equal intervals. The guide vanes 20 are similar to fans or guide vanes and are used to introduce the tangential component into the radial distribution and generate a circumferential uniform distribution. The inclination angle of the guide vanes 20 is in the range of 20–60°, which can generate a significant tangential component and reduce the direct impact; the parameters of the baffle 12: helix angle (spiral angle): 10°–30°, used to generate a rotating downward flow along the wall in the buffer cavity 13, improve radial and circumferential homogenization and prolong the residence time.

[0026] The circulation pipeline structure of this utility model is the core of achieving forced external circulation and graded homogenization of materials. One end of the return pipe 6 is preferably connected tangentially to the conical bottom or flat-bottomed center area of ​​the pre-reaction chamber 14 to ensure effective extraction of materials that may settle. The other end is firmly connected to the suction port of the circulation pump 3. One end of the reflux pipe 8 is connected to the outlet of the circulation pump 3, and the other end is preferably connected tangentially to the upper side wall of the buffer chamber 13. The opening is located above the guide plate 18 and directly opposite the spiral baffle 12 on the inner wall of the buffer chamber 13, so that the pumped material can fall smoothly along the spiral trajectory of the tank wall to achieve initial dispersion. The pipe diameters of the return pipe 6 and the reflux pipe 8 are determined according to the rated flow rate of the circulation pump 3 to ensure that the resistance of material circulation is minimized and the efficiency is maximized.

[0027] Those skilled in the art should understand that the discussion of any of the above embodiments is merely exemplary and is not intended to imply that the scope of the present invention (including the claims) is limited to these examples; within the framework of the present invention, the technical features of the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other variations of the different aspects of the present invention as described above, which are not provided in the details for the sake of brevity.

[0028] This utility model is intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A pre-reaction apparatus for mixing ingredients in the preparation of ibuprofen ester, characterized in that, include: A base (1), on one side of which a bracket (2) is installed; a pre-reaction assembly, on one side of which the pre-reaction assembly is installed, the pre-reaction assembly being used to mix and pre-react the ingredients for ibuprofen ester preparation, the pre-reaction assembly including a pre-reaction tank (10), a maintenance cover (23) on one side of the pre-reaction tank (10), a buffer chamber (13) and a pre-reaction chamber (14) being formed sequentially from top to bottom inside the pre-reaction tank (10), and a feed pipe (11) connected to one side of the pre-reaction tank (10). The pre-reaction tank (10) is provided with a discharge port (7) at the bottom; a buffer assembly is installed on the upper part of the pre-reaction assembly. The buffer assembly is used to buffer and disperse the incoming material. The buffer assembly includes a guide plate (18) horizontally arranged in the pre-reaction tank (10). A sleeve (17) is installed in the center of the guide plate (18). The sleeve (17) is connected to the inner side of the inspection cover (23). Several guide blades (20) are installed on the guide plate (18) along the circumferential direction.

2. The pre-reaction apparatus for mixing and reacting ingredients for the preparation of ibuprofen ester according to claim 1, characterized in that, The pre-reaction tank (10) is provided with a maintenance cover (23) on one side. The maintenance cover (23) is detachably connected to the opening of the side wall of the pre-reaction tank (10) through a flange.

3. The pre-reaction apparatus for mixing ingredients for the preparation of ibuprofen ester according to claim 2, characterized in that, A motor (4) is installed on one side of the bracket (2). The output end of the motor (4) is connected to a power shaft (5). The power shaft (5) passes through the pre-reaction tank (10) and extends into the pre-reaction chamber (14). An agitator (15) and a dispersion disc (16) are installed on the power shaft (5) in sequence along the axial direction.

4. The pre-reaction apparatus for mixing ingredients for the preparation of ibuprofen ester according to claim 3, characterized in that, The stirring paddle (15) is arranged in the upper middle part of the pre-reaction chamber (14); the dispersing disk (16) is arranged in the bottom area of ​​the pre-reaction chamber (14).

5. The pre-reaction apparatus for mixing ingredients for the preparation of ibuprofen ester according to claim 3, characterized in that, The base (1) is equipped with a circulation pump (3). The inlet of the circulation pump (3) is connected to the bottom of the pre-reaction chamber (14) via a return pipe (6). The outlet of the circulation pump (3) is connected to the buffer chamber (13) via a reflux pipe (8). The reflux pipe (8) is equipped with a thermometer (9) and a one-way valve (22).

6. The pre-reaction apparatus for mixing ingredients for the preparation of ibuprofen ester according to claim 5, characterized in that, The guide plate (18) is used to separate the buffer chamber (13) from the pre-reaction chamber (14).

7. The pre-reaction apparatus for mixing and reacting ingredients for the preparation of ibuprofen ester according to claim 1, characterized in that, The guide vanes (20) are evenly distributed along the circumference of the sleeve (17) and are arranged at an inclined angle relative to the guide disk (18).

8. The pre-reaction apparatus for mixing ingredients for the preparation of ibuprofen ester according to claim 7, characterized in that, The buffer cavity (13) is provided with baffles (12) along its inner wall, and the baffles (12) are arranged in a spiral upward shape.

9. The pre-reaction apparatus for mixing and reacting ingredients for the preparation of ibuprofen ester according to claim 8, characterized in that, The outer circumference of the guide plate (18) is provided with several evenly arranged guide ports (19).

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