A micro-liquid well-plate dispensing device

Abstract

The utility model relates to the technical field of trace liquid precision processing, concretely relates to a trace liquid orifice plate liquid separation device, including the cover plate, the upper end surface of cover plate is provided with the feed pipe, the upper end surface of cover plate still is provided with the discharge pipe, and the lower end surface of cover plate is provided with the bending flow groove, the flow groove is used to drain the liquid medicine that enters from the feed pipe to the discharge pipe, to this to complete the liquid separation to liquid medicine, the lower end surface of cover plate is provided with the magnetic attraction groove, the lower end of magnetic attraction groove is provided with the magnetic attraction piece, the lower end surface of magnetic attraction piece is fixedly connected with the hole plate, the upper end surface of hole plate is provided with the penetration trapezoidal groove, the diameter of the end surface of trapezoidal groove towards cover plate one end is greater than the end surface of trapezoidal groove away from cover plate one end, the inner wall of hole plate is connected with capsule holder and slides, the upper end surface of capsule holder is provided with the mark groove, the number of trapezoidal groove is multiple, multiple trapezoidal grooves evenly distribute in the upper end surface of hole plate, have the effect that simplify the liquid separation structure, improve the precision degree of liquid separation.

Description

Technical Field

[0001] This utility model relates to the technical field of precise processing of micro-liquids, and specifically to a micro-liquid orifice plate liquid separator. Background Technology

[0002] In fields such as life sciences, biomedicine, food safety, and environmental monitoring, micro-liquid separation is a core step in experimental procedures, directly impacting the reliability of experimental data and research efficiency. Traditional manual separation methods suffer from insufficient precision, low efficiency, high risk of cross-contamination, and high labor costs, making them difficult to meet the high-throughput and automated demands of modern laboratories. In micro-liquid processing, such as reagent dispensing, sample dilution, and reaction system construction, precise quantification of liquids with volumes ranging from 1 to 10 μL is often required, necessitating compatibility with different sizes of well plates.

[0003] Existing technologies suffer from poor adaptability and complex structures. Most quantitative devices are specially designed and can only correspond to orifice plates with a specific number of holes or specifications. When changing application scenarios, the entire device needs to be replaced, which is costly and inefficient. At the same time, they rely on precision pumps or multiple sets of drive valves, resulting in large device size, high assembly difficulty, and difficulty in integrating them into miniaturized systems. Utility Model Content

[0004] In view of the above-mentioned shortcomings of the existing technology, the present invention provides a micro-liquid orifice plate liquid separation device, which can effectively solve the technical problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] This utility model provides a micro-liquid orifice plate separation device, including a cover plate, an inlet pipe provided on the upper end face of the cover plate, an outlet pipe provided on the upper end face of the cover plate, and a bent flow groove provided on the lower end face of the cover plate. The flow groove is used to guide the liquid entering from the inlet pipe to the outlet pipe, thereby completing the separation of the liquid.

[0007] Furthermore, a magnetic groove is provided on the lower end face of the cover plate, a magnetic block is provided at the lower end of the magnetic groove, and a perforated plate is fixedly connected to the lower end face of the magnetic block.

[0008] Furthermore, the upper end face of the perforated plate is provided with a through trapezoidal groove, and the diameter of the end face of the trapezoidal groove facing the cover plate is larger than the diameter of the end face of the trapezoidal groove facing away from the cover plate.

[0009] Furthermore, a capsule holder is slidably connected to the inner wall of the perforated plate, and an identification groove is provided on the upper surface of the capsule holder.

[0010] Furthermore, there are multiple trapezoidal grooves, which are evenly distributed on the upper surface of the perforated plate. The capsule holder is provided with multiple collection slots, and the lower outlets of the multiple trapezoidal grooves are respectively facing the multiple collection slots.

[0011] Furthermore, a magnetic suction plate is provided on the lower end face of the capsule holder. The magnetic suction plate is a rectangular plate. The upper end face of the magnetic suction plate is tightly attached to the lower end face of the perforated plate by magnetic attraction, and the lower end face of the magnetic suction plate is provided with anti-slip texture.

[0012] Furthermore, both the feed pipe and the discharge pipe are cylindrical pipes, and both the feed pipe and the discharge pipe are provided with connecting flanges at their upper ends, which are used to connect to external pipes.

[0013] Furthermore, the flow channel includes a first straight section, a bent section, and a second straight section connected in sequence. The first straight section is connected to the lower end of the feed pipe, and the second straight section is connected to the lower end of the discharge pipe. The widths of the first straight section, the bent section, and the second straight section are all the same.

[0014] Beneficial effects

[0015] The technical solution provided by this utility model has the following advantages compared with the known prior art:

[0016] I. This utility model achieves synchronous self-driven filling of multiple micro-volume liquids without the need for precision components such as pump bodies and valve groups by utilizing the strong hydrophilic capillary force of trapezoidal micropores during the quantitative stage. The quantitative volume is naturally locked by the micropore size and surface tension, which solves the problems of complex drive structure, high cost and poor synchronization of traditional multi-channel pumps.

[0017] During the release phase: By precisely breaking through the capillary locking force through equalizing air pressure, the liquid is released in batches, avoiding the instability of gravity release affected by viscosity and angle, and minimizing the release residue rate.

[0018] It not only simplifies the separation structure but also improves the accuracy of separation.

[0019] Second, this utility model can be adapted to multiple devices with simple modifications: the lower quantitative well plate can be replaced, and different hole spacing and number of micro-holes can be designed to adapt to well plates of various specifications such as 96-well plates and 384-well plates, without the need to replace the upper chip, which greatly improves the efficiency of scene switching.

[0020] Third, the magnetic connection of each part in this utility model not only makes disassembly more convenient and cleaning easier, but also makes the connection between each part tighter, reduces gaps during the connection process, and improves the accuracy of liquid separation. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is the front view of the present invention;

[0023] Figure 2 This is a cross-sectional view of the structure of this utility model;

[0024] Figure 3 In this utility model Figure 2 Enlarged view of the structure at point A inside;

[0025] Figure 4 This is an exploded view of the present invention;

[0026] Figure 5 This is a bottom view of the flow channel structure in this utility model.

[0027] Reference numerals: 1. Cover plate; 2. Feed pipe; 3. Discharge pipe; 4. Perforated plate; 5. Capsule holder; 6. Magnetic plate; 7. Collection trough; 8. Trapezoidal trough; 9. Magnetic block; 10. Identification trough; 11. Magnetic trough; 12. Flow trough. Detailed Implementation

[0028] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0029] The present invention will be further described below with reference to the embodiments.

[0030] Example 1:

[0031] Reference Figures 1-5This utility model provides a technical solution: a micro-liquid orifice plate liquid separation device, including a cover plate 1, an inlet pipe 2 provided on the upper end face of the cover plate 1, an outlet pipe 3 provided on the upper end face of the cover plate 1, and a bent flow channel 12 provided on the lower end face of the cover plate 1. The flow channel 12 is used to guide the liquid entering from the inlet pipe 2 to the outlet pipe 3, thereby completing the liquid separation. The inlet pipe 2 and the outlet pipe 3 are both cylindrical pipes, and the upper end of the inlet pipe 2 and the outlet pipe 3 are both provided with connecting flanges for connecting to external pipes. The flow channel 12 includes a first straight section, a bent section and a second straight section connected in sequence. The first straight section is connected to the lower end of the inlet pipe 2 and the second straight section is connected to the lower end of the outlet pipe 3. The widths of the first straight section, the bent section and the second straight section are the same.

[0032] A magnetic groove 11 is provided on the lower end face of the cover plate 1. A magnetic block 9 is provided at the lower end of the magnetic groove 11. A perforated plate 4 is fixedly connected to the lower end face of the magnetic block 9. A through trapezoidal groove 8 is provided on the upper end face of the perforated plate 4. The diameter of the end face of the trapezoidal groove 8 facing the cover plate 1 is larger than the diameter of the end face of the trapezoidal groove 8 away from the cover plate 1. There are multiple trapezoidal grooves 8, which are evenly distributed on the upper end face of the perforated plate 4. Multiple collection slots 7 are correspondingly provided on the capsule holder 5. The lower outlets of the multiple trapezoidal grooves 8 are respectively facing the multiple collection slots 7.

[0033] More specifically, in this embodiment: during use, the magnetic connection between the magnetic block 9 and the magnetic groove 11 allows for better alignment of the cover plate 1 and the perforated plate 4, and also aligns the flow groove 12 on the cover plate 1 with the perforated plate 4. Adhesive is applied between the cover plate 1 and the perforated plate 4, and with the magnetic cooperation of the magnetic block 9 and the magnetic groove 11, the cover plate 1 and the perforated plate 4 are tightly fitted, ensuring that the liquid can flow smoothly within the flow groove 12 without leakage. This also reduces the pressing work required when the adhesive between the cover plate 1 and the perforated plate 4 is drying. The agent is added into the flow tank 12 through the feed pipe 2. Under the action of liquid capillary effect, the liquid will flow in the flow tank 12 and be evenly distributed along the flow tank 12. During the flow of the liquid in the flow tank 12, it will enter the trapezoidal tank 8 and enter the collection tank 7 through the opening at the lower end of the trapezoidal tank 8. When the liquid in the collection tank 7 is filled, under the action of liquid tension, it will seal the opening at the lower end of the trapezoidal tank 8, thereby preventing the liquid from continuing to flow out of the trapezoidal tank 8. When the agent is found at the discharge pipe 3, it means that the agent dispensing is complete.

[0034] Furthermore, the walls of the trapezoidal trough 8 have been treated with water immersion to reduce frictional resistance during liquid flow, making the surface tension of the liquid more concentrated, which in turn can better drive the liquid to flow, making it easier for the liquid to flow into different collection troughs 7 along the flow trough 12.

[0035] Quantitative stage: Utilizing the strong hydrophilic capillary force of the conical micropores, the synchronous self-driven filling of 24 to 384 parts of micro liquid can be achieved without the need for precision components such as pump body and valve group. The quantitative volume is naturally locked by the micropore size and surface tension, which solves the problems of complex drive structure, high cost and poor synchronization of traditional multi-channel pumps.

[0036] Release phase: By precisely breaking through the capillary locking force through equalizing air pressure, the liquid is released in batches, avoiding the instability of gravity release affected by viscosity and angle, and ensuring that the release residue rate is ≤0.5%.

[0037] Simple modifications allow for compatibility with multiple devices: The lower-layer quantitative well plate is replaceable, and different well spacing and number of microwells can be designed to adapt to various well plate specifications such as 96-well plate and 384-well plate without replacing the upper-layer chip, greatly improving the efficiency of scene switching.

[0038] Example 2:

[0039] Based on the above embodiments, in this embodiment: the inner wall of the perforated plate 4 is slidably connected to a capsule holder 5, and the upper end surface of the capsule holder 5 is provided with an identification groove 10.

[0040] More specifically, in this embodiment: after the liquid separation is completed, the setting of the marking groove 10 allows the staff to more intuitively observe the liquid separation status in each collection groove 7 of the capsule rack 5.

[0041] Example 3:

[0042] Based on the above embodiments, in this embodiment: a magnetic suction plate 6 is provided on the lower end face of the capsule holder 5. The magnetic suction plate 6 is a rectangular plate. The upper end face of the magnetic suction plate 6 is tightly attached to the lower end face of the perforated plate 4 by magnetic attraction. The lower end face of the magnetic suction plate 6 is provided with anti-slip texture.

[0043] More specifically, in this embodiment: the magnetic connection allows each capsule holder 5 to fit more tightly with the perforated plate 4, thereby preventing liquid leakage and improving the accuracy of liquid separation. The anti-slip texture on the lower end of the magnetic plate 6 also makes the liquid separation device more stable, indirectly improving the accuracy of liquid separation during use.

[0044] The above embodiments are only used to illustrate the technical solutions of this utility model, and are not intended to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the protection scope of the technical solutions of the embodiments of this utility model.

Claims

1. A micro-liquid orifice plate liquid separator, comprising a cover plate (1), characterized in that: The upper end face of the cover plate (1) is provided with a feed pipe (2), and the upper end face of the cover plate (1) is also provided with a discharge pipe (3). The lower end face of the cover plate (1) is provided with a bent flow groove (12). The flow groove (12) is used to guide the liquid medicine entering from the feed pipe (2) to the discharge pipe (3) to complete the separation of the liquid medicine.

2. The micro-liquid orifice plate liquid separator according to claim 1, characterized in that, The lower end face of the cover plate (1) is provided with a magnetic suction groove (11), and a magnetic suction block (9) is provided at the lower end of the magnetic suction groove (11). A perforated plate (4) is fixedly connected to the lower end face of the magnetic suction block (9).

3. The micro-liquid orifice plate liquid separator according to claim 2, characterized in that, The upper end face of the perforated plate (4) is provided with a through trapezoidal groove (8), and the diameter of the end face of the trapezoidal groove (8) facing the cover plate (1) is larger than the diameter of the end face of the trapezoidal groove (8) away from the cover plate (1).

4. The micro-liquid orifice plate liquid separator according to claim 3, characterized in that, The inner wall of the perforated plate (4) is slidably connected to a capsule holder (5), and the upper surface of the capsule holder (5) is provided with an identification groove (10).

5. A micro-liquid orifice plate liquid separator according to claim 4, characterized in that, The trapezoidal grooves (8) are multiple in number and are evenly distributed on the upper surface of the perforated plate (4). The capsule frame (5) is provided with multiple collection slots (7) respectively, and the lower outlets of the multiple trapezoidal grooves (8) are respectively facing the multiple collection slots (7).

6. A micro-liquid orifice plate liquid separator according to claim 4, characterized in that, The lower end face of the capsule holder (5) is provided with a magnetic suction plate (6). The magnetic suction plate (6) is a rectangular plate. The upper end face of the magnetic suction plate (6) is tightly attached to the lower end face of the perforated plate (4) by magnetic attraction. The lower end face of the magnetic suction plate (6) is provided with anti-slip texture.

7. A micro-liquid orifice plate liquid separator according to claim 1, characterized in that, Both the feed pipe (2) and the discharge pipe (3) are cylindrical pipes, and both the feed pipe (2) and the discharge pipe (3) are provided with connecting flanges at their upper ends. The connecting flanges are used to connect with external pipes.

8. A micro-liquid orifice plate liquid separator according to claim 7, characterized in that, The flow channel (12) includes a first straight section, a bent section and a second straight section connected in sequence. The first straight section is connected to the lower end of the feed pipe (2) and the second straight section is connected to the lower end of the discharge pipe (3). The widths of the first straight section, the bent section and the second straight section are all the same.

Images