Hydrogel mold with improved curing effect and anti-crossing

Abstract

The utility model discloses a solidification effect promotes and the water gel mould of preventing the current, its characterized is, including the upper plate, the middle plate, the lower plate, the middle plate is opened and is fixed with the pipe body that passes through the through hole and goes up and down in the through hole, the upper plate is equipped with the sealing recess of cooperation pipe body upper end, the lower plate is equipped with the spherical convex of cooperation pipe body lower end, and the upper plate is closed when folding with the lower plate and blocks the pipe body upper and lower port, and the four corners of upper plate are equipped with the support and are clamped in the card seat four corners of middle plate through chucking structure, and the four corners of lower plate are equipped with the support and are clamped in the card seat four corners of middle plate through chucking structure (7), and the four corners outside of upper plate and lower plate still are equipped with the seat pad (6). This scheme is applicable to the multi-component water gel experimental scene, can promote the technical effect of photosensitive type and temperature -sensitive type water gel solidification efficiency and prevent the current before the technical effect of forming the glue, still has convenient to use, the characteristics of strong practicality.

Description

Technical Field

[0001] This technical solution relates to the field of hydrogel mold technology, specifically a hydrogel mold that improves curing effect and prevents crossflow. Background Technology

[0002] As is well known, it is often necessary to construct hydrogels with different components in hospital laboratories or simple industrial production. For example, in the repair of tissue defects (such as skin, cartilage, and nerve damage), it is necessary to construct hydrogel scaffolds with different components and achieve independent molding and precise composite through molds. Another example is when studying the degradation rate and drug loading capacity of hydrogels with different components as carriers for different drugs or cells.

[0003] All of the above experiments rely on hydrogel curing molds, but existing molds have many shortcomings. The closest prior art to this patent is Chinese patent application number 201720930016.1, which discloses a hydrogel curing mold. This patent uses a separate base plate and fixing plate, making the cured hydrogel easier to remove and facilitating photocuring of photosensitive hydrogels and high / low temperature curing of temperature-sensitive hydrogels. However, this technical solution has the following shortcomings: First, the mold does not consider multi-component (different components) hydrogel experimental scenarios. The fit between the base plate and fixing plate is not independently sealed. Before gelation, the hydrogel is in a liquid state and can easily flow through the gaps in the base plate between the through holes, leading to mixing and contamination of different hydrogel components and affecting the experimental results. Second, for photosensitive hydrogels, although the open structure of the mold is conducive to light exposure, the sealing is insufficient, resulting in light energy loss, which needs further optimization. Third, the mold lacks measurement capabilities, requiring additional tools to measure the hydrogel injection height during the experiment, which is cumbersome and increases experimental errors. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of existing technologies and provide a hydrogel mold with improved curing effect and anti-crossflow properties. It is suitable for multi-component hydrogel experiments, improves the curing efficiency of photosensitive and thermosensitive hydrogels, prevents liquid crossflow before gelation, and is easy to use and highly practical. The specific solution is as follows.

[0005] A hydrogel mold for improving curing effect and preventing crossflow includes an upper plate, a middle plate, and a lower plate. The middle plate has a through hole through which a tube is fixed. The upper plate has a sealing groove that matches the upper end of the tube. The lower plate has a spherical protrusion that matches the lower end of the tube. When the upper plate and the lower plate are closed, they seal the upper and lower ends of the tube. The four corners of the upper plate are provided with brackets and are locked in the four corners of the middle plate by a clamping structure. The four corners of the lower plate are provided with brackets and are locked in the four corners of the middle plate by a clamping structure. The outer sides of the four corners of the upper plate and the lower plate are also provided with cushions.

[0006] The tube body is marked with graduations.

[0007] The sealing groove is cylindrical and contains a sealing ring.

[0008] The specific structure of the sealing groove refers to the following: multiple through holes are distributed on the upper plate to fit the upper end of the tube body. A convex ring is provided at the through hole, and a cap is connected through the convex ring. The cap is concave to form a groove. The cap has a flat bottom and is threaded or interference-fitted to the through hole.

[0009] The aforementioned clamping structure refers to the presence of a matching arc-shaped protrusion and an arc-shaped groove on the interface between the bracket and the card seat.

[0010] This device is also equipped with a ejector pin assembly, which includes a base plate on which ejector pins (or ejector posts) that match the position of the tube body are provided. The ejector pin assembly has guide grooves at its four corners, which cooperate with the seat pad.

[0011] The tube matrix is ​​arranged in a horizontal matrix of 2-6 tubes and a vertical matrix of 4-8 tubes.

[0012] The inner diameter of the tube is 10-30mm.

[0013] The sealing material is polytetrafluoroethylene.

[0014] The upper, middle, and lower plates are made of transparent polycarbonate.

[0015] The scale line has a range of 0-15mm and a graduation value of 1mm.

[0016] Compared with the prior art, the technical effects of this utility model are as follows: 1. High flexibility of use: First, with the help of the four corner pads, it can be placed normally (top plate facing up) or flipped up (top plate facing down) according to the operation requirements; second, the disassembly method is flexible, and the top plate, bottom plate or cap can be removed separately. The cured hydrogel can be taken out in batches or individually, which is suitable for different experimental scenarios. 2. Convenient and precise operation: The scale lines on the outer wall of the tube can be used to directly read the hydrogel injection height, eliminating the need for additional measuring tools, reducing the difficulty of experimental operation, reducing errors, and meeting the needs of refined experiments; 3. Stable structure and good protection: The bracket and the card holder are clamped together to form a rectangular frame structure, which not only improves the overall stability of the device, but also protects the tube from damage. At the same time, the clamping design makes it easy to disassemble and install the upper or lower plate separately. 4. Significantly improved curing efficiency: On the one hand, the sealing is enhanced by the cap, sealing ring, and spherical protrusion, reducing the loss of light energy after the tube is closed; on the other hand, the side wall of the tube is fully exposed, allowing the hydrogel to have better contact with light or constant temperature solution, thus improving the curing effect. 5. Guaranteed experimental accuracy: The independent opening at the bottom of the tube is adapted to the sealing groove of the cap, realizing independent sealing of a single hydrogel molding cavity, effectively preventing different components of hydrogel solution from flowing and mixing through gaps before gelation, thus ensuring the accuracy of experimental results; 6. Wide range of applications: It meets the curing requirements of both temperature-sensitive and photosensitive hydrogels, and can satisfy multiple parallel experiments. It can be applied to laboratory and simple industrial production scenarios, making it highly practical. Attached Figure Description

[0017] Figure 1 This is a disassembled structural diagram of Embodiment 1 of this utility model; Figure 2 This is a three-dimensional structural diagram of Embodiment 1 of this utility model; Figure 3 This is a schematic diagram of the ejector pin assembly structure in Embodiment 1 of this utility model; Figure 4 This is a schematic diagram of the clamping structure in Embodiment 1 of this utility model; Figure 5 This is a schematic diagram of the first embodiment of the present invention when it is flipped for use.

[0018] Explanation of reference numerals in the attached drawings: 1 upper plate, 1-1 bracket, 2 middle plate, 2-1 card seat, 3 lower plate, 3-1 spherical protrusion, 4 tube body, 5 cap, 6 seat pad, 7 clamping structure, 8 ejector pin assembly, 8-1 ejector pin, 8-2 guide groove. Detailed Implementation

[0019] Example 1, see appendix Figure 1-4 A hydrogel mold for improving curing effect and preventing crossflow includes an upper plate 1, a middle plate 2, and a lower plate 3. The middle plate has a through hole and a tube 4 that runs vertically through the through hole is fixed therethrough. The upper plate has a sealing groove that matches the upper end of the tube. The lower plate has a spherical protrusion 3-1 that matches the lower end of the tube. When the upper plate and the lower plate are closed, the upper and lower ends of the tube are sealed. The four corners of the upper plate are provided with brackets 1-1 and are locked in the four corners of the middle plate with a clamping structure. The four corners of the lower plate are provided with brackets and are locked in the four corners of the middle plate with a clamping structure 7. The four corners of the upper plate and the lower plate are also provided with cushions 6.

[0020] The tube body is equipped with graduations. The graduation range is 0-15mm, with a division value of 1mm. This graduation can accurately meet the requirements for hydrogel height measurement without the need for additional tools.

[0021] The sealing groove is cylindrical and contains a sealing ring.

[0022] The specific structure of the sealing groove refers to the following: multiple through holes are distributed on the upper plate to fit the upper end of the tube body. A convex ring is provided at the through hole, and a cover 5 is connected through the convex ring. The cover is concave to form a groove. The cover has a flat bottom and is threaded or interference-fitted to the through hole.

[0023] The aforementioned clamping structure refers to the presence of a matching arc-shaped protrusion and an arc-shaped groove on the interface between the bracket and the card seat.

[0024] This device is also equipped with an ejector assembly 8, which includes a base plate with ejector pins 8-1 that match the position of the tube. The ejector assembly has guide grooves at its four corners, which engage with the seat pad. Technicians can use the ejector pins to quickly extrude batches of hydrogel formed inside the tube, and the guide grooves ensure precise positioning during hydrogel extrusion.

[0025] The tube matrix is ​​arranged in a matrix of 2-6 units horizontally and 4-8 units vertically. This distribution can accommodate the needs of multiple parallel tests in conventional experiments.

[0026] The inner diameter of the tube is 10-30mm. This ensures that the hydrogel has sufficient space for molding and is easy to handle.

[0027] The cap material is polytetrafluoroethylene (PTFE). This material reduces the adhesion of hydrogel to the cap wall, while improving the temperature resistance and durability of the base.

[0028] The upper, middle, and lower plates are made of transparent polycarbonate. This material does not block light, meeting the photocuring requirements of photosensitive hydrogels, and also facilitates observation of the curing process.

[0029] The spherical protrusions are made of elastic silicone. They can fit tightly against the tube opening when the cap is closed, increasing the seal.

[0030] Method 1 of this embodiment (curing of photosensitive hydrogel): like Figure 5 As shown, seal the cap, flip the device, open the tube at one end of the lower plate with the tube facing upward, and inject photosensitive hydrogels of different components into each tube to a height of 8 mm. Close the lower cover (at the top), first gently press to expel the air from the tube, then fully compact it to ensure that the spherical raised silicone layer fits tightly against the tube opening to form a sealed space; Place the mold under a UV lamp for 2 minutes; After the hydrogel has cured, turn off the UV lamp, open the bottom cover, unscrew the removable cap, and use the ejector pin assembly to remove the complete hydrogel. Alternatively, you can accurately record the hydrogel's molding height using the scale lines.

[0031] Method 2 of this embodiment (curing of temperature-sensitive hydrogel): like Figure 5 As shown, seal the cap, flip the device, open the tube at one end of the lower plate with the tube facing upward, and inject different components of temperature-sensitive hydrogel into each tube to a height of 8mm. First, gently press the top and bottom caps (at the top) to expel the air from the tube, then press them completely to ensure that the spherical raised silicone layer fits tightly against the tube opening, forming a sealed space. Leave at room temperature for 30 minutes (or pass constant temperature water through as needed) until the hydrogel has solidified. Then, open the bottom cover, unscrew the removable cap, and use the ejector pin assembly to remove the complete hydrogel.

[0032] Further explanation of the effects of this technology 1. The cushions at the four corners of the upper and lower plates of this device have the function of raising the plate, allowing it to be placed normally (upper plate facing up) or flipped over (upper plate facing down), making the device very flexible in use: (1) When removing the cap, we can place it normally for easy disassembly and maintenance; (2) During the hydrogel curing experiment, we can flip it over periodically as needed to ensure that the hydrogel is evenly exposed to light and heated. Since the cushions raise the plate, wear on the cap can be effectively avoided. Specific use is flexible as needed. The "upper" and "lower" in the component names of this technical solution are based on the attached... Figure 1 The placement direction is indicated to facilitate understanding of this patent in conjunction with the accompanying drawings, and does not limit the direction of use of this patent. 2. This device is convenient and flexible to use: (1) It can remove the upper plate to take out the cured hydrogel in batches, or remove the cap without removing the upper plate to take out the required cured hydrogel individually; (2) It can remove only the upper plate, or only the lower plate, or both the upper and lower plates at the same time, depending on the chemical properties of the hydrogel solution and the requirements; (3) The scale line on the outer wall of the tube can be used to directly read the hydrogel injection height without the need for additional measuring tools, reducing the difficulty and error of experimental operation and adapting to the needs of refined experiments; 3. The device has a stable structure: the bracket and the card holder are interlocked to form a rectangular frame structure, which not only enhances the overall stability but also protects the tube from damage. In addition, this interlocking method makes it easy to disassemble the upper or lower plate separately. 4. This device has high curing efficiency: (1) Firstly, it increases the sealing performance through various methods such as capping, sealing rings, and spherical protrusions, so that the light energy is not easily lost after the tube is closed; (2) Secondly, it fully exposes the side wall of the tube, which can fully contact the light or constant temperature solution, thus improving the curing effect. Through experiments, under the same conditions, this device can shorten the photosensitive curing time by about 40%; 5. This device solves the problem of multi-component crossflow: Through the adaptive design of the independent opening at the bottom of the tube and the sealing groove of the cap, an independent seal is achieved for each hydrogel molding cavity, effectively preventing the mixing of different hydrogel solutions through gaps before gelation, thus ensuring experimental accuracy. Simultaneously, it accommodates the curing requirements of both temperature-sensitive and photosensitive hydrogels, can meet the needs of multiple parallel experiments, and is suitable for laboratory and simple industrial production scenarios, demonstrating strong practicality. 6. If necessary, the middle plate can be numbered horizontally on the side wall (e.g., 1, 2, 3, 4, 5, 6) and vertically on the side wall (e.g., a, b, c, d). Each tube can be located by combining the numbers, which facilitates experimental recording.

Claims

1. A hydrogel mold with improved curing effect and anti-crossflow properties, characterized in that, It includes an upper plate (1), a middle plate (2), and a lower plate (3). The middle plate has a through hole and a tube (4) that runs vertically through the through hole is fixed therethrough. The upper plate has a sealing groove that matches the upper end of the tube. The lower plate has a spherical protrusion (3-1) that matches the lower end of the tube. When the upper plate and the lower plate are closed, the upper and lower ends of the tube are sealed. The four corners of the upper plate are provided with brackets (1-1) and are clamped in the card seats (2-1) at the four corners of the middle plate through a clamping structure. The four corners of the lower plate are provided with brackets and are clamped in the card seats at the four corners of the middle plate through a clamping structure (7). The four corners of the upper plate and the lower plate are also provided with cushions (6).

2. The hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The tube body is marked with graduations.

3. The hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The sealing groove is cylindrical and contains a sealing ring.

4. The hydrogel mold for improved curing effect and anti-crossflow as described in claim 3, characterized in that, The specific structure of the sealing groove is as follows: multiple through holes are distributed on the upper plate to fit the upper end of the tube body. A convex ring is provided at the through hole, and a cover (5) is connected through the convex ring. The cover is concave to form a groove. The cover has a flat bottom and is threaded or interference-fitted to the through hole.

5. The hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The aforementioned clamping structure refers to the presence of a matching arc-shaped protrusion and an arc-shaped groove on the interface between the bracket and the card seat.

6. The hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The device is also equipped with a ejector assembly (8), which includes a base plate and an ejector (8-1) that matches the position of the tube body.

7. The hydrogel mold for improved curing effect and anti-crossflow according to claim 6, characterized in that, The ejector pin assembly has guide grooves at its four corners, which cooperate with the seat pad.

8. The hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The tube matrix is ​​arranged in a horizontal matrix of 2-6 tubes and a vertical matrix of 4-8 tubes.

9. A hydrogel mold for improving curing effect and preventing crossflow according to claim 1, characterized in that, The spherical protrusions are made of elastic silicone.

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