Accurate feeding tube and mouse test accurate feeding device

Abstract

The utility model relates to the technical field of mouse drinking water test mainly discloses a kind of precision feeding tube and mouse test precision feeding device, including first storage pipe, it is equipped with sealing element in one end of liquid evaporation direction;Second storage pipe, it is equipped with feeding piece in one end of liquid natural release;The docking piece is connected the first storage pipe with second storage pipe;Wherein, the first storage pipe and second storage pipe are arranged at angle;Test box, the feeding connector is arranged in the test box top, at least one set of precision feeding tube is fixed on the feeding connector;The utility model solves the problem that existing feeding device cannot be adapted to IV system, and inconvenient to observe the problem of degree.

Description

Technical Field

[0001] This utility model relates to the technical field of mouse drinking water experiments, and in particular to a precision feeding tube and a precision feeding device for mouse experiments. Background Technology

[0002] In pharmacological, toxicological, and behavioral studies (such as the Drinking in the Dark, DID paradigm), precise measurement of fluid (water or ethanol solution) intake in mice is essential. Currently, the most common laboratory method uses ordinary water bottles, calculating consumption by weighing the bottles before and after alcohol consumption. However, this method has the following serious drawbacks when applied to modern IVC (Indoor Volunteer Care) systems:

[0003] 1. Incompatible with IVC systems: The IVC cages are enclosed designs with standardized feed troughs and water bottle interfaces. The reserved space cannot accommodate traditional ball-operated bottles, and measurements taken with the original bottles will have significant errors. For example, a DID (Dietary Intake Disorder) consumes approximately 1ml of alcohol per serving, while the compatible bottle is 300ml.

[0004] 2. Poor installation stability: The drinking interface of the IVC cage is a spring-loaded metal plate structure. The nozzles of traditional water bottles (whether ball-type or silicone stopper type) are not designed for this purpose and cannot form a reliable seal with the metal plate interface. This easily leads to liquid leakage from the interface gaps, contaminating the external environment of the cage and damaging the SPF barrier.

[0005] 3. Inconvenient observation and reading: IVC cages are usually stacked in multiple layers, and the water bottles fixed at the back are difficult to observe directly. Experimenters need to repeatedly pull out the cage to read the values, which is cumbersome and frequently disturbs the animals. Utility Model Content

[0006] Therefore, the technical problem to be solved by this utility model is that the existing feeding device cannot be adapted to the IV system and is not convenient for observing the degree.

[0007] The above-mentioned technical problems are solved by the following technical solution: This utility model proposes a precision feeding tube, which includes a first storage tube with a sealing element at one end in the direction of liquid evaporation; a second storage tube with a feeding element at the end where the liquid is naturally released; and a docking element connecting the first storage tube and the second storage tube; wherein the first storage tube and the second storage tube are arranged at an angle.

[0008] In a preferred embodiment of the precision feeding tube of this utility model: both the first storage tube and the second storage tube are provided with reading scales, and the first storage tube and the second storage tube are one of transparent glass and transparent plastic tubes.

[0009] In a preferred embodiment of the precision feeding tube of this utility model: a first liquid storage space is provided in the first storage tube, a second liquid storage space is provided in the second storage tube, and a third liquid storage space is provided in the docking member, wherein the first liquid storage space, the second liquid storage space and the third liquid storage space are interconnected.

[0010] In a preferred embodiment of the precision feeding tube of this utility model: the outer diameter of the first storage tube is equal to the outer diameter of the second storage tube; the connecting member is fixedly sleeved on the outside of the first storage tube and the second storage tube, or the connecting member is fixedly inserted into the first storage tube and the second storage tube.

[0011] In a preferred embodiment of the precision feeding tube of this utility model: the sealing element is provided with an installation groove, and the end of the first storage tube away from the second storage tube is sealed and inserted into the installation groove.

[0012] In a preferred embodiment of the precision feeding tube of this utility model: a fourth liquid storage space is provided inside the feeding component, the fourth liquid storage space is connected to the second liquid storage space, and a water guide bead is rolled and fixed at the end away from the second storage tube; the feeding component is fixedly sleeved outside the second storage tube; or, the feeding component is fixedly inserted into the second storage tube.

[0013] To address the aforementioned problems, the present invention also proposes the following technical solution: a precise feeding device for mouse experiments, comprising a precise feeding tube and a test chamber, wherein a feeding connector is provided on the top of the test chamber, and at least one set of precise feeding tubes is fixed on the feeding connector.

[0014] In a preferred embodiment of the present invention: the feeding connector includes a mounting plate and a plug tube fixed in the mounting plate, and at least one set of plug tubes is provided, and the feeding component is detachably plugged into and fixed in the plug tube.

[0015] In a preferred embodiment of this utility model: when one or more sets of precision feeding tubes are fixed on the feeding connector, a fixing sleeve is fixedly connected between the first storage tubes in two adjacent sets of precision feeding tubes.

[0016] In a preferred embodiment of this utility model: the insertion tube includes an inner end and an outer end, the inner diameter of the insertion tube tends to contract from the outer end to the inner end, and the inner end is always fixedly sleeved on the outside of the feeding device, and the water guide beads of the feeding device extend into the outer end of the box.

[0017] The beneficial effects of this utility model are as follows: This precision feeding tube and device are perfectly compatible with IVC systems. The shrinkable design and sealing structure of the feeding connector plug solve the leakage problem of traditional devices, ensuring the integrity of the SPF barrier. The storage tube has an adjustable angle and a compact size, which does not take up extra space in the cage. In addition, it has high measurement accuracy, with a transparent tube body and graduated scale, no sudden changes in the inner diameter of the liquid storage space, and low residue.

[0018] This device is highly safe, made of non-toxic and corrosion-resistant medical-grade materials, with water droplets sized to prevent mice from swallowing them, and a smooth surface that poses no risk of scratching. It is also highly practical, with multiple feeding tubes that can be combined using a fixed sleeve rod to accommodate different preference tests on a single mouse at the same time, facilitating efficient research in pharmacology, toxicology, and other fields. Attached Figure Description

[0019] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings of the embodiments of this utility model will be briefly described below. Obviously, the drawings described below only relate to some embodiments of this utility model and are not intended to limit the scope of this utility model. Wherein: Figure 1 The overall structure diagram of the precision feeding tube is shown; Figure 2 The diagram shows the structure of the first and second storage tubes of the precision feeding tube; Figure 3 A cross-sectional view of the precision feeding tube is shown; Figure 4 A diagram showing the connection method of the first storage tube, the second storage tube, and the docking component of the precision feeding tube is provided. Figure 5 A diagram showing the angle adjustment of the precision feeding tube is provided. Figure 6 The overall structure of the precise feeding device for mouse experiments is shown; Figure 7 A structural diagram of the feeding connector of the precise feeding device for mouse experiments is shown; Figure 8 The installation distribution diagram for multiple sets of precision feeding tubes is shown; Figure 9 The diagram shows the installation and fixation of the feeding component of the precise feeding device for mouse experiments. Detailed Implementation

[0020] To enable those skilled in the art to better understand this utility model, the present utility model will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0021] The terminology used in this invention refers to those general terms currently widely used in the art in consideration of the functionality of this invention; however, these terms may vary according to the intent, precedent, or new technology of those skilled in the art. Furthermore, specific terms may be chosen by the applicant, and in such cases, their detailed meanings will be described in the detailed description of this invention. Therefore, the terminology used in this specification should not be construed as simple names, but rather based on the meaning of the terms and the overall description of this invention.

[0022] Reference Figures 1-9 This embodiment provides a precision feeding tube G, which includes a first storage tube 100 with a sealing element 101 at one end in the direction of liquid evaporation; a second storage tube 200 with a feeding element 201 at the end where the liquid is naturally released; and a docking element 300 connecting the first storage tube 100 and the second storage tube 200. The first storage tube 100 and the second storage tube 200 are set at an angle, which can be set from 90° to 120°, so as to flexibly adapt to different installation positions in the IVC test chamber, avoid interference with other components in the chamber, and ensure that the liquid in the tube flows smoothly to the feeding element 201, reducing residue.

[0023] Specifically, both the first storage tube 100 and the second storage tube 200 are equipped with a reading scale A. The range of scale A is adapted to the single feeding volume requirements of mice, set to 0~5mL, with a minimum division value of 0.05mL. It is made using laser engraving technology, and the scale lines are black, forming a sharp contrast with the transparent tube wall, which makes it easy for experimental personnel to quickly and accurately read the remaining liquid volume and consumption.

[0024] The first storage tube 100 and the second storage tube 200 are either transparent glass or transparent plastic tubes. The transparent glass is preferably high borosilicate glass, which is resistant to alcohol corrosion, high temperature disinfection, and can withstand high-pressure sterilization at 121°C. The transparent plastic tube is preferably made of medical-grade PETG material, which is lightweight and impact-resistant. Both materials meet the national standard for biological evaluation of medical devices, ensuring that they are safe and non-toxic when in contact with liquids and mice.

[0025] The first storage tube 100 has a first liquid storage space B1, the second storage tube 200 has a second liquid storage space B2, and the docking part 300 has a third liquid storage space B3. The first liquid storage space B1, the second liquid storage space B2, and the third liquid storage space B3 are interconnected, and their inner diameters are consistent, preferably set to 5~8mm, to avoid liquid stagnation caused by sudden changes in inner diameter, to ensure that the liquid in the tube can flow completely to the feeding part 201, to reduce measurement errors, and to facilitate subsequent cleaning and disinfection, thereby reducing the risk of cross-contamination caused by liquid residue.

[0026] Furthermore, the outer diameter of the first storage tube 100 is equal to that of the second storage tube 200, which is set to 8~12mm, to facilitate the uniform adaptation and installation of the docking parts 300 and improve the versatility of the components; the docking parts 300 are fixedly sleeved on the outside of the first storage tube 100 and the second storage tube 200, or the docking parts 300 are fixedly inserted into the first storage tube 100 and the second storage tube 200.

[0027] If it is a socket connection, the inner wall of the connector 300 can be provided with two annular sealing ribs to fit tightly against the outer wall of the storage tube and prevent liquid leakage; if it is a plug connection, the outer wall of the insertion end of the connector 300 is coated with medical-grade sealant, which forms a gapless seal after curing. Both connection methods can ensure the airtightness of the liquid storage space and prevent liquid leakage from contaminating the test environment.

[0028] Furthermore, the sealing element 101 has an installation groove 101a, and the end of the first storage tube 100 away from the second storage tube 200 is sealed and inserted into the installation groove 101a. The sealing element 101 is preferably made of medical-grade butyl rubber with a Shore hardness of 50±5, which has good elasticity and sealing performance, effectively preventing the liquid inside the tube from evaporating, and can withstand repeated punctures, facilitating the replenishment of liquid. The inner diameter of the installation groove 101a and the outer diameter of the first storage tube 100 are interference fit, with a gap of ≤0.1mm. After insertion, a reliable seal can be achieved without the need for an additional sealing element, and there is no liquid leakage after being inverted for 10 minutes.

[0029] Furthermore, the feeding device 201 has a fourth liquid storage space B4, which is connected to the second liquid storage space B2. A water guide bead 201a is rolled and fixed at the end of the water guide bead 201a away from the second storage tube 200. The water guide bead 201a is preferably made of 304 stainless steel with a polished surface and a roughness Ra≤0.8μm. Its diameter is set to 2.5~3mm, which is larger than the diameter of the mouse esophagus. This can effectively prevent the mouse from swallowing the bead. At the same time, the bead can roll flexibly when the mouse licks it, controlling the liquid outflow rate. The single outflow volume is ≤0.1mL / lick, avoiding excessive liquid overflow.

[0030] The inner diameter of the fourth liquid storage space B4 is set to 2~3mm to match the size of the water guide bead 201a, ensuring that the liquid can evenly coat the water guide bead 201a for easy ingestion by mice. The feeding device 201 is fixedly sleeved outside the second storage tube 200; or, the feeding device 201 is fixedly inserted into the second storage tube 200. Both connection methods are sealed with medical glue to ensure that the liquid can only flow through the fourth liquid storage space B4 to the water guide bead 201a, without the risk of side leakage.

[0031] Furthermore, this embodiment also provides a precise feeding device for mouse experiments, which includes a precise feeding tube G and a test chamber 400. The test chamber 400 is a closed cage adapted to the IVC system, made of transparent PC board material, which has good light transmittance and impact resistance, making it easy to observe the activity status of mice, and at the same time meets the requirements of SPF-grade animal breeding environment.

[0032] The test chamber 400 is equipped with a feeding connector 401 on the top. At least one set of precision feeding tubes G is fixed on the feeding connector 401. The number of feeding tubes can be flexibly configured according to the test requirements. A single set is suitable for a single mouse. When there are multiple sets, different types of liquids, such as sugar water and alcohol, can be stored in the precision feeding tubes G to meet the licking preferences of a single mouse being tested at the same time.

[0033] Furthermore, the feeding connector 401 includes a mounting plate 401a and a plug tube 401b fixed inside the mounting plate 401a. The mounting plate 401a is a circular structure made of ABS engineering plastic and can be detachably fixed to the top of the test chamber 400 by screws, snap-fit ​​structure or interference fit, which facilitates later maintenance and replacement.

[0034] At least one set of insertion tubes 401b is provided, the number of which is the same as the number of precision feeding tubes G. The feeding component 201 is detachably inserted and fixed inside the insertion tube 401b. A silicone sealing ring can be provided at the insertion point to ensure the stability of the installation and to prevent the air inside and outside the test chamber 400 from communicating with each other, thus maintaining the integrity of the SPF barrier inside the chamber.

[0035] When one or more sets of precision feeding tubes G are fixed on the feeding connector 401, a fixing sleeve 402 is fixedly connected between the first storage tubes 100 in two adjacent sets of precision feeding tubes G. The fixing sleeve 402 is made of lightweight aluminum alloy, with a diameter of 3-4 mm and a length set according to the distance between adjacent storage tubes. It is detachably connected to the first storage tube 100 through a snap-fit ​​structure, which can enhance the overall stability of multiple sets of feeding tubes, prevent the feeding tubes from tilting or shifting due to mouse collisions, and ensure that the distance between each set of feeding tubes is uniform and does not affect the normal activities of the mice.

[0036] The insertion tube 401b includes an inner end C1 and an outer end C2. The inner diameter of the insertion tube 401b tends to narrow from the outer end C2 to the inner end C1. The inner diameter of the outer end C2 is set to 8~10mm to facilitate the insertion of the feeding device 201. The inner diameter of the inner end C1 is set to 5~7mm, and the inner end C1 is always fixedly sleeved on the outside of the feeding device 201. The step-like fixation of the feeding device 201 is achieved through the inner diameter narrowing structure, which improves the installation firmness. The water guide 201a of the feeding device 201 extends into the outer end C2, and the distance between the water guide 201a and the port of the outer end C2 is set to 2~3mm. This facilitates the mouse to lick the water guide 201a from inside the box and prevents the water guide 201a from being dragged by the mouse, which would cause the feeding device 201 to loosen.

[0037] Finally, it should be noted that the methods and devices described in detail above are merely embodiments, and those skilled in the art can modify these embodiments in different ways as long as they do not depart from the scope of this utility model.

Claims

1. A precision feeding tube (G), characterized in that: include, The first storage tube (100) has a sealing element (101) at one end in the direction of liquid evaporation. The second storage tube (200) has a feeding device (201) at the end where the liquid is naturally released. A docking component (300) connects the first storage tube (100) and the second storage tube (200). The first storage tube (100) and the second storage tube (200) are arranged at an angle.

2. The precision feeding tube according to claim 1, characterized in that: Both the first storage tube (100) and the second storage tube (200) are provided with reading scales (A). The first storage tube (100) and the second storage tube (200) are either transparent glass or transparent plastic tubes.

3. The precision feeding tube according to claim 1 or 2, characterized in that: The first storage tube (100) has a first liquid storage space (B1), the second storage tube (200) has a second liquid storage space (B2), and the docking part (300) has a third liquid storage space (B3). The first liquid storage space (B1), the second liquid storage space (B2) and the third liquid storage space (B3) are interconnected.

4. The precision feeding tube according to claim 1 or 2, characterized in that: The outer diameter of the first storage tube (100) is equal to the outer diameter of the second storage tube (200); The docking component (300) is fixedly sleeved on the outside of the first storage tube (100) and the second storage tube (200). Alternatively, the docking member (300) is fixedly inserted into the first storage tube (100) and the second storage tube (200).

5. The precision feeding tube according to claim 4, characterized in that: The sealing element (101) has an installation groove (101a) and the end of the first storage tube (100) away from the second storage tube (200) is sealed and inserted into the installation groove (101a).

6. The precision feeding tube according to claim 5, characterized in that: The feeding device (201) has a fourth liquid storage space (B4) which is connected to the second liquid storage space (B2). A water guide bead (201a) is rolled and fixed at the end of the feeding device (200) that is away from the second storage tube (200). The feeding component (201) is fixedly sleeved on the outside of the second storage tube (200); Alternatively, the feeding device (201) is fixedly inserted into the second storage tube (200).

7. A precise feeding device for mouse experiments, characterized in that: Including the precision feeding tube (G) as described in any one of claims 1 to 6, and further comprising, The test chamber (400) has a feeding connector (401) on its top, and at least one set of precision feeding tubes (G) are fixed on the feeding connector (401).

8. The precise feeding device for mouse experiments according to claim 7, characterized in that: The feeding connector (401) includes a mounting plate (401a) and a plug tube (401b) fixed in the mounting plate (401a). At least one set of plug tubes (401b) is provided. The feeding component (201) is detachably plugged into and fixed in the plug tube (401b).

9. The precise feeding device for mouse experiments according to claim 8, characterized in that: When one or more precision feeding tubes (G) are fixed on the feeding connector (401), a fixing sleeve (402) is fixedly connected between the first storage tubes (100) in two adjacent precision feeding tubes (G).

10. The precise feeding device for mouse experiments according to claim 8 or 9, characterized in that: The insertion tube (401b) includes an inner end (C1) and an outer end (C2). The inner diameter of the insertion tube (401b) tends to contract from the outer end (C2) to the inner end (C1). The inner end (C1) is always fixedly sleeved on the outside of the feeding device (201). The water guide beads (201a) of the feeding device (201) extend into the outer end (C2).

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