Sampling capsule and sampling system

Abstract

The utility model discloses a kind of sampling capsules and sampling systems thereof, the sampling capsule includes: shell, storage cavity is formed inside it;Sampling assembly includes: deformation piece, for flexible structure and enclose sampling cavity, the sampling cavity with the storage cavity are used to accommodate fluid sample in external environment;First check valve, controlled communication the sampling cavity with the external environment of the sampling capsule;And second check valve, controlled communication the sampling cavity with the storage cavity;And drive assembly, including being set in the shell permanent magnet, the permanent magnet is used to rotate in the shell in response to intermittent external magnetic field, drive the deformation piece occurs elastic deformation to change the pressure in the sampling cavity, to control further: (a) the first check valve opens, so that the fluid sample flows into the sampling cavity;Or (b) the second check valve opens, fluid sample in the sampling cavity is extruded and stored to the storage cavity.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a sampling capsule and sampling system. Background Technology

[0002] Due to their high reliability and safety, gastrointestinal sampling capsules have become an effective diagnostic tool for gastrointestinal diseases and have received high recognition in the international medical device field. Existing sampling capsules can be divided into active and passive sampling capsules based on their power source.

[0003] Existing active sampling capsules include a power supply unit, a camera unit, a data processing unit, and a wireless transmission unit. Swallowed orally by the subject, they can capture images of organs such as the stomach or intestines as they pass through the digestive tract. The captured information is then wirelessly transmitted to an external receiving device, which receives the data and displays it on a display screen. Under painless and non-invasive conditions during human gastrointestinal peristalsis, medical personnel can diagnose gastrointestinal diseases based on the images displayed on the screen.

[0004] The passive sampling capsule uses a biodegradable material to seal the negative pressure sampling tube inside the capsule. In a specific digestive fluid, the biodegradable material degrades, thereby drawing external substances into the negative pressure sampling tube, thus completing the sampling. This design utilizes the biodegradable material as a sampling trigger.

[0005] However, the intestinal environment is complex and not completely filled with digestive fluids. The sampling capsule is very prone to inhaling air, which occupies the space where digestive fluids are stored. The sampling capsule is generally disposable and cannot be used again after one sampling. This will result in insufficient or no digestive fluid samples, and the probability of successful sampling is extremely low, leading to sampling failure. Utility Model Content

[0006] In order to solve at least one of the above-mentioned technical problems existing in the prior art, this application provides a sampling capsule and a sampling system having the sampling capsule.

[0007] The first aspect of this application provides a sampling capsule, comprising: The casing has a storage cavity inside; Sampling components, including: The deformable component is a flexible structure that forms a sampling cavity, both of which are used to accommodate fluid samples from the digestive tract. A first one-way valve, controllably connecting the sampling chamber to the intestine of the sampling capsule; and A second one-way valve, controllably connecting the sampling chamber and the storage chamber; and The driving assembly includes a permanent magnet disposed within the housing, the permanent magnet being rotated within the housing in response to an intermittent external magnetic field, driving the deformable element to undergo elastic deformation to change the pressure within the sampling chamber, thereby controlling: (a) The first one-way valve opens under the pressure difference between the sampling chamber and the intestine, allowing the fluid sample to flow into the sampling chamber; or (b) The second one-way valve opens under the pressure difference between the sampling chamber and the storage chamber, and the fluid sample in the sampling chamber is squeezed and transferred to the storage chamber.

[0008] A second aspect of this application provides a sampling system including a sampling capsule as described above, and a control magnet and / or an electromagnetic coil for controlled generation of the external magnetic field.

[0009] The sampling capsule and sampling system provided in this application utilize an external magnetic field to control the torque output of a permanent magnet, driving the deformable component to produce elastic deformation, thereby dynamically adjusting the pressure in the sampling chamber and achieving the collection of fluid samples from the digestive tract. This magnetic drive mechanism places the sampling capsule in the category of passive medical devices, as its energy supply relies entirely on an external magnetic field. This fundamentally avoids the biosafety risks of active implants, reduces design complexity and cost, and enhances system safety. Even if the fluid sample in the sampling capsule leaks, it will only render the collected sample ineffective and will not affect the human body. Simultaneously, the intermittent external magnetic field can be controlled and repeatedly excited, enabling the sampling capsule to support on-demand repeated sampling at multiple anatomical sites in the digestive tract. The success rate can be improved by increasing the number of samplings. Combined with the high torque output generated by the rotation of the permanent magnet, which drives significant deformation of the deformable component, an effective negative pressure field is established within the sampling chamber, ensuring stable aspiration and storage of fluid samples. Attached Figure Description

[0010] The accompanying drawings are provided to further illustrate the embodiments of the present invention and constitute a part of the specification. They are used together with the following detailed description to explain the embodiments of the present invention, but do not constitute a limitation on the embodiments of the present invention. It should be noted that, in order to clearly illustrate the technical solutions of this application, some drawings are not drawn strictly according to the scale, and key parts have been enlarged or shifted.

[0011] Figure 1 This is a schematic diagram of the sampling system provided in the first embodiment of this application; Figure 2 for Figure 1 A schematic diagram of the three-dimensional structure of the sampling capsule shown; Figure 3 for Figure 2 The side view of the sampling capsule shown; Figure 4 for Figure 3 The diagram shows a cross-sectional view of the sampling capsule along line AA, where the sampling capsule is in a balanced and locked state. Figure 5 for Figure 2 The diagram shows the exploded structure of the sampling capsule; Figure 6 for Figure 5 The diagram shows the exploded structure of the sampling component and the first end cap. Figure 7 for Figure 5 The diagram shows the exploded structure of the middle section and the waterproof and breathable membrane. Figure 8 for Figure 3 The diagram shows a partial cross-sectional view of the sampling capsule along line AA, where the sampling capsule is in a transfer state. Figure 9 for Figure 3 The diagram shows a cross-sectional view of the sampling capsule along line AA, with the sampling capsule in a sampling state. Figure 10 for Figure 4 A schematic diagram of the three-dimensional structure of the bracket shown; Figure 11 for Figure 4 The diagram shows the structure after the bracket and the first end cap are combined. Figure 12 Showing Figure 4 The flow direction of the fluid sample in the sampling assembly shown; Figure 13 It shows Figure 4 The flow direction of the fluid sample in the sampling capsule is shown. To clearly show the flow direction, the first end cap of the sampling capsule has been removed. Figure 14 for Figure 3 The schematic diagram of the cross-sectional structure of the sampling capsule along line BB shows the flow direction of gas in the storage chamber; Figure 15 for Figure 14 The schematic diagram of the sampling capsule in the intestine shows the force relationship and movement trend of the sampling capsule in the intestine when the permanent magnet rotates; Figure 16 This is a schematic diagram of the permanent magnet torque output verification experiment in this application, which specifically shows the layout of the core components for torque generation under the condition of permanent magnet rotation. Figure 17 This is a schematic diagram of the sampling system provided in the second embodiment of this application; Figure 18 for Figure 17 A schematic diagram of the three-dimensional structure of the sampling capsule shown; Figure 19for Figure 18 The side view of the sampling capsule shown; Figure 20 for Figure 19 The cross-sectional view of the sampling component and related parts in the sampling capsule shown in the figure along the CC direction (with the second end cap and drive component removed) shows that the deformable part is in an uncompressed state. Figure 21 for Figure 19 The cross-sectional view of the sampling capsule along the CC direction is shown, with the sampling capsule in a transfer state; Figure 22 for Figure 19 The cross-sectional view of the sampling capsule along the CC direction is shown, with the sampling capsule in a sampling state. Figure 23 for Figure 18 The diagram shows the exploded structure of the sampling capsule; Figure 24 for Figure 22 The diagram shows a cross-sectional view of the exhaust check valve during exhaust.

[0012] Icon labels: 1000, Sampling system; 2000, External environment; 2100, Fluid sample; 100. Sampling capsule; 101. Axial direction; 110. Housing; 102. Storage cavity; 111. First end cap; 112. Second end cap; 113. Intermediate section; 115. Sampling port; 116. Exhaust port; 120. Sampling component; 130. Deformable component; 132. Sampling chamber; 135. Support; 136. Sampling channel; 137. Transfer channel; 138. Gap; 140. First check valve; 141. First sealing ring; 142. First sealing ball; 143. First spring; 144. First gap; 150. Second check valve; 151. Second sealing ring; 152. Second sealing ball; 153. Second spring; 154. Second gap; 160. Drive assembly; 161. Support frame; 162. Permanent magnet; 163. Rotating shaft; 170. One-way exhaust system; 200. Sampling capsule; 202. Storage chamber; 210. Shell; 211. First end cap; 212. Second end cap; 213. Intermediate section; 215. Sampling port; 216. Vent hole; 217. Through hole; 218. Liquid outlet; 219. Sealing component; 220. Sampling component; 230. Deformable component; 232. Sampling chamber; 240. First check valve; 241. First sealing ring; 242. First sealing ball; 243. First spring; 244. First gap; 250. Second check valve; 251. Second sealing ring; 252. Second sealing ball; 253. Second spring; 254. Second gap; 260. Drive component; 262. Permanent magnet; 270. One-way exhaust component; 271. Third sealing ring; 272. Third sealing ball; 273. The third spring; 274. The third gap; 662. Permanent magnet; 663. Rotating shaft; 700. Weight; 800. Control magnet; 850. Rotating shaft; 900. Control magnet. Detailed Implementation

[0013] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.

[0014] The technical solution of this patent will be further described in detail below with reference to specific embodiments.

[0015] The embodiments of this patent are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this patent, and should not be construed as limiting this patent.

[0016] In the description of this patent, it should be understood that the terms “center,” “upper,” “lower,” “front,” “back,” “left,” “right,” “vertical,” “horizontal,” “top,” “bottom,” “inner,” and “outer,” etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this patent and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this patent.

[0017] In the description of this patent, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "setting" should be interpreted broadly. For example, they can refer to a fixed connection or setting, a detachable connection or setting, or an integral connection or setting. Those skilled in the art can understand the specific meaning of the above terms in this patent according to the specific circumstances.

[0018] Please see Figure 1 This application provides a sampling system 1000, which includes a sampling capsule 100 and a control magnet 900. The control magnet 900 is used to generate an external magnetic field by rotating in a controlled manner, thereby using the external magnetic field to drive the sampling capsule 100 to collect digestive fluid in the digestive tract.

[0019] The Sampling Capsule 100 is a swallowable miniature medical device used for non-invasive collection of digestive fluids from the intestines, followed by in vitro recovery for subsequent analysis. The Sampling Capsule 100 enables precise sampling without interfering with normal physiological processes, providing crucial samples for the diagnosis of digestive system diseases, microbiome research, and metabolic analysis.

[0020] Please combine Figure 1 See Figures 2 to 7 The sampling capsule 100 provided in this application includes: The housing 110 has a storage cavity 102 formed inside it; Sampling component 120 includes: The deformable component 130 is a flexible structure that surrounds the sampling cavity 132. Both the sampling cavity 132 and the storage cavity 102 are used to accommodate the fluid sample 2100 in the external environment 2000. The first one-way valve 140 is controlled to connect the sampling chamber 132 to the external environment 2000 of the sampling capsule 100; and The second one-way valve 150 is controlled to connect the sampling chamber 132 and the storage chamber 102; and The drive assembly 160 includes a permanent magnet 162 disposed within the housing. The permanent magnet 162 rotates within the housing 110 in response to an intermittent external magnetic field, driving the deformable member 130 to undergo elastic deformation to change the pressure within the sampling chamber 132, thereby controlling: (a) The first one-way valve 140 opens under the pressure difference between the sampling chamber 132 and the external environment 2000, allowing the fluid sample 2100 to flow into the sampling chamber 132; or (b) The second one-way valve 150 is opened under the action of the pressure difference between the sampling chamber 132 and the storage chamber 102, and the fluid sample 2100 in the sampling chamber 132 is squeezed and transferred to the storage chamber 102.

[0021] In the sampling capsule 100 and sampling system 1000 provided in this application, the torque output of the permanent magnet 162 is controlled by an external magnetic field, driving the deformable component 130 to produce elastic deformation, thereby dynamically adjusting the pressure of the sampling chamber 132 and realizing the collection of digestive tract fluid samples 2100. This magnetic drive mechanism makes the sampling capsule 100 fall into the category of passive medical devices, as its energy supply depends entirely on the external magnetic field, fundamentally avoiding the biosafety risks of active implants, reducing design complexity and cost, with only structural costs, and higher system safety. Even if the fluid sample 2100 in the sampling capsule 100 leaks, it will only cause the collected sample to become invalid and will not affect the human body. At the same time, the intermittent external magnetic field can be controlled and repeatedly excited, enabling the sampling capsule 100 to support on-demand repeated sampling at multiple anatomical sites in the digestive tract. The success rate can be improved by increasing the number of samplings. Combined with the high torque output generated by the rotation of the permanent magnet 162, the deformable component 130 is driven to deform significantly, ensuring the establishment of an effective negative pressure field in the sampling chamber 132, realizing the stable aspiration and transfer of fluid samples 2100.

[0022] The external environment 2000 refers to the external medium space in which the sampling capsule 100 is located, typically including biological or physical fields such as the digestive tract cavity and open atmospheric environment. The sampling capsule 100 provided in this application is particularly suitable for collecting digestive fluids in the intestine.

[0023] The intestinal environment is complex and not completely filled with digestive fluids. The sampling capsule 100 is highly susceptible to air intake, which occupies the space for storing digestive fluids (sampling chamber 132 and / or storage chamber 102). If the sampling capsule's power source is disposable, it cannot be used for sampling again after the first sampling, resulting in insufficient or no digestive fluid sample, and an extremely low probability of successful sampling.

[0024] In this application, the sampling capsule 100 is magnetically driven to sample using an external magnetic field, thereby achieving the active sampling function of the sampling capsule 100. Specifically, after the subject swallows the sampling capsule 100, the control magnet 900 is controlled to undergo intermittent rotation to generate an external magnetic field. That is, the rotation of the control magnet 900 is paused and segmented, generating an intermittent external magnetic field, which drives the sampling capsule 100 to perform on-demand repeated sampling at multiple anatomical sites in the intestine, helping to improve the sampling success rate. For example, through experience or other methods, it is determined that after the sampling capsule 100 enters the intestine, the control magnet 900 is driven to rotate in multiple discontinuous time periods, thereby enabling the sampling capsule 100 to sample at different anatomical sites, which helps to ensure the amount of digestive fluid sampled and improves the success rate of digestive fluid collection.

[0025] The time interval and duration of the sequentially generated external magnetic fields can be set as needed, and the number of times the external magnetic fields are generated during the entire process of the sampling capsule inside the subject's body can also be set as needed. In some embodiments, after the subject swallows the sampling capsule 100, 5-10 external magnetic fields can be generated, with each external magnetic field lasting for 3-5 minutes, and the time interval between sequentially generated external magnetic fields can be 10-20 minutes.

[0026] like Figure 1 As shown, in the embodiments provided in this application, the control magnet 900 is a permanent magnet that can be controlled to rotate in any direction to generate an external magnetic field. The control magnet 900 shown in the figure is a circular magnet that can rotate about any axis of symmetry. In other embodiments, the control magnet 900 can be a square magnet, a horseshoe magnet, a ring magnet, or have other regular or irregular shapes. In some embodiments, the control magnet 900 may include an electromagnetic coil for generating the external magnetic field. In some embodiments, the control magnet 900 may include both an electromagnetic coil for generating the external magnetic field and the control magnet.

[0027] The deformable component 130 is a flexible structure capable of elastic deformation under the drive of the permanent magnet 162. A flexible structure refers to a structure that can undergo significant deformation without breaking under external force. Elastic deformation of the deformable component 130 means that after the external force applied by the permanent magnet 162 is removed, the deformable component 130 returns to its original shape. This satisfies the requirement of repeated sampling by the sampling capsule 100 and the controllable volume change of the sampling chamber 132, thus conforming to the pressure difference driving mechanism between the first one-way valve 140 and the second one-way valve 150. In this embodiment, the deformable component 130 is an elastic structure and can be made of a biocompatible flexible material such as silicone, and can be a soft rubber airbag.

[0028] The permanent magnet 162 drives the deformable part 130 to undergo elastic deformation. Specifically, the permanent magnet 162 gradually approaches and squeezes the deformable part 130, causing the volume of the sampling cavity 132 inside the deformable part 130 to gradually decrease and the pressure to gradually increase. After the permanent magnet 162 squeezes the deformable part 130 to its limit position, it gradually moves away and reduces the pressure on the deformable part 130. During the elastic recovery process of the deformable part 130, the volume inside the sampling cavity 132 gradually increases and the pressure gradually decreases until the deformable part 130 returns to its original shape. The control magnet 900 is used to periodically generate an external magnetic field to control the permanent magnet 162 to periodically adjust the volume of the sampling cavity 132 enclosed by the deformable part 130 and its internal pressure, so as to drive the first one-way valve 140 or the second one-way valve 150 to open, thereby realizing the collection and transfer of fluid sample 2100.

[0029] Please see Figure 16 , can be adopted Figure 16The experiment shown verifies the magnitude of the torque output by the rotational motion of permanent magnet 162: A permanent magnet 662 is provided and fixed to a rotation axis 663. Permanent magnet 662 is suitable for use in sampling capsules and can be a single-sided truncated circular magnet with a diameter of 8-10 mm and a thickness of 2-3 mm. A traction wire is fixed to the surface of permanent magnet 662 along a direction perpendicular to the rotation axis 663, with a 20g weight 700 suspended at its end. A control magnet 800 is provided, which is equivalent to... Figure 1 The control magnet 900 is used for controlled rotation around its rotation axis 850. The control magnet 800 weighs 10KG and can be a circular magnet as shown in the figure, or a permanent magnet of other shapes, which is not limited here. The distance between the permanent magnet 662 and the rotation center of the control magnet 800 is 0.2m. When the control magnet 800 is driven to rotate around the rotation axis 850, the permanent magnet 662 is coupled through an external magnetic field. It was observed that the permanent magnet 662 rotates around the rotation axis 663, and drives the weight 700 to rise continuously. Based on the above experimental parameters, it can be inferred that the torque generated by the permanent magnet 662 is large enough to overcome the weight of at least 20g of weight 700, which is sufficient to drive the deformable part 130 to undergo significant deformation.

[0030] The sampling capsule 100 can be in a balanced locked state or an operating state.

[0031] In the balanced lockout state, both the first check valve 140 and the second check valve 150 are closed, and the sampling capsule 100 does not sample or transfer the fluid sample 2100.

[0032] In operation, an external magnetic field drives the permanent magnet 162 to rotate, adjusting the deformation degree of the deformable part 130, so that the sampling capsule 100 is in either sampling or storage mode. In sampling mode, the inlet of the sampling chamber 132 is open, i.e., the first one-way valve 140 is open, allowing the fluid sample 2100 to flow from the external environment 2000 into the sampling chamber 132 through the first one-way valve 140. In storage mode, the outlet of the sampling chamber 132 is open, i.e., the second one-way valve 150 is open, allowing the fluid sample 2100 to flow from the sampling chamber 132 into the storage chamber 102 through the second one-way valve 150.

[0033] like Figures 2 to 4 As shown, Figure 4 for Figure 3 The cross-sectional view of the sampling capsule 100 along line AA is shown, in which the sampling capsule 100 is in a balanced locked state.

[0034] The sampling capsule 100 is capsule-shaped with two opposite ends, the ends of which are rounded for swallowing. The axial direction 101 of the sampling capsule 100, i.e., its axis, passes through the geometric centers of both ends of the sampling capsule 100. The dimension of the sampling capsule 100 along the axial direction 101 is larger than the diameter of the sampling capsule 100.

[0035] like Figures 2 to 4 As shown, the shell 110 of the sampling capsule 100 includes a first end cap 111, a middle section 113, and a second end cap 112 connected in sequence. The first end cap 111 and the second end cap 112 are respectively disposed at one end of the sampling capsule 100, and the first end cap 111 and the second end cap 112 are respectively connected to one end of the middle section 113. In some embodiments, the shell 110 may be formed by splicing two or more sections.

[0036] The sampling component 120 is disposed at the end of the sampling capsule 100, and the permanent magnet 162 is used to rotate around the rotation axis 163, which is parallel to the radial direction of the permanent magnet 162 (including the case where the rotation axis 163 and the permanent magnet 162 coincide in any radial direction).

[0037] The rotating shaft 163 is parallel to the radial direction of the permanent magnet 162, used to improve the efficiency of the permanent magnet 162 in driving the deformation member 130 to deform. The permanent magnet 162 can be at least partially circular, toroidal, square, or horseshoe-shaped. Specifically, the radial direction of the permanent magnet 162 is as follows: If the permanent magnet 162 is at least partially circular or annular, the radial direction of the permanent magnet 162 is the diameter direction of the at least partially cylindrical body containing the outer contour of the permanent magnet 162.

[0038] If the permanent magnet 162 is at least a partially square magnet, then the radial direction of the permanent magnet 162 passes through the smallest surface of the square magnet and the other surface opposite it.

[0039] If the permanent magnet 162 is at least partially a horseshoe magnet, then the radial direction of the permanent magnet 162 passes through the opening between the two ends of the horseshoe magnet.

[0040] The rotation axis 163 is set at an angle to the axis 101 of the sampling capsule 100, that is, the rotation axis 163 and the axis 101 are not parallel, and the angle between the rotation axis 163 and the axis 101 is greater than 0 degrees and less than 180 degrees. In this embodiment, the rotation axis 163 and the axis 101 are perpendicular to each other.

[0041] Please see Figure 15The rotating shaft 163 is parallel to the radial direction of the permanent magnet 162 and is angled to the axial direction 101 of the sampling capsule 100. The deformable part 130 at least partially covers the cross-section of the sampling capsule 100, so that during the rotation of the permanent magnet 162 around the rotating shaft 163, the permanent magnet 162 contacts and presses the two edge portions of the deformable part 130, generating a torque that rotates in the direction of the first end cap 111 and the second end cap 112, specifically as follows: Figure 15 As shown, the first end cap 111 moves towards the bottom of the external environment 2000, and the second end cap 112 moves towards the top of the external environment 2000, causing the sampling capsule 100 to generate a tendency to tumble with its two ends.

[0042] If the sampling capsule 100 is in an open space or a large space such as the stomach, and the inner wall of the environment cannot effectively constrain the end of the sampling capsule 100, the two ends of the sampling capsule 100 will roll up and down alternately, causing the sampling capsule 100 to tumble in the space. As a result, the permanent magnet 162 cannot squeeze the deformable part 130, and cannot form a pressure difference to achieve sampling and transfer of the fluid sample 2100.

[0043] However, if the sampling capsule 100 moves into the intestine, the narrow space inside the intestine will restrict the rolling motion of both ends of the sampling capsule 100, so that the sampling capsule 100 can only move with the peristalsis of the intestine. This avoids the problem that the permanent magnet 162 cannot squeeze the deformable part 130 and thus cannot sample when it rotates. The torque output by the permanent magnet 162 can be successfully applied to the deformable part 130, driving the deformable part 130 to undergo elastic deformation.

[0044] Please combine Figure 5 See Figure 8 and Figure 9 , Figure 8 for Figure 3 The diagram shows a partial cross-sectional view of the sampling capsule 100 along line AA, where the sampling capsule 100 is in a transfer state. Figure 9 for Figure 3 The diagram shows a cross-sectional view of the sampling capsule 100 along line AA, where the sampling capsule 100 is in a sampling state.

[0045] A change in the external magnetic field drives the permanent magnet 162 inside the sampling capsule 100 to rotate, triggering the sampling capsule 100 to enter either a transfer state or a sampling state. In the transfer state, the fluid sample 2100 in the sampling chamber 132 is squeezed into the storage chamber 102; in the sampling state, the fluid sample 2100 in the external environment 2000 flows into the sampling chamber 132.

[0046] The permanent magnet 162 is at least a partially circular magnet. In this embodiment, the permanent magnet 162 is a circular magnet with a single-sided cut edge. In other embodiments, the permanent magnet 162 can be a complete circular magnet, a circular magnet with symmetrical double-sided cut edges, or other symmetrical polygonal magnets.

[0047] In this embodiment, the permanent magnet 162 is magnetized along the axial direction. In other modified embodiments, the magnetization direction of the permanent magnet 162 can be adjusted as needed, such as radial magnetization.

[0048] In this embodiment, the permanent magnet 162 is a neodymium iron boron magnet, which is lighter and stronger than a ferrite magnet of the same volume, and can respond sensitively to external magnetic fields. In some embodiments, the permanent magnet 162 is of grade N52 or higher.

[0049] like Figure 5 As shown, in this embodiment, the drive assembly 160 includes a support frame 161, which is rotatably connected to the housing 110. The support frame 161 carries a permanent magnet 162 and is used to follow the rotation of the permanent magnet 162 relative to the housing 110. In this embodiment, the support frame 161 and the inner wall of the housing 110 are engaged by a mating concave-convex structure.

[0050] Specifically, the permanent magnet 162 is fixed to the support frame 161. During the assembly of the sampling capsule 100, firstly, the middle section 113 of the shell 110 is squeezed, causing the middle section 113 to deform slightly. At this time, the end of the support frame 161 can be engaged with the inner wall of the middle section 113. This ensures that the support frame 161, which carries the permanent magnet 162, can rotate under the influence of an external magnetic field. The rotation direction of the permanent magnet 162 is determined by the change in the external magnetic field and the direction of the rotation axis 163.

[0051] In the modified embodiment, the permanent magnet 162 is provided with an end that is rotatably connected to the housing 110, so that the permanent magnet 162 can be directly installed on the housing 110, and the drive assembly 160 can avoid the need to provide a support frame 161.

[0052] like Figure 4 , Figure 5 , Figure 8 as well as Figure 9As shown, the housing 110 is provided with a sampling port 115 that extends through its thickness direction to the first one-way valve 140. The sampling port 115 is connected to the first one-way valve 140. The first one-way valve 140 is provided with a first sealing ring 141, a first sealing ball 142 and a first spring 143 in sequence along the direction from the outer surface of the housing 110 to the sampling chamber 132. The first spring 143 is used to press the first sealing ball 142 against the first sealing ring 141. When the forces on both sides of the first sealing ball 142 are balanced, the first spring 143 maintains the pressing state between the first sealing ball 142 and the first sealing ring 141, so that the first one-way valve 140 is closed.

[0053] Along the direction from the sampling chamber 132 to the storage chamber 102, the second one-way valve 150 is provided with a second sealing ring 151, a second sealing ball 152 and a second spring 153 in sequence. The second spring 153 is used to press the second sealing ball 152 against the second sealing ring 151. When the forces on both sides of the second sealing ball 152 are balanced, the second spring 153 maintains the pressing state between the second sealing ball 152 and the second sealing ring 151, so that the second one-way valve 150 is closed.

[0054] The first sealing ring 141 and the second sealing ring 151 are elastic and can be made of materials such as rubber, which facilitates tight contact with the corresponding sealing ball, ensuring the sealing performance of the first one-way valve 140 and the second one-way valve 150, and reducing the tolerance requirements of the mating parts.

[0055] like Figure 4 As shown, in the balanced locked state, the first sealing ball 142 is pressed against the first sealing ring 141, and the second sealing ball 152 is pressed against the second sealing ring 151, meaning that both the first one-way valve 140 and the second one-way valve 150 are closed. Before the sampling capsule 100 is put into use, the pressure in each space of the sampling capsule 100 is basically the same as the ambient atmospheric pressure.

[0056] like Figure 8 As shown, the external magnetic field drives the permanent magnet 162 to rotate, compressing the deformable part 130, which increases the pressure in the sampling chamber 132, pushing the second sealing ball 152 away from the second sealing ring 151 to form the second gap 154. The second one-way valve 150 opens, and the sampling capsule 100 enters the transfer state. The fluid sample 2100 in the sampling chamber 132 is squeezed and flows into the storage chamber 102 from the second gap 154. The first sealing ball 142 moves closer to the first sealing ring 141, and the first one-way valve 140 closes.

[0057] That is, the permanent magnet 162 rotates and squeezes the deformed part 130, compressing the volume of the sampling cavity 132, increasing the degree of compression of the deformed part 130, reducing the volume of the sampling cavity 132, increasing the internal pressure, forming high-pressure gas (relative to the ambient atmospheric pressure), and generating positive pressure.

[0058] In the direction from the sampling chamber 132 to the storage chamber 102, the second sealing ball 152 is subjected to a thrust from the high-pressure gas in the sampling chamber 132, and in the opposite direction, the second sealing ball 152 is subjected to the elastic force of the second spring 153 and the pressure from the gas in the storage chamber 102. When the deformation of the deformable part 130 is large enough and the pressure inside the sampling chamber 132 is large enough, the second sealing ball 152 is pushed by the high-pressure gas, which is greater than the sum of the elastic force of the second spring 153 and the pressure of the gas in the storage chamber 102. Then the high pressure of the sampling chamber 132 pushes the second sealing ball 152 open, and a second gap 154 ​​is formed between the second sealing ball 152 and the second sealing ring 151. The outlet of the sampling chamber 132 (the second one-way valve 150) opens, the sampling capsule 100 enters the transfer state, and the fluid sample 2100 can be continuously transferred from the sampling chamber 132 to the storage chamber 102 until the forces on both sides of the second sealing ball 152 are balanced, the second spring 153 pushes the second sealing ball 152 to press against the second sealing ring 151, and the second one-way valve 150 closes.

[0059] In the transfer state, along the direction from sampling chamber 132 to sampling port 115, the first sealing ball 142 is subjected to the elastic force of the first spring 143, as well as the pressure of high-pressure gas from sampling chamber 132 in the same direction. Based on the balanced locking state (the first sealing ball 142 is pressed against the first sealing ring 141), the pressure of the high-pressure gas in sampling chamber 132 will cause the first sealing ball 142 to press the first sealing ring 141 even tighter. The inlet of sampling chamber 132 (first one-way valve 140) is in a sealed state, and the fluid sample 2100 in the external environment 2000 cannot enter the sampling capsule 100. When both the first one-way valve 140 and the second one-way valve 150 are closed, the sampling capsule 100 switches from the transfer state to the balanced locking state.

[0060] like Figure 9 As shown, the external magnetic field drives the permanent magnet 162 to rotate, moving it away from the deformable part 130, which reduces the pressure in the sampling chamber 132. This attracts the first sealing ball 142 to move away from the first sealing ring 141, forming the first gap 144. The first one-way valve 140 opens, and the sampling capsule 100 enters the sampling state. The fluid sample 2100 in the external environment 2000 flows into the sampling chamber 132 from the first gap 144. The second sealing ball 152 moves closer to the second sealing ring 151, and the second one-way valve 150 closes.

[0061] That is, as the permanent magnet 162 rotates away from the deformable part 130, the deformable part 130 elastically recovers, the degree of compression of the deformable part 130 decreases, the volume of the sampling cavity 132 gradually increases, the internal pressure gradually decreases, and a negative pressure is formed.

[0062] At this time, in the direction from sampling port 115 to sampling chamber 132, the first sealing ball 142 is subjected to the suction force from the negative pressure in sampling chamber 132 and the pressure of the external environment 2000. In the opposite direction, the first sealing ball 142 is subjected to the elastic force of the first spring 143. When the sum of the suction force on the first sealing ball 142 and the pressure of the external environment 2000 is greater than the elastic force of the first spring 143, the first sealing ball 142 is attracted away from the first sealing ring 141, forming the first gap 144. The first one-way valve 140 opens, the sampling capsule 100 enters the sampling state, and the fluid sample 2100 in the external environment 2000 is drawn into the sampling chamber 132 from the first one-way valve 140. In the sampling state, the fluid sample 2100 continuously flows into the sampling chamber 132 from sampling port 115 until the forces on both sides of the first sealing ball 142 are balanced. The first spring 143 pushes the first sealing ball 142 to press against the first sealing ring 141, and the first one-way valve 140 closes.

[0063] When the transfer state ends and the system enters the balanced lockout state, the volume of the sampling chamber 132 is compressed to its minimum, the second sealing ball 152 presses against the second sealing ring 151, and the second one-way valve 150 closes. After switching from the balanced lockout state to the sampling state, the volume of the sampling chamber 132 gradually increases, and the positive pressure on the second sealing ball 152 is converted into a negative pressure. The negative pressure causes the second sealing ball 152 to press the second sealing ring 151 even tighter, and the second one-way valve 150 remains sealed, preventing the transfer of the fluid sample 2100.

[0064] After the sampling process is completed, both the first one-way valve 140 and the second one-way valve 150 are closed, and the sampling capsule 100 enters a balanced lock-up state.

[0065] Based on the above analysis, we can conclude that: During sampling, the first one-way valve 140 is open and the second one-way valve 150 is closed.

[0066] In the transfer state, the first one-way valve 140 is closed and the second one-way valve 150 is open.

[0067] In the balanced lockout state, the first check valve 140 is closed and the second check valve 150 is closed.

[0068] An external magnetic field can continuously control the rotation of the permanent magnet 162. The sampling capsule 100 will repeat the next working cycle, from the transfer state to the balance lock state, then to the acquisition state, then to the balance lock state, and so on.

[0069] like Figure 7As shown, in this embodiment, the sampling capsule 100 further includes a one-way vent 170, which connects the storage cavity 102 to the external environment 2000. The shell 110 forms a vent 116 corresponding to the one-way vent 170. The storage cavity 102 is used to store the collected digestive fluid. The fluid sample 2100 flowing into the storage cavity 102 may contain collected gas, which needs to be discharged through the one-way vent 170 to avoid the problem of insufficient space for storing digestive fluid caused by gas occupying space in the storage cavity 102. The gas in the fluid sample 2100 in the storage cavity 102 can be discharged to the external environment 2000 through the one-way vent 170 without occupying the space of the storage cavity 102, thus improving the fault tolerance and success rate of sampling.

[0070] like Figure 4 and Figure 7 As shown, both gas and digestive fluid in fluid sample 2100 may be drawn into sampling chamber 132 and transferred to storage chamber 102. The digestive fluid in fluid sample 2100 has a higher density than gas and is stored at the bottom of storage chamber 102, while gas is stored at the top of storage chamber 102. As sampling capsule 100 rotates and tumbles randomly in the digestive tract, the relative positions of digestive fluid and gas in storage chamber 102 with respect to fixed points on shell 110 (such as vent 116) also change accordingly.

[0071] Because the one-way vent 170 has the characteristic of venting but blocking liquid flow, its venting aperture is relatively small. If the sampling capsule 100 only has one one-way vent 170, and the digestive fluid just happens to cover the one-way vent 170 and the vent hole 116, with the small venting aperture of the one-way vent 170, neither the digestive fluid nor the gas in the storage cavity 102 can flow out from the one-way vent 170. This causes the pressure inside the storage cavity 102 to gradually increase, the permanent magnet 162 will be unable to compress the deformable part 130, the second one-way valve 150 will be unable to open again, and the transfer of the fluid sample 2100 will fail, resulting in a failure of the transfer function. Furthermore, the sampling capsule 100 will also be unable to continue sampling. If the amount of gas randomly sampled inside the sampling capsule 100 is too large, it will lead to insufficient digestive fluid collection and sampling failure. In other words, the sampling capsule 100 having only one one-way vent 170 easily causes the transfer function of the sampling capsule 100 to fail, significantly impacting the sampling success rate.

[0072] like Figure 7As shown in the embodiment of this application, the sampling capsule 100 includes two unidirectional exhaust elements 170, and the structures of the two unidirectional exhaust elements 170 may be the same or different. Each unidirectional exhaust element connects the storage cavity 102 to the external environment 2000, and the shell 110 forms exhaust holes 116 corresponding to the unidirectional exhaust elements 170. The angle between the geometric centers of the two unidirectional exhaust elements 170 and the circumference of the sampling capsule 100 is greater than 90 degrees.

[0073] In this embodiment, the two unidirectional exhaust elements 170 are arranged opposite each other in the circumferential direction of the sampling capsule 100, that is, the angle between the geometric centers of the two unidirectional exhaust elements 170 and the circumferential direction of the sampling capsule 100 is 180 degrees. Correspondingly, the exhaust holes 116 formed by the housing 110 are also arranged opposite each other. In some other embodiments, the angle between the geometric centers of the two unidirectional exhaust elements 170 and the circumferential direction of the sampling capsule 100 is 120 degrees, 150 degrees, or other angles, which can improve the success rate of exhaust from the storage cavity 102 while avoiding interference between the unidirectional exhaust elements 170 and other components.

[0074] Two one-way exhaust pipes 170 are provided to ensure that at least one one-way exhaust pipe 170 is not submerged by the digestive fluid collected in the storage chamber 102. The gas in the storage chamber 102 will be stably discharged from the unsubmerged one-way exhaust pipe 170. As the digestive fluid is continuously transferred to the storage chamber 102, when the storage chamber 102 is full of digestive fluid, the pressure inside the storage chamber 102 gradually increases, making it impossible for the second one-way valve 150 to open again, preventing transfer, and therefore the sampling capsule 100 cannot enter the sampling state again.

[0075] Therefore, under this working mechanism, the sampling capsule 100 can automatically identify whether the sample collection process has been completed. That is, after the storage cavity 102 is filled with digestive fluid, the sampling capsule 100 cannot enter the sampling and storage state, and the sampling capsule 100 will not enter the working state again.

[0076] In this embodiment, the two unidirectional exhaust elements 170 occupy the same area along the axial direction 101 of the sampling capsule 100, that is, the two unidirectional exhaust elements 170 are positioned identically along the axial direction 101 of the sampling capsule 100. In some other embodiments, the two unidirectional exhaust elements 170 occupy different areas along the axial direction 101 of the sampling capsule 100, thereby improving the success rate of venting from the storage cavity 102 when the sampling capsule 100 is tilted.

[0077] like Figure 4 , Figure 7 and Figure 14As shown, at least one unidirectional exhaust element 170 is a waterproof and breathable membrane. When the pressure inside the storage cavity 102 is greater than the pressure of the external environment, the gas inside the storage cavity 102 passes through the waterproof and breathable membrane and the exhaust hole 116 to enter the external environment 2000. The liquid in the storage cavity 102 cannot pass through the waterproof and breathable membrane and remains inside the storage cavity 102.

[0078] During operation, as the sampling and transfer processes are repeated, more and more fluid samples 2100 are discharged into the storage chamber 102, and the pressure inside the storage chamber 102 gradually increases until the one-way exhaust device 170 opens to exhaust the fluid. An intermittent external magnetic field drives the sampling capsule 100 to repeatedly sample, and the one-way exhaust device 170 can also open intermittently as the pressure inside the storage chamber 102 changes.

[0079] In other modified embodiments, the exhaust direction of the one-way exhaust device 170 is bidirectional. The gas in the storage cavity 102 can be discharged to the external environment 2000 through the one-way exhaust device 170, and the gas in the external environment 2000 can also enter the storage cavity 102 through the one-way exhaust device 170, thereby maintaining the pressure of the storage cavity 102 consistent with that in the external environment 2000.

[0080] like Figure 4 and Figure 5 As shown, in this embodiment, the sampling capsule 100 includes two sampling components 120, which are respectively disposed at one end of the sampling capsule 100. The posture of the sampling capsule 100 in the intestine is uncertain. This structure with sampling components 120 at both ends can ensure that the sampling port 115 corresponding to any sampling component 120 is immersed in the digestive fluid and may be sucked into the sampling capsule 100, thereby improving the sampling efficiency and success rate.

[0081] The housing 110 includes a middle section 113 disposed between its two ends. The middle section 113 and two deformable members 130 located on both sides of it together form a storage cavity 102. An exhaust port 116 is formed in the middle section 113. A waterproof and breathable membrane covers the exhaust port 116. A drive assembly 160 is disposed in the storage cavity 102. When the permanent magnet 162 rotates, it can drive the two deformable members 130 located on both sides of it to undergo elastic deformation.

[0082] like Figure 4As shown, two sampling components 120 are respectively disposed at one end of the sampling capsule 100. The sampling capsule 100 does not have a driving component 160 and a storage cavity 102 corresponding to each sampling component 120. Specifically, the two sampling components 120 share a driving component 160 and a storage cavity 102. That is, the same driving component 160 is used to realize the sampling and transfer of samples from the two sampling components 120. The fluid samples in the two sampling cavities 132 are all transferred to the same storage cavity 102, which simplifies the structure of the sampling capsule 100, makes it easier to reduce the difficulty of structural design, and reserves a large space margin for the permanent magnet 162, sampling cavity 132, storage cavity 102 and other structures, thereby improving the reliability of sample collection and transfer and the sampling success rate.

[0083] like Figure 4 and Figure 5 As shown, the first end cap 111 is fixedly connected to a sampling component 120, and the second end cap 112 is fixedly connected to another sampling component 120. Both the first end cap 111 and the second end cap 112 can rotate relative to the middle section 113, which facilitates the flexible adjustment of the relative positions of the two first one-way valves 140 on the circumference as needed when assembling the sampling capsule 100. For example, the two first one-way valves 140 can be set relative to each other or spaced at a certain angle in the circumferential direction of the sampling capsule 100, which is beneficial to improving the sample collection efficiency.

[0084] In some modified embodiments, the first end cap 111, the intermediate section 113 and the second end cap 112 are fixedly connected in sequence. For example, after the sampling capsule 100 is assembled, the connection between the first end cap 111 and the intermediate section 113, and the connection between the intermediate section 113 and the second end cap 112 are fixed by adhesive bonding, thereby fixing the relative positions of the two first one-way valves 140 in the sampling capsule 100.

[0085] Since the sampling capsule 100 provided in this application can perform multiple samplings, in an embodiment where the sampling capsule 100 has only one sampling component 120, as long as the number of samplings is sufficient, a sufficient amount of digestive fluid can be collected.

[0086] When assembling the sampling capsule 100, the waterproof and breathable membrane can first be pasted onto the inner wall of the middle section 113 to cover the vent 116 formed by the middle section 113. The middle section 113 is squeezed to deform it slightly, and then the support frame 161 carrying the permanent magnet 162 is installed on the inner wall of the middle section 113, so that the support frame 161 carrying the permanent magnet 162 can rotate under the action of an external magnetic field.

[0087] Please combine Figure 4 and Figure 6 See Figure 10 and Figure 11Each sampling component 120 includes a bracket 135, the periphery of which is fixed to the inner wall of the housing 110. In this embodiment, the first end cap 111 is fixedly connected to the periphery of the bracket 135 of one sampling component 120, and the second end cap 112 is fixedly connected to the periphery of the bracket 135 of another sampling component 120, which can be achieved by means of adhesive or snap-fit.

[0088] Each bracket 135 forms a sampling channel 136 and a transfer channel 137, wherein a first one-way valve 140 is housed in the sampling channel 136 and a second one-way valve 150 is housed in the transfer channel 137. The end of the deformable member 130 is sealed to one side surface of the bracket 135, thereby enabling the sampling cavity 132 to communicate with both the sampling channel 136 and the transfer channel 137. Specifically, the end of the deformable member 130 is sealed to the surface of the bracket 135 facing the drive assembly 160, and the sampling port 115, sampling channel 136, sampling cavity 132, transfer channel 137, and storage cavity 102 are sequentially connected.

[0089] A notch 138 is formed around the periphery of the bracket 135. After the bracket 135 is fixed to the inner wall of the housing 110, the notch 138 connects the transfer channel 137 and the storage cavity 102.

[0090] Please combine Figure 4 See Figure 12 and Figure 13 , Figure 12 and Figure 13 The flow direction of the fluid sample 2100 in the sampling capsule 100 is shown. Based on the working principle of the first one-way valve 140 and the second one-way valve 150, it can be known that the fluid sample 2100 can only flow in one direction. Driven by the drive component 160, the sampling component 120 realizes the collection and transfer of the fluid sample 2100. The fluid sample 2100 enters the storage chamber 102 from the external environment 2000 through the sampling port 115, the sampling channel 136 and the first one-way valve 140, the sampling chamber 132, the transfer channel 137 and the second one-way valve 150, and the notch 138.

[0091] Please see Figures 17 to 24 The sampling system 1000 provided in the second embodiment of this application includes a sampling capsule 200 and a control magnet 900 as described in the first embodiment. The main differences between the sampling capsule 200 and the sampling capsule 100 provided in the first embodiment are as follows. The similarities between the sampling capsule 200 and the sampling capsule 100 provided in the first embodiment will not be described here.

[0092] In this embodiment, the one-way exhaust component 270 is implemented differently from the one-way exhaust component 170 in the first embodiment. The one-way exhaust component 270 adopts a valve structure. Specifically, in the sampling capsule 200, at least one one-way exhaust component 270 is an exhaust one-way valve. Along the direction from the storage cavity 202 to the outer surface of the shell 210, the exhaust one-way valve is sequentially provided with a third sealing ring 271, a third sealing ball 272, and a third spring 273. The third spring 273 is used to press the third sealing ball 272 against the third sealing ring 271. When the forces on both sides of the third sealing ball 272 are balanced, the third spring 273 maintains the pressing state between the third sealing ball 272 and the third sealing ring 271, thereby closing the exhaust one-way valve.

[0093] like Figure 24 As shown, as the amount of fluid sample flowing into the storage cavity 202 increases, the internal pressure of the storage cavity 202 increases, pushing the third sealing ball 272 away from the third sealing ring 271 to move away from the third sealing ring 271, forming a third gap 274, which causes the one-way exhaust device 270 to open, and the fluid sample 2100 in the storage cavity 202 is squeezed and flows into the external environment 2000 from the third gap 274.

[0094] like Figure 24 As shown, in the direction from the storage cavity 202 to the exhaust port 216, the third sealing ball 272 is subjected to the high pressure thrust of the storage cavity 202. In the opposite direction, the third sealing ball 272 is subjected to the sum of the elastic force of the third spring 273 and the pressure in the external environment 2000. When the pressure in the storage cavity 202 is large enough, that is, the thrust applied to the third sealing ball 272 is large enough, so that the thrust from the storage cavity 202 on the third sealing ball 272 is greater than the sum of the elastic force of the third spring 273 and the pressure in the external environment 2000, a third gap 274 is formed between the third sealing ball 272 and the third sealing ring 271. The third gap 274 forms a channel connecting the storage cavity 202 and the external environment 2000. The gas in the storage cavity 202 is discharged from the third gap to the external environment 2000 preferentially over the digestive fluid. Then, the fluid sample 2100 in the sampling cavity 232 can continue to be transferred to the storage cavity 202.

[0095] In this embodiment, all of the multiple one-way exhaust elements 270 employ the valve structure described above. It is understood that in other embodiments, only one of the multiple one-way exhaust elements 270 employs the valve structure described above, while the other one-way exhaust elements 270 may employ other valve structures not mentioned in this application or the waterproof and breathable membrane provided in the first embodiment.

[0096] In this embodiment, as long as the thrust from the storage cavity 202 on the third sealing ball 272 is greater than the sum of the elastic force of the third spring 273 and the pressure in the external environment 2000, the third sealing ball 272 will tend to move away from the third sealing ring 271, thereby forming the third gap 274.

[0097] The gas in fluid sample 2100 has lower viscosity and surface tension than the digestive fluid, making it easier to pass through narrow pores. Furthermore, when only one unidirectional vent 270 forms a narrow pore in storage cavity 202, the outflow of digestive fluid will reduce the internal pressure of storage cavity 202. When digestive fluid submerges the unidirectional vent 270, fluid from the external environment 2000 cannot quickly replenish storage cavity 202 through the narrow pore, leading to a pressure imbalance inside and outside storage cavity 202, creating resistance and preventing digestive fluid from flowing out through the narrow third slit 274 formed by the unidirectional vent 270. Meanwhile, gas, due to its high fluidity, can quickly enter and exit through the narrow pore, balancing the pressure inside and outside storage cavity 202, a pressure difference that the viscous digestive fluid struggles to overcome. Therefore, for the same one-way exhaust device 270, when the third gap 274 has just been formed and the gap is small, the gas in the storage cavity 202 is easier to expel than the digestive fluid. When the gas pressure inside and outside the storage cavity 202 can be quickly balanced, the one-way exhaust device 270 can be closed in time, thereby retaining as much digestive fluid as possible in the storage cavity 202. This is beneficial to ensure that the sampling capsule 200 can collect a sufficient amount of digestive fluid and improve the sampling success rate.

[0098] The geometric centers of the two unidirectional venting elements 270 in the sampling capsule 200 are at an angle greater than 90 degrees in the circumferential direction of the sampling capsule 200, and occupy different areas in the axial direction of the sampling capsule 200. Therefore, when one unidirectional venting element 270 of the sampling capsule 200 is immersed in the digestive fluid in the storage cavity 202, the other unidirectional venting element 270 is likely surrounded by gas. The gas in the storage cavity 202 can be discharged from the unidirectional venting element 270 that is not submerged in the digestive fluid, providing storage space for the storage cavity 202 to store more fluid samples 2100. Specifically, one unidirectional venting element 270 is located at one end of the sampling capsule 200, and the first end cap 211 is provided with a vent hole 216 corresponding to the unidirectional venting element 270. The other unidirectional venting element 270 is located away from the unidirectional venting element 270 located at the end in both the axial and circumferential directions of the sampling capsule 200. In this embodiment, the other one-way exhaust member 270 is disposed radially inside the middle section 213, and the middle section 213 is provided with an exhaust hole 216 corresponding to the other one-way exhaust member 270.

[0099] In this embodiment, the sampling capsule 200 includes only one sampling component 220. The sampling component 220 and the driving component 260 are respectively disposed at one end of the sampling capsule 200. The shell 210 includes a second end cap 212, which is disposed corresponding to the driving component 260. The second end cap 212 forms a through hole 217 that extends through its thickness direction. Therefore, during the process of the permanent magnet 262 in the driving component 260 changing the elastic deformation of the deformable part 230, the interior of the shell 210 can be connected to the external environment 2000 through the through hole 217. The pressure inside the shell 210 is consistent with the pressure of the external environment 2000, ensuring the reliability of the elastic deformation of the deformable part 230. This avoids the problem that the output torque of the permanent magnet 262 cannot drive the deformable part 230 to continue to undergo elastic deformation due to the change in air pressure inside the shell 210 after the deformable part 230 undergoes elastic deformation.

[0100] like Figures 20 to 23 As shown, the sampling component 220 is disposed on the left side of the sampling capsule 200, and the driving component 260 is disposed on the right side of the sampling capsule 200. The sampling component 220 includes a first one-way valve 240, a second one-way valve 250, and a deformable member 230. The storage cavity 202 is disposed on the side of the deformable member 230 opposite to the driving component 260. One one-way exhaust member 270 is disposed at the end of the first end cap 211, and another one-way exhaust member 270 is disposed on the side wall of the sampling capsule 200, specifically in the middle section 213.

[0101] The shell 210 of the sampling capsule 200 is also provided with a liquid extraction port 218, which is connected to the storage cavity 202. The sampling capsule 200 has a sealing member 219 inside the liquid extraction port 218 that can be pierced by a syringe needle. The sealing member 219 is made of soft materials such as silicone or rubber, so that after the sampling capsule 200 is discharged from the body, the sealing member 219 can be pierced by a syringe needle to draw up the collected fluid sample 2100 for testing.

[0102] like Figures 20 to 23 As shown, similar to the first embodiment, the first one-way valve 240 is provided with a first sealing ring 241, a first sealing ball 242 and a first spring 243 in sequence along the direction from the outer surface of the housing 210 to the sampling chamber 232. The first spring 243 is used to press the first sealing ball 242 against the first sealing ring 241. The housing 210 has a sampling port 215 corresponding to the first one-way valve 240. When the forces on both sides of the first sealing ball 242 are balanced, the first spring 243 maintains the pressing state between the first sealing ball 242 and the first sealing ring 241, so that the first one-way valve 240 is closed.

[0103] Along the direction from the sampling chamber 232 to the storage chamber 202, the second one-way valve 250 is provided with a second sealing ring 251, a second sealing ball 252 and a second spring 253 in sequence. The second spring 253 is used to press the second sealing ball 252 against the second sealing ring 251. When the forces on both sides of the second sealing ball 252 are balanced, the second spring 253 maintains the pressing state between the second sealing ball 252 and the second sealing ring 251, so that the second one-way valve 250 is closed.

[0104] An external magnetic field drives the permanent magnet 262 to rotate, adjusting the degree of deformation of the deformable part 230, so that the sampling capsule 100 is in a sampling state or a storage state.

[0105] like Figure 21 As shown, the permanent magnet 262 rotates and compresses the deformed part 230, increasing the pressure inside the sampling chamber 232. This pushes the second sealing ball 252 away from the second sealing ring 251, forming a second gap 254. The second one-way valve 250 opens, and the sampling capsule enters the transfer state. The fluid sample 2100 inside the sampling chamber 232 is compressed and flows into the storage chamber 202 from the second gap 254. The first sealing ball 242 moves closer to the first sealing ring 241, and the first one-way valve 240 closes. Or like Figure 22 As shown, the permanent magnet 262 rotates away from the deformable part 230, which reduces the pressure in the sampling chamber 232, attracting the first sealing ball 242 away from the first sealing ring 241 to move, forming the first gap 244. The first one-way valve 240 opens, the sampling capsule enters the sampling state, and the fluid sample 2100 in the external environment flows into the sampling chamber 232 from the first gap 244. The second sealing ball 252 moves closer to the second sealing ring 251, and the second one-way valve 250 closes.

[0106] For specific implementation details of the above-mentioned devices, please refer to the detailed description of the above method embodiments, which will not be repeated here.

[0107] The optional embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present utility model, various simple modifications can be made to the technical solutions of the present utility model, and these simple modifications all fall within the protection scope of the present utility model.

[0108] It should also be noted that the various specific technical features described in the above embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the various possible combinations will not be described separately in this embodiment.

[0109] Furthermore, various different implementation methods of this utility model can be arbitrarily combined, as long as they do not violate the spirit of this utility model, they should also be regarded as the content disclosed by this utility model.

Claims

1. A sampling capsule, characterized in that, include: The casing has a storage cavity inside; Sampling components, including: The deformable component is a flexible structure that forms a sampling cavity, both of which are used to contain fluid samples from the external environment; A first one-way valve, controllably connecting the sampling chamber to the external environment of the sampling capsule; and A second one-way valve, controllably connecting the sampling chamber and the storage chamber; and The driving assembly includes a permanent magnet disposed within the housing, the permanent magnet being rotated within the housing in response to an intermittent external magnetic field, driving the deformable element to undergo elastic deformation to change the pressure within the sampling chamber, thereby controlling: (a) The first one-way valve opens under the pressure difference between the sampling chamber and the external environment, allowing the fluid sample to flow into the sampling chamber; or (b) The second one-way valve opens under the pressure difference between the sampling chamber and the storage chamber, and the fluid sample in the sampling chamber is squeezed and transferred to the storage chamber.

2. The sampling capsule as described in claim 1, characterized in that, The sampling capsule is capsule-shaped, the sampling assembly is disposed at the end of the sampling capsule, the permanent magnet is used to rotate around a rotation axis, the rotation axis is parallel to the radial direction of the permanent magnet and is angled to the axial direction of the sampling capsule, and the deformable member at least partially covers the cross-section of the sampling capsule; and / or The permanent magnet is at least partially circular; and / or The permanent magnet is magnetized axially or radially; and / or The permanent magnet is a neodymium iron boron magnet.

3. The sampling capsule as described in claim 1 or 2, characterized in that, The first one-way valve is provided with a first sealing ring, a first sealing ball, and a first spring in sequence along the direction from the outer surface of the housing to the sampling chamber. The first spring is used to press the first sealing ball against the first sealing ring. When the forces on both sides of the first sealing ball are balanced, the first spring maintains the pressing state between the first sealing ball and the first sealing ring, thereby closing the first one-way valve. The second one-way valve is provided with a second sealing ring, a second sealing ball, and a second spring in sequence along the direction from the sampling chamber to the storage chamber. The second spring is used to press the second sealing ball against the second sealing ring. When the forces on both sides of the second sealing ball are balanced, the second spring maintains the pressing state between the second sealing ball and the second sealing ring, thereby closing the second one-way valve. The external magnetic field drives the permanent magnet to rotate, adjusting the degree of deformation of the deformable part, so that the sampling capsule is in a sampling state or a storage state. The permanent magnet rotates and compresses the deformable part, increasing the pressure inside the sampling chamber. This pushes the second sealing ball away from the second sealing ring, forming a second gap. The second one-way valve opens, and the sampling capsule enters the storage state. The fluid sample inside the sampling chamber is compressed and flows into the storage chamber through the second gap. The first sealing ball moves closer to the first sealing ring, and the first one-way valve closes. Or The permanent magnet rotates away from the deformable part, causing the pressure in the sampling chamber to decrease. This attracts the first sealing ball away from the first sealing ring, forming a first gap. The first one-way valve opens, and the sampling capsule enters the sampling state. The fluid sample from the external environment flows into the sampling chamber from the first gap. The second sealing ball moves closer to the second sealing ring, and the second one-way valve closes.

4. The sampling capsule as described in any one of claims 1-2, characterized in that, The sampling capsule also includes two one-way exhaust pipes, each of which connects the storage cavity to the external environment. The shell forms exhaust holes that correspond one-to-one with the one-way exhaust pipes. The angle between the geometric centers of the two one-way exhaust pipes in the circumferential direction of the sampling capsule is greater than 90 degrees.

5. The sampling capsule as described in claim 4, characterized in that, The two unidirectional exhaust components occupy different areas along the axial direction of the sampling capsule.

6. The sampling capsule as described in claim 4, characterized in that, At least one of the unidirectional exhaust components is a waterproof and breathable membrane. When the pressure inside the storage cavity is greater than the pressure of the external environment, the gas inside the storage cavity can pass through the waterproof and breathable membrane and the exhaust hole into the external environment.

7. The sampling capsule as described in claim 6, characterized in that, The sampling capsule includes two sampling components, which are respectively disposed at one end of the sampling capsule. The shell includes a middle section disposed between its two ends. The middle section and the two deformable members located on both sides of it together form the storage cavity. The vent is formed in the middle section. The waterproof and breathable membrane covers the vent. The driving component is disposed in the storage cavity. When the permanent magnet rotates, it can drive the two deformable members located on both sides of it to undergo elastic deformation.

8. The sampling capsule as described in claim 7, characterized in that, The housing also includes a first end cap and a second end cap respectively connected to one end of the intermediate section. The first end cap and the second end cap are respectively disposed at one end of the sampling capsule. The first end cap is fixedly connected to one of the sampling components, and the second end cap is fixedly connected to another sampling component. Both the first end cap and the second end cap are rotatable relative to the intermediate section.

9. The sampling capsule as described in claim 4, characterized in that, At least one of the one-way venting components is a one-way venting valve. The one-way venting valve is provided with a third sealing ring, a third sealing ball, and a third spring in sequence along the direction from the storage cavity to the outer surface of the housing. The third spring is used to press the third sealing ball against the third sealing ring. When the forces on both sides of the third sealing ball are balanced, the third spring maintains the pressing state between the third sealing ball and the third sealing ring, thereby closing the one-way venting valve. As the amount of fluid sample flowing into the storage cavity increases, the internal pressure of the storage cavity increases, pushing the third sealing ball away from the third sealing ring to form a third gap, which causes the one-way exhaust device to open, and the fluid sample in the storage cavity is squeezed and flows into the external environment from the third gap.

10. The sampling capsule as described in claim 9, characterized in that, The sampling capsule includes a sampling component, and the sampling component and the driving component are respectively disposed at one end of the sampling capsule. The shell includes a second end cap, which is disposed corresponding to the driving component, and the second end cap forms a through hole in its thickness direction.

11. The sampling capsule as described in claim 3, characterized in that, Each of the sampling components includes a bracket, the periphery of which is fixed to the inner wall of the housing. The bracket forms a sampling channel and a transfer channel, wherein a first one-way valve is housed in the sampling channel and a second one-way valve is housed in the transfer channel. The end of the deformable member is sealed to one side surface of the bracket, thereby enabling the sampling cavity to communicate with the sampling channel and the transfer channel.

12. The sampling capsule as described in claim 11, characterized in that, The sampling capsule includes two sampling components, which are respectively disposed at one end of the sampling capsule. The shell includes a middle section disposed between its two ends. The middle section and the two deformable members located on both sides of it together form the storage cavity. The driving component is disposed in the storage cavity. When the permanent magnet rotates, it can drive the two deformable members located on both sides of it to undergo elastic deformation. A notch is formed around the periphery of the bracket, and the notch connects the transfer channel and the storage cavity.

13. A sampling system, characterized in that, Includes a sampling capsule as described in any one of claims 1-12, and a control magnet and / or an electromagnetic coil, said control magnet and / or said electromagnetic coil being used to controllably generate said external magnetic field intermittently.

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