A device for cooling and crystallizing nicotinamide mononucleotide

Abstract

The utility model provides a kind of nicotinamide mononucleotide cooling crystallization device, it is related to nicotinamide mononucleotide preparation technical field, including crystallization kettle, the pipeline is connected with crystallization kettle, the pipeline is connected with pneumatic diaphragm pump in one end away from crystallization kettle, the pneumatic diaphragm pump is connected with centrifuge by pipeline, the centrifuge is provided with liquid outlet, the utility model is not directly discharged by mother liquor after centrifugal separation, but the fine filter effectively intercepts residual fine crystal and small particle therein, and the purified mother liquor is all backflowed to crystallization kettle by circulating pump, realizes the depth extraction of residual solute in mother liquor and the recycling of solvent, forms the intensified extraction process, significantly improves the final crystallization yield of nicotinamide mononucleotide, fully exploits the residual value of mother liquor, while greatly reduces the consumption of fresh solvent and the processing cost of subsequent waste liquid, realizes the double promotion of economic benefit and environmental benefit.

Description

Technical Field

[0001] This invention relates to the field of nicotinamide mononucleotide preparation technology, and in particular to a nicotinamide mononucleotide cooling crystallization device. Background Technology

[0002] The core function of the nicotinamide mononucleotide cooling crystallization device is to promote the efficient precipitation of nicotinamide mononucleotide dissolved in the solution into crystal form by precisely controlling the solution temperature. During the crystallization process, the device slowly reduces the material temperature to make the solution reach a supersaturated state, creating ideal conditions for the formation and growth of crystal nuclei. This process can effectively separate the target product from impurities, significantly improve the purity and crystal quality of the product, thereby meeting the needs of subsequent processing and high-quality applications.

[0003] The existing equipment has an inaccurate temperature control curve during the cooling crystallization process, which can easily cause local overcooling or uneven cooling rate. This results in a wide crystal size distribution and a high proportion of fine crystals, affecting the uniformity of the final product and filtration efficiency. Scale is easily generated on the tank wall and internal components, which not only reduces heat transfer efficiency and requires frequent shutdowns for cleaning, but may also peel off and become impurities. The solution supersaturation lacks effective online monitoring and relies heavily on manual experience, causing fluctuations in batch stability and product yield, making it difficult to meet high-standard production requirements. Utility Model Content

[0004] The purpose of this invention is to overcome the shortcomings of the existing technology and provide a nicotinamide mononucleotide cooling crystallization device.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a nicotinamide mononucleotide cooling crystallization device, comprising a crystallization vessel, the crystallization vessel being connected to a pipe, a pneumatic diaphragm pump being connected to the end of the pipe away from the crystallization vessel, the pneumatic diaphragm pump being connected to a centrifuge through a pipe, the centrifuge being provided with a liquid outlet, the liquid outlet being connected to a circulation pump through a pipe, a precision filter being connected to the side of the circulation pump away from the centrifuge through a pipe, and the precision filter being connected to the crystallization vessel through a pipe.

[0006] In a preferred embodiment, one end of the crystallization vessel is connected to a motor, the motor is connected to a transmission rod, and the transmission rod is connected to a stirring baffle.

[0007] In a preferred embodiment, a feed pipe is provided at the end of the crystallization vessel furthest from the pipeline.

[0008] In a preferred embodiment, an insulation layer is provided on the outside of the crystallization vessel, and a refrigeration pipe is provided on the side of the insulation layer near the crystallization vessel. One end of the refrigeration pipe is connected to a circulation pump, and the circulation pump is connected to a storage tank.

[0009] In a preferred embodiment, the centrifuge has a crystal outlet at the end furthest from the liquid outlet, and the crystal outlet is connected to a storage frame.

[0010] In a preferred embodiment, the crystallization vessel is connected to an ultrasonic transducer, the ultrasonic transducer is connected to a cable, and an ultrasonic generator is connected to the side of the cable away from the ultrasonic transducer.

[0011] In a preferred embodiment, the end of the refrigeration pipe furthest from the circulation pump is connected to the storage tank.

[0012] Compared with the prior art, the advantages and positive effects of this utility model are as follows:

[0013] This invention eliminates the direct discharge of mother liquor after centrifugation. Instead, a precision filter effectively traps residual fine crystals and microparticles. The purified mother liquor is then returned to the crystallization vessel via a circulation pump. This process achieves deep extraction of residual solutes and recycling of the solvent, resulting in an enhanced extraction process. This significantly improves the final crystallization yield of nicotinamide mononucleotide, fully exploits the remaining value of the mother liquor, and substantially reduces the consumption of fresh solvent and the cost of subsequent wastewater treatment, thus achieving a dual improvement in economic and environmental benefits. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of a nicotinamide mononucleotide cooling crystallization device provided by this utility model.

[0015] Figure 2 Rear view of a nicotinamide mononucleotide cooling crystallization apparatus provided by this utility model.

[0016] Figure 3 A side view of a nicotinamide mononucleotide cooling crystallization apparatus provided by this utility model.

[0017] Figure 4 A schematic diagram of the cooling structure of a nicotinamide mononucleotide cooling crystallization device provided by this utility model.

[0018] Figure 5 A cross-sectional view of the crystallization vessel of a nicotinamide mononucleotide cooling crystallization device provided by this utility model.

[0019] Legend:

[0020] 1. Crystallization vessel; 11. Motor; 111. Drive rod; 112. Stirring baffle; 12. Feed pipe; 13. Pipeline;

[0021] 2. Insulation layer; 21. Ultrasonic generator; 211. Cable; 212. Ultrasonic transducer;

[0022] 3. Storage tank; 31. Circulation pump; 32. Refrigeration pipe; 4. Pneumatic diaphragm pump; 5. Centrifuge; 51. Liquid outlet; 52. Crystal outlet; 53. Storage frame; 6. Precision filter. Detailed Implementation

[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0024] Example 1

[0025] like Figure 1 - Figure 5 As shown, this utility model provides a technical solution: a nicotinamide mononucleotide cooling crystallization device, comprising: a crystallization vessel 1, the crystallization vessel 1 being connected to a pipe 13, a pneumatic diaphragm pump 4 being connected to the end of the pipe 13 away from the crystallization vessel 1, the pneumatic diaphragm pump 4 being connected to a centrifuge 5 through the pipe 13, the centrifuge 5 being provided with a liquid outlet 51, the liquid outlet 51 being connected to a circulation pump 31 through the pipe 13, a precision filter 6 being connected to the side of the circulation pump 31 away from the centrifuge 5 through the pipe 13, and the precision filter 6 being connected to the crystallization vessel 1 through the pipe 13.

[0026] In this embodiment, a spirally coiled cooling pipe 32 is tightly welded to the outer wall of the crystallization vessel 1. An ethylene glycol aqueous solution supplied by the storage tank 3 via a circulating pump 31 continuously flows through the cooling pipe 32 as a cooling medium, achieving uniform and efficient cooling of the material inside the crystallization vessel 1. Multiple high-power ultrasonic transducers 212 are arranged on the upper part of the outer wall of the crystallization vessel 1. Each ultrasonic transducer 212 is connected to an independent ultrasonic generator 21 via a cable 211. Its vibration output end is coupled to the wall of the crystallization vessel 1 by welding, transmitting mechanical vibrations of a specific frequency into the crystallization vessel 1, thereby enhancing mass transfer, promoting uniform nucleation, and preventing online scaling. The bottom of the crystallizer 1 is connected to the pneumatic diaphragm pump 4 and the centrifuge 5 in sequence through the pipe 13. The pneumatic diaphragm pump 4 gently transports the crystallized slurry to the centrifuge 5 for solid-liquid separation. The centrifuge 5 has an outlet 51 at the bottom. The mother liquor is transported through the pipe 13 to the precision filter 6 set on one side by the circulation pump 31. The precision filter 6 can effectively trap the fine crystals and tiny particles remaining in the mother liquor. The purified mother liquor is returned to the crystallizer 1 through the pipe 13 to realize the recycling of solvent and further crystallization of residual solute. The ultrasonic disturbance, mother liquor reflux and other components work together to improve the crystallization efficiency and product quality of nicotinamide mononucleotide.

[0027] Example 2

[0028] like Figure 1 - Figure 5 As shown, one end of the crystallization vessel 1 is connected to a motor 11, the motor 11 is connected to a transmission rod 111, the transmission rod 111 is connected to a stirring baffle 112, the end of the crystallization vessel 1 away from the pipe 13 is provided with a feed pipe 12, the outside of the crystallization vessel 1 is provided with a heat insulation layer 2, the side of the heat insulation layer 2 close to the crystallization vessel 1 is provided with a cooling pipe 32, one end of the cooling pipe 32 is connected to a circulation pump 31, the circulation pump 31 is connected to a storage tank 3, the end of the centrifuge 5 away from the liquid outlet 51 is provided with a crystal outlet 52, the crystal outlet 52 is connected to a storage frame 53, the crystallization vessel 1 is connected to an ultrasonic transducer 212, the ultrasonic transducer 212 is connected to a cable 211, the side of the cable 211 away from the ultrasonic transducer 212 is connected to an ultrasonic generator 21, and the end of the cooling pipe 32 away from the circulation pump 31 is connected to the storage tank 3.

[0029] In this embodiment, a motor 11 is fixedly installed on the top of the crystallization vessel 1. The output shaft of the motor 11 is connected to a transmission rod 111 that extends vertically into the vessel via a coupling. A stirring baffle 112 is connected to the transmission rod 111. The outline of the stirring baffle 112 is adapted to the curvature of the inner wall of the crystallization vessel 1 to form a contoured structure, which can effectively eliminate fluid dead zones and scrape away microcrystals that may adhere to the wall during stirring. A feed pipe 12 is provided on one side of the top of the crystallization vessel 1 for feeding and replenishing liquid. The outer side of the crystallization vessel 1 is covered with a heat insulation layer 2. The heat insulation layer 2 is made of polyurethane foam material to effectively prevent cold loss. A refrigeration pipe 32 is tightly wound between the heat insulation layer 2 and the outer wall of the crystallization vessel 1. The refrigeration pipe 32 adopts a semi-tube coiled structure and is welded to the vessel wall to form a high-efficiency heat exchange jacket. The outlet end of the refrigeration pipe 32 is connected to the circulation pump 31 via a pipe 13 and then connected to the storage tank 3. The inlet end is directly connected to the storage tank 3, forming a closed loop. The storage tank 3 is filled with ethylene glycol aqueous solution as a cooling medium. Two high-power ultrasonic transducers 212 are fixedly installed on the side wall and bottom of the crystallization vessel 1, respectively. Each ultrasonic transducer 212 is connected to the same ultrasonic generator 21 through a cable 211. The ultrasonic generator 21 has automatic frequency tracking and pulse modulation functions, and can output mechanical vibration with specific parameters to the liquid in the vessel, which plays a synergistic role in enhancing mass transfer, inducing uniform nucleation and inhibiting crystal adhesion. The pneumatic diaphragm pump 4 is used to steadily transport the crystal slurry. The centrifuge 5 has a liquid outlet 51 on one side for discharging the separated mother liquor, and a crystal outlet 52 at the bottom of the other side. The obtained wet crystals fall into the collection frame 53 below for collection. The upper part of the collection frame 53 away from the precision filter 6 has a groove, which makes it easy to pull out the collection frame 53 from the side close to the precision filter 6, which significantly improves the crystallization efficiency and product particle size uniformity of nicotinamide mononucleotide.

[0030] Working principle:

[0031] like Figure 1 - Figure 5 As shown, a spirally coiled cooling pipe 32 is tightly welded to the outer wall of the crystallizer 1. An ethylene glycol aqueous solution supplied by the storage tank 3 via a circulating pump 31 continuously flows through the cooling pipe 32 as the cooling medium, achieving uniform and efficient cooling of the material inside the crystallizer 1. Multiple high-power ultrasonic transducers 212 are arranged on the upper part of the outer wall of the crystallizer 1. Each ultrasonic transducer 212 is connected to an independent ultrasonic generator 21 via a cable 211. Its vibration output end is coupled to the wall of the crystallizer 1 by welding, transmitting mechanical vibrations of a specific frequency. Inside the crystallization vessel 1, a pneumatic diaphragm pump 4 and a centrifuge 5 are connected sequentially via pipe 13 at the bottom of the crystallization vessel 1. The pneumatic diaphragm pump 4 gently transfers the crystallized slurry to the centrifuge 5 for solid-liquid separation. The centrifuge 5 has an outlet 51 at its lower part. The mother liquor is transported via pipe 13 and a circulation pump 31 to a precision filter 6 located on one side. The precision filter 6 effectively traps residual fine crystals and tiny particles in the mother liquor. The purified mother liquor is returned to the crystallization vessel 1 via pipe 13. To achieve solvent recycling and further crystallization of residual solute, components such as ultrasonic disturbance and mother liquor reflux work together to improve the crystallization efficiency and product quality of nicotinamide mononucleotide. A motor 11 is fixedly installed on the top of the crystallization vessel 1. The output shaft of the motor 11 is connected to a vertically extending transmission rod 111 into the vessel via a coupling. A stirring baffle 112 is connected to the transmission rod 111. The contour of the stirring baffle 112 is adapted to the curvature of the inner wall of the crystallization vessel 1 to form a contoured structure, which can effectively eliminate fluid dead zones and scrape away any fluid that may adhere to the vessel during stirring. The microcrystals on the wall are fed through a feed pipe 12 on one side of the top of the crystallizer 1 for feeding and replenishing liquid. A pneumatic diaphragm pump 4 is used to steadily transport the crystal slurry. A liquid outlet 51 is provided on one side of the centrifuge 5 for discharging the separated mother liquor, and a crystal outlet 52 is provided at the bottom of the other side. The obtained wet crystals fall into the storage frame 53 below for collection. A groove is provided on the upper part of the storage frame 53 on the side away from the precision filter 6, which makes it easy to pull out the storage frame 53 from the side close to the precision filter 6. This significantly improves the crystallization efficiency and particle size uniformity of nicotinamide mononucleotide.

[0032] The above description is merely a preferred embodiment of the present utility model and is not intended to limit the present utility model in any other way. Any person skilled in the art may make changes or modifications to the above-disclosed technical content to create equivalent embodiments for application in other fields. However, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present utility model without departing from the technical solution of the present utility model shall still fall within the protection scope of the technical solution of the present utility model.

Claims

1. A nicotinamide mononucleotide cooling crystallization apparatus, characterized in that, include: A crystallization vessel (1) is connected to a pipe (13). A pneumatic diaphragm pump (4) is connected to one end of the pipe (13) away from the crystallization vessel (1). The pneumatic diaphragm pump (4) is connected to a centrifuge (5) through the pipe (13). The centrifuge (5) is provided with an outlet (51). The outlet (51) is connected to a circulation pump (31) through the pipe (13). A precision filter (6) is connected to the side of the circulation pump (31) away from the centrifuge (5) through the pipe (13). The precision filter (6) is connected to the crystallization vessel (1) through the pipe (13).

2. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 1, characterized in that: One end of the crystallization vessel (1) is connected to a motor (11), the motor (11) is connected to a transmission rod (111), and the transmission rod (111) is connected to a stirring baffle (112).

3. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 1, characterized in that: The crystallizer (1) is provided with a feed pipe (12) at the end away from the pipe (13).

4. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 1, characterized in that: The crystallization vessel (1) is provided with an insulation layer (2) on the outside. A cooling pipe (32) is provided on the side of the insulation layer (2) close to the crystallization vessel (1). One end of the cooling pipe (32) is connected to a circulation pump (31), and the circulation pump (31) is connected to a storage tank (3).

5. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 1, characterized in that: The centrifuge (5) has a crystal outlet (52) at the end away from the liquid outlet (51), and the crystal outlet (52) is connected to a storage frame (53).

6. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 1, characterized in that: The crystallization vessel (1) is connected to an ultrasonic transducer (212), the ultrasonic transducer (212) is connected to a cable (211), and an ultrasonic generator (21) is connected to the side of the cable (211) away from the ultrasonic transducer (212).

7. The nicotinamide mononucleotide cooling crystallization apparatus according to claim 4, characterized in that: The end of the refrigeration pipe (32) away from the circulation pump (31) is connected to the storage tank (3).

Images