A high-throughput horizontal liquid phase microextraction device

Abstract

The utility model relates to a kind of high-flux horizontal liquid phase microextraction devices, including extraction pool, spacer, first flat film and second flat film, extraction pool is circular, multiple spacers are evenly vertically arranged in extraction pool inside along radial, first flat film is arranged between the connecting end of adjacent two spacers, multiple first flat films and multiple spacers enclose first sample cavity, first sample cavity is located in extraction pool center, second flat film is arranged between the middle of adjacent two spacers, all second flat films and multiple spacers enclose big regular polygon frame, the area surrounded by first flat film and second flat film and adjacent two spacers is extraction cavity, the area surrounded between big regular polygon frame and extraction pool is second sample cavity, the utility model is formed multiple extraction cavities by setting multiple spacers, first flat film and second flat film, increase the contact area of extraction film and sample solution, to improve extraction efficiency.

Description

Technical Field

[0001] This utility model relates to the field of liquid phase extraction device technology, specifically a high-throughput horizontal liquid phase microextraction device. Background Technology

[0002] Liquid-phase microextraction (LPME) is an emerging sample pretreatment technique with wide applications in environmental, pharmaceutical, food, and clinical fields. It is based on the equilibrium distribution of the analyte between the sample and a small volume of organic solvent, essentially a miniaturized liquid-liquid extraction method. It integrates sampling, extraction, and enrichment, avoiding the problems of long processing times and complex operations associated with traditional liquid-liquid extraction.

[0003] Existing liquid phase microextraction devices typically use extraction tubes to perform vertical extraction of sample solutions. The contact area between the extraction membrane and the sample solution is small, resulting in low extraction efficiency. Some semi-automatic microextraction devices use extraction tubes for closed extraction, which makes it inconvenient to sample the extract and add sample solutions. Utility Model Content

[0004] The technical problem to be solved by this invention is to provide a high-throughput horizontal liquid phase microextraction device to address the above-mentioned shortcomings.

[0005] To solve the above technical problems, the present invention adopts the following technical solution:

[0006] A high-throughput horizontal liquid phase microextraction device includes an extraction cell, spacers, a first flat membrane, and a second flat membrane. The extraction cell is circular, and multiple spacers are uniformly and vertically arranged radially along its inner side. A first flat membrane is detachably disposed between the connecting ends of two adjacent spacers. The multiple first flat membranes and the multiple spacers form a small regular polygon frame, and the area enclosed by the small regular polygon frame is a first sample chamber located at the center of the extraction cell. A second flat membrane parallel to the first flat membrane is detachably disposed between the middle of two adjacent spacers. All the second flat membranes and the multiple spacers form a large regular polygon frame. The area enclosed by the first and second flat membranes and two adjacent spacers is the extraction chamber. The area enclosed between the large regular polygon frame and the extraction cell is the second sample chamber. A transparent cap is provided on the extraction cell.

[0007] Furthermore, a fixing groove is provided on the inner side of the extraction pool, and a slot communicating with the fixing groove is provided on the partition plate. Two opposing slots and the fixing groove form a flat membrane insertion port. Clamping frames are provided on the front and rear sides of the first flat membrane and the second flat membrane. The left and right ends of the clamping frames are respectively embedded in the two side slots and the bottom end is embedded in the fixing groove.

[0008] Furthermore, the clamping frame, spacer, and extraction pool are all made of borosilicate glass, and the contact surfaces of the clamping frame, slot, and fixing groove are all frosted surfaces. The clamping frame is used to form a frosted sealing structure with the slot and fixing groove.

[0009] Furthermore, the clamping frame, spacer, and extraction tank are all made of polypropylene. Multiple first sealing strips are vertically arranged on the outer side of the clamping frame, and second sealing strips are vertically arranged on the inner side of the slot, corresponding to and intersecting with the first sealing strips. The first and second sealing strips form a sealing structure. Third sealing strips are horizontally arranged on the front and rear sides of the fixing groove. The clamping frame and the third sealing strips form a sealing structure. The first, second, and third sealing strips are all polytetrafluoroethylene sealing strips compatible with solvents.

[0010] Furthermore, a frustum is provided inside the first sample chamber, the number of edges of the frustum being the same as the number of spacers, and each side of the frustum corresponding to a first flat membrane.

[0011] Furthermore, the second sample chamber is provided with an arc-shaped inner wall that extends along the inner wall of the extraction cell and gradually widens from top to bottom.

[0012] Furthermore, the extraction cell has a diameter of 100 mm and a height of 50 mm, and the distance between the first flat membrane and the second flat membrane is 15 mm.

[0013] Furthermore, both the first flat sheet membrane and the second flat sheet membrane are polypropylene membranes.

[0014] Furthermore, the transparent cap is made of borosilicate glass.

[0015] Compared with the prior art, the present invention, by adopting the above technical solution, has the following advantages:

[0016] This invention improves extraction efficiency by uniformly and vertically arranging multiple spacers in a circular extraction cell, and forming multiple extraction chambers with a first flat plate membrane and a second flat plate membrane. Compared with the existing method of closed extraction with extraction tubes and small contact area between the extraction membrane and the sample solution, this invention increases the contact area between the extraction membrane and the sample solution.

[0017] The first sample chamber has a number of frustums that match the number of spacers, with each side of the frustum corresponding to a first flat plate membrane. The second sample chamber has an arc surface extending along the inner wall of the extraction cell, allowing the sample solution inside the first and second sample chambers to flow to the first and second flat plate membranes under gravity, thereby improving extraction efficiency.

[0018] Compared to existing vertical extraction devices such as extraction tubes, the horizontal extraction structure of this invention makes it easier to perform operations such as sampling and adding sample solutions.

[0019] The extraction tank of this invention has a diameter of 100mm, and its overall size is compact and easy to carry.

[0020] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. Attached Figure Description

[0021] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0022] Figure 2 This is a schematic diagram of the three-dimensional structure of the extraction tank;

[0023] Figure 3 Top view of this utility model Figure 1 (Frosted glass interface is selected);

[0024] Figure 4 Top view of this utility model Figure 2 (Select sealing strip);

[0025] Figure 5 for Figure 4 Enlarged view of point A in the middle;

[0026] Figure 6 This is a cross-sectional view of the inner structure of the extraction tank (using a sealing strip);

[0027] Figure 7 for Figure 6 Enlarged view of section B in the middle.

[0028] The attached diagram lists the components represented by each number as follows:

[0029] 1. Extraction cell; 2. Spare plate; 3. First flat sheet membrane; 4. Second flat sheet membrane; 5. First sample chamber; 6. Extraction chamber; 7. Second sample chamber; 8. Transparent cap; 9. Frustum; 10. Arc-shaped inner wall; 11. Fixing groove; 12. Slot; 13. Clamping frame; 14. First sealing strip; 15. Second sealing strip; 16. Third sealing strip. Detailed Implementation

[0030] The principles and features of this utility model are described below with reference to the accompanying drawings. The examples given are only for explaining this utility model and are not intended to limit the scope of this utility model.

[0031] In the description of this utility model, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", "clockwise", "counterclockwise", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0032] like Figure 1-7 As shown, a high-throughput horizontal liquid phase microextraction device includes an extraction cell 1, spacers 2, a first flat membrane 3, and a second flat membrane 4. The extraction cell 1 is circular. Multiple spacers 2 are uniformly and vertically arranged radially along the inner side of the extraction cell 1. A first flat membrane 3 is detachably arranged between the connecting ends of two adjacent spacers 2. Multiple first flat membranes 3 and multiple spacers 2 form a small regular polygon frame. The area enclosed by the small regular polygon frame is a first sample chamber 5, which is located at the center of the extraction cell 1. A second flat membrane 4 parallel to the first flat membrane 3 is detachably arranged between the middle of two adjacent spacers 2. All second flat membranes 4 and multiple spacers 2 form a large regular polygon frame. The area enclosed by the first flat membrane 3, the second flat membrane 4, and two adjacent spacers 2 is an extraction chamber 6. The area enclosed between the large regular polygon frame and the extraction cell 1 is a second sample chamber 7. A transparent cap 8 is provided on the extraction cell 1.

[0033] In one embodiment, a fixing groove 11 is provided on the inner side of the extraction pool 1, and a slot 12 communicating with the fixing groove 11 is provided on the partition plate 2. The two opposing slots 12 and the fixing groove 11 form a flat membrane insertion port. Clamping frames 13 are provided on the front and rear sides of the first flat membrane 3 and the second flat membrane 4. The left and right ends of the clamping frames 13 are respectively embedded in the two side slots 12 and the bottom end is embedded in the fixing groove 11.

[0034] In one embodiment, when a frosted glass interface is used to fix the flat film, the clamping frame 13, the spacer 2 and the extraction tank 1 are all made of borosilicate glass, the first flat film 3 and the second flat film 4 are both polypropylene films, the mutual contact surfaces of the clamping frame 13, the slot 12 and the fixing groove 11 are all frosted surfaces, and the clamping frame 13 is used to form a frosted sealing structure with the slot 12 and the fixing groove 11.

[0035] In one embodiment, when the sealing strip is used to fix the flat sheet membrane, the clamping frame 13, the spacer 2, and the extraction tank 1 are all made of polypropylene. The first flat sheet membrane 3 and the second flat sheet membrane 4 are both polypropylene membranes. Multiple first sealing strips 14 are vertically arranged on the outer side of the clamping frame 13. Second sealing strips 15, which are corresponding to and intersecting with the first sealing strips 14, are vertically arranged on the inner side of the slot 12. The first sealing strips 14 and the second sealing strips 15 form a sealing structure. Third sealing strips 16 are horizontally arranged on the front and rear sides of the fixing groove 11. The clamping frame 13 and the third sealing strips 16 form a sealing structure. The first sealing strips 14, the second sealing strips 15, and the third sealing strips 16 are all polytetrafluoroethylene sealing strips compatible with solvents.

[0036] In one embodiment, a frustum 9 is provided inside the first sample cavity 5. The number of edges of the frustum 9 is the same as the number of spacers 2, and each side of the frustum 9 corresponds to a first flat membrane 3.

[0037] In one embodiment, the inner side of the second sample chamber 7 is provided with an arc-shaped inner wall 10 that extends along the inner wall of the extraction pool 1 and gradually widens from top to bottom.

[0038] In one embodiment, the extraction tank 1 has a diameter of 100 mm and a height of 50 mm, and the distance between the first flat plate membrane 3 and the second flat plate membrane 4 is 15 mm.

[0039] In one embodiment, both the first flat sheet and the second flat sheet are polypropylene films.

[0040] In one embodiment, the transparent cover is made of borosilicate glass.

[0041] In this invention, there are six spacers 2, six first flat membranes 3, and six second flat membranes 4.

[0042] The working process of this utility model is as follows: Open the transparent cover 8 on the extraction tank 1, add extractant to multiple first flat plate membranes 3 and second flat plate membranes 4 according to the type of target extractant, and add the same extractant to the corresponding first flat plate membranes 3 and second flat plate membranes 4. Then insert the first extraction membranes 3 and second extraction membranes 4 into their corresponding positions.

[0043] When using a frosted glass interface for sealing, the clamping frame 13 and the slot 12 seal the left and right sides of the flat film, and the clamping frame 13 and the fixing groove 11 seal the bottom of the flat film.

[0044] When sealing is performed using sealing strips, the first sealing strip 14 and the second sealing strip 15 are arranged alternately and press against each other to seal the left and right sides of the flat film, while the third sealing strip 16 and the clamping frame 13 press against each other to seal the bottom of the flat film.

[0045] The sample solutions to be processed are then added to the first sample chamber 5 and the second sample chamber 7, respectively, and the extraction solution is added to the extraction chamber 6. The transparent cap 8 is then placed on top. The first flat plate membrane 3 and the second flat plate membrane 4 extract the target substances from the sample solutions in the first sample chamber 5 and the second sample chamber 7 into the extraction solution, respectively. When the sample solution in the first sample chamber 5 and the second sample chamber 7 decreases, the sample solution flows along the inclined surface of the frustum 9 or along the inner wall 10 of the arc surface to the first flat plate membrane 3 or the second flat plate membrane 4, reducing the movement distance between the residual target extract and the first flat plate membrane 3 or the second flat plate membrane 4, thus improving the extraction efficiency.

[0046] When it is necessary to add sample solution or take samples of the extraction solution, simply open the transparent cap 8 to proceed.

[0047] The above description provides examples of the preferred embodiments of this utility model. Any aspects not detailed herein are common knowledge to those skilled in the art. The scope of protection of this utility model is determined by the claims. Any equivalent modifications based on the technical teachings of this utility model are also within the scope of protection of this utility model.

Claims

1. A high-throughput horizontal liquid-phase microextraction device, characterized in that, The extraction pool (1) includes an extraction cell (1), a spacer plate (2), a first flat membrane (3), and a second flat membrane (4). The extraction cell (1) is circular. Multiple spacer plates (2) are evenly and vertically arranged along the radial direction on the inner side of the extraction cell (1). A first flat membrane (3) is detachably arranged between the connecting ends of two adjacent spacer plates (2). Multiple first flat membranes (3) and multiple spacer plates (2) form a small regular polygon frame. The area enclosed by the small regular polygon frame is the first sample chamber (5). The first sample chamber (5) is located at the center of the extraction cell (1). A second flat membrane (4) parallel to the first flat membrane (3) is detachably arranged between the middle of two adjacent spacer plates (2). All second flat membranes (4) and multiple spacer plates (2) form a large regular polygon frame. The area enclosed by the first flat membrane (3), the second flat membrane (4), and two adjacent spacer plates (2) is the extraction chamber (6). The area enclosed between the large regular polygon frame and the extraction cell (1) is the second sample chamber (7). A transparent cap (8) is provided on the extraction cell (1).

2. The high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, The extraction pool (1) has a fixed groove (11) on its inner side. The partition plate (2) has a slot (12) that communicates with the fixed groove (11). The two opposing slots (12) and the fixed groove (11) form a flat membrane insertion port. The first flat membrane (3) and the second flat membrane (4) are provided with clamping frames (13) on their front and rear sides. The left and right ends of the clamping frames (13) are respectively embedded in the slots (12) on both sides and the bottom end is embedded in the fixed groove (11).

3. The high-throughput horizontal liquid-phase microextraction device according to claim 2, characterized in that, The clamping frame (13), the spacer (2) and the extraction pool (1) are all made of borosilicate glass. The contact surfaces of the clamping frame (13), the slot (12) and the fixing groove (11) are all frosted surfaces. The clamping frame (13) is used to form a frosted sealing structure with the slot (12) and the fixing groove (11).

4. The high-throughput horizontal liquid-phase microextraction device according to claim 2, characterized in that, The clamping frame (13), the spacer (2), and the extraction tank (1) are all made of polypropylene. Multiple first sealing strips (14) are vertically arranged on the outer side of the clamping frame (13). A second sealing strip (15) corresponding to and intersecting with the first sealing strips (14) is vertically arranged on the inner side of the slot (12). The first sealing strip (14) and the second sealing strip (15) form a sealing structure. A third sealing strip (16) is horizontally arranged on the front and rear sides of the fixing groove (11). The clamping frame (13) and the third sealing strip (16) form a sealing structure. The first sealing strip (14), the second sealing strip (15), and the third sealing strip (16) are all polytetrafluoroethylene sealing strips compatible with solvents.

5. The high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, A frustum (9) is provided inside the first sample chamber (5). The number of edges of the frustum (9) is the same as the number of spacers (2), and each side of the frustum (9) corresponds to a first flat membrane (3).

6. The high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, The second sample chamber (7) is provided with an arc-shaped inner wall (10) that extends along the inner wall of the extraction cell (1) and gradually widens from top to bottom.

7. The high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, The extraction tank (1) has a diameter of 100 mm and a height of 50 mm, and the distance between the first flat plate membrane (3) and the second flat plate membrane (4) is 15 mm.

8. The high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, Both the first flat sheet membrane (3) and the second flat sheet membrane (4) are polypropylene membranes.

9. A high-throughput horizontal liquid-phase microextraction device according to claim 1, characterized in that, The transparent cap (8) is made of borosilicate glass.

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