A heparin sodium adsorption purification device

Abstract

The utility model discloses a heparin sodium adsorption purification equipment, including frame, raw material liquid storage tank, collection jar and adsorption subassembly, raw material liquid storage tank and collection jar all are fixed on the frame, and are communicated with adsorption subassembly through the pipeline, adsorption subassembly includes adsorption column, cloth liquid mechanism and temperature control mechanism, cloth liquid mechanism coaxial setting is in the inside top end of adsorption column, is used for even dispersion raw material liquid to the surface of adsorption medium, temperature control mechanism is wrapped in the outside of adsorption column, is used for temperature regulation and control to the adsorption environment in adsorption column, the utility model discloses adsorption column adopts buckle type quick -release structure, compares traditional integral type adsorption column, and the assembly and disassembly time shorten, when needing to replace adsorption medium or clean column body, operating personnel can complete operation fast, greatly reduces equipment downtime maintenance time, improves the continuous operation efficiency of equipment.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical purification technology, specifically to a heparin sodium adsorption and purification device. Background Technology

[0002] Heparin sodium is an important anticoagulant drug, and the efficiency and quality of its purification process directly affect the drug's production benefits and safety of use. Currently, the industry commonly uses adsorption to purify heparin sodium raw material solution. This method requires heparin sodium adsorption purification equipment to realize operations such as raw material solution transfer, adsorption, and purified solution collection.

[0003] In existing heparin sodium adsorption and purification equipment, the adsorption column is mostly an integral structure, which is inconvenient to disassemble and assemble. When it is necessary to replace the adsorption medium or clean and maintain the inside of the column, the operation is cumbersome and time-consuming, which seriously affects the continuous operation efficiency of the equipment. At the same time, there is often an uneven distribution of the raw material liquid when it enters the adsorption column, resulting in insufficient contact between the raw material liquid and the adsorption medium. Some areas are over-adsorbed while other areas are not fully utilized, which reduces the adsorption efficiency and purification effect. Utility Model Content

[0004] This invention addresses the technical problems existing in the prior art by providing a heparin sodium adsorption and purification device, which solves the problems of inconvenient disassembly and assembly of the adsorption column and uneven liquid distribution in existing heparin sodium adsorption and purification devices.

[0005] To achieve the above objectives, this utility model provides a heparin sodium adsorption and purification device, including a frame, a raw material liquid storage tank, a collection tank, and an adsorption assembly. The raw material liquid storage tank and the collection tank are both fixed on the frame and connected to the adsorption assembly through pipelines. The adsorption assembly includes an adsorption column, a liquid distribution mechanism, and a temperature control mechanism. The liquid distribution mechanism is coaxially arranged at the top of the adsorption column and is used to uniformly disperse the raw material liquid onto the surface of the adsorption medium. The temperature control mechanism is wrapped around the outside of the adsorption column and is used to regulate the temperature of the adsorption environment inside the adsorption column.

[0006] Based on the above technical solution, the present invention can be further improved as follows.

[0007] Preferably, the adsorption column consists of an upper cover, a middle column, and a lower bottom. The upper cover, middle column, and lower bottom are coaxially arranged and detachably connected by a snap-on quick-release structure. The contact surfaces between the upper cover, middle column, and lower bottom are all fitted with sealing rings. A stainless steel sieve plate is fixed to the bottom of the middle column.

[0008] Preferably, the upper end face of the upper cover is provided with a liquid inlet, and the lower end face of the lower cover is provided with a liquid outlet.

[0009] Preferably, the snap-on quick-release structure includes an elastic snap and an annular side skirt; the elastic snap is symmetrically fixed to the bottom edge of the upper cover and the bottom edge of the middle column, and the top and bottom edges of the middle column are integrally formed with an annular side skirt, and the annular side skirt has a notch adapted to the elastic snap; after rotating the upper cover or the middle column, the elastic snap engages and is fixed to the edge of the annular side skirt.

[0010] Preferably, the liquid distribution mechanism includes a conical liquid distributor, a porous liquid distribution plate, and a support bracket. The tip of the conical liquid distributor faces upward and is directly opposite the liquid inlet. The porous liquid distribution plate is horizontally fixed to the bottom of the conical liquid distributor. One end of the support bracket is fixedly connected to the inner wall of the upper cover, and the other end is welded and fixed to the outer wall of the conical liquid distributor. Both the conical liquid distributor and the porous liquid distribution plate are coaxially arranged with the upper cover.

[0011] Preferably, the temperature control mechanism includes an insulation cotton sleeve, which consists of an insulation cotton layer and an aluminum foil insulation layer from the outside to the inside. The insulation cotton sleeve is wrapped around the outside of the middle column, and the two ends of the insulation cotton sleeve are closed and fixed by Velcro.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: The adsorption column adopts a snap-on quick-release structure, which shortens the assembly and disassembly time compared with the traditional integral adsorption column. When it is necessary to replace the adsorption medium or clean the column, the operator can quickly complete the operation, which greatly reduces the equipment downtime for maintenance and improves the continuous operation efficiency of the equipment. The liquid distribution mechanism uses the dual action of a conical liquid distributor and a porous liquid distribution plate to evenly disperse the raw material liquid onto the surface of the adsorption medium, avoiding the waste of some adsorption medium caused by uneven liquid distribution in traditional equipment, while improving the purification efficiency and purification quality of heparin sodium. The temperature control mechanism's insulation sleeve adopts a dual structure of insulation cotton layer and aluminum foil insulation layer, which can effectively maintain the temperature stability inside the adsorption column, ensure that the adsorption process is carried out in a suitable temperature environment, avoid the problem of decreased adsorption performance due to temperature fluctuations, and further guarantee the purification effect of heparin sodium. Attached Figure Description

[0013] Figure 1 This is an isometric view of one side of the overall structure of this utility model; Figure 2 This is a schematic diagram of the adsorption component structure of this utility model; Figure 3 This is a schematic diagram of the cross-sectional structure of the upper cover of this utility model; Figure 4 This is a schematic diagram of the bottom structure of this utility model.

[0014] The meanings of the labels in the diagram are as follows: 1. Frame; 2. Raw material liquid storage tank; 3. Collection tank; 4. Adsorption column; 401. Top cover; 402. Middle column; 403. Bottom; 404. Elastic buckle; 405. Annular side skirt; 406. Notch; 407. Sealing ring; 408. Stainless steel sieve plate; 409. Liquid inlet; 410. Liquid outlet; 5. Liquid distribution mechanism; 501. Conical liquid distributor; 502. Perforated liquid distribution plate; 503. Support bracket; 6. Temperature control mechanism; 601. Insulation cotton sleeve; 602. Velcro. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figures 1-4 As shown, this embodiment provides a heparin sodium adsorption and purification device, including a frame 1, a raw material liquid storage tank 2, a collection tank 3, and an adsorption assembly. The raw material liquid storage tank 2 and the collection tank 3 are both fixed on the frame 1 and are connected to the adsorption assembly through pipelines. The raw material liquid storage tank 2 is used to store the heparin sodium raw material liquid to be purified, and the collection tank 3 is used to collect the qualified liquid after adsorption and purification. The frame 1 provides a stable installation support foundation for each component.

[0017] The adsorption assembly includes an adsorption column 4, a liquid distribution mechanism 5, and a temperature control mechanism 6.

[0018] In summary, the improvement of this embodiment is that the adsorption column 4 adopts a snap-on quick-release structure, which shortens the assembly and disassembly time compared with the traditional integral adsorption column 4. When it is necessary to replace the adsorption medium or clean the column, the operator can quickly complete the operation, greatly reducing the equipment downtime for maintenance and improving the continuous operation efficiency of the equipment.

[0019] Based on the above, other structures also need to be disclosed in detail, such as: The adsorption column 4 consists of an upper cover 401, a middle column 402, and a lower base 403. The upper cover 401, the middle column 402, and the lower base 403 are coaxially arranged and detachably connected by a snap-on quick-release structure. This layered and detachable design solves the problem of cumbersome disassembly and assembly of the traditional integral adsorption column 4, making it convenient to quickly replace the adsorption medium and clean the inside of the column. The contact surfaces between the upper cover 401, the middle column 402, and the lower base 403 are all equipped with sealing rings 407, which can effectively prevent the raw material liquid or purified liquid from leaking at the connection and ensure the airtightness of the equipment operation. A stainless steel sieve plate 408 is fixed at the bottom of the middle column 402, which can support the adsorption medium and allow the liquid to pass through smoothly, preventing the adsorption medium from flowing into the subsequent pipeline with the liquid.

[0020] The snap-on quick-release structure includes an elastic snap 404 and an annular side skirt 405. The elastic snap 404 is symmetrically fixed to the bottom edge of the upper cover 401 and the bottom edge of the middle column 402. The top of the middle column 402 and the top of the bottom 403 are both integrally formed with an annular side skirt 405. The annular side skirt 405 has a notch 406 that matches the elastic snap 404. During installation, the elastic snap 404 is aligned with the notch 406 and inserted. After rotating the upper cover 401 or the middle column 402, the elastic snap 404 and the edge of the annular side skirt 405 are snapped and fixed, realizing the quick assembly and disassembly of each component and greatly improving the equipment maintenance efficiency.

[0021] The upper end face of the top cover 401 is provided with a liquid inlet 409, which serves as a channel for the raw material liquid to enter the adsorption column 4, and the lower end face of the bottom 403 is provided with a liquid outlet 410, which is used to export the purified liquid to the collection tank 3.

[0022] The liquid distribution mechanism 5 is coaxially mounted at the top of the adsorption column 4, and includes a conical liquid distributor 501, a porous liquid distribution plate 502, and a support bracket 503. The tip of the conical liquid distributor 501 faces upward and is directly opposite the liquid inlet 409. After the raw liquid flows in from the liquid inlet 409, it first contacts the conical liquid distributor 501. The conical liquid distributor 501 can play a preliminary diversion role for the raw liquid, avoiding direct impact of the liquid on the surface of the adsorption medium. The porous liquid distribution plate 502 is horizontally fixed to the bottom of the conical liquid distributor 501. The holes on it can further disperse the liquid evenly, ensuring that the raw liquid evenly covers the surface of the adsorption medium, solving the problem of low adsorption efficiency caused by uneven liquid distribution in traditional equipment. One end of the support bracket 503 is fixedly connected to the inner wall of the upper cover 401, and the other end is welded to the outer wall of the conical liquid distributor 501, providing stable support for the conical liquid distributor 501 and the porous liquid distribution plate 502, while ensuring the coaxiality of the liquid distribution mechanism 5 and the upper cover 401, ensuring the liquid distribution effect.

[0023] The temperature control mechanism 6 is wrapped around the outside of the adsorption column 4 and includes an insulation cotton sleeve 601. The insulation cotton sleeve 601 consists of an insulation cotton layer and an aluminum foil insulation layer from the outside to the inside. The insulation cotton layer can effectively reduce heat loss inside the column, and the aluminum foil insulation layer can block the influence of the external ambient temperature on the inside of the column. The dual structure works together to accurately maintain the stable temperature environment required for the adsorption process inside the adsorption column 4 and improve the adsorption performance. The insulation cotton sleeve 601 is wrapped around the outside of the middle column 402 and the two ends are closed and fixed by Velcro 602. The Velcro 602 is designed to facilitate the quick installation and removal of the insulation cotton sleeve 601, which is convenient for the maintenance or adjustment of the temperature control structure of the middle column 402.

[0024] In summary, the workflow of this solution is as follows: Open the valve at the outlet of the raw material storage tank 2 and adjust the valve opening to control the flow rate of the raw material (e.g., 1 L / min). The raw material flows out of the raw material storage tank 2 and enters the inlet port 409 of the top cover 401 of the adsorption column 4 through the pipeline. The raw material first contacts the conical distributor 501 and, under the diversion action of the conical distributor 501, disperses and flows to all sides. Then it flows into the porous distribution plate 502 and is further evenly dispersed through the holes on the porous distribution plate 502, and evenly drips onto the surface of the adsorption medium inside the middle column 402. The raw material slowly permeates downward under the action of gravity and comes into full contact with the adsorption medium. The adsorption medium resin column adsorbs the heparin sodium in the raw material and achieves the purification of heparin sodium.

[0025] After adsorption and purification, the waste liquid continues to permeate downwards, passing through the stainless steel sieve plate 408 at the bottom of the middle column 402, entering the interior of the lower bottom 403, and then flowing out from the liquid outlet 410 of the lower bottom 403, flowing into the collection tank 3 through the pipeline.

[0026] After all the raw material liquid in the raw material storage tank 2 has been processed, close the valve at the outlet of the raw material storage tank 2. After all the liquid in the adsorption column 4 has flowed into the collection tank 3, shut down the relevant equipment. If it is necessary to replace the adsorption medium or clean the column, first remove the insulation cotton sleeve 601 of the temperature control mechanism 6, then rotate the upper cover 401 and the middle column 402 respectively to separate the elastic buckle 404 from the annular side skirt 405, remove the upper cover 401 and the middle column 402, pour out the waste adsorption medium, and clean the middle column 402, upper cover 401 and bottom 403 with clean water or special cleaning agent. After cleaning, reinstall the new adsorption medium.

[0027] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A heparin sodium adsorption purification device, comprising a frame (1), a raw material liquid storage tank (2), a collection tank (3), and an adsorption assembly, wherein the raw material liquid storage tank (2) and the collection tank (3) are both fixed on the frame (1) and connected to the adsorption assembly through pipelines, characterized in that: The adsorption assembly includes an adsorption column (4), a liquid distribution mechanism (5), and a temperature control mechanism (6). The liquid distribution mechanism (5) is coaxially arranged at the top of the adsorption column (4) to uniformly disperse the raw material liquid onto the surface of the adsorption medium. The temperature control mechanism (6) is wrapped around the outside of the adsorption column (4) and is used to regulate the temperature of the adsorption environment inside the adsorption column (4).

2. The heparin sodium adsorption and purification equipment according to claim 1, characterized in that: The adsorption column (4) consists of an upper cover (401), a middle column (402) and a lower bottom (403). The upper cover (401), the middle column (402) and the lower bottom (403) are coaxially arranged and can be detachably connected by a snap-on quick-release structure. The contact surfaces between the upper cover (401), the middle column (402) and the lower bottom (403) are all fitted with sealing rings (407). A stainless steel sieve plate (408) is fixed at the bottom of the middle column (402).

3. The heparin sodium adsorption and purification equipment according to claim 2, characterized in that: The upper end face of the upper cover (401) is provided with a liquid inlet (409), and the lower end face of the lower bottom (403) is provided with a liquid outlet (410).

4. The heparin sodium adsorption and purification equipment according to claim 3, characterized in that: The snap-on quick-release structure includes an elastic snap (404) and an annular side skirt (405); the elastic snap (404) is symmetrically fixed to the bottom edge of the upper cover (401) and the bottom edge of the middle column (402). The top of the middle column (402) and the top of the bottom (403) are integrally formed with an annular side skirt (405). The annular side skirt (405) has a notch (406) that matches the elastic snap (404). After rotating the upper cover (401) or the middle column (402), the elastic snap (404) is engaged and fixed with the edge of the annular side skirt (405).

5. The heparin sodium adsorption and purification equipment according to claim 4, characterized in that: The liquid distribution mechanism (5) includes a conical liquid distributor (501), a porous liquid distribution plate (502), and a support bracket (503). The tip of the conical liquid distributor (501) faces upward and is directly opposite the liquid inlet (409). The porous liquid distribution plate (502) is horizontally fixed to the bottom of the conical liquid distributor (501). One end of the support bracket (503) is fixedly connected to the inner wall of the upper cover (401), and the other end is welded and fixed to the outer wall of the conical liquid distributor (501). Both the conical liquid distributor (501) and the porous liquid distribution plate (502) are coaxially arranged with the upper cover (401).

6. The heparin sodium adsorption and purification device according to claim 5, characterized in that: The temperature control mechanism (6) includes a thermal insulation cotton sleeve (601), which consists of a thermal insulation cotton layer and an aluminum foil insulation layer from the outside to the inside. The thermal insulation cotton sleeve (601) is wrapped around the outside of the middle column (402), and the two ends of the thermal insulation cotton sleeve (601) are closed and fixed by Velcro (602).

Images