A stirring device for use in pharmaceutical analysis experiments

Abstract

The utility model discloses a kind of stirring device for pharmaceutical analysis experiment, including base, the upper end of the base is equipped with stirring barrel, the outer camber of stirring barrel is equipped with temperature control component, further include stirring mechanism;Stirring mechanism includes main shaft, strip port, stirring column, stirring frame and stirring vane, the lower side wall of stirring barrel is rotatably connected in the main shaft, the outer camber upper end of main shaft is equipped with the stirring vane of uniform distribution, the lower end of main shaft is through the through-hole of base upper end and located in the lower end inside of base, the middle of the part of main shaft located in stirring barrel interior is equipped with strip port, stirring column is rotatably connected between the front and rear inner wall of strip port.The utility model is rotated by main shaft and drives stirring vane to form axial flow, stirring column linkage stirring frame periodic swing generates the rotation+swing three-dimensional mixing mode of transverse shear force, can effectively eliminate stirring blind area, improve mixing uniformity and efficiency.

Description

Technical Field

[0001] This utility model relates to the field of pharmacokinetic research technology, specifically a stirring device used in drug analysis experiments. Background Technology

[0002] In pharmacokinetic studies of pharmaceutical analysis, homogeneous mixing of samples and precise temperature control are crucial for ensuring the accuracy of analytical results. With advancements in drug development technology, the types of samples involved in experiments are becoming increasingly complex, such as high-viscosity solutions and multi-component suspensions, placing higher demands on the mixing efficiency and temperature control precision of stirring devices.

[0003] The stirring devices used in existing drug analysis experiments typically employ a single axial stirring structure. A motor drives the main shaft to rotate the stirring blades, creating a simple axial flow within the stirring tank to tumble the sample. The working process is as follows: after the sample is added to the stirring tank, the motor is started to rotate the stirring blades, and at the same time, a heat transfer medium or a cold transfer medium is injected into the jacket through an external heat source to regulate the sample temperature.

[0004] The existing stirring mechanism can only provide axial stirring force in one direction, which cannot form an effective lateral shearing effect on the sample in the central area of ​​the stirring tank and around the main shaft. This makes it easy for high viscosity samples to form a stirring blind zone in the central area, making it difficult for multi-component mixtures to achieve sufficient horizontal diffusion. The mixing uniformity is insufficient and the time is long. It is difficult to adapt to the stirring requirements of samples with different viscosities and lacks the ability to dynamically adjust the stirring path. As a result, the device has poor adaptability to complex samples and cannot meet the diverse mixing requirements in drug analysis experiments. Utility Model Content

[0005] The technical problem to be solved by this utility model is to overcome the existing defects and provide a stirring device for drug analysis experiments. Through the three-dimensional mixing mode of rotation and oscillation of the stirring mechanism, the problems in the background technology can be effectively solved.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a stirring device for drug analysis experiments, comprising a base and a controller, wherein a stirring tank is provided at the upper end of the base, a temperature control component is provided on the outer arc surface of the stirring tank, and a stirring mechanism is also included; The stirring mechanism includes a main shaft, a strip-shaped inlet, a stirring column, a stirring frame, and stirring blades. The main shaft is rotatably connected to the lower side wall of the stirring tank. The upper end of the outer arc surface of the main shaft is provided with uniformly distributed stirring blades. The lower end of the main shaft passes through the through hole at the upper end of the base and is located inside the lower end of the base. The strip-shaped inlet is located in the middle of a part of the main shaft inside the stirring tank. The stirring column is rotatably connected between the front and rear inner walls of the strip-shaped inlet. The outer arc surface of the stirring column is provided with uniformly distributed stirring frames.

[0007] Furthermore, the stirring mechanism also includes a gear and a rack plate. The stirring column and the strip-shaped inlet are rotatably connected by a rotating shaft. The gear is rotatably connected to the rear end of the main shaft. The front side of the gear is fixedly connected to the center of the rear end face of the rotating shaft. An adjustable movable plate is provided inside the main shaft. A rack plate is provided on the upper side of the movable plate. The rack plate is meshed with the gear to facilitate the movement of the rack plate. Through the meshing transmission of the gear and the rack plate, the reciprocating oscillation of the stirring frame is realized.

[0008] Furthermore, the stirring mechanism also includes a guide column and a wave-shaped boss. The lower left side of the moving plate is provided with a mounting bracket, the left end of the mounting bracket is provided with a guide column, the lower end of the base is provided with a mounting plate, the lower side of the main shaft is rotatably connected to the upper side of the mounting plate, the upper side of the mounting plate is provided with a wave-shaped boss, the guide column is configured to cooperate with the wave-shaped boss, the lower outer arc surface of the main shaft is provided with a clearance groove corresponding to the mounting bracket, the lower end of the outer arc surface of the main shaft is provided with a guide frame, the upper end of the outer arc surface of the guide column is slidably connected to the left end of the guide frame, a spring is provided between the mounting bracket and the left end of the guide frame, the spring is sleeved on the upper end of the guide column to facilitate the reciprocating up and down movement of the moving plate.

[0009] Furthermore, a motor is mounted on the lower side of the mounting plate, and the output shaft of the motor is fixedly connected to the center of the lower end face of the main shaft. The input end of the motor is electrically connected to the output end of the controller for stable driving.

[0010] Furthermore, the temperature control component is a jacket, which is disposed on the outer arc surface of the mixing tank. An inlet pipe is provided at the inlet at the upper end of the jacket, and a outlet pipe is provided at the outlet at the lower end of the jacket, for adjusting the temperature inside the mixing tank.

[0011] Furthermore, a temperature sensor is provided on the upper side wall of the mixing tank. The probe of the temperature sensor penetrates the upper side wall of the mixing tank and extends into the interior of the mixing tank. The input end of the temperature sensor is electrically connected to the output end of the controller to detect the temperature inside the mixing tank.

[0012] Compared with the prior art, the beneficial effects of this utility model are: This stirring device uses a main shaft to drive the stirring blades to rotate, creating radial and axial flow to achieve basic mixing by tumbling the sample. At the same time, the guide column moves along the wave-shaped protrusion, causing the stirring column to oscillate periodically and generate lateral shear force, which compensates for the stirring blind zone in the central area and forms a three-dimensional mixing effect of "rotation + oscillation". This can significantly improve the uniformity of sample mixing and shorten the mixing time, and is especially suitable for efficient mixing of high viscosity or multi-component drug samples. Attached Figure Description

[0013] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2This is a schematic diagram of the front cross-section of the jacket of this utility model; Figure 3 This is a structural schematic diagram of the front cross-section of the mixing tank of this utility model; Figure 4 This is a partial structural schematic diagram of the main shaft of this utility model; Figure 5 This is a schematic diagram of the internal structure of the strip-shaped opening of this utility model; Figure 6 This is a structural schematic diagram showing a cross-section of the left end of the main shaft of this utility model; Figure 7 This is an enlarged schematic diagram of point A in this utility model; Figure 8 This is an enlarged structural schematic diagram of section B of this utility model; Figure 9 This is a partial structural diagram of the mixing tank of this utility model.

[0014] In the diagram: 1. Base, 2. Stirring mechanism, 21. Main shaft, 22. Strip-shaped inlet, 23. Stirring column, 24. Stirring frame, 25. Stirring blade, 26. Gear, 27. Rack plate, 28. Guide column, 29. Wave-shaped boss, 3. Stirring tank, 4. Jacket, 5. Inlet pipe, 6. Outlet pipe, 7. Moving plate, 8. Mounting frame, 9. Guide frame, 10. Spring, 11. Motor, 12. Temperature sensor, 13. Controller. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figure 1-9This embodiment provides a technical solution: a stirring device for drug analysis experiments, including a base 1 and a controller 13. The upper end of the base 1 is provided with a stirring tank 3. The upper side wall of the stirring tank 3 is provided with a drug pipeline (the drug pipeline is used for taking out and putting out drugs. When taking out the stirred drugs, the worker needs to use an external material pump to assist. The hose set at the suction port of the material pump is inserted into the interior of the stirring tank 3 through the drug pipeline. The material pump is started to pump the stirred drugs out of the interior of the stirring tank 3). The upper end of the drug pipeline is provided with a material door. A door bolt is provided between the material door and the drug pipeline (the door bolt consists of a mounting seat on the outer arc surface of the drug pipeline, a rotating pin inside the mounting seat, a knob fixedly connected to the upper end of the pin, and a limiting plate provided on the knob. When locking the material door, the material door is first placed on the upper end of the drug pipeline, and then the knob is rotated to make the limiting plate rotate and lock the upper end of the material door). The door bolt is used to lock the material door and the drug pipeline. A rubber sealing strip is provided at the edge of the material door.

[0017] The outer arc surface of the stirring tank 3 is equipped with a temperature control component, which is a jacket 4. The jacket 4 is set on the outer arc surface of the stirring tank 3. An inlet pipe 5 is provided at the inlet at the upper end of the jacket 4, and an outlet pipe 6 is provided at the outlet at the lower end of the jacket 4. A temperature sensor 12 is provided on the upper side wall of the stirring tank 3. The probe of the temperature sensor 12 penetrates the upper side wall of the stirring tank 3 and extends into the interior of the stirring tank 3. The input end of the temperature sensor 12 is electrically connected to the output end of the controller 13. The temperature sensor 12 monitors the sample temperature inside the stirring tank 3 in real time and feeds the data back to the controller 13. An external heat source, such as a constant temperature water bath, is injected into the jacket 4 through the inlet pipe 5 to provide a high-temperature heat medium or a low-temperature heat medium. After flowing through the jacket, the heat medium flows back from the outlet pipe 6, raising the sample temperature through heat conduction and adjusting the temperature.

[0018] The system also includes a stirring mechanism 2. The stirring mechanism 2 includes a main shaft 21, a strip-shaped inlet 22, a stirring column 23, a stirring frame 24, and stirring blades 25. The main shaft 21 is rotatably connected to the lower side wall of the mixing tank 3 (the main shaft 21 rotates with the lower side wall of the mixing tank 3 via a sealed bearing). The upper end of the outer arc surface of the main shaft 21 is provided with evenly distributed stirring blades 25. The lower end of the main shaft 21 passes through a through hole at the upper end of the base 1 and is located inside the lower end of the base 1. A strip-shaped inlet 22 is opened in the middle of a portion of the main shaft 21 inside the mixing tank 3. A stirring column 23 is rotatably connected between the front and rear inner walls of the strip-shaped inlet 22 (a rubber sealing sleeve is provided inside the strip-shaped inlet 22; the right end of the rubber sealing sleeve is fixedly connected to the left side of the outer arc surface of the stirring column 23, and the right end of the rubber sealing sleeve can naturally extend and retract with the swing of the stirring column 23). Evenly distributed stirring frames 24 are provided on the outer arc surface of the stirring column 23. The stirring mechanism 2 also includes a gear 26 and a rack plate 27. The stirring column 23 and the strip-shaped inlet 22 are connected by a rotating shaft. The gear 26 is rotatably connected to the rear end of the main shaft 21. The front side of the gear 26 is fixedly connected to the center of the rear end face of the rotating shaft. An adjustable movable plate 7 is provided inside the main shaft 21. A rack plate 27 is provided on the upper side of the movable plate 7, and the rack plate 27 meshes with the gear 26. The stirring mechanism 2 also includes a guide post 28 and a wave-shaped boss 29. A mounting bracket 8 is provided on the lower left side of the movable plate 7. A guide post 28 is provided on the left end of the mounting bracket 8. A mounting bracket 28 is provided inside the lower end of the base 1. The lower side of the main shaft 21 is rotatably connected to the upper side of the mounting plate. The upper side of the mounting plate is provided with a wave-shaped boss 29. The guide post 28 is matched with the wave-shaped boss 29. The lower end of the main shaft 21 has a relief groove corresponding to the mounting frame 8. The lower end of the outer arc surface of the main shaft 21 is provided with a guide frame 9. The upper end of the outer arc surface of the guide post 28 is slidably connected to the left end of the guide frame 9. A spring 10 is provided between the mounting frame 8 and the left end of the guide frame 9. The spring 10 is sleeved on the upper end of the guide post 28.

[0019] The mounting plate has a motor 11 mounted on its lower side. The output shaft of the motor 11 is fixedly connected to the center of the lower end face of the main shaft 21. The input end of the motor 11 is electrically connected to the output end of the controller 13.

[0020] The working principle of this utility model is as follows: The sample to be analyzed is added to the mixing tank 3 through the drug pipeline. The material door is closed and the bolt is locked. The controller 13 controls the motor 11 to start, driving the main shaft 21 to rotate at high speed. This drives the stirring blades 25 on the upper part of the outer arc surface to rotate synchronously. The stirring blades 25 form radial and axial flows in the mixing tank 3, pushing the sample to make circular motion and tumbling up and down to achieve basic mixing. When the main shaft 21 rotates, the guide post 28 on the mounting frame 8 moves along the undulating trajectory of the wave-shaped boss 29. (When the lower end of the guide post 28 reaches the highest point of the wave-shaped boss 29, the spring 10 is in a compressed state and stores elastic potential energy; when the lower end of the guide post 28 leaves the highest point, the spring 10 releases elastic potential energy, pushing the mounting frame 8 to drive the lower end of the guide post 28 to continue sliding along the wave surface of the wave-shaped boss 29. Through the periodic undulation of the boss contour, the guide post 28...) The reciprocating up and down movement of the moving plate 7 drives the moving plate 7 to reciprocate up and down. The moving plate 7 meshes with the gear 26 through the rack plate 27, converting the linear motion of the moving plate into the rotational motion of the stirring column 23. The stirring column 23 drives the stirring frame 24 to oscillate periodically within the strip-shaped opening 22, generating a transverse shearing force on the sample around the main shaft, making up for the blind spot of traditional single-axial stirring, and forming a three-dimensional mixing effect of "rotation + oscillation". Temperature sensor 12 monitors the sample temperature inside the stirring tank 3 in real time and feeds the data back to controller 13. An external heat source, such as a constant temperature water bath, is injected into the jacket 4 through the inlet pipe 5 to provide a high-temperature heat medium or a low-temperature medium. After flowing through the jacket, the heat medium flows back from the outlet pipe 6, raising the sample temperature through heat conduction.

[0021] It is worth noting that the motor 11 disclosed in the above embodiments can be model GJ315A1-8, the temperature sensor 12 can be a TT-K-30-36 thermocouple, and the controller 13 can be an STC89C52 controller. The controller 13 controls the operation of the motor 11 and the temperature sensor 12 using methods commonly used in the prior art.

[0022] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A stirring device for use in drug analysis experiments, comprising a base (1) and a controller (13), wherein a stirring tank (3) is provided at the upper end of the base (1), and a temperature control component is provided on the outer arc surface of the stirring tank (3), characterized in that: It also includes a stirring mechanism (2); The stirring mechanism (2) includes a main shaft (21), a strip-shaped opening (22), a stirring column (23), a stirring frame (24), and stirring blades (25). The main shaft (21) is rotatably connected to the lower side wall of the stirring tank (3). The upper end of the outer arc surface of the main shaft (21) is provided with uniformly distributed stirring blades (25). The lower end of the main shaft (21) passes through the through hole at the upper end of the base (1) and is located inside the lower end of the base (1). The main shaft (21) is located in the middle of a part inside the stirring tank (3) with a strip-shaped opening (22). The stirring column (23) is rotatably connected between the front and rear inner walls of the strip-shaped opening (22). The outer arc surface of the stirring column (23) is provided with uniformly distributed stirring frames (24).

2. The stirring device for drug analysis experiments according to claim 1, characterized in that: The stirring mechanism (2) also includes a gear (26) and a rack plate (27). The stirring column (23) and the strip-shaped opening (22) are rotatably connected by a rotating shaft. The gear (26) is rotatably connected to the rear end of the main shaft (21). The front side of the gear (26) is fixedly connected to the center of the rear end face of the rotating shaft. An adjustable movable plate (7) is provided inside the main shaft (21). The upper side of the movable plate (7) is provided with a rack plate (27). The rack plate (27) is meshed with the gear (26).

3. A stirring device for drug analysis experiments according to claim 2, characterized in that: The stirring mechanism (2) also includes a guide column (28) and a wave-shaped boss (29). The lower left side of the moving plate (7) is provided with a mounting bracket (8). The left end of the mounting bracket (8) is provided with a guide column (28). The lower end of the base (1) is provided with a mounting plate. The lower side of the main shaft (21) is rotatably connected to the upper side of the mounting plate. The upper side of the mounting plate is provided with a wave-shaped boss (29). The guide column (28) and the wave-shaped boss (29) are fitted together. The lower outer arc surface of the main shaft (21) is provided with a clearance groove corresponding to the mounting bracket (8). The lower end of the outer arc surface of the main shaft (21) is provided with a guide frame (9). The upper end of the outer arc surface of the guide column (28) is slidably connected to the left end of the guide frame (9). A spring (10) is provided between the left end of the mounting bracket (8) and the guide frame (9). The spring (10) is sleeved on the upper end of the guide column (28).

4. A stirring device for drug analysis experiments according to claim 3, characterized in that: A motor (11) is mounted on the lower side of the mounting plate. The output shaft of the motor (11) is fixedly connected to the center of the lower end face of the main shaft (21). The input end of the motor (11) is electrically connected to the output end of the controller (13).

5. A stirring device for drug analysis experiments according to claim 1, characterized in that: The temperature control component is a jacket (4), which is set on the outer arc surface of the mixing tank (3). The upper end of the jacket (4) is provided with an inlet pipe (5), and the lower end of the jacket (4) is provided with a outlet pipe (6).

6. A stirring device for drug analysis experiments according to claim 1, characterized in that: A temperature sensor (12) is provided on the upper side wall of the mixing tank (3). The probe of the temperature sensor (12) penetrates the upper side wall of the mixing tank (3) and extends into the interior of the mixing tank (3). The input end of the temperature sensor (12) is electrically connected to the output end of the controller (13).

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