Immunohistochemical reagent bottle and reagent bottle rack

Abstract

The application discloses an immunohistochemical reagent bottle and a reagent bottle rack. The immunohistochemical reagent bottle comprises a bottle body and a bottle cap matched with the bottle body. The bottom of the transparent bottle body of the bottle body is provided with a conductive part fixedly connected with the bottle body. The conductive part is in direct contact with the reagent in the bottle and is used for being in contact with the rack of an external device to enhance the capacitance detection signal. The surface of the conductive part facing the direction of the bottle mouth is concave. The contact surface facing the rack of the external device is provided with a plurality of ribs. The bottle cap is of a flip structure. The top of the bottle body is provided with an inner cap of the bottle mouth fixedly welded with the bottle body. The bottle cap is provided with a sampling hole. The conductive part and the transparent bottle body are fused and formed into an integrated structure through a secondary forming process. The bottom surface of the conductive part is perpendicular to the axis of the bottle body and is coplanar with the contact surface of the rack of the external device. The application achieves the technical effects of enhancing the capacitance detection signal, facilitating sampling, ensuring sealing and the like.

Description

Technical Field

[0001] This application relates to the field of biological testing reagent containers, and in particular to an immunohistochemistry reagent bottle and reagent bottle rack. Background Technology

[0002] Immunohistochemical staining plays a crucial role in medical and laboratory testing, helping doctors and researchers analyze biological samples more accurately and providing key evidence for disease diagnosis and pathological research. With the continuous development of immunohistochemical technology, the requirements for related testing equipment and reagents are also increasing. As a commonly used device in this field, the performance and stability of the immunohistochemical staining machine directly affect the accuracy of the test results. Reagent vials, as an important component of the immunohistochemical staining machine, play a key role in the quality and characteristics of the entire testing process.

[0003] When using an immunohistochemical staining machine, liquid level monitoring of reagent vials is necessary to ensure the accuracy and reliability of the detection. Among existing technologies, capacitance detection is a commonly used method for detecting liquid levels in reagent vials. Traditional reagent vials are typically made of fully transparent PP material. While the transparency allows for easy visual observation of the liquid level, this material lacks conductivity and cannot amplify the capacitance detection signal.

[0004] Therefore, existing reagent bottles cannot simultaneously meet the requirements of conductivity and ease of observation, which has become an urgent problem to be solved in the field of immunohistochemistry reagent bottles. Summary of the Invention

[0005] To simultaneously meet the requirements of conductivity and ease of observation of the reagent bottle, this application provides an immunohistochemistry reagent bottle.

[0006] The immunohistochemistry reagent bottle provided in this application adopts the following technical solution: An immunohistochemistry reagent bottle includes a bottle body and a cap that fits into the bottle body. The bottle body includes a transparent body, a conductive part, and a bottle opening. The bottle opening is located at the top of the bottle body, and the conductive part is located at the bottom of the bottle body and is fixedly connected to the bottle body. The conductive part is in direct contact with the reagent contained in the bottle body, and the conductive part is used to contact an external equipment frame to enhance the capacitance detection signal.

[0007] By adopting the above technical solution, the transparent bottle body facilitates observation of the reagent status, and the conductive part is located at the bottom of the bottle body, which is in direct contact with the reagent and the external equipment frame, which can enhance the capacitance detection signal and realize effective monitoring of the liquid level in the reagent bottle.

[0008] Preferably, the bottle body further includes a recess on the side of the conductive part that contacts the reagent, facing away from the bottle opening.

[0009] By adopting the above technical solution, the surface of the conductive part facing the bottle opening is set as a recessed structure, which can increase the conductive area and further enhance the capacitance detection signal.

[0010] Preferably, the side of the conductive part that contacts the reagent has a concave apex, and the side of the conductive part that contacts the reagent gradually narrows towards the concave apex.

[0011] By adopting the above technical solution, the side of the conductive part that contacts the reagent gradually narrows towards the apex of the depression, which increases the conductive area of ​​the conductive part and also allows the reagent to converge at the apex of the depression, making it convenient for the sampler to draw up enough reagent.

[0012] Preferably, the bottle opening is positioned to correspond to the apex of the concave part of the conductive portion.

[0013] Preferably, when the bottle body adopts a cylindrical structure, the concave apex of the conductive part is located on the central axis of the bottle body.

[0014] By adopting the above technical solution, the concave apex of the conductive part corresponds to the bottle mouth and is set on the central axis of the bottle body. After the bottle cap is opened, it is convenient for the sampler to directly enter the bottle body through the bottle mouth and reach the concave apex of the conductive part to carry out the addition and sampling operation. It is also more convenient for the sampler to draw up enough reagent.

[0015] Preferably, the contact surface of the conductive part facing the external equipment frame is provided with multiple ribs.

[0016] Preferably, a plurality of the ribs are arranged symmetrically along the central axis of the conductive portion.

[0017] By adopting the above technical solution, the conductive part of the reagent bottle is fixedly connected to the bottom of the bottle body, the transparent bottle body is easy to observe, and the conductive part contacts the reagent inside the bottle and the external equipment frame to enhance the capacitance detection signal; multiple ribs are set on the contact surface of the conductive part facing the external equipment frame, which extend outward from the central area and are evenly distributed, saving materials and enhancing structural stability while meeting the conductivity requirements.

[0018] Preferably, the bottle cap has a flip-top structure, and the top of the bottle body is provided with an inner cap at the bottle mouth. The inner cap at the bottle mouth is welded and fixed to the bottle body and abuts against the bottle cap when it is closed.

[0019] By adopting the above technical solution, the bottle cap adopts a flip-type structure, and the inner cap of the bottle mouth is welded and fixed to the bottle mouth and abuts against it when the bottle cap is closed, which can increase the sealing performance of the reagent bottle.

[0020] Preferably, the welding surface between the inner cap of the bottle neck and the bottle body is an annular structure, and the annular structure completely covers the edge of the inner cap of the bottle neck.

[0021] By adopting the above technical solution, the welding surface between the inner cap and the bottle mouth is designed as a ring structure that completely wraps around the edge of the inner cap, further increasing the sealing performance of the reagent bottle.

[0022] Preferably, the bottom surface of the conductive part is perpendicular to the axis of the bottle body and coplanar with the contact surface of the external equipment frame.

[0023] By adopting the above technical solution, the reagent bottle can make full contact with the external equipment frame, ensuring effective contact between the conductive part and the metal frame of the equipment, thereby further enhancing the capacitance detection signal.

[0024] In summary, this application includes at least one of the following beneficial technical effects: 1. The conductive part is in direct contact with the reagent contained in the bottle and is also used for contact with the external equipment frame, which can enhance the capacitance detection signal; 2. The bottle is made of transparent material, making it easy to directly observe the reagents inside; 3. The bottle cap adopts a flip-top structure, and the inner cap of the bottle mouth is welded and fixed to the bottle body and abuts against the bottle cap when closed, which can increase the sealing performance of the reagent bottle. Attached Figure Description

[0025] Figure 1 This is a schematic diagram of the assembly of an immunohistochemistry reagent bottle and a rack according to an embodiment of this application.

[0026] Figure 2 This is a schematic diagram of the top structure of an immunohistochemistry reagent bottle according to an embodiment of this application.

[0027] Figure 3 This is a schematic diagram of the bottom structure of an immunohistochemistry reagent bottle according to an embodiment of this application.

[0028] Figure 4 This is a cross-sectional view of an immunohistochemistry reagent bottle (cylindrical structure) according to an embodiment of this application.

[0029] Figure 5 This is a cross-sectional view of an immunohistochemistry reagent bottle (non-cylindrical structure) according to an embodiment of this application.

[0030] Figure 6 This is a schematic diagram illustrating the combination of a reagent bottle holder and a reagent bottle in one embodiment of this application.

[0031] Figure 7 This is a schematic diagram illustrating the combination of a reagent bottle holder and a reagent bottle in another embodiment of this application.

[0032] Explanation of reference numerals in the attached drawings: 1. Bottle body; 2. Bottle cap; 3. Inner cap of bottle mouth; 4. Sampling hole; 5. Conductive part; 6. Rib; 7. Bottle mouth; 8. Positioning support part; 9. Frame; 10. Hollow cavity; 11. Bottom sealing cavity. Detailed Implementation

[0033] The following is in conjunction with the appendix Figure 1-7 This application will be described in further detail.

[0034] This application discloses an immunohistochemistry reagent bottle, as described in the embodiments below. Figures 1 to 3 The reagent bottle includes a bottle body and a cap 2 that fits into the bottle body. The cap 2 fits into the bottle body to open and close the reagent bottle. The conductive part 5 of the bottle body is in contact with the reagent inside the bottle and with the external equipment frame, thereby enhancing the capacitance detection signal. The conductive material of the conductive part 5 can conduct the reagent to the frame, thereby enhancing the capacitance detection signal.

[0035] Reference Figure 3 and Figure 4 Specifically, the bottle body includes a transparent bottle body 1, a conductive part 5, and a bottle mouth 7. The transparent bottle body 1 is made of a transparent material, such as PP transparent plastic, which has good transparency, allowing users to easily observe the state of the reagents inside. Besides PP transparent plastic, other transparent plastic materials can also be used, such as PET (polyethylene terephthalate). The transparent bottle body 1 is the reagent storage space, and its shape is generally a common bottle shape, capable of holding a certain amount of reagent.

[0036] The top of the bottle body is the bottle opening 7. A connecting position is provided at the lower end of the inner side of the bottle body 1, which is integrally formed with the bottle body 1. The conductive part 5 is located at the bottom of the bottle body 1 and is fixedly connected to the connecting position of the bottle body 1. The lower end of the conductive part 5 protrudes from the lower end of the bottle body 1. The conductive part 5 can be made of transparent conductive material, or it can be made of conductive materials with certain conductivity, such as conductive carbon black, nano carbon, graphene, etc. Alternatively, the conductive part 5 can also be made of PP material mixed with black conductive material, and then formed into a specific bottle bottom encapsulation structure through secondary injection molding technology and fused together with the bottle body 1. The conductive part 5 can directly contact the reagent contained in the bottle and is also used to contact the external equipment frame to enhance the capacitance detection signal. The reagent is contained in the bottle body 1 and can effectively contact the conductive material at the bottom of the bottle. The effective contact between the conductive material and the metal frame of the equipment can enhance the capacitance detection signal.

[0037] The bottle cap 2 has a flip-top design, which facilitates easy opening and closing of the reagent bottle. An inner cap 3 is located at the top of the bottle body, and the bottle cap 2 is hinged to one side of the inner cap 3. The inner cap 3 is ultrasonically welded to the bottle mouth 7. The inner cap 3 has a sampling hole 4, which corresponds to the apex of the recessed conductive part 5. Furthermore, the sampling hole 4 and the apex of the recessed conductive part 5 are positioned on the central axis of the bottle body for convenient sample collection. When the bottle cap 2 is closed, the periphery of the bottle cap 2 abuts against the inner periphery of the sampling hole in the inner cap 3, achieving a seal. The welding surface between the inner cap 3 and the bottle mouth 7 has a ring-shaped structure, completely enclosing the edge of the inner cap 3. This design enhances the sealing performance of the reagent bottle and prevents reagent leakage.

[0038] In addition, the bottom surface of the conductive part 5 is perpendicular to the axis of the bottle and coplanar with the contact surface of the external equipment frame. This ensures good contact between the conductive part 5 and the frame, thereby better enhancing the capacitance detection signal.

[0039] The bottom of the conductive part 5 is cylindrical and has multiple ribs 6. The ribs 6 extend outward from the central area of ​​the conductive part 5 and are evenly distributed, with several ribs 6 arranged symmetrically along the central axis of the conductive part 5. In other embodiments, the ribs 6 can also be arranged in a crisscross pattern to form a grid or mesh. These ribs 6 can save materials and enhance structural stability while meeting conductivity requirements. The shape of each rib 6 can be strip-shaped, and its height and width can be designed according to actual needs.

[0040] The conductive part 5 has a concave side that contacts the reagent, which is further away from the bottle opening 7. The conductive part 5 has a concave apex on the side that contacts the reagent, and the side that contacts the reagent gradually narrows towards the concave apex. This increases the conductive area of ​​the conductive part 5 and also allows the reagent to converge at the concave apex, making it easier for the sampler to draw up enough reagent.

[0041] In this embodiment, the bottle body adopts a cylindrical structure, and the sampling hole 4 of the inner cap 3 and the apex of the concave part 5 are both located on the central axis of the bottle body. The concave shape of the conductive part 5 can be hemispherical or conical, which can increase the conductive area to a certain extent. When the reagent is small, due to the presence of the concave apex, the reagent will accumulate in the concave area, thereby ensuring full contact with the conductive part 5 and further enhancing the capacitance detection signal.

[0042] The implementation principle of this embodiment is as follows: The immunohistochemistry reagent bottle combines a transparent bottle body 1 and a conductive part 5. The transparent bottle body 1 facilitates the observation of the reagent, while the conductive part 5 enhances the capacitive detection signal through contact with the reagent and the frame. The special structural design of the conductive part 5, such as the recessed structure 7 and the ribs 6, further optimizes the conductivity and structural stability. The flip-top structure of the bottle cap 2 and the design of the inner cap 3 at the bottle mouth ensure the airtightness of the reagent bottle. This design solves the problem of traditional reagent bottles being non-conductive and avoids the defects of inconvenient observation caused by the use of fully conductive materials. At the same time, it reduces costs and is more conducive to large-scale application and promotion, representing a significant improvement and enhancement compared to existing technologies.

[0043] Reference Figure 5 In another embodiment, the bottle body is a non-cylindrical column, and the sampling hole 4 of the inner cap 3 is located on one side of the plane of the bottle mouth 7 rather than in the center. In this case, the concave apex of the concave surface of the conductive part 5 is set to correspond to the sampling hole 4 to ensure sampling efficiency.

[0044] In other embodiments, besides using PP material mixed with black conductive material and then injection molded twice, the conductive part 5 can also be manufactured by embedding metal material and other conductive materials at the bottom during the first injection molding of the bottle body 1 to achieve conductivity, such as pre-embedding stainless steel pillars. This method also enables the conductive part 5 to have conductive properties, achieving conductivity with reagents and the frame, and enhancing the capacitance detection signal.

[0045] The preferred conductive materials are dark-colored conductive materials such as conductive carbon black, nano-carbon, and graphene.

[0046] The implementation principle of this embodiment is as follows: by embedding conductive materials such as metal at the bottom of the bottle body 1, the reagent can also be made conductive to the frame, thereby enhancing the capacitive detection signal. This alternative solution allows for the selection of appropriate conductive materials according to different needs, further expanding the manufacturing methods of immunohistochemistry reagent bottles and improving their applicability and flexibility.

[0047] This application also provides a reagent bottle rack, applied to the aforementioned reagent bottles, as described above. Figure 6 The reagent bottle rack includes a frame body with a strip-shaped structure. The frame body has at least two perforated cavities that fit the lower part of the reagent bottle, arranged side-by-side along the length of the frame body. In this embodiment, a positioning support is provided on the outer side of the reagent bottle. When the reagent bottle is placed in the perforated cavity, the lower end of the positioning support abuts against the upper surface of the frame body for positioning and support. The bottom of the conductive part of the reagent bottle extends out from the bottom of the perforated cavity to facilitate contact and conductivity with an external equipment frame.

[0048] Specifically, the positioning support can be a strip-shaped support beam, a block-shaped support, or a support structure formed by surface recesses. When a reagent bottle is placed in the receiving cavity of the strip-shaped reagent bottle rack with a hollow bottom, it can pass through the rack, and the bottom of the bottle can contact the flat plate of the equipment frame. The flat plate is also made of metal and connected to the ground of the equipment, providing conductivity. The reagent rack can be made of any non-conductive material, serving only the function of positioning and sorting support. The design of the positioning support optimizes the human operating experience. When a person needs to remove the reagent bottle rack, the bottle falls due to gravity, and the uprights on the side of the bottle provide support, preventing excessive leakage.

[0049] In other embodiments, a reagent bottle rack is also provided, which differs from the reagent bottle rack described above in that, with reference to... Figure 7 The cavities in the frame are all sealed cavities, and the frame itself is made of conductive materials, such as conductive metal, to ensure contact and conductivity with the conductive parts of the reagent bottles and the external equipment rack. The frame can be placed directly on the equipment rack, serving as a conductive medium to connect the conductive parts of the reagent bottles to the external equipment rack, offering high ease of use.

[0050] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. An immunohistochemistry reagent bottle, characterized in that: The device includes a bottle body and a bottle cap (2) that cooperates with the bottle body. The bottle body includes a transparent bottle body (1), a conductive part (5) and a bottle mouth (7). The bottle mouth (7) is located at the top of the bottle body (1). The conductive part (5) is located at the bottom of the bottle body (1) and is fixedly connected to the bottle body (1). The conductive part (5) is in direct contact with the reagent contained in the bottle body, and the conductive part (5) is used to contact the external equipment frame to enhance the capacitance detection signal.

2. The immunohistochemistry reagent bottle according to claim 1, characterized in that: The conductive part (5) is recessed on the side that contacts the reagent, away from the bottle opening (7).

3. An immunohistochemistry reagent bottle according to claim 2, characterized in that: The conductive part (5) has a concave apex on the side that contacts the reagent, and the side that contacts the reagent gradually narrows towards the concave apex.

4. An immunohistochemistry reagent bottle according to claim 3, characterized in that: The bottle opening (7) is positioned corresponding to the apex of the concave part (5).

5. An immunohistochemistry reagent bottle according to claim 4, characterized in that: When the bottle body adopts a cylindrical structure, the concave apex of the conductive part (5) is set on the central axis of the bottle body (1).

6. An immunohistochemistry reagent bottle according to claim 1, characterized in that: The conductive part (5) has multiple ribs (6) on the contact surface facing the external equipment frame.

7. An immunohistochemistry reagent bottle according to claim 6, characterized in that: Several of the ribs (6) are arranged symmetrically along the central axis of the conductive part (5).

8. An immunohistochemistry reagent bottle according to claim 1, characterized in that: The bottle cap (2) has a flip-type structure. The bottle body is provided with an inner cap (3) at the top of the bottle mouth. The inner cap (3) is welded and fixed to the bottle mouth (7) and abuts against the bottle cap (2) when closed.

9. An immunohistochemistry reagent bottle according to claim 8, characterized in that: The welding surface between the inner cap (3) and the bottle mouth (7) is an annular structure, and the annular structure completely covers the edge of the inner cap (3).

10. An immunohistochemistry reagent bottle according to claim 1, characterized in that: The bottom surface of the conductive part (5) is perpendicular to the axis of the bottle body and coplanar with the contact surface of the external equipment frame.

11. An immunohistochemistry reagent bottle according to claim 1, characterized in that: The bottle body (1) is provided with a positioning support (8).

12. A reagent bottle rack, applied to an immunohistochemistry reagent bottle as described in claim 11, characterized in that: Includes a frame (9), which is provided with a hollow cavity (10) adapted to the lower part of the reagent bottle. When the reagent bottle is placed in the hollow cavity (10), the lower end of the positioning support part (8) abuts against the upper surface of the frame (9) for positioning support. The bottom of the conductive part (5) extends out of the bottom of the hollow cavity (10) so as to make contact with the external equipment frame for conduction.

13. A reagent bottle rack, used in any one of the immunohistochemistry reagent bottles according to claims 1 to 11, characterized in that: Includes a frame (9), and the cavities provided in the frame (9) are all sealed cavities (11). The frame (9) is made of conductive material and is used to make contact with the conductive part (5) and the external equipment frame for conducting electricity.

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