Pulmonary hypertension cell culture test tube rack with tilt angle adjustment function
Patent Information
- Application Number
- CN202621488742.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2026-09-21
- Publication Date
- 2026-10-23
- Estimated Expiration
- 2036-09-21
AI Technical Summary
[0003]肺动脉高压细胞体外培养过程中，试管摆放倾角直接影响细胞贴壁状态、培养液浸润面积与气体交换效率，而常规试管支架大多仅支持水平或竖直固定摆放，难以统一调节倾斜角度，且部分可调支架只能单组独立调节，多组试管容易出现倾角不一致，于是，角度差异会造成各组细胞受液条件、氧接触环境不同，诱发细胞增殖、表型分化出现组间偏差，并且，传统的试管架多为一体结构，无法进行有效的分离使用与培养集中组装
本实用新型中，通过齿轮与双齿轨啮合的传动结构，可实现多组试管架同步角度调节，杜绝传统支架的单组调节或多组调节角度偏差不一的问题，能够有效保障肺动脉高压细胞培养实验的均一性，同时，试管架采用插接卡合式可拆卸结构，既方便实验人员批量装卸、清理试管，也便于单独检修更换部件。
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Figure CN224878072U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of test tube rack technology, and in particular to a pulmonary hypertension cell culture test tube rack with tilt angle adjustment function. Background Technology
[0002] Pulmonary hypertension cell culture is a common experimental method for constructing pulmonary hypertension research models in vitro. Most of the time, pulmonary artery smooth muscle cells and pulmonary artery endothelial cells are selected for culture. This method is free from in vivo interference, which makes it convenient to observe cellular and molecular changes. It is often used to explore the pathogenesis of pulmonary vascular remodeling and to screen potential targeted drugs.
[0003] In the in vitro culture of pulmonary hypertension cells, the tilt angle of the test tubes directly affects cell adhesion, the wetting area of the culture medium, and gas exchange efficiency. However, most conventional test tube racks only support horizontal or vertical fixed placement, making it difficult to uniformly adjust the tilt angle. Furthermore, some adjustable racks can only be adjusted independently for a single group, which can easily lead to inconsistent tilt angles among multiple groups of test tubes. As a result, the angle differences will cause different liquid conditions and oxygen contact environments for cells in each group, inducing inter-group deviations in cell proliferation and phenotypic differentiation. Moreover, traditional test tube racks are mostly of a single structure, which cannot be effectively separated for use or centrally assembled for culture. Utility Model Content
[0004] The purpose of this invention is to provide a pulmonary hypertension cell culture test tube rack with tilt angle adjustment function, which can realize the synchronous angle adjustment and positioning of multiple test tubes, thereby ensuring the uniformity of experimental conditions for pulmonary hypertension cell culture and effectively solving the problems in the background art.
[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows: A pulmonary hypertension cell culture tube rack with tilt angle adjustment function includes a base plate, side plates fixedly installed on both sides of the base plate, and a first groove opened on the opposite side of each of the two side plates. Gear rails are slidably installed on the inner top and inner bottom surfaces of the first grooves. Multiple carrier plates are movably installed on one side of each side plate near the first groove. A tube rack is detachably fixedly connected between two carrier plates arranged on one side and opposite to each other on the two side plates. The tube rack includes a support plate, and a perforated plate is fixedly installed on the top of the support plate through multiple front connecting plates. Side connecting plates are fixedly installed on both sides of the support plate and the perforated plate.
[0006] As a further preferred embodiment of this utility model, two second slide grooves are symmetrically opened on the inner top surface and inner bottom surface of the first slide groove, which are used to provide a foundation for the installation of the gear rail and to provide a path for the sliding of the gear rail in the first slide groove. Multiple positioning shafts are fixedly installed at equal intervals on the inner side surface of the first slide groove, and the positioning shafts provide the axis for the rotation of the carrier plate.
[0007] As a further preferred embodiment of this utility model, two sliders adapted to the second slide groove are symmetrically fixedly installed on the side of the toothed rail away from the teeth. The sliders are slidably connected in the corresponding second slide groove. By setting the two toothed rails, conditions can be provided for the synchronous rotation of multiple carrier plates.
[0008] As a further preferred embodiment of this utility model, the side plate located above the first slide groove is provided with multiple arc-shaped slides, and the inner top surface and inner bottom surface of the slides are provided with multiple positioning grooves.
[0009] As a further preferred embodiment of this utility model, two guide rails are symmetrically fixedly installed on one side of the carrier plate to provide a positioning and installation base for the test tube rack to be inserted between the two carrier plates, and a slot is provided on one side of the guide rail.
[0010] As a further preferred embodiment of this utility model, a gear is fixedly installed on the side of the carrier plate away from the guide rail. The gear has a shaft groove. A guide shaft is fixedly installed on the carrier plate above the gear. A rubber sleeve is fixedly installed on the outer surface of the guide shaft. The gear is inserted into the corresponding first slide groove and meshes with the two gear rails. The shaft groove is inserted into the corresponding positioning shaft. The guide shaft is inserted into and slidably connected in the corresponding slide. Thus, the carrier plate can rotate around the positioning shaft via the gear. The gear meshes with the two gear rails, so that when the angle of one test tube rack is adjusted, the angle of the other test tube racks is adjusted simultaneously. When the guide shaft slides in the slide, the outer rubber sleeve is engaged into the corresponding positioning groove to achieve angle positioning.
[0011] As a further preferred embodiment of this utility model, two slots adapted to the guide rail are symmetrically opened on the side of the side plate away from the support plate. A locking block is fixedly installed on the inner side of the slot. The slot is inserted and connected to the corresponding guide rail, and the locking block is locked in the slot on the inner side of the guide rail. When a single test tube rack is used to load and unload test tubes, it can be quickly installed between the two corresponding carrier plates by means of the two side plates, which facilitates subsequent experimental processing such as centralized culture of cells inside the test tube.
[0012] Compared with the prior art, the present invention has the following beneficial effects: In this invention, the transmission structure of gears and double toothed rails can realize the synchronous angle adjustment of multiple test tube racks, eliminating the problem of inconsistent angle deviations in single or multiple adjustments of traditional racks. This can effectively ensure the uniformity of pulmonary hypertension cell culture experiments. At the same time, the test tube rack adopts a plug-in snap-fit detachable structure, which is convenient for experimental personnel to load, unload and clean test tubes in batches, and also facilitates individual inspection and replacement of parts. Attached Figure Description
[0013] Figure 1This is a schematic diagram of the first state of the main structure of this utility model; Figure 2 This is a schematic diagram of the second state of the main structure of this utility model; Figure 3 This is a schematic diagram of the base plate, side plates, and carrier plate structure of this utility model; Figure 4 This is a schematic diagram of the assembly of the toothed rail and the second slide groove of this utility model; Figure 5 This is a schematic diagram of the carrier plate structure of this utility model; Figure 6 This is a schematic diagram of the test tube rack structure of this utility model.
[0014] In the diagram: 1. Base plate; 2. Side plate; 3. First slide groove; 4. Gear rail; 5. Carrier plate; 6. Test tube rack; 7. Support plate; 8. Hole plate; 9. Front connecting plate; 10. Side connecting plate; 11. Second slide groove; 12. Positioning shaft; 13. Slider; 14. Slide rail; 15. Positioning groove; 16. Guide rail; 17. Slot; 18. Gear; 19. Shaft groove; 20. Guide shaft; 21. Slot; 22. Locking block. Detailed Implementation
[0015] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.
[0016] like Figures 1-6 As shown, the pulmonary hypertension cell culture test tube rack with tilt angle adjustment function provided by this utility model includes a base plate 1, side plates 2 are fixedly installed on both sides of the base plate 1, and a first groove 3 is opened on the opposite side of the two side plates 2 respectively. The inner top surface and inner bottom surface of the first groove 3 are slidably installed with toothed rails 4. Multiple carrier plates 5 are movably installed on one side of the side plate 2 near the first groove 3. A test tube rack 6 is detachably fixedly connected between the two carrier plates 5 arranged on one side of the two side plates 2 and opposite to each other. The test tube rack 6 includes a support plate 7. A perforated plate 8 is fixedly installed on the top of the support plate 7 through multiple front connecting plates 9. Side connecting plates 10 are fixedly installed on both sides of the support plate 7 and the perforated plate 8.
[0017] Two second slide grooves 11 are symmetrically opened on the inner top and inner bottom surfaces of the first slide groove 3 to provide a foundation for the installation of the gear rail 4 and to provide a path for the sliding of the gear rail 4 in the first slide groove 3. Multiple positioning shafts 12 are fixedly installed at equal intervals on the inner side of the first slide groove 3. The positioning shafts 12 provide the axis for the rotation of the carrier plate 5. Two sliders 13 adapted to the second slide groove 11 are symmetrically fixedly installed on the side of the gear rail 4 away from the teeth. The sliders 13 are slidably connected in the corresponding second slide groove 11. The arrangement of the two gear rails 4 can provide conditions for the synchronous rotation of multiple carrier plates 5. Multiple arc-shaped slides 14 are opened on the side plate 2 located above the first slide groove 3. Multiple positioning grooves 15 are opened on the inner top and inner bottom surfaces of the slides 14. Two guide rails 16 are symmetrically fixedly installed on one side of the carrier plate 5 to provide a positioning and installation foundation for the test tube rack 6 to be inserted between the two carrier plates 5. A slot 17 is opened on one side of the guide rail 16.
[0018] A gear 18 is fixedly installed on the side of the carrier plate 5 away from the guide rail 16. A shaft groove 19 is formed inside the gear 18. A guide shaft 20 is fixedly installed on the carrier plate 5 above the gear 18. A rubber sleeve is fixedly installed on the outer surface of the guide shaft 20. The gear 18 is inserted into the corresponding first slide groove 3 and meshes with the two gear rails 4. The shaft groove 19 is inserted into the corresponding positioning shaft 12. The guide shaft 20 is inserted into and slidably connected to the corresponding slide rail 14. Thus, the carrier plate 5 can rotate around the positioning shaft 12 via the gear 18, and the gear 18 meshes with the two gear rails 4, allowing for synchronous adjustment when adjusting the angle of one of the test tube racks 6. The angle of the remaining test tube rack 6 is adjusted, and when the guide shaft 20 slides in the slide rail 14, the outer rubber sleeve is inserted into the corresponding positioning groove 15 to achieve angle positioning. The side plate 10 has two slots 21 that are adapted to the guide rail 16 symmetrically opened on the side away from the support plate 7. The slot 21 is fixedly installed with a card block 22. The slot 21 is inserted and connected to the corresponding guide rail 16, and the card block 22 is engaged in the card groove 17 on the inner side of the guide rail 16. When a single test tube rack 6 is used to load and unload test tubes, it can be quickly installed between the two corresponding carrier plates 5 by means of the two side plates 10, which facilitates subsequent experimental processing such as centralized culture of cells inside the test tube.
[0019] It should be noted that this utility model is a pulmonary hypertension cell culture test tube rack with tilt angle adjustment function. During operation, the operator first loads multiple pulmonary hypertension cell culture test tubes into the test tube rack 6 one by one. The bottom of the tube falls into the support plate 7, and the tube body passes through the perforated plate 8 for positioning. When multiple test tube racks 6 need to be assembled together and the test tubes loaded are sent into the incubator for culture, the operator can hold the test tube rack 6 and align the slots 21 on the side plates 10 on both sides with the guide rails 16 on the corresponding side of the carrier plate 5 and push it vertically until the locking block 22 pops into the slot 17, thus completing the assembly of the test tube rack 6 and the carrier plate 5. When disassembling, the test tube rack 6 can be pulled outwards to detach it. When the incubation tilt angle needs to be adjusted uniformly, any set of installed test tube racks 6 is moved. The carrier plates 5 of that set immediately swing around the positioning shaft 12. The gears 18 on the back of the carrier plates 5 rotate synchronously on the corresponding positioning shaft 12 through the shaft groove 19, thereby driving the upper and lower gear rails 4 that mesh with them to move in opposite directions in the first slide groove 3. The gear rails 4 are smoothly guided along the second slide groove 11 by their own slider 13, thereby forcing the gears 18 on all other carrier plates 5 to rotate at the same amplitude. All test tube racks 6 then obtain the same tilt angle. During the adjustment process, the guide shaft 20 at the top of the carrier plate 5 slides along the arc-shaped slide 14 of the side plate 2. The outer rubber sleeve of the shaft squeezes through the corresponding positioning groove 15 in the slide 14 in sequence, thereby completing the synchronous angle adjustment and positioning of multiple test tube racks 6.
[0020] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.
Claims
1. A pulmonary hypertension cell culture tube rack with tilt angle adjustment function, characterized in that: The system includes a base plate (1), on both sides of which side plates (2) are fixedly installed. A first groove (3) is opened on the opposite side of the two side plates (2). A toothed rail (4) is slidably installed on the inner top and inner bottom surfaces of the first groove (3). Multiple carrier plates (5) are movably installed on one side of the side plate (2) near the first groove (3). A test tube rack (6) is detachably fixed between the two carrier plates (5) on one side of the two side plates (2) and opposite to each other. The test tube rack (6) includes a support plate (7). A perforated plate (8) is fixedly installed on the top of the support plate (7) through multiple front connecting plates (9). Side connecting plates (10) are fixedly installed on both sides of the support plate (7) and the perforated plate (8).
2. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 1, characterized in that: The inner top and inner bottom surfaces of the first slide groove (3) are symmetrically provided with two second slide grooves (11), and multiple positioning shafts (12) are fixedly installed at equal intervals on the inner side surface of the first slide groove (3).
3. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 1, characterized in that: Two sliders (13) adapted to the second slide groove (11) are symmetrically fixed on the side of the toothed rail (4) away from the tooth. The sliders (13) are slidably connected in the corresponding second slide groove (11).
4. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 1, characterized in that: The side plate (2) located above the first slide (3) has multiple arc-shaped slides (14), and the inner top surface and inner bottom surface of the slides (14) have multiple positioning grooves (15).
5. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 2, characterized in that: Two guide rails (16) are symmetrically fixedly installed on one side of the carrier plate (5), and a slot (17) is provided on one side of the guide rail (16).
6. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 5, characterized in that: A gear (18) is fixedly installed on the side of the carrier plate (5) away from the guide rail (16). A shaft groove (19) is opened in the gear (18). A guide shaft (20) is fixedly installed on the carrier plate (5) above the gear (18). A rubber sleeve is fixedly installed on the outer surface of the guide shaft (20). The gear (18) is inserted into the corresponding first slide groove (3) and meshes with the two gear rails (4). The shaft groove (19) is inserted into the corresponding positioning shaft (12). The guide shaft (20) is inserted into and slidably connected in the corresponding slide rail (14).
7. The pulmonary hypertension cell culture tube rack with tilt angle adjustment function according to claim 6, characterized in that: The side plate (10) has two symmetrical slots (21) that are adapted to the guide rail (16) on the side away from the support plate (7). A card block (22) is fixedly installed on the inner side of the slot (21). The slot (21) is inserted into the corresponding guide rail (16), and the card block (22) is engaged in the card groove (17) on the inner side of the guide rail (16).