A biological sample separation device

Abstract

The utility model discloses a biological sample separation device, including separation shell, the middle part of separation shell is equipped with separation groove, still includes stable mechanism, stable mechanism includes mounting panel, strip shape mouth, mounting bracket, dynamic sliding plate and arc clamping plate, the inside of separation groove is provided with mounting panel, and the left and right two ends of mounting panel all are equipped with strip shape mouth, and the inside of strip shape mouth all is connected with mounting bracket slidingly, and the inside of the slide rail of mounting bracket upper end all is connected with dynamic sliding plate slidingly. The opposite inner side of two dynamic sliding plates all is equipped with arc clamping plate, and the front side of mounting bracket upper end slide rail all is connected with the top screw of screw thread, and the rear end of top screw all is in contact with the front side of dynamic sliding plate of rear side adjacent. The utility model can realize stable clamping fixed to the sample container of different diameter, improves the stability and the operating convenience in biological sample separation process, and the adaptation range is wider.

Description

Technical Field

[0001] This utility model relates to the field of biological sample separation technology, specifically a biological sample separation device. Background Technology

[0002] In the fields of biomedicine, biotechnology, and clinical testing, the separation and purification of biological samples are crucial fundamental operations. Whether it is separating plasma and blood cells from blood, screening target cells in cell suspensions, or extracting proteins or nucleic acids from tissue homogenates, precise separation of sample components is required through specific separation devices. The stability and accuracy of this process directly affect the reliability of subsequent experimental results. For example, in disease diagnosis, the purity of blood samples may directly determine the accuracy of detection indicators; in drug development, the effective separation of cell samples is related to the scientific validity of drug action mechanism research. Therefore, developing efficient and stable biological sample separation devices has always been an important issue in related technical fields.

[0003] In existing technologies, biological sample separation devices mostly use centrifugation as their core principle. By generating strong centrifugal acceleration through high-speed rotation, components with different densities in the mixture (such as liquid and solid particles, or two liquids with large density differences) are subjected to different centrifugal forces, thereby overcoming the effects of gravity and buoyancy, achieving rapid stratification or sedimentation according to density differences, and ultimately achieving separation. Such devices usually require selecting centrifuge tubes or containers that match the diameter of the centrifuge rotor holes, inserting the container into the rotor holes to ensure stability during rotation.

[0004] In existing technologies, containers placed into the rotor often require a specific size to fit, which exposes several obvious shortcomings. First, it limits the flexibility of experimental and production processes. Different experimental or production scenarios have different requirements for the quantity and properties of samples, thus requiring the use of containers of different diameters. For example, in scientific research laboratories, micro-experiments may require smaller diameter centrifuge tubes to precisely control the sample volume; while in large-scale biopharmaceutical production, larger diameter centrifuge containers are needed to process large amounts of culture medium in order to improve efficiency. However, traditional centrifuges are only compatible with containers of specific sizes. If containers of other diameters are to be used, the entire rotor or centrifuge must be replaced, which undoubtedly increases the complexity and cost of operation. Utility Model Content

[0005] The technical problem to be solved by this invention is to overcome the existing defects and provide a biological sample separation device that can stably clamp and fix sample containers of different diameters, which can effectively solve the problems in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a biological sample separation device, comprising a separation shell and a control switch assembly, wherein a separation groove is provided in the middle of the separation shell, and a stabilizing mechanism is also included; The stabilizing mechanism includes a mounting plate, a strip-shaped opening, a mounting frame, a movable slide plate, and an arc-shaped clamping plate. The mounting plate is located inside the separation groove. Both ends of the mounting plate have strip-shaped openings, and the mounting frame is slidably connected inside each strip-shaped opening. Movable slide plates are slidably connected inside the slide rails at the upper end of the mounting frame. Arc-shaped clamping plates are provided on the opposite inner sides of the two movable slide plates. Tightening screws are threaded to the front side of the slide rails at the upper end of the mounting frame, and the rear ends of the tightening screws are in contact with the front side of the adjacent movable slide plate.

[0007] Furthermore, the stabilizing mechanism also includes a scale recognition groove and scale lines. The scale lines are respectively set on the front side of the movable slide plate. The upper slide rail of the mounting bracket is provided with a scale recognition groove at the end near the center of the mounting plate. The scale recognition groove is set in conjunction with the adjacent scale lines on the rear side to facilitate the display of the moving position.

[0008] Furthermore, the stabilizing mechanism also includes connecting rods and C-shaped frames. The outer arc surface of the pins at the lower end of the mounting frame is rotatably connected to the connecting rods. The C-shaped frame is located inside the lower side of the separation groove. Mounting columns are provided between the front and rear inner walls of the C-shaped frame. The lower ends of the connecting rods are rotatably connected to the mounting columns, which facilitates the synchronous movement of the mounting frames on both sides.

[0009] Furthermore, an electric cylinder is installed on the bottom wall of the separation tank. The telescopic end of the electric cylinder is rotatably connected to the lower side of the C-shaped frame, and the input end of the electric cylinder is electrically connected to the output end of the control switch group for stable driving.

[0010] Furthermore, a rotating plate is rotatably connected to the middle of the inner arc surface of the separation groove. The middle of the upper side of the rotating plate is fixedly connected to the lower side of the mounting plate. The middle of the rotating plate is provided with clearance grooves corresponding to the two mounting brackets to facilitate rotation.

[0011] Furthermore, a motor is installed on the rear side of the bottom wall of the separation tank. The input end of the motor is electrically connected to the output end of the control switch group. A gear is provided at the end of the output shaft of the motor. An internal gear ring is provided under the rotating plate. The internal gear ring meshes with the gear for stable driving.

[0012] Compared with the prior art, the beneficial effects of this utility model are: This biological sample separation device achieves stable clamping of sample containers of different diameters through a stabilizing mechanism. The movable sliding plate and the arc-shaped clamping plate work together to flexibly adjust the clamping range, and the scale recognition groove and scale line work together to ensure adjustment accuracy. The linkage, C-shaped frame and electric cylinder work together to realize synchronous movement of the clamping structures on both sides, ensuring symmetrical clamping and avoiding container shaking. Attached Figure Description

[0013] Figure 1 This is a three-dimensional structural diagram of the present invention; Figure 2 This is an enlarged structural schematic diagram of point A of this utility model; Figure 3 This is a schematic diagram of the structure of the present invention from a front sectional view; Figure 4 This is an enlarged structural schematic diagram of section B of this utility model; Figure 5 This is a partial structural diagram of the stabilizing mechanism of this utility model; Figure 6 This is a schematic diagram of the structure of the present invention in cross-section from the rear.

[0014] In the diagram: 1 Separating shell, 2 Stabilizing mechanism, 21 Mounting plate, 22 Strip opening, 23 Mounting bracket, 24 Scale recognition slot, 25 Moving slide plate, 26 Arc-shaped clamping plate, 27 Scale line, 28 Connecting rod, 29 C-shaped frame, 291 Mounting column, 3 Turning plate, 4 Internal gear ring, 5 Gear, 6 Motor, 7 Electric cylinder, 8 Control switch group, 9 Separating slot, 10 Tightening screw. Detailed Implementation

[0015] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0016] Please see Figure 1-6 This embodiment provides a technical solution: a biological sample separation device, including a separation shell 1 (the rear end of the separation shell 1 is connected to a cover via a hinge, the front edge of the lower side of the cover has a protruding buckle, and the upper side of the separation shell 1 has a groove or locking tongue at a corresponding position. When the cover is closed, the buckle engages with the groove, and the locking tongue presses the buckle by the action of a spring or gravity. To lock or open the cover, an external force needs to be applied to the unlocking part of the cover, such as the edge of the cover, usually by pulling or pressing upwards. The external force acts on the buckle or the elastic structure connecting the buckle, causing it to undergo elastic deformation again. During the deformation process, the vertical engagement surface of the buckle separates from the inner wall of the groove, and the buckle slides out of the groove along the inclined guide surface of the groove. When the buckle is completely disengaged from the groove, the elastic structure resets, the cover loses its locking constraint, and can be opened). The front side of the separation shell 1 is provided with a control switch group 8, the input end of the control switch group 8 is electrically connected to an external power source, and the middle part of the separation shell 1 is provided with a separation groove 9.

[0017] The system also includes a stabilizing mechanism 2. The stabilizing mechanism 2 comprises a mounting plate 21, slots 22, a mounting frame 23, movable slide plates 25, and arc-shaped clamping plates 26. The mounting plate 21 is located inside the separation groove 9. Slots 22 are provided at both ends of the mounting plate 21. The mounting frame 23 is slidably connected inside each slot 22. Movable slide plates 25 are slidably connected inside the slide rails at the upper end of the mounting frame 23. Arc-shaped clamping plates 26 are provided on the opposite inner surfaces of the two movable slide plates 25. Tightening screws 10 are threadedly connected to the front side of the slide rails at the upper end of the mounting frame 23. The rear ends of the tightening screws 10 are connected to the front side of the adjacent movable slide plate 25. The stabilizing mechanism 2 also includes a scale recognition groove 24 and a scale line 27. The scale line 27 is respectively set on the front side of the movable slide plate 25. The upper slide rail of the mounting bracket 23 is provided with a scale recognition groove 24 near the center of the mounting plate 21. The scale recognition groove 24 is configured to cooperate with the adjacent scale line 27 on the rear side. The stabilizing mechanism 2 also includes a connecting rod 28 and a C-shaped frame 29. The outer arc surface of the pin at the lower end of the mounting bracket 23 is rotatably connected to the connecting rod 28. The C-shaped frame 29 is set on the lower side inside the separation groove 9. The mounting column 291 is provided between the front and rear inner walls of the C-shaped frame 29. The lower end of the connecting rod 28 is rotatably connected to the mounting column 291.

[0018] Among them, an electric cylinder 7 is installed on the bottom wall of the separation tank 9. The telescopic end of the electric cylinder 7 is rotatably connected to the lower side of the C-shaped frame 29. The input end of the electric cylinder 7 is electrically connected to the output end of the control switch group 8. A rotating plate 3 is rotatably connected to the middle of the inner arc surface of the separation tank 9. The middle of the upper side of the rotating plate 3 is fixedly connected to the lower side of the mounting plate 21. The middle of the rotating plate 3 has a clearance groove corresponding to the two mounting frames 23. A motor 6 is installed on the rear side of the bottom wall of the separation tank 9. The input end of the motor 6 is electrically connected to the output end of the control switch group 8. A gear 5 is provided at the end of the output shaft of the motor 6. An internal gear ring 4 is provided under the rotating plate 3. The internal gear ring 4 is meshed with the gear 5.

[0019] The working principle of this utility model is as follows: First, the worker measures the diameter of the container containing the biological sample and calculates the radius of the container. Then, the worker adjusts the position of the movable slide plate 25 inside the upper slide rail of the mounting frame 23. The moving distance of the mounting frame 23 is constant at X, the radius of the container is variable ΔY, and the distance that the movable slide plate 25 needs to move is X + ΔY. When adjusting the position of the movable slide plate 25, the worker judges the distance that the movable slide plate 25 moves by observing the length of the adjacent scale recognition groove 24 that is exposed on the scale line 27. Subsequently, the container containing the biological sample is placed in the area between the two arc-shaped clamping plates 26 on the mounting plate 21. The electric cylinder 7 is activated by the control switch group 8. The telescopic end of the electric cylinder 7 pushes the C-shaped frame 29 down. When the C-shaped frame 29 descends, the connecting rod 28 pulls the mounting frame 23 to slide away from the center. During this process, the two mounting frames 23 move synchronously through the linkage between the connecting rod 28 and the C-shaped frame 29, ensuring that the arc-shaped clamping plates 26 on both sides move symmetrically closer to the container and finally fit tightly against the outer arc surface of the container. After clamping is completed, the motor 6 is started by controlling the switch group 8. The output shaft of the motor 6 drives the gear 5 to rotate. The gear 5 meshes with the internal gear ring 4, which in turn drives the rotating plate 3 to rotate around the central axis of the separation groove 9. Since the rotating plate 3 is fixedly connected to the mounting plate 21, the mounting plate 21 and the container fixed by the arc-shaped clamping plate 26 rotate synchronously with the rotating plate 3, so that the internal biological sample can achieve component separation such as liquid stratification and solid-liquid separation under the action of centrifugal force. After a period of time, the electric cylinder 7 is activated by the control switch group 8. The telescopic end of the electric cylinder 7 pushes the C-shaped frame 29 upward. When the C-shaped frame 29 rises, it drives the lower end of the connecting rod 28 to rotate upward through the mounting column 291. The upper end of the connecting rod 28 pushes the mounting frame 23 to slide along the strip opening 22 away from the center of the mounting plate 21 through the pin shaft. During this process, the two mounting frames 23 move synchronously through the linkage of the connecting rod 28 and the C-shaped frame 29, ensuring that the arc-shaped clamping plates 26 on both sides are symmetrically away from the container. After that, the worker can remove the container.

[0020] It is worth noting that the motor 6 disclosed in the above embodiments can be a 57HS series stepper motor, the electric cylinder 7 can be a KSD series electric cylinder, and the control switch group 8 is provided with control buttons that correspond one-to-one with the motor 6 and the electric cylinder 7 and are used for controller switching.

[0021] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the content of this utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A biological sample separation device, comprising a separation shell (1) and a control switch assembly (8), wherein a separation groove (9) is provided in the middle of the separation shell (1), characterized in that: It also includes stabilizing mechanisms (2); The stabilizing mechanism (2) includes a mounting plate (21), a strip opening (22), a mounting frame (23), a movable slide plate (25), and an arc-shaped clamping plate (26). The mounting plate (21) is located inside the separation groove (9). Both ends of the mounting plate (21) have strip openings (22). The mounting frame (23) is slidably connected inside the strip openings (22). The movable slide plate (25) is slidably connected inside the slide rail at the upper end of the mounting frame (23). The two movable slide plates (25) have arc-shaped clamping plates (26) on their opposite inner sides. The front side of the slide rail at the upper end of the mounting frame (23) is threaded with a tightening screw (10). The rear end of the tightening screw (10) is in contact with the front side of the adjacent movable slide plate (25) on the rear side.

2. The biological sample separation device according to claim 1, characterized in that: The stabilizing mechanism (2) also includes a scale recognition groove (24) and a scale line (27). The scale line (27) is respectively set on the front side of the sliding plate (25). The upper slide rail of the mounting bracket (23) is provided with a scale recognition groove (24) near the center of the mounting plate (21). The scale recognition groove (24) is set in conjunction with the scale line (27) adjacent to the rear side.

3. The biological sample separation device according to claim 1, characterized in that: The stabilizing mechanism (2) also includes a connecting rod (28) and a C-shaped frame (29). The outer arc surface of the pin at the lower end of the mounting frame (23) is rotatably connected to the connecting rod (28). The C-shaped frame (29) is located on the lower side inside the separation groove (9). A mounting column (291) is provided between the front and rear inner walls of the C-shaped frame (29). The lower ends of the connecting rod (28) are rotatably connected to the mounting column (291).

4. The biological sample separation device according to claim 3, characterized in that: An electric cylinder (7) is installed on the bottom wall of the separation tank (9). The telescopic end of the electric cylinder (7) is rotatably connected to the lower side of the C-shaped frame (29). The input end of the electric cylinder (7) is electrically connected to the output end of the control switch group (8).

5. A biological sample separation device according to claim 1, characterized in that: The inner arc surface of the separation groove (9) is rotatably connected to a rotating plate (3). The middle of the upper side of the rotating plate (3) is fixedly connected to the lower side of the mounting plate (21). The middle of the rotating plate (3) is provided with clearance grooves corresponding to the two mounting brackets (23).

6. A biological sample separation device according to claim 5, characterized in that: A motor (6) is installed on the rear side of the bottom wall of the separation tank (9). The input end of the motor (6) is electrically connected to the output end of the control switch group (8). A gear (5) is provided at the end of the output shaft of the motor (6). An internal gear ring (4) is provided under the rotating plate (3). The internal gear ring (4) meshes with the gear (5).

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