A Shenqi Cai Tai mixture liquid fermentation system

Abstract

The utility model discloses a kind of shenqi changtai mixture liquid fermentation systems, including fermentation subsystem and shenqi changtai mixture liquid preparation subsystem, fermentation subsystem and shenqi changtai mixture liquid preparation subsystem are communicated with liquid medicine mixing tank;Fermentation subsystem includes sterilized culture medium storage tank, primary seed tank, secondary seed tank, tertiary fermentation tank and bifidobacterium culture solution storage tank, sterilized culture medium storage tank is filled with culture medium after sterilization, primary seed tank, secondary seed tank, tertiary fermentation tank are communicated with sterilized culture medium storage tank by culture medium delivery pipeline;Tertiary fermentation tank discharge port is communicated with bifidobacterium culture solution storage tank, and culture solution transfer pipeline is provided with delivery pump, and bifidobacterium culture solution storage tank discharge port is communicated with liquid medicine mixing tank, and the bottom of liquid medicine mixing tank is provided with discharge port, and is communicated with shenqi changtai mixture storage tank, can stably configure bifidobacterium culture solution and shenqi changtai mixture precision liquid preparation, to realize the preparation of shenqi changtai mixture liquid.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical production technology, specifically to a fermentation system for a ginseng and intestinal tract preparation. Background Technology

[0002] Shenqi Changtai Mixture is a "Chinese and Western medicine combined" microecological preparation composed of red ginseng, Atractylodes macrocephala, Poria cocos, licorice, Bifidobacterium culture medium, and tangerine peel syrup. Its preparation system relies heavily on the crucial step of inoculating Bifidobacterium. Traditional Bifidobacterium inoculation often involves manual operation, which is prone to the following problems: improper operation by personnel; untimely or insufficient nitrogen aeration during the culture medium cooling stage, resulting in ineffective replacement of dissolved oxygen; and the potential for introducing contaminating bacteria, increasing the risk of batch contamination and leading to substandard viable bacterial counts and poor product stability. Utility Model Content

[0003] This invention aims to solve the technical problems existing in the prior art, and innovatively proposes a fermentation system for the preparation of Bifidobacterium bifidum culture medium and refined solution of Bifidobacterium bifidum, so as to realize the preparation of Bifidobacterium bifidum infusion.

[0004] To achieve the above objectives, this utility model provides a fermentation system for the Shenqi Changtai compound preparation solution, comprising a fermentation subsystem and a Shenqi Changtai compound preparation solution preparation subsystem. The fermentation subsystem is used to prepare a culture medium of Bifidobacteria, and the Shenqi Changtai compound preparation solution preparation subsystem is used to prepare a refined solution of Shenqi Changtai compound preparation solution. Both the fermentation subsystem and the Shenqi Changtai compound preparation solution preparation subsystem are connected to a drug solution mixing tank. The fermentation subsystem includes a sterilized culture medium storage tank, a primary seed tank, a secondary seed tank, a tertiary fermentation tank, and a Bifidobacterium culture medium storage tank. The sterilized culture medium storage tank contains sterilized culture medium. The primary seed tank, secondary seed tank, and tertiary fermentation tank are all connected to the sterilized culture medium storage tank through culture medium delivery pipelines, and the primary seed tank, secondary seed tank, and tertiary fermentation tank are all connected to the nitrogen supply system through nitrogen pipelines. The discharge port of the tertiary fermenter is connected to the Bifidobacterium culture medium storage tank via a culture medium transfer pipeline. A delivery pump is installed on the culture medium transfer pipeline, and the beginning of the culture medium transfer pipeline extends to the bottom of the tertiary fermenter. The discharge port of the Bifidobacterium culture medium storage tank is connected to the drug solution mixing tank via a culture medium supply pipeline. The bottom of the drug solution mixing tank is provided with a discharge port, which is connected to the Shenqi Changtai compound storage tank via a drug solution transfer pipeline.

[0005] In the above scheme: the Shenqi Changtai compound preparation subsystem includes a Shenqi Changtai compound extract storage tank, a tangerine peel syrup storage tank, a Shenqi Changtai compound preparation tank, and a primary storage tank for the refined Shenqi Changtai compound solution. The outlet of the Shenqi Changtai compound extract storage tank is connected to the Shenqi Changtai compound preparation tank via an extract delivery pipeline. The tangerine peel syrup storage tank is connected to the Shenqi Changtai compound preparation tank via a syrup delivery pipeline. Metering pumps and electric valves are installed on both the extract delivery pipeline and the syrup delivery pipeline. The can is also connected to a pure water supply system, through which pure water is added to the preparation tank of Shenqi Changtai Mixture. The preparation tank of Shenqi Changtai Mixture is equipped with a second stirring mechanism, which mixes the tangerine peel syrup and Shenqi Changtai Mixture extract to form a refined solution of Shenqi Changtai Mixture. The solution outlet of the preparation tank of Shenqi Changtai Mixture is connected to the storage container of the refined solution of Shenqi Changtai Mixture through a solution delivery pipeline. The storage container of the refined solution of Shenqi Changtai Mixture is connected to the medicine mixing tank.

[0006] In the above scheme: the bottom of the preparation tank of the Shenqi Changtai compound is equipped with a filter structure, and the filter residue outlet of the preparation tank of the Shenqi Changtai compound is connected to a screw conveyor for slag discharge.

[0007] In the above scheme: the storage container for the refined solution of Shenqi Changtai Mixture includes a primary storage tank for the refined solution of Shenqi Changtai Mixture and a sterilized solution storage tank for Shenqi Changtai Mixture; the primary storage tank for the refined solution of Shenqi Changtai Mixture is used to store the refined solution of Shenqi Changtai Mixture before high-temperature sterilization, and the sterilized solution storage tank for Shenqi Changtai Mixture is used to store the refined solution of Shenqi Changtai Mixture after high-temperature sterilization; The dispensing outlet of the Shenqi Changtai compound preparation tank is connected to the primary storage tank of the refined Shenqi Changtai compound solution via a dispensing pipeline, and is stored in the primary storage tank of the refined Shenqi Changtai compound solution. After high-temperature sterilization, the refined Shenqi Changtai compound solution is transferred to the sterilized Shenqi Changtai compound solution storage tank for storage. The sterilized Shenqi Changtai compound solution storage tank is connected to the drug mixing tank via a sterilized solution pipeline.

[0008] In the above scheme: the tangerine peel syrup storage tank is also connected to a tangerine peel syrup preparation subsystem, which includes a percolation tank, a tangerine peel tincture storage tank, and a tangerine peel syrup preparation tank. The top of the percolation tank is provided with a tangerine peel inlet for adding tangerine peel granules. The top of the percolation tank is connected to an ethanol supply system via an ethanol delivery pipeline. A third stirring mechanism is provided inside the percolation tank. The discharge port at the bottom of the percolation tank is connected to a tangerine peel tincture storage tank via a tangerine peel tincture transfer pipeline. A delivery pump is provided on the tangerine peel tincture transfer pipeline. The liquid outlet of the tangerine peel tincture storage tank is connected to the tangerine peel syrup preparation tank via a tangerine peel tincture supply pipeline. The top of the tangerine peel syrup preparation tank is also provided with a material inlet for adding excipients and purified water. A fourth stirring mechanism is provided inside the tangerine peel syrup preparation tank. The discharge port at the bottom of the tangerine peel syrup preparation tank is connected to the tangerine peel syrup storage tank via a tangerine peel syrup transfer pipeline.

[0009] In the above scheme: the drug solution mixing tank is equipped with a first stirring mechanism for mixing the refined solution of Ginseng and Bifidobacterium intestinal remedy and the culture medium of Bifidobacterium, so as to improve the mixing efficiency and ensure the quality of drug solution production.

[0010] In the above scheme, metering pumps and electric valves are installed on the culture medium delivery pipelines to improve the degree of automation and enable automatic metering and shut-off of delivery.

[0011] In summary, the beneficial effects of this invention are: it can stably prepare Bifidobacterium culture medium and refined solution of Shenqi Changtai compound, and subsequently prepare Shenqi Changtai compound solution, thus meeting the process requirements for Bifidobacterium culture medium and refined solution of Shenqi Changtai compound, and ensuring production efficiency. The simultaneously installed primary seed tank, secondary seed tank, and tertiary fermentation tank can meet the inoculation and culture requirements for Bifidobacterium activation, expansion, and fermentation, with a high degree of automation, facilitating precise parameter control, improving production efficiency, ensuring production quality, and reducing the risk of contamination. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the present invention. Detailed Implementation

[0013] The present invention will be further described below with reference to embodiments and accompanying drawings: like Figure 1 As shown, a fermentation system for a ginseng and bifidobacteria-containing compound preparation solution includes a fermentation subsystem and a ginseng and bifidobacteria-containing compound preparation solution subsystem. The fermentation subsystem is used to prepare a culture medium of bifidobacteria, and the ginseng and bifidobacteria-containing compound preparation solution subsystem is used to prepare a refined solution of ginseng and bifidobacteria-containing compound preparation solution. Both the fermentation subsystem and the ginseng and bifidobacteria-containing compound preparation solution subsystem are connected to a mixing tank 21, which is equipped with a first stirring mechanism 23 for mixing the refined solution of ginseng and bifidobacteria-containing compound preparation solution and the culture medium.

[0014] The fermentation subsystem includes a sterile culture medium storage tank 11, a primary seed tank 12, a secondary seed tank 13, a tertiary fermenter 14, and a Bifidobacterium culture medium storage tank 15. The sterile culture medium storage tank 11 contains sterilized culture medium. The primary seed tank 12, secondary seed tank 13, and tertiary fermenter 14 are all connected to the sterile culture medium storage tank 11 via culture medium delivery pipelines. Each of the primary seed tank 12, secondary seed tank 13, and tertiary fermenter 14 is equipped with a Bifidobacterium inoculum inlet. Metering pumps 51 and electric valves 52 are installed on the culture medium delivery pipelines, and the primary seed tank 12, secondary seed tank 13, and tertiary fermenter 14 are all connected to the nitrogen supply system via nitrogen pipelines.

[0015] Primary seed tank 12 is used for the activation culture of Bifidobacterium strains. The culture medium volume is 60-70% of the tank volume, and the temperature is controlled at 37±0.1℃, pH 6.5±0.05, in an anaerobic environment (nitrogen replacement, oxygen partial pressure ≤5%). The culture time is 8-10 hours to achieve strain recovery and initial proliferation (viable count ≥1×10⁻⁶). 7 (CFU / mL) The secondary seed tank is used to receive the primary seed culture, expand the culture scale, maintain a temperature of 38±0.1℃ and a pH of 6.3±0.05, and improve the mass transfer efficiency of nutrients through a stirring system (80 r / min). The culture time is 12-14 hours, and the viable cell count is increased to ≥1×10⁻⁶. 8 CFU / mL; The tertiary fermenter is used to receive the secondary seed culture (inoculum 15-20%) for high-yield cultivation. The carbon-to-nitrogen ratio is optimized (glucose 5g / L, peptone 10g / L), dissolved oxygen is controlled to ≤3%, and the stirring speed is 60 rpm (to avoid shear force damage to the strain). The cultivation time is 16-18 hours, ultimately achieving a Bifidobacterium viable count ≥1×10⁻⁶. 9 CFU / mL, meeting formulation requirements.

[0016] First, Bifidobacteria are activated in the primary seed tank 12, then transferred to the secondary seed tank 13 for culture and expansion, and finally transferred to the tertiary fermentation tank 14 for fermentation, which conforms to the growth cycle of Bifidobacteria to form a Bifidobacteria culture medium.

[0017] The discharge port of the tertiary fermenter 14 is connected to the Bifidobacterium culture medium storage tank 15 through a culture medium transfer pipeline. A transfer pump 53 is installed on the culture medium transfer pipeline, and the beginning of the culture medium transfer pipeline extends into the bottom of the tertiary fermenter 14.

[0018] The outlet of the Bifidobacterium culture medium storage tank 15 is connected to the drug mixing tank 21 via a culture medium supply pipeline. A metering pump 51 and an electric valve 52 are also installed on the culture medium supply pipeline. The bottom of the drug mixing tank 21 is provided with an outlet, which is connected to the Ginseng and Ginseng Intestinal Health Agent storage tank 22 via a drug transfer pipeline. A transfer pump 53 is also installed on the drug transfer pipeline.

[0019] The Ginseng and Intestinal Health Formula preparation subsystem includes a Ginseng and Intestinal Health Formula extract storage tank 34, a tangerine peel syrup storage tank 35, a Ginseng and Intestinal Health Formula preparation tank 31, and a primary storage tank for the refined Ginseng and Intestinal Health Formula solution. The outlet of the Ginseng and Intestinal Health Formula extract storage tank 34 is connected to the Ginseng and Intestinal Health Formula preparation tank 31 via an extract delivery pipeline. The tangerine peel syrup storage tank 35 is connected to the Ginseng and Intestinal Health Formula preparation tank 31 via a syrup delivery pipeline. Metering pumps 51 and electric valves 52 are installed on both the extract delivery pipeline and the syrup delivery pipeline. A pure water supply system is also connected to the Ginseng and Intestinal Health Formula preparation tank 31, through which pure water is added. A second stirring mechanism 37 is installed inside the Ginseng and Intestinal Health Formula preparation tank 31, and the tangerine peel syrup and Ginseng and Intestinal Health Formula extract are mixed by the second stirring mechanism 37 to form the refined Ginseng and Intestinal Health Formula solution. The bottom of the Shenqi Changtai preparation tank 31 is equipped with a filter structure. The filter residue outlet of the Shenqi Changtai preparation tank is connected to a screw conveyor 36 for slag discharge. The solution outlet of the Shenqi Changtai preparation tank 31 is connected to the primary storage tank 32 of the refined solution of Shenqi Changtai through a solution delivery pipeline, and is stored in the primary storage tank 32. After high-temperature sterilization, the refined solution of Shenqi Changtai is manually transferred to the sterilized solution storage tank 33 for storage, and then added to the drug solution mixing tank 21 for preparation. Specifically, the sterilized solution storage tank 33 of Shenqi Changtai is connected to the drug solution mixing tank 21 through a sterilized solution pipeline, and a metering pump 51 and an electric valve 52 are also installed on the sterilized solution pipeline.

[0020] The tangerine peel syrup storage tank 35 is also connected to a tangerine peel syrup preparation subsystem, which includes a percolation tank 41, a tangerine peel tincture storage tank 42, and a tangerine peel syrup preparation tank 43. The percolation tank 41 has a tangerine peel inlet 44 at its top for adding tangerine peel granules. The top of the percolation tank 41 is connected to an ethanol supply system via an ethanol delivery pipeline, which is also equipped with a metering pump 51 and an electric valve 52. A third stirring mechanism is installed inside the percolation tank 41. The outlet at the bottom of the percolation tank 41 is connected to the tangerine peel tincture storage tank 42 via a tangerine peel tincture transfer pipeline, which is equipped with a delivery pump 53. The outlet of the tangerine peel tincture storage tank 42 is connected to the tangerine peel syrup preparation tank 43 via a tangerine peel tincture supply pipeline, which is also equipped with a metering pump 51 and an electric valve 52. The top of the tangerine peel syrup preparation tank 43 is also equipped with a material inlet 46 for adding excipients and purified water. A fourth stirring mechanism 45 is installed inside the tangerine peel syrup preparation tank 43. The discharge port at the bottom of the tangerine peel syrup preparation tank 43 is connected to the tangerine peel syrup storage tank 35 via a tangerine peel syrup transfer pipeline, and a delivery pump 53 is installed on the tangerine peel syrup transfer pipeline.

Claims

1. A fermentation system for a ginseng and intestinal health preparation, characterized in that: It includes a fermentation subsystem and a ginseng and bifidobacteria preparation subsystem. The fermentation subsystem is used to prepare bifidobacteria culture medium, and the ginseng and bifidobacteria preparation subsystem is used to prepare ginseng and bifidobacteria preparation solution. Both the fermentation subsystem and the ginseng and bifidobacteria preparation subsystem are connected to the drug solution mixing tank (21). The fermentation subsystem includes a sterile culture medium storage tank (11), a primary seed tank (12), a secondary seed tank (13), a tertiary fermentation tank (14), and a Bifidobacterium culture medium storage tank (15). The sterile culture medium storage tank (11) contains sterilized culture medium. The primary seed tank (12), the secondary seed tank (13), and the tertiary fermentation tank (14) are all connected to the sterile culture medium storage tank (11) through culture medium delivery pipelines. The primary seed tank (12), the secondary seed tank (13), and the tertiary fermentation tank (14) are all connected to the nitrogen supply system through nitrogen pipelines. The outlet of the tertiary fermenter (14) is connected to the Bifidobacterium culture medium storage tank (15) through a culture medium transfer pipeline. A transfer pump (53) is provided on the culture medium transfer pipeline, and the beginning of the culture medium transfer pipeline extends into the bottom of the tertiary fermenter (14). The outlet of the Bifidobacterium culture medium storage tank (15) is connected to the drug mixing tank (21) through a culture medium supply pipeline. The bottom of the drug mixing tank (21) is provided with an outlet and is connected to the Shenqi Changtai compound storage tank (22) through a drug transfer pipeline.

2. The fermentation system for the ginseng and intestinal liquid preparation according to claim 1, characterized in that: The Ginseng and Citrus Intestinal Health Solution Preparation Subsystem includes a Ginseng and Citrus Intestinal Health Solution Extract Storage Tank (34), a Tangerine Peel Syrup Storage Tank (35), a Ginseng and Citrus Intestinal Health Solution Preparation Tank (31), and a Ginseng and Citrus Intestinal Health Solution Refined Preparation Primary Storage Tank. The outlet of the Ginseng and Citrus Intestinal Health Solution Extract Storage Tank (34) is connected to the Ginseng and Citrus Intestinal Health Solution Preparation Tank (31) via an extract conveying pipeline. The Tangerine Peel Syrup Storage Tank (35) is connected to the Ginseng and Citrus Intestinal Health Solution Preparation Tank (31) via a syrup conveying pipeline. Metering pumps (51) and electric valves (52) are installed on both the extract conveying pipeline and the syrup conveying pipeline. The preparation tank (31) is also connected to a pure water supply system. Pure water is added to the preparation tank (31) of the Ginseng and Ginseng Intestinal Health Agent through the pure water supply system. The preparation tank (31) of the Ginseng and Ginseng Intestinal Health Agent is equipped with a second stirring mechanism (37). The second stirring mechanism (37) is used to mix the tangerine peel syrup and the Ginseng and Ginseng Intestinal Health Agent extract to form a refined solution of the Ginseng and Ginseng Intestinal Health Agent. The solution outlet of the preparation tank (31) of the Ginseng and Ginseng Intestinal Health Agent is connected to the storage container of the refined solution of the Ginseng and Ginseng Intestinal Health Agent through a solution delivery pipeline. The storage container of the refined solution of the Ginseng and Ginseng Intestinal Health Agent is connected to the medicine mixing tank (21).

3. The fermentation system for the ginseng and intestinal liquid preparation according to claim 2, characterized in that: The bottom of the preparation tank (31) for the preparation of the ginseng and ginseng is equipped with a filter structure, and the filter residue outlet of the preparation tank is connected to a screw conveyor (36) for slag discharge.

4. The fermentation system for the ginseng and intestinal liquid preparation according to claim 2, characterized in that: The storage container for the refined solution of Shenqi Changtai is divided into a primary storage tank (32) for the refined solution of Shenqi Changtai and a sterilized solution storage tank (33) for the sterilized solution of Shenqi Changtai. The primary storage tank (32) for the refined solution of Shenqi Changtai is used to store the refined solution of Shenqi Changtai before high-temperature sterilization, and the sterilized solution storage tank (33) for the sterilized solution of Shenqi Changtai is used to store the refined solution of Shenqi Changtai after high-temperature sterilization. The dispensing outlet of the preparation tank (31) of the Shenqi Changtai compound is connected to the primary storage tank (32) of the refined dispensing solution of the Shenqi Changtai compound through the dispensing delivery pipeline, and is stored in the primary storage tank (32) of the refined dispensing solution of the Shenqi Changtai compound. The refined dispensing solution of the Shenqi Changtai compound is sterilized at high temperature and then transferred to the sterilized liquid storage tank (33) of the Shenqi Changtai compound for storage. The sterilized liquid storage tank (33) of the Shenqi Changtai compound is connected to the drug mixing tank (21) through the sterilized liquid pipeline.

5. The fermentation system for the ginseng and intestinal liquid preparation according to claim 2, characterized in that: The tangerine peel syrup storage tank (35) is also connected to a tangerine peel syrup preparation subsystem, which includes a percolation tank (41), a tangerine peel tincture storage tank (42), and a tangerine peel syrup preparation tank (43). The top of the percolation tank (41) is provided with a tangerine peel inlet (44) for adding tangerine peel particles. The top of the percolation tank (41) is connected to an ethanol supply system through an ethanol delivery pipeline. A third stirring mechanism is provided inside the percolation tank (41). The discharge port at the bottom of the percolation tank (41) is connected to the tangerine peel tincture through a tangerine peel tincture transfer pipeline. The storage tank (42) is connected, and a delivery pump (53) is provided on the tangerine peel tincture transfer pipeline. The outlet of the tangerine peel tincture storage tank (42) is connected to the tangerine peel syrup preparation tank (43) through the tangerine peel tincture supply pipeline. The top of the tangerine peel syrup preparation tank (43) is also provided with a material inlet (46) for adding excipients and purified water. The tangerine peel syrup preparation tank (43) is provided with a fourth stirring mechanism (45). The outlet at the bottom of the tangerine peel syrup preparation tank (43) is connected to the tangerine peel syrup storage tank (35) through the tangerine peel syrup transfer pipeline.

6. The fermentation system for the ginseng and intestinal liquid preparation according to claim 1, characterized in that: The mixing tank (21) is equipped with a first stirring mechanism (23) for mixing the refined solution of Ginseng and Bifidobacterium intestinal remedy and the culture solution of Bifidobacterium.

7. The fermentation system for the ginseng and intestinal liquid preparation according to claim 1, characterized in that: Each culture medium delivery pipeline is equipped with a metering pump (51) and an electric valve (52).

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