A micro-hybrid device
Patent Information
- Application Number
- CN202522549706.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-12-01
- Publication Date
- 2026-10-23
- Estimated Expiration
- 2035-12-01
AI Technical Summary
缺点是人工搅动精子或卵子的频率难以恒定,长时间操作容易疲劳;另外人工操作无法很好控制DNA碎片化结果,搅拌过程中需要反复在显微镜下观察
1、本实用新型提出的一种微杂交设备,设备搭载摇摆电机与旋转电机,摇摆电机通过转轴连接摇摆组件,启动后可带动培养皿及上端零件以设定角度来回摆动;旋转电机则经转轴联动旋转组件与培养皿托盘,驱动培养皿同步旋转。双运动模式协同运作,能让培养皿内的反应液充分混合,避免人工操作带来的问题,保障杂交反应的一致性。
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Figure CN224884074U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of intelligent equipment for micro-hybrid incubation, and in particular to a micro-hybridization device. Background Technology
[0002] Microhybridization hatching typically requires first fragmenting sperm DNA under ultraviolet light with low-temperature stirring. This process can screen out high-quality sperm DNA. Then, the low-temperature fragmented sperm and eggs are hatched together with stirring at room temperature.
[0003] Currently, microhybridization fertilization mainly relies on manual operation, involving continuous stirring by hand under ultraviolet light. The disadvantages are that the frequency of stirring sperm or eggs is difficult to maintain consistently, and prolonged operation can lead to fatigue; furthermore, manual operation cannot effectively control DNA fragmentation, requiring repeated observation under a microscope during the stirring process. This is easily affected by the external environment and natural light, resulting in poor sperm processing and low fertilization success rates; moreover, ultraviolet light poses significant health risks to laboratory personnel.
[0004] Therefore, this application provides a microhybridization device to solve the problems mentioned in the background art. Utility Model Content
[0005] The purpose of this invention is to address the shortcomings of existing technologies by proposing a microhybridization device that is simple to operate and highly safe.
[0006] To achieve the above objectives, the present invention provides the following technical solution: A microhybridization device includes a cabinet. A first support plate is fixedly installed in the middle of the cabinet. A rocking motor is fixedly installed on one side of the upper end of the first support plate. Two rocking components are fixedly connected to the output end of the rocking motor. A second support plate is fixedly installed on the upper end of the two rocking components. A rotary motor is fixedly connected to one side of the lower end of the second support plate. A first rotary component is fixedly connected to the output end of the rotary motor. A culture dish tray is rotatably connected to the upper end of the first rotary component.
[0007] Furthermore, a support frame is fixedly installed inside the cabinet, a guide rail is fixedly installed on one side of the support frame, and a linear motor is slidably installed on one side of the guide rail.
[0008] Furthermore, a mounting bracket is fixedly installed on one side of the linear motor, and four ultraviolet lamps are fixedly installed on one side of the lower end of the mounting bracket.
[0009] Furthermore, two second rotating components are rotatably connected to the upper end of the second support plate.
[0010] Furthermore, two support components are fixedly installed at the middle of the upper end of the first support plate.
[0011] Furthermore, a temperature control system is fixedly installed at the lower end of the cabinet, and casters are fixedly installed at the four corners of the bottom of the cabinet.
[0012] Furthermore, a control panel is fixedly installed on one side of the upper end of the cabinet, and a cabinet door is hinged to one side of the middle part of the cabinet.
[0013] This utility model has the following beneficial effects: 1. This utility model proposes a microhybridization device, which is equipped with a rocking motor and a rotary motor. The rocking motor is connected to the rocking assembly via a rotating shaft, and after starting, it can drive the culture dish and its upper part to swing back and forth at a set angle. The rotary motor, through the rotating shaft, links the rotating assembly and the culture dish tray, driving the culture dish to rotate synchronously. The dual motion modes work together to ensure that the reaction solution in the culture dish is fully mixed, avoiding problems caused by manual operation and ensuring the consistency of the hybridization reaction.
[0014] 2. This utility model proposes a microhybridization device that uses a mounting bracket to fix the ultraviolet lamp to a linear motor. After the cabinet door is closed, the distance between the ultraviolet lamp and the culture dish can be precisely adjusted via the linear motor. This allows for fine-tuning of the distance according to the different requirements of ultraviolet irradiation intensity and range in hybridization experiments, ensuring the consistency and stability of the irradiation effect. This design avoids errors from manual adjustment and, because the cabinet door is closed before operation, isolates the risk of direct ultraviolet exposure, preventing operators from being burned. It maximizes operational safety while improving experimental accuracy. Attached Figure Description
[0015] Figure 1 This is a first axonometric schematic diagram of the microhybridization device of this utility model; Figure 2 This is a schematic diagram of the second axonometric side of the microhybridization device of this utility model; Figure 3 This is a front view of the internal structure of the microhybridization device of this utility model; Figure 4 This is a first cross-sectional schematic diagram of the microhybridization device of this utility model; Figure 5 This is a second cross-sectional schematic diagram of the microhybridization device of this utility model.
[0016] Legend: 1. Cabinet body; 2. Control panel; 3. Cabinet door; 4. Casters; 5. Mounting rack; 6. UV lamp; 7. Petri dish tray; 8. Temperature control system; 9. Linear motor; 10. Support frame; 11. Guide rail; 12. Rotary motor; 13. Swing assembly; 14. Swing motor; 15. Support assembly; 16. First rotating assembly; 17. First support plate; 18. Second rotating assembly; 19. Second support plate. Detailed Implementation
[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0018] Reference Figure 2 , Figure 4 , Figure 5 One embodiment provided by this utility model: A microhybridization device includes a cabinet 1. A first support plate 17 is fixedly installed in the middle of the cabinet 1. A rocking motor 14 is fixedly installed on one side of the upper end of the first support plate 17. Two rocking components 13 are fixedly connected to the output end of the rocking motor 14. A second support plate 19 is fixedly installed on the upper end of the two rocking components 13. A rotary motor 12 is fixedly connected to one side of the lower end of the second support plate 19. A first rotating component 16 is fixedly connected to the output end of the rotary motor 12. A culture dish tray 7 is rotatably connected to the upper end of the first rotating component 16.
[0019] Specifically, cabinet 1 serves as the overall support frame for the equipment, forming a closed experimental space that isolates the external environment and natural light interference, ensuring experimental stability, and providing an installation reference for each component. The first support plate 17 is horizontally positioned, providing a mounting platform for the swing motor 14 and support assembly 15, supporting the weight of the upper swing and rotation mechanism. The swing motor 14 has a built-in drive motor that provides power to the swing assembly 13. The swing angle and frequency can be set via control panel 2 to achieve the reciprocating swing of the petri dish. Two swing assemblies 13 are symmetrically arranged and fixed to the output end of the swing motor 14 via rotating shafts. Their upper ends are fixed to the second support plate 19, converting the rotational motion of the swing motor 14 into reciprocating swing motion, driving the second support plate 19 and the upper parts to swing synchronously. The second support plate 19 provides a mounting platform for the rotation motor 12 and the second rotation assembly 18, supporting the weight of the petri dish tray 7 and the petri dish, swinging synchronously with the swing assembly 13. The rotation motor 12 provides rotational power to the first rotation assembly 16, and the rotation speed can be set via control panel 2 to achieve uniform rotation of the petri dish. The first rotating component 16 is fixedly connected to the output end of the rotary motor 12 via a rotating shaft. Its upper end is rotatably connected to the culture dish tray 7 via the rotating shaft, transmitting the power of the rotary motor 12 to the culture dish tray 7 and driving it to rotate smoothly. The culture dish tray 7 is made of 304 stainless steel and has four rubber limit blocks at the bottom and upper end for precise positioning and fixing of the culture dish. It is driven to rotate by the first rotating component 16 via the rotating shaft, and simultaneously sways with the second support plate 19 to achieve thorough mixing of the reaction solution in the culture dish.
[0020] Reference Figure 2 , Figure 3 Inside the cabinet 1, a support frame 10 is fixedly installed. A guide rail 11 is fixedly installed on one side of the support frame 10. A linear motor 9 is slidably installed on one side of the guide rail 11. A mounting bracket 5 is fixedly installed on one side of the linear motor 9. Four ultraviolet lamps 6 are fixedly installed on one side of the lower end of the mounting bracket 5.
[0021] Specifically, the support frame 10 provides a stable mounting support for the guide rail 11, ensuring the stability of the linear motor 9 during sliding. The guide rail 11 is vertically fixed on the support frame 10, providing a sliding guide for the linear motor 9 and limiting its movement to the vertical direction, ensuring the accuracy of the UV lamp 6's lifting and lowering. Limit plates are also provided at both ends of the guide rail to limit the movement of the linear motor 9. The linear motor 9 can move up and down along the guide rail 11, with one side fixed to the mounting frame 5. The movement distance is controlled by the control panel 2, allowing for precise adjustment of the distance between the UV lamp 6 and the culture dish. The mounting frame 5 provides a mounting carrier for the UV lamps 6, fixing the four UV lamps 6 together and allowing them to rise and fall synchronously with the linear motor 9. The four UV lamps 6 are evenly distributed and emit ultraviolet light to fragment the sperm DNA in the culture dish. The UV intensity is stable, avoiding the uncertainty of manual operation, and they operate only after the cabinet door 3 is closed, isolating the risk of UV exposure.
[0022] Reference Figure 5 The upper end of the second support plate 19 is rotatably connected to two second rotating components 18.
[0023] Specifically, two second rotating components 18 are rotatably connected to the upper end of the second support plate 19 via a rotating shaft, and are symmetrically distributed on both sides of the culture dish tray 7. The upper end is connected to the bottom of the culture dish tray 7 via a rotating shaft, and has the same thickness as the first rotating component 16. The two components work together to provide auxiliary support for the culture dish tray 7, reduce its shaking during rotation, and ensure the stability of the rotation and swaying process.
[0024] Reference Figure 4 Two support components 15 are fixedly installed at the upper middle part of the first support plate 17.
[0025] Specifically, two support components 15 are fixedly installed at the upper middle part of the first support plate 17, symmetrically distributed on both sides of the shaft of the rocking motor 14. They are rotatably connected to the shaft through a bearing structure to support the shaft of the rocking motor 14. This effectively disperses the force on the shaft and prevents the shaft from bending and deforming due to long-term bearing of the weight of the rocking component 13, the second support plate 19, and the upper parts. At the same time, the rotatable connection does not affect the normal rotation of the shaft, ensuring the smooth power transmission of the rocking motor 14, thereby improving the stability of the rocking motion and the overall service life of the mechanism.
[0026] Reference Figure 1 , Figure 2 A temperature control system 8 is fixedly installed at the lower end of the cabinet 1, and casters 4 are fixedly installed at the four corners of the bottom of the cabinet 1.
[0027] Specifically, the temperature control system 8 is fixed inside the lower part of the cabinet 1 and is used to regulate the temperature inside the cabinet 1. It can be set to low or normal temperature via the control panel 2 to ensure the required temperature conditions for the experiment and avoid temperature fluctuations affecting the experimental results. Four casters 4 facilitate the movement and adjustment of the equipment, and two of them have a self-locking function to easily fix the equipment in place, improving the flexibility of equipment use. The temperature control system 8 is a mature and publicly available technology; therefore, its specific structure and working principle will not be elaborated upon in this paper.
[0028] Reference Figure 1 A control panel 2 is fixedly installed on one side of the upper part of the cabinet 1, and a cabinet door 3 is hinged to one side of the middle part of the cabinet 1.
[0029] Specifically, the control panel 2 is the core operating component of the equipment, with a built-in control module. It allows setting the swing angle and frequency of the swing motor 14, the rotation speed of the rotary motor 12, the travel distance of the linear motor 9, the working time of the ultraviolet lamp 6, and the temperature parameters of the temperature control system 8, achieving automated control of the experimental process. Operation is simple and convenient. The cabinet door 3 is easy to open and close and is equipped with a sealing ring. When closed, it forms a sealed experimental space, effectively isolating the external environment, natural light interference, and ultraviolet exposure, ensuring experimental stability and protecting the safety of operators.
[0030] Working principle: First, push the cabinet 1 to move the equipment to the designated experimental position using the four casters 4 at the bottom and lock them in place to prevent slippage; open the cabinet door 3 with the sealing ring, place the culture dish containing sperm stably on the culture dish tray 7, and close the cabinet door 3, which fits snugly against the cabinet 1 to form a closed experimental space; set the experimental parameters through the control panel 2 at the top of the cabinet 1: the low temperature parameters of the temperature control system 8, the working time of the ultraviolet lamp 6, the distance between the ultraviolet lamp 6 and the culture dish, the swing angle and frequency of the swing motor 14, and the rotation speed of the rotary motor 12. After setting the parameters, the equipment enters the standby state. Afterwards, the equipment operation command is initiated, and the temperature control system 8 quickly adjusts the internal temperature of the cabinet 1 to the set low temperature and maintains it stably. Subsequently, the linear motor 9 moves downward along the vertically fixed guide rail 11, driving the fixed mounting bracket 5 on one side and the four evenly distributed ultraviolet lamps 6 to descend synchronously until they reach the height set by the control panel 2, maintaining a precise distance from the culture dish. The ultraviolet lamps 6 are activated, emitting stable intensity ultraviolet light into the culture dish to fragment the sperm DNA. At the same time, the swing motor 14 is activated, and its shaft rotates smoothly with the auxiliary support of the bearing structure of the two support components 15, driving two The symmetrically connected rocking components 13 reciprocate, causing the second support plate 19 and the upper culture dish tray 7 to rock synchronously. At the same time, the rotary motor 12 starts, transmitting power through the first rotating component 16 to drive the culture dish tray 7 to rotate at a constant speed. The second rotating components 18 on both sides of the culture dish tray 7 cooperate with the first rotating component 16 to provide stable support for the tray and reduce the shaking caused by the superposition of rotation and rocking. Under the synergistic effect of the rocking and rotation dual motion modes, the sperm and reaction solution in the culture dish are fully mixed, ensuring that each sperm can be evenly irradiated by ultraviolet light, thereby improving the consistency and effectiveness of DNA fragmentation treatment.
[0031] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A microhybridization device, comprising a cabinet (1), characterized in that: A first support plate (17) is fixedly installed in the middle of the cabinet (1). A rocking motor (14) is fixedly installed on one side of the upper end of the first support plate (17). Two rocking components (13) are fixedly connected to the output end of the rocking motor (14). A second support plate (19) is fixedly installed on the upper end of the two rocking components (13). A rotary motor (12) is fixedly connected to one side of the lower end of the second support plate (19). A first rotary component (16) is fixedly connected to the output end of the rotary motor (12). A petri dish tray (7) is rotatably connected to the upper end of the first rotary component (16).
2. The microhybridization device according to claim 1, characterized in that: The cabinet (1) is fixedly equipped with a support frame (10), and a guide rail (11) is fixedly equipped on one side of the support frame (10). A linear motor (9) is slidably equipped on one side of the guide rail (11).
3. The microhybridization device according to claim 2, characterized in that: A mounting bracket (5) is fixedly installed on one side of the linear motor (9), and four ultraviolet lamps (6) are fixedly installed on one side of the lower end of the mounting bracket (5).
4. The microhybridization device according to claim 1, characterized in that: The upper end of the second support plate (19) is rotatably connected to two second rotating components (18).
5. A microhybridization device according to claim 1, characterized in that: Two support components (15) are fixedly installed at the upper middle part of the first support plate (17).
6. A microhybridization device according to claim 1, characterized in that: A temperature control system (8) is fixedly installed at the lower end of the cabinet (1), and casters (4) are fixedly installed at the four corners of the bottom of the cabinet (1).
7. A microhybridization device according to claim 1, characterized in that: A control panel (2) is fixedly installed on one side of the upper end of the cabinet (1), and a cabinet door (3) is hinged to one side of the middle part of the cabinet (1).