An integrated anti-embolic brain protection system

Abstract

The application provides an integrated anti-embolism brain protection system, which comprises an outer sheath, a brain protection device, a handle and a shape-adjustable wire; the brain protection device comprises a tube body for the shape-adjustable wire to penetrate through and proximal and distal filter screens which are connected to the tube body in a closable manner; the shape-adjustable wire extends into the handle and the tube body, the tube body is connected to the handle through the outer sheath, and the outer sheath is used for controlling the opening and closing of the proximal and distal filter screens; the handle is connected to the outer sheath and the shape-adjustable wire, and is used for controlling the deformation of the shape-adjustable wire to guide the brain protection device to enter a preset target position and adjusting the movement of the outer sheath along the shape-adjustable wire to realize the release and contraction of the brain protection device. The shape-adjustable wire, the brain protection device and the outer sheath are integrated into a cooperative working integrated structure, and the centralized control of multiple components is realized by relying on the handle, the high integration of the anti-embolism brain protection device is realized, the operation process is significantly simplified, and the clinical safety is further ensured while the operation efficiency is improved.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and more specifically, to an integrated anti-embolism brain protection system. Background Technology

[0002] With the global trend of increasing population aging, the prevalence of valvular degenerative diseases in the elderly is rising at an alarming rate. Among them, aortic stenosis accounts for an increasingly large proportion of valvular heart disease in the elderly, and has become one of the major cardiovascular diseases threatening the health of the elderly population. Severe aortic stenosis can severely impair the heart's pumping function, causing a series of symptoms such as shortness of breath, angina pectoris, and syncope, greatly reducing the patient's quality of life and even endangering their life.

[0003] Previously, surgical aortic valve replacement was considered a key treatment for severe aortic stenosis and a means of prolonging patients' lives. This surgery directly replaces the diseased aortic valve, restoring normal blood flow to the heart. However, the unique characteristics of elderly patients present numerous challenges to this traditional procedure. Elderly patients typically experience declining physical function and suffer from multiple chronic diseases such as hypertension, coronary heart disease, and diabetes. They may also experience reduced function in multiple organs, including the lungs and kidneys. These combined factors make it difficult for elderly patients to withstand the significant trauma and risks associated with open-heart surgery.

[0004] To overcome this challenge, transcatheter aortic valve implantation (TAVI) has gradually gained widespread clinical application due to its advantages such as minimal invasiveness and rapid recovery. TAVI surgery uses catheter technology to deliver an artificial valve via a blood vessel to the location of the diseased aortic valve and release it, thereby replacing the diseased valve and restoring normal heart function. This technology offers new treatment hope for high-risk patients who cannot tolerate traditional surgery. In TAVI surgery, a brain protection device is an important surgical component.

[0005] However, clinically used neuroprotective devices generally suffer from low integration, primarily because they consist of multiple independent components that require separate operation. This decentralized structure and operating mode leads to several clinical drawbacks: First, coordination among multiple components is difficult, adjustments must be made step-by-step, and motion accuracy depends on the doctor's experience, making it easy for coordination deviations to cause inaccurate filter positioning; second, the operation process is cumbersome, requiring frequent switching between different handles and instruments, which not only prolongs the operation time but also increases the probability of friction between the instruments and the blood vessel wall, increasing the risk of vascular intimal damage, dissection, or embolus dislodgement.

[0006] Therefore, the shortcomings of existing brain protection devices in terms of integration and ease of operation have become key bottlenecks restricting their clinical application efficiency and safety. There is an urgent need for an integrated brain protection device that can organically integrate core functional components and achieve centralized control. Summary of the Invention

[0007] To address the problems existing in the current technology, this application provides an integrated anti-embolism brain protection system. The specific solution is as follows:

[0008] An integrated anti-embolism brain protection system includes an outer sheath, a brain protection device, a handle, and an adjusting wire; the brain protection device includes a tube through which the adjusting wire passes and a proximal filter and a distal filter that can be opened and closed and connected to the periphery of the tube; the adjusting wire extends into the handle and the tube, the tube passes through the outer sheath and is connected to the handle, and the outer sheath is used to control the opening and closing of the proximal filter and the distal filter;

[0009] The handle connects the outer sheath and the adjusting wire, and is used to control the deformation of the adjusting wire to guide the brain protection device into a preset target position, and to adjust the movement of the outer sheath along the adjusting wire to release and retract the brain protection device.

[0010] In some specific embodiments, the brain protection device further includes a fixing member located on the tube body for fixing the brain protection device.

[0011] In some specific embodiments, the front end of the outer sheath is provided with an arc-shaped tip to reduce damage to the blood vessel wall during movement.

[0012] In some specific embodiments, the fastener includes at least one of a braided support, a balloon, or a self-expanding support.

[0013] In some specific embodiments, the distal filter and / or the proximal filter includes an annular support frame and a woven mesh surface connected to the annular support frame. The annular support frame is closable and connected to the tube body for contracting and expanding the woven mesh surface. The woven mesh surface is used to intercept thrombi and detached debris.

[0014] In some specific embodiments, the bending wire has a developing mark at the end away from the handle.

[0015] In some specific embodiments, the handle is provided with a first trigger and a second trigger for connecting the bending wire. The first trigger is used to adjust the length of the bending wire entering the blood vessel, and the second trigger is used to adjust the degree of deformation of the bending wire.

[0016] In some specific embodiments, the handle is provided with a third trigger element connected to the outer sheath tube, the third trigger element being used to adjust the movement of the sheath tube along the bending wire.

[0017] In some specific embodiments, the mesh diameter of the woven surface of the distal filter and / or the proximal filter is between 120μm and 200μm.

[0018] In some specific embodiments, the opening direction of the proximal filter is opposite to the opening direction of the distal filter.

[0019] Beneficial effects: This application provides an integrated anti-embolism brain protection system, which integrates the bending wire, brain protection device and external sheath into a co-working integrated structure, and realizes centralized control of multiple components by relying on the handle, thereby achieving a high degree of integration of the anti-embolism brain protection device. This changes the way the components of the traditional brain protection device are operated separately, greatly reduces the operator's hand-eye coordination load and operation error tolerance, significantly simplifies the surgical operation process, and further ensures clinical safety while improving surgical efficiency.

[0020] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the normal structure of the brachiocephalic trunk-aortic arch-left common carotid artery pathway;

[0023] Figure 2 This is a schematic diagram of the overall structure of the integrated anti-thrombotic brain protection system of this application;

[0024] Figure 3 yes Figure 2 A cross-sectional view of the integrated anti-thrombotic brain protection system shown.

[0025] Figure 4 This is a schematic diagram of the handle structure of this application;

[0026] Figure 5 This is a schematic diagram of the brain protection device structure of this application.

[0027] Reference numerals: 1-Outer sheath; 2-Brain protection device; 3-Handle; 4-Adjusting screw; 21-Tube body; 22-Proximal filter; 23-Distal filter; 24-Fixing component; 31-Sheath push button; 32-Adjusting knob; 33-Front handle; 34-Rear handle; 35-Brain protection component fixing seat; 36-Outer sheath fixing seat; 37-Adjusting screw fixing seat; 38-Threaded structure. Detailed Implementation

[0028] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0029] This application proposes an integrated anti-embolism cerebral protection system capable of effectively establishing the brachiocephalic trunk-aortic arch-left common carotid artery pathway. The normal structure of the brachiocephalic trunk-aortic arch-left common carotid artery pathway is shown in the attached figure. Figure 1 As shown in the diagram, A1 is the aortic arch, A2 is the brachiocephalic trunk, A3 is the left common carotid artery, A4 is the left subclavian artery, A5 is the brachiocephalic trunk shunt, A6 is the left common carotid artery shunt, A7 is the right subclavian artery, and A8 is the right common carotid artery. The structure of the integrated anti-embolism cerebral protection system is shown in the attached diagram. Figure 2-5 As shown, the specific solution is as follows:

[0030] An integrated anti-thrombotic brain protection system includes an outer sheath 1, a brain protection device 2, a handle 3, and an adjusting wire 4. The brain protection device 2 includes a tube 21 through which the adjusting wire 4 passes, and proximal filters 22 and distal filters 23 that can be opened and closed and connected to the periphery of the tube 21. These filters are used to intercept thrombi and dislodged debris during release. The adjusting wire 4 extends into the handle 3 and the tube 21. The tube 21 extends into the outer sheath 1 and connects to a brain protection component fixing seat 35 in the handle 3. The brain protection component fixing seat 35 stabilizes the tube 21. The outer sheath 1 controls the opening and closing of the proximal filters 22 and distal filters 23. The handle 3 connects the outer sheath 1 and the adjusting wire 4, and is used to control the deformation of the adjusting wire 4 to guide the brain protection device 2 to a preset target position, and to adjust the movement of the outer sheath 1 along the adjusting wire 4 proximally or distally to achieve the release and retraction of the brain protection device 2. (See attached...) Figure 3 In this case, the end of the outer sheath tube 1 is connected to the outer sheath tube fixing seat 36 located inside the handle 3, and the outer sheath tube fixing seat 36 is responsible for stabilizing the outer sheath tube 3. Similarly, the end of the bending wire 4 is connected to the bending wire fixing part 37 located inside the handle 3 to stabilize the bending wire 4 in the handle 3.

[0031] The outer sheath 1 of this application adopts a hollow tubular structure that can be pushed back and forth. The inner diameter of the hollow part is slightly larger than the outer diameter of the brain protection device 2, forming a sliding gap for the tube body 21 to accommodate and allow the brain protection device 2 to pass through. This provides a channel for the delivery and retrieval of the brain protection device 2, ensuring that the brain protection device 2 can pass smoothly while providing stable constraint during the pushing process. By pushing and pulling the outer sheath 1 back and forth, the retrieval and release operation of the brain protection device 2 can be realized. The structural design of the outer sheath 1 of this application enables it to accommodate the filter assembly in a retracted state, and achieves mechanical constraint control of the filter through axial movement.

[0032] Preferably, the outer sheath 1 is made of medical-grade polymer material, which has good flexibility, elasticity, and biocompatibility. The sheath wall is of uniform thickness and has undergone special treatment, resulting in a smooth outer surface and a low coefficient of friction, allowing it to pass smoothly within blood vessels while effectively reducing irritation and damage to the vessel wall. The front end of the outer sheath 1 needs to be smooth to reduce resistance and abrasion of the blood vessel, while the rear end is securely connected to the handle 3.

[0033] The brain protection device 2 of this application is the core actuator for achieving the anti-embolism function. It includes a tube 21 through which the adjusting wire 4 passes, and a proximal filter 22 and a distal filter 23 that can be opened and closed and connected to the periphery of the tube 21, as detailed below. Figure 5 As shown. The tube body 21 serves as the main support structure of the device. The cavity in the middle of the tube body 21 is a cylindrical channel with an inner diameter that matches the outer diameter of the bending wire 4. The inner wall can be coated with a lubricating layer to reduce the friction when the bending wire 4 passes through, so that the bending wire 4 can smoothly guide the direction of travel of the brain protection device 2. This ensures that the bending wire 4 can pass through flexibly and can also drive the overall direction of rotation through the deformation of the bending wire 4.

[0034] Preferably, the tube body 21 is made of a high-molecular composite material that has both good flexibility and strength, which can adapt to the curved shape of the blood vessel and is not easily deformed or damaged when subjected to a certain external force.

[0035] The closable connection between the proximal filter 22 and the distal filter 23 in this application allows the brain protection device 2 to have two states: release and contraction. The two filters contract under constraint and unfold due to shape memory effect after the constraint is released, forming a petal-like opening and closing structure. The filters in this application can achieve precise switching from contraction to unfolding within the blood vessel. The mesh of the proximal filter 22 and the distal filter 23 can effectively intercept thrombi, plaques, and other emboli with a diameter larger than the specified size, while ensuring normal blood flow with low resistance.

[0036] In some specific embodiments, the distal filter 23 and / or the proximal filter 22 include an annular support frame and a woven mesh surface connecting the annular support frame. The annular support frame is closable and connected to the tube body 21, used to contract and expand the woven mesh surface; the woven mesh surface is used to intercept thrombi and detached debris. The annular support frame determines the unfolded shape, support force, and opening and closing flexibility of the filter, and is the basis for realizing the openable and closable function. It can be made of nickel-titanium alloy, which has both shape memory effect and super elasticity. The woven mesh surface is the interception barrier of the filter, which directly contacts the blood flow, intercepting thrombi / plaque detachment, while allowing normal blood flow.

[0037] Preferably, the mesh diameter of the distal filter 23 and / or the proximal filter 22 is between 120 μm and 200 μm. Setting the mesh diameter of the woven mesh to 120-200 μm can intercept harmful emboli >200 μm, while allowing components such as red blood cells in the blood to pass through, avoiding excessive interception that would increase blood flow resistance.

[0038] The bending wire 4 in this application is made of a flexible and maneuverable material. It contains an internal metal wire, one end of which is fixed to the front end of the bending wire 4, and the other end extends into the handle 3, forming a wire-driven structure. The bending wire 4 passes sequentially through the handle 3, the outer sheath 1, and the tube 21 of the brain protection device 2, forming a mechanical transmission path throughout the entire device. This ensures that the maneuvering force is effectively transmitted to the front end, allowing indirect control of the bending direction and angle of the front end of the bending wire 4 via the handle 3. The bending wire 4 can be freely maneuvered and deformed. By pre-shaping the front end of the shape-memory bending wire 4 (e.g., a J-shape), it guides the device through bends in blood vessels, flexibly guiding the brain protection device 2 into complex vascular locations. This ensures the brain protection device 2 accurately reaches the surgical site, improving the accuracy and reliability of device positioning. Preferably, the bending wire 4 is made of nickel-titanium shape memory alloy wire with a diameter of 0.014-0.035 inches. The nickel-titanium shape memory alloy wire is smooth and has good flexibility, allowing it to travel flexibly within blood vessels.

[0039] In some embodiments, the bending wire 4 has an ultra-soft tip at one end of the handle 3, which is compliant and reduces damage to the blood vessel wall. Preferably, the tip of the bending wire 4 is also provided with a contrast marker. The contrast marker provides the doctor with a precise visual anchor point, which is clearly visible under X-ray fluoroscopy, allowing the doctor to observe the position and direction of the bending wire 4 in real time during the operation, ensuring that the guiding direction of the bending wire 4 is perfectly matched with the target blood vessel. Preferably, the contrast marker is preferably made of platinum-iridium alloy. The X-ray attenuation coefficient of platinum-iridium alloy is 8-10 times that of nickel-titanium alloy, and it appears as a clear bright spot or bright ring under fluoroscopy. It also has excellent biocompatibility and will not cause thrombosis with long-term contact with blood. When the bending wire 4 is deformed by manipulating the handle 3, the movement trajectory of the contrast marker can be clearly observed under X-ray fluoroscopy.

[0040] The rear end of the bending wire 4 is connected to the handle 3. A metal wire is installed inside the wire, with one end fixed to the front end of the bending wire 4 and the other end extending into the handle 3. This allows for deformation control of the bending wire 4, thereby guiding the brain protection device 2 accurately into the surgical position. In some embodiments, the outer surface of the bending wire 4 is also coated with a hydrophilic coating. When it comes into contact with blood or saline solution, it quickly absorbs moisture to form a lubricating layer, further reducing resistance during its movement within blood vessels.

[0041] The handle 3 in this application is the control center of the overall device. It is mechanically connected to the outer sheath 1 and the adjusting wire 4, forming a transmission relationship. It includes both a pushing mechanism to control the axial movement of the outer sheath 1 and an adjusting mechanism (such as a knob and screw transmission structure) to control the deformation of the adjusting wire 4. The integrated design of the handle 3 avoids the coordination problems of traditional multi-instrument operations, allowing all key operations to be completed with a single hand. The structure of the handle 3 is as follows: Figure 4 As shown.

[0042] In some specific embodiments, the brain protection device 2 also includes a fixing member 24, which is located on the tube body 21 and is used to fix the brain protection device 2. If the filter screen only adheres to the blood vessel wall, the device may shift due to blood flow, which may weaken or fail the embolus capture function. The function of the fixing member 24 is to stably anchor the brain protection device 2 at the target blood vessel position and ensure that the filter screen always covers the brachiocephalic trunk and the entrance of the left common carotid artery.

[0043] In some specific embodiments, the fixation element 24 includes at least one of a braided stent, a balloon, and a self-expanding stent. These three structures correspond to different vascular anatomy scenarios, and can be selected according to specific needs in practical applications.

[0044] Preferably, the braided stent is made of ultra-fine nickel-titanium alloy wire, in a cylindrical or conical shape, with high porosity, which does not affect the blood supply to the vessel wall. Utilizing the shape memory effect of nickel-titanium alloy, it conforms to the vessel wall through radial support force, and the fixation strength increases with the increase of the vessel diameter. The braided stent has good flexibility, can adapt to slight vascular pulsation, and its high porosity will not compress the vessel wall and cause local ischemia.

[0045] Preferably, the balloon includes a balloon body and an inflation tubing. The inflation tubing extends along the inside of the tube body 21 to the handle 3, allowing the physician to control the inflation / deflation of the balloon body via the inflation tubing on the handle 3. The balloon is first delivered to the target location, then inflated using the handle 3. The outer surface of the balloon has micro-textured surfaces, which help to fix its position through friction and radial compression. During retrieval, the balloon deflates first, shrinking back to its original size and being withdrawn along with the outer sheath 1. The balloon can be adapted to blood vessels of different diameters by adjusting the inflation pressure, and its flexibility prevents it from compressing calcified plaques and causing them to dislodge like a stent.

[0046] Preferably, the self-expanding stent is made of nickel-titanium alloy tubing through laser cutting. A guide groove is provided on the inner side of the stent, which engages with a protrusion on the outer side of the tubing 21 to ensure that the stent can only move axially along the tubing 21. When the outer sheath 1 is in a constricted state, the stent is in a contracted state. After the outer sheath 1 is retracted, the stent expands elastically to conform to the vessel wall. Simultaneously, the guide groove on the inner side of the stent engages with the protrusion on the tubing 21, locking the relative position of the stent and the tubing 21 and preventing the stent from sliding distally into the vessel. The self-expanding stent has high rigidity, providing sufficient support in small-diameter vessels, and the laser-cut stent wire is thicker, making it less susceptible to being scratched by calcified plaques.

[0047] In some embodiments, the handle 3 shell is made of medical-grade polymer material and has an ergonomically designed non-slip texture on the surface for comfortable grip by doctors.

[0048] In some specific embodiments, the outer sheath 1 has an arc-shaped tip at its front end to reduce damage to the vessel wall during movement. If the front end is straight or sharp, it is easy to scrape the vessel intima when passing through a curved vessel, leading to intimal tearing or bleeding. The arc-shaped tip is a targeted optimization to address this risk. The arc-shaped tip can be hemispherical or elliptical, ensuring that the contact between the end of the outer sheath 1 and the vessel wall is surface contact during pushing. The outer surface of the arc-shaped tip needs to be polished and coated with a hydrophilic coating so that the outer sheath 1 can glide over the vessel wall rather than scrape it.

[0049] In some specific embodiments, the distal filter 23 and / or the proximal filter 22 include an annular support frame and a woven mesh surface connected to the annular support frame. The annular support frame is closable and connected to the tube body 21 for contracting and unfolding the woven mesh surface; the woven mesh surface is used to intercept thrombi and detached debris. The annular support frame is made of nickel-titanium alloy and has shape memory function. At low temperatures, it can be compressed and folded into the outer sheath 1. When it reaches body temperature, it quickly returns to a preset unfolded shape, ensuring that the filter can fully unfold and conform to the blood vessel wall. The front and rear filters are used to collect thrombi and detached debris in the brachiocephalic trunk and the left common carotid artery, respectively.

[0050] In some specific embodiments, the handle 3 is provided with a first trigger and a second trigger for connecting the bending wire 4. The first trigger is used to adjust the length of the bending wire 4 entering the blood vessel, and the second trigger is used to adjust the degree of deformation of the bending wire 4.

[0051] For example, the handle 3 includes a bending knob 32, a front handle 33, a rear handle 34, and a threaded structure 38, as shown in the attached diagram. Figure 4As shown. The first triggering element is the front handle 33 and the rear handle 34, and the second triggering element is the bending adjustment knob 32, which is connected to the threaded structure 38. The control wire of the bending wire 4 is fixed to the screw of the threaded structure 38, and the body of the bending wire 4 is fixed to the guide wire fixing seat, which is fixed to the rear handle 34. By adjusting the distance between the front handle 33 and the rear handle 34, the bending wire 4 can be extended and retracted. Rotating the rear handle 34 will rotate the bending wire 4. Rotating the bending adjustment knob 32 will drive the screw to move back and forth, thus bending and straightening the bending wire 4.

[0052] In some specific embodiments, the handle 3 is provided with a third trigger element connected to the outer sheath 1, which is used to adjust the movement of the sheath along the bending screw 4. Exemplarily, the handle 3 also includes a sheath push button 31, as shown in the attached figure. Figure 4 As shown, the sheath push button 31 is fixed to the outer sheath 1 fixing seat by mechanical connection. The outer sheath 1 fixing seat and the outer sheath 1 are fixed by bonding, hot melting, inlay injection molding and other methods. By pushing and pulling the sheath push button 31, the outer sheath 1 can be moved forward and backward, thereby realizing the inclusion and release of the filter screen at the distal end of the outer sheath 1 relative to the tube body of the outer sheath 1. The brain protection device 2 fixing seat and the tube body 21 are fixed by bonding, hot melting, inlay injection molding and other methods. At the same time, the brain protection device 2 fixing seat and the front handle 33 are fixed by mechanical connection.

[0053] In some specific embodiments, the opening direction of the proximal filter 22 is opposite to the opening direction of the distal filter 23. The brachiocephalic trunk and the left common carotid artery are two key branches originating from the aortic arch. The brachiocephalic trunk opens towards the proximal end of the aortic arch, while the left common carotid artery opens towards the distal end. If the filter openings are in the same direction, only one branch can be covered, leaving the other branch still at risk of embolism. The design with opposite openings allows the two filters to be aligned with the two branches respectively, achieving whole-brain protection.

[0054] This application provides an integrated anti-embolism brain protection system, which integrates the bending wire, brain protection device and external sheath into a co-working integrated structure, and realizes centralized control of multiple components by relying on the handle. This achieves a high degree of integration of the anti-embolism brain protection device, changes the way the components of the traditional brain protection device are operated separately, greatly reduces the operator's hand-eye coordination load and operation error tolerance, significantly simplifies the surgical procedure, and further ensures clinical safety while improving surgical efficiency.

[0055] Note that the above description is merely a preferred embodiment and the technical principles employed in this application. Those skilled in the art will understand that this application is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of this application. Therefore, although this application has been described in detail through the above embodiments, this application is not limited to the above embodiments. Many other equivalent embodiments may be included without departing from the concept of this application, and the scope of this application is determined by the scope of the appended claims.

[0056] The above disclosures are only a few specific implementation scenarios of this application. However, this application is not limited to these. Any variations that can be conceived by those skilled in the art should fall within the protection scope of this application.

Claims

1. An integrated anti-embolism brain protection system, characterized in that, The device includes an outer sheath, a brain protection device, a handle, and an adjusting wire. The brain protection device includes a tube through which the adjusting wire passes and a proximal filter and a distal filter that can be opened and closed and connected to the periphery of the tube. The adjusting wire extends into the handle and the tube, and the tube passes through the outer sheath and connects to the handle. The outer sheath is used to control the opening and closing of the proximal filter and the distal filter. The handle connects the outer sheath and the adjusting wire, and is used to control the deformation of the adjusting wire to guide the brain protection device into a preset target position, and to adjust the movement of the outer sheath along the adjusting wire to release and retract the brain protection device.

2. The integrated anti-embolism cerebral protection system according to claim 1, characterized in that, The brain protection device also includes a fixing member located on the tube body for fixing the brain protection device.

3. The integrated anti-embolism cerebral protection system according to claim 1, characterized in that, The outer sheath has an arc-shaped tip at its front end to reduce damage to the blood vessel wall during movement.

4. The integrated anti-embolism cerebral protection system according to claim 2, characterized in that, The fastener includes at least one of the following: a braided support, a balloon, or a self-expanding support.

5. The integrated anti-embolism cerebral protection system according to claim 1, characterized in that, The distal filter and / or the proximal filter includes an annular support frame and a woven mesh surface connected to the annular support frame. The annular support frame is openable and closable connected to the tube body for contracting and expanding the woven mesh surface. The woven mesh surface is used to intercept thrombi and detached debris.

6. The integrated anti-embolism cerebral protection system according to claim 1, characterized in that, The bending wire has a developing mark at the end away from the handle.

7. The integrated anti-embolism cerebral protection system according to claim 1, characterized in that, The handle is provided with a first trigger and a second trigger for connecting the bending wire. The first trigger is used to adjust the length of the bending wire entering the blood vessel, and the second trigger is used to adjust the degree of deformation of the bending wire.

8. The integrated anti-embolism cerebral protection system according to claim 7, characterized in that, The handle is provided with a third trigger element connected to the outer sheath tube, and the third trigger element is used to adjust the movement of the sheath tube along the bending wire.

9. The integrated anti-embolism cerebral protection system according to claim 5, characterized in that, The mesh diameter of the woven surface of the distal filter and / or the proximal filter is between 120μm and 200μm.

10. The integrated anti-embolism cerebral protection system according to claim 5, characterized in that, The opening direction of the near-end filter is opposite to the opening direction of the far-end filter.

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