A radio frequency ablation system integrating cooling and drug delivery functions

Abstract

The application relates to a radio frequency ablation system integrating cooling and drug administration functions, and relates to the technical field of medical devices, which comprises an ablation electrode handle, an electrode needle, a cooling liquid tank and a drug storage tank, the electrode needle is arranged on the ablation electrode handle, a cooling cavity and a drug delivery cavity are arranged in the electrode needle, a first inner tube and a second inner tube are arranged in the cooling cavity and the drug delivery cavity respectively, an inflow pipe is arranged between the first inner tube and the cooling liquid tank, a recovery pipe is arranged between the cooling cavity and the cooling liquid tank, and a first driving pump is arranged on the inflow pipe; a drug delivery pipe is arranged between the second inner tube and the drug storage tank, a second driving pump is arranged on the drug delivery pipe, a drug outlet communicating with the second inner tube is arranged on the electrode needle, and the drug outlet is used for injecting drugs into a lesion area. The application realizes synchronous drug administration during radio frequency ablation treatment, and has the effects of improving drug penetration efficiency and reducing drug side effects.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a radiofrequency ablation system that integrates cooling and drug delivery functions. Background Technology

[0002] Radiofrequency ablation technology holds significant importance in the medical field, and its applications are becoming increasingly widespread with the continuous development of medicine. This technology centers on a radiofrequency therapy device with ablation and cutting functions, utilizing the thermal effect to achieve therapeutic goals: when radiofrequency current flows through human tissue, the high-speed movement of polar water molecules within the tissue generates heat, causing the evaporation, drying, shrinkage, and shedding of water inside and outside cells until aseptic necrosis occurs, thus achieving the therapeutic objective. Furthermore, after radiofrequency ablation treatment, the local tissue changes created by the ablation process allow for the precise delivery of targeted drugs to the lesions or residual cancer cells, which can improve efficacy to some extent while reducing systemic side effects of the drugs.

[0003] Currently, common drug delivery routes in radiofrequency ablation therapy and targeted drug delivery include local administration and systemic administration. Local administration typically involves a second puncture after ablation to directly inject the drug into the lesion area; systemic administration involves delivering the drug throughout the body via the bloodstream, aiming to reach the lesion site. However, neither of these methods allows for simultaneous targeted drug delivery during radiofrequency ablation; both require instrument readjustment and coordination after ablation.

[0004] However, existing drug delivery routes have significant drawbacks in practical treatment. Since neither route allows for simultaneous drug administration during radiofrequency ablation, the brief window of increased vascular permeability in the lesion area after ablation is missed. Subsequent manual local administration makes it difficult for the drug to efficiently penetrate the periphery of the ablation site, potentially leading to incomplete removal of residual cancer cells and increasing the risk of recurrence. Furthermore, local puncture administration may result in inaccurate dosage due to positioning errors, further increasing patient trauma; while systemic administration causes a large amount of drug to act on normal tissue, increasing the probability of systemic side effects such as rash and liver damage. In addition, separate procedures not only prolong the operation time but may also increase the risk of complications such as infection and bleeding due to multiple procedures, affecting the overall safety and efficiency of the treatment process. Therefore, existing drug delivery methods require improvement. Utility Model Content

[0005] To address the problem that existing drug delivery methods cannot simultaneously administer drugs during radiofrequency ablation treatment, thus affecting the treatment effect, this application provides a radiofrequency ablation system that integrates cooling and drug delivery functions.

[0006] This application provides a radiofrequency ablation system that integrates cooling and drug delivery functions, employing the following technical solution: A radiofrequency ablation system integrating cooling and drug delivery functions includes an ablation electrode handle, an electrode needle, a coolant tank, and a drug reservoir. The electrode needle is mounted on the ablation electrode handle and has a cooling chamber and a drug delivery chamber inside. A first inner tube and a second inner tube are respectively installed in the cooling chamber and the drug delivery chamber. An inflow pipe is provided between the first inner tube and the coolant tank, and a return pipe is provided between the cooling chamber and the coolant tank. A first drive pump is installed on the inflow pipe. A drug delivery pipe is provided between the second inner tube and the drug reservoir, and a second drive pump is installed on the drug delivery pipe. The electrode needle has a drug outlet connected to the second inner tube, and the drug outlet is used to inject drugs into the lesion area.

[0007] By adopting the above technical solution, the ablation electrode handle is used to install the electrode needle, which facilitates operation. The cooling chamber and drug delivery chamber inside the electrode needle are used for the flow of coolant and drug, respectively. The first inner tube is connected to the coolant tank through an inflow pipe, and the first drive pump provides power for the flow of coolant. At the same time, the coolant flowing into the cooling chamber can be returned to the coolant tank through a recovery pipe to realize the circulation of the cooling system, which can continuously cool the electrode needle, prevent the temperature of the tissue around the electrode needle from getting too high, and reduce the risk of carbonization. The second inner tube is connected to the drug storage tank through a drug delivery pipe, and the second drive pump provides power for the delivery of drug. The drug is delivered through the second inner tube to the drug outlet on the electrode needle and injected into the lesion area. In vivo drug delivery can be performed on the affected area when needed, thereby realizing simultaneous drug delivery during radiofrequency ablation treatment, avoiding missing the short window period of increased vascular permeability in the lesion area after ablation, improving drug penetration efficiency and treatment effect, and avoiding the positioning deviation of local puncture drug delivery and the side effects of systemic drug delivery.

[0008] Preferably, it also includes a controller; the first inner tube is provided with a first sensing module for monitoring the temperature of the electrode needle, and the first sensing module, the first drive pump and the second drive pump are all electrically connected to the controller.

[0009] By adopting the above technical solution, the first sensing module can monitor the temperature change of the electrode needle in real time and transmit the temperature data to the controller. After receiving the temperature data, the controller can adjust the power of the first drive pump according to the actual temperature of the electrode needle to ensure the flow rate and velocity of the coolant, thereby maintaining a stable cooling effect and preventing the temperature of the tissue around the electrode needle from becoming too high. At the same time, the controller can also control the second drive pump according to the treatment needs to achieve precise operation of drug delivery, administering drugs to the affected area when necessary, thereby improving drug penetration efficiency and treatment effect.

[0010] Preferably, multiple first sensing modules are arranged along the axial direction of the first inner tube.

[0011] By adopting the above technical solution, multiple first sensing modules are arranged along the axial direction of the first inner tube, which can expand the temperature monitoring range, make the temperature monitoring of the electrode needle more comprehensive and stable, effectively avoid the problem of small monitoring range and unstable effect of a single first sensing module, and thus better cooperate with the controller to accurately regulate the first drive pump, ensuring the stable cooling operation of the system.

[0012] Preferably, the coolant outlet end of the first inner tube is provided with multiple outlet holes.

[0013] By adopting the above technical solution, multiple outflow holes are opened at the coolant outflow end of the first inner tube, which can ensure that the coolant flows out of the first inner tube stably and evenly into the cooling chamber, making the coolant circulation smoother, avoiding local accumulation or poor flow of coolant in the cooling chamber, so that each area of ​​the electrode needle can be cooled evenly, preventing damage to the surrounding normal tissue due to excessive local temperature of the electrode needle, and further ensuring the stability and safety of the radiofrequency ablation process.

[0014] Preferably, the coolant tank is provided with a storage tank and a recovery tank. The first inner pipe is connected to the storage tank through an inflow pipe, and the cooling chamber is connected to the recovery tank through a recovery pipe. A connecting pipe is provided between the storage tank and the recovery tank, and a control pump is provided on the connecting pipe.

[0015] By adopting the above technical solution, a storage tank and a recovery tank are set up inside the coolant tank, which can realize the classified storage of coolant, effectively avoid the mixing of high-temperature recovered coolant with unused low-temperature coolant, and prevent the temperature of low-temperature coolant from being raised, thus ensuring the cooling effect of the coolant at all times. At the same time, with the connecting pipe and control pump, after the coolant in the recovery tank has been cooled down, it can be precisely controlled by the control pump to flow back to the storage tank to realize the recycling of coolant. In addition, the coolant flow between the two tanks can be regulated by the control pump to maintain the internal pressure of the cooling system, avoid the coolant delivery obstruction caused by pressure fluctuations, and ensure the continuous reliability of the entire cooling function.

[0016] Preferably, the recovery tank is equipped with a second sensing module for monitoring the coolant temperature, and both the second sensing module and the control pump are electrically connected to the controller.

[0017] By adopting the above technical solution, the second sensing module can monitor the temperature change of the coolant in the recovery tank in real time and transmit the temperature data to the controller. After receiving the temperature data, the controller can drive the control pump to operate according to the temperature information fed back by the second sensing module, thereby adjusting the flow of coolant between the storage tank and the recovery tank, ensuring that the coolant temperature is suitable and the pressure is stable, and thus ensuring the stable operation of the cooling system.

[0018] Preferably, the recycling bin is wrapped with a water-cooled circulation pipe.

[0019] By adopting the above technical solution, water-cooled circulation pipes are wrapped around the outside of the recovery tank, which can quickly reduce the temperature of the coolant that has absorbed heat in the recovery tank, allowing the coolant to recover to a low temperature suitable for reuse more quickly, thereby improving the recycling rate of the coolant; at the same time, it avoids the overall efficiency of the cooling system from decreasing due to the continuous rise in the temperature of the coolant in the recovery tank, ensuring that the cooling system can stably cool the electrode needles for a long time.

[0020] Preferably, the distance between the bottom of the cooling chamber and the tip of the electrode needle is greater than the distance between the bottom of the drug delivery chamber and the tip of the electrode needle.

[0021] By adopting the above technical solution, the distance between the bottom of the cooling chamber and the tip of the electrode needle is greater than the distance between the bottom of the drug delivery chamber and the tip of the needle. This allows the drug outlet to be closer to the core area of ​​the lesion, enabling the drug to be directly delivered to the lesion or the area where residual cancer cells are most concentrated. This reduces drug loss and diffusion during delivery and significantly improves the accuracy of drug action. At the same time, it avoids the cooling chamber being too close to the tip of the needle, which would cause the tip temperature to be too low, ensuring that the tip of the needle can maintain a sufficient ablation temperature to guarantee the treatment effect.

[0022] In summary, this application includes at least one of the following beneficial technical effects: 1. The drug is delivered through the second inner tube to the drug outlet on the electrode needle and injected into the lesion area. It can be used to administer drugs to the affected area when needed, so as to achieve simultaneous drug administration during radiofrequency ablation treatment, avoid missing the short window period of increased vascular permeability in the lesion area after ablation, and improve drug penetration efficiency and treatment effect. 2. Multiple outflow holes are opened at the coolant outlet of the first inner tube to ensure that the coolant can flow out stably and evenly, avoiding local accumulation or poor flow of coolant in the cooling chamber, and preventing damage to surrounding normal tissues due to excessive local temperature of the electrode needle; multiple first sensing modules for monitoring the temperature of the electrode needle are set on the first inner tube, which can expand the temperature monitoring range, make the temperature monitoring of the electrode needle more comprehensive and stable, effectively avoid the problem of small monitoring range and unstable effect of a single first sensing module, and ensure the stable operation of the cooling system; 3. The coolant tank is equipped with a storage tank and a recovery tank, which enables the classified storage of coolant and prevents the temperature of low-temperature coolant from rising, thus ensuring the cooling effect of the coolant at all times. At the same time, with the connecting pipe and control pump, the coolant in the recovery tank can be cooled down and then precisely controlled by the control pump to flow back to the storage tank, realizing the recycling of coolant. The water-cooled circulation pipe wrapped around the recovery tank can quickly reduce the temperature of the coolant that has absorbed heat in the recovery tank, thereby improving the recycling rate of coolant. Attached Figure Description

[0023] Figure 1 This is a front view (partial sectional view) that mainly reflects the overall structure in the embodiments of this application. Figure 2 This is a partial cross-sectional view of the internal structure of the ablation electrode handle, which is the main feature of this application embodiment; Figure 3 yes Figure 2 The enlarged view of part A in the middle mainly shows the connection relationship between the inflow pipe, the recovery pipe and the drug delivery pipe; Figure 4 This is a partial cross-sectional view of the internal structure of the electrode needle, which is the main feature of this application embodiment.

[0024] Reference numerals: 1. Ablation electrode handle; 2. Electrode needle; 21. Cooling chamber; 211. First inner tube; 2111. Outlet hole; 22. Drug delivery chamber; 221. Second inner tube; 23. Drug outlet; 3. Coolant tank; 31. Storage tank; 32. Recovery tank; 321. Water-cooled circulation pipe; 322. Second sensing module; 33. Connecting pipe; 331. Control pump; 4. Drug storage tank; 5. Controller; 6. Radio frequency energy transmission line; 7. Inlet pipe; 71. First drive pump; 8. Recovery pipe; 9. Drug delivery pipe; 91. Second drive pump; 10. First sensing module. Detailed Implementation

[0025] The following is in conjunction with the appendix Figure 1 - Appendix Figure 4 This application will be described in further detail.

[0026] This application discloses a radiofrequency ablation system that integrates cooling and drug delivery functions.

[0027] Reference Figures 1-4A radiofrequency ablation system integrating cooling and drug delivery functions includes an ablation electrode handle 1, an electrode needle 2, a coolant tank 3, a drug storage tank 4, and a controller 5. The electrode needle 2 is detachably and fixedly connected to the ablation electrode handle 1, and a radiofrequency energy transmission line 6 for outputting radiofrequency energy is fixedly connected to the electrode needle 2. A cooling chamber 21 and a drug delivery chamber 22 are respectively formed along the length of the electrode needle 2, and the distance between the bottom of the cooling chamber 21 and the tip of the electrode needle 2 is greater than the distance between the bottom of the drug delivery chamber 22 and the tip of the electrode needle 2. A first inner tube 211 and a second inner tube 221 are respectively embedded in the cooling chamber 21 and the drug delivery chamber 22. The coolant tank 3 contains... The device includes a storage tank 31 and a recovery tank 32. An inflow pipe 7 is connected between the first inner tube 211 and the storage tank 31, and a recovery pipe 8 is connected between the cooling chamber 21 and the recovery tank 32. A first drive pump 71 is fixedly connected to the inflow pipe 7. A connecting pipe 33 is connected between the storage tank 31 and the recovery tank 32, and a control pump 331 is fixedly connected to the connecting pipe 33. A drug delivery pipe 9 is connected between the second inner tube 221 and the drug storage tank 4, and a second drive pump 91 is fixedly connected to the drug delivery pipe 9. The electrode needle 2 has a drug outlet 23 that communicates with the second inner tube 221, and the drug outlet 23 is used to inject drugs into the lesion area. Reference Figure 1 and Figure 4 The first inner tube 211 is fixedly installed with a first sensing module 10 for monitoring the temperature of the electrode needle 2. The outer wall of the recovery box 32 is wound with a water-cooled circulation pipe 321, and the inner wall of the recovery box 32 is fixedly installed with a second sensing module 322 for monitoring the temperature of the coolant. The first sensing module 10, the second sensing module 322, the first drive pump 71, the second drive pump 91, and the control pump 331 are all electrically connected to the controller 5. In this embodiment, the first sensing module 10 and the second sensing module 322 are both thermocouple temperature sensors.

[0028] In practical use, the electrode needle 2 is installed inside the ablation electrode handle 1 for easy operation during treatment. The radiofrequency energy transmission line 6 continuously inputs energy to the electrode needle 2 for ablation treatment. The cooling chamber 21 and the drug delivery chamber 22 inside the electrode needle 2 are used for the flow of coolant and drug, respectively. The distance between the bottom of the cooling chamber 21 and the tip of the electrode needle 2 is greater than the distance between the bottom of the drug delivery chamber 22 and the tip, so that the drug outlet 23 is closer to the core area of ​​the lesion, which greatly improves the accuracy of drug action and avoids the tip temperature being too low due to the cooling chamber 21 being too close to the tip, ensuring that the tip can maintain a sufficient ablation temperature to ensure the treatment effect. During treatment, the first sensing module 10 on the first inner tube 211 monitors the temperature change of the electrode needle 2 in real time and transmits the temperature data to the controller 5. The controller 5 then adjusts the power of the first drive pump 71 according to the actual temperature of the electrode needle 2 to ensure the flow rate and velocity of the coolant in the inflow pipe 7 and the first inner tube 211, thereby maintaining a stable cooling effect and preventing the temperature of the tissue around the electrode needle 2 from becoming too high. The high-temperature coolant in the cooling chamber 21 can be returned to the coolant tank 3 through the recovery pipe 8. The coolant tank 3 is equipped with a storage tank 31 and a recovery tank 32 to achieve classified storage of the coolant and avoid the high-temperature coolant being mixed with the unused low-temperature coolant, thereby ensuring the cooling effect of the coolant. A water-cooled circulation pipe 321 is wrapped around the outside of the recovery tank 32, which can quickly reduce the temperature of the coolant that has absorbed heat in the recovery tank 32, thereby improving the circulation rate of the coolant and preventing the overall efficiency of the cooling system from decreasing due to the continuous rise in the temperature of the coolant in the recovery tank 32. The second sensor in the recovery tank 32 monitors the temperature change of the coolant in the recovery tank 32 in real time and transmits the temperature data to the controller 5. The controller 5 drives the control pump 331 to operate according to the temperature information, thereby regulating the flow of coolant in the connecting pipe 33 between the storage tank 31 and the recovery tank 32, ensuring that the coolant temperature is suitable and the pressure is stable. During treatment, the controller 5 can also control the second drive pump 91 according to the actual treatment needs, and deliver the drug to the drug outlet 23 through the drug delivery tube 9 and the second inner tube 221, thereby realizing simultaneous drug delivery during radiofrequency ablation treatment, avoiding missing the short window period of increased vascular permeability in the lesion area after ablation, improving drug penetration efficiency and treatment effect, while avoiding positioning deviation of local puncture drug delivery and side effects of systemic drug delivery.

[0029] Reference Figure 4 Multiple first sensing modules 10 are arranged along the axial direction of the first inner tube 211. In this embodiment, two first sensing modules 10 are arranged along the axial direction of the first inner tube 211, and the distances between the two first sensing modules 10 and the tip of the electrode needle 2 are 5mm and 25mm, respectively. In actual use, the two first sensing modules 10 simultaneously monitor the temperature of the electrode needle 2 at different positions inside the electrode needle 2, which can expand the temperature monitoring range, make the temperature monitoring of the electrode needle 2 more comprehensive and stable, effectively avoid the problem of small monitoring range and unstable effect of a single first sensing module 10, and ensure the stable cooling operation of the system.

[0030] Reference Figure 4The first inner tube 211 has multiple outflow holes 2111 at its coolant outlet end. In this embodiment, four outflow holes 2111 are provided, and the four outflow holes 2111 are respectively opened on both sides of the first inner tube 211 radially. In actual use, the multiple outflow holes 2111 can ensure that the coolant flows out of the first inner tube 211 stably and evenly into the cooling chamber 21, avoiding local accumulation or poor flow of coolant in the cooling chamber 21, preventing damage to surrounding normal tissue due to excessive local temperature of the electrode needle 2, and further ensuring the stability and safety of the radiofrequency ablation process.

[0031] The implementation principle of this application embodiment is as follows: The detachable electrode needle 2 is installed on the ablation electrode handle 1 to facilitate treatment operation. The radio frequency energy transmission line 6 continuously delivers energy to the electrode needle 2 to carry out ablation treatment. When the cooling system is operating, the storage tank 31 in the coolant tank 3 delivers coolant through the inflow pipe 7, the first drive pump 71, and the first inner tube 211 in the cooling chamber 21 of the electrode needle 2. Two first sensing modules 10 arranged axially on the first inner tube 211 monitor the temperature of the electrode needle 2 in real time and feed it back to the controller 5. The controller 5 adjusts the first drive pump accordingly. 71 power is used to control the flow rate and velocity of the coolant to ensure stable cooling and avoid overheating of surrounding tissues. After absorbing heat, the high-temperature coolant flows back to the recovery tank 32 of the coolant tank 3 through the recovery pipe 8. The water-cooled circulation pipe 321 on the outer wall of the recovery tank 32 quickly cools down the coolant inside to improve the recycling rate. After the second sensing module 322 on the inner wall of the recovery tank 32 monitors the coolant temperature, the controller 5 adjusts the control pump 331 on the connecting pipe 33 to realize the reasonable flow of coolant between the storage tank 31 and the recovery tank 32, ensuring that the coolant temperature is suitable and the pressure is stable. The drug delivery system is controlled by the controller 5, which adjusts the second drive pump 91 according to the treatment needs. The drug in the drug storage tank 4 is injected into the lesion through the drug outlet 23 via the drug delivery tube 9 and the second inner tube 221 in the drug delivery chamber 22 of the electrode needle 2. This allows for simultaneous radiofrequency ablation and drug delivery, taking advantage of the brief window of increased vascular permeability in the lesion area after ablation to improve drug penetration efficiency. At the same time, because the bottom of the drug delivery chamber 22 is closer to the needle tip than the cooling chamber 21, the accuracy of drug action can be improved, and the needle tip temperature can be prevented from being too low due to the cooling chamber 21 being too close to the needle tip. This ensures that the needle tip can maintain a sufficient ablation temperature to guarantee the treatment effect. In addition, the four outflow holes 2111 on the first inner tube 211 can ensure that the coolant flows evenly into the cooling chamber 21, avoiding local accumulation or poor flow. Combined with the comprehensive temperature monitoring of the dual first sensing modules 10, the stability, safety and treatment effect of the radiofrequency ablation process are guaranteed.

[0032] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A radiofrequency ablation system integrating cooling and drug delivery functions, characterized in that: The device includes an ablation electrode handle (1), an electrode needle (2), a coolant tank (3), and a drug storage tank (4). The electrode needle (2) is mounted on the ablation electrode handle (1). The electrode needle (2) has a cooling chamber (21) and a drug delivery chamber (22). A first inner tube (211) and a second inner tube (221) are respectively installed in the cooling chamber (21) and the drug delivery chamber (22). An inflow pipe (7) is installed between the first inner tube (211) and the coolant tank (3). A recovery pipe (8) is provided between the cooling chamber (21) and the coolant tank (3), and a first drive pump (71) is provided on the inflow pipe (7); a drug delivery pipe (9) is provided between the second inner tube (221) and the drug storage tank (4), and a second drive pump (91) is provided on the drug delivery pipe (9); a drug outlet (23) connected to the second inner tube (221) is provided on the electrode needle (2), and the drug outlet (23) is used to inject the drug into the lesion area.

2. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 1, characterized in that: It also includes a controller (5); a first sensing module (10) for monitoring the temperature of the electrode needle (2) is provided on the first inner tube (211), and the first sensing module (10), the first drive pump (71) and the second drive pump (91) are all electrically connected to the controller (5).

3. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 2, characterized in that: The first sensing module (10) has multiple components arranged along the axial direction of the first inner tube (211).

4. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 1, characterized in that: The first inner tube (211) has multiple outlet holes (2111) at the outlet end of the coolant.

5. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 2, characterized in that: The coolant tank (3) is provided with a storage tank (31) and a recovery tank (32). The first inner tube (211) is connected to the storage tank (31) through an inflow pipe (7), and the cooling chamber (21) is connected to the recovery tank (32) through a recovery pipe (8). A connecting pipe (33) is provided between the storage tank (31) and the recovery tank (32), and a control pump (331) is provided on the connecting pipe (33).

6. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 5, characterized in that: The recycling tank (32) is equipped with a second sensing module (322) for monitoring the temperature of the coolant, and the second sensing module (322) and the control pump (331) are both electrically connected to the controller (5).

7. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 5, characterized in that: The recycling bin (32) is wrapped with a water-cooled circulation pipe (321).

8. The radiofrequency ablation system integrating cooling and drug delivery functions according to claim 1, characterized in that: The distance between the bottom of the cooling chamber (21) and the tip of the electrode needle (2) is greater than the distance between the bottom of the drug delivery chamber (22) and the tip of the electrode needle (2).

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