A laboratory mouse injector fixer

Abstract

The utility model relates to experimental mouse injection technical field, and disclose a mouse injection fixing device for laboratory, including fixed cylinder, the fixed cylinder bottom is opened and has injection window no.

Description

Technical Field

[0001] This utility model relates to the field of laboratory mouse injection technology, and in particular to a fixator for laboratory mouse injection. Background Technology

[0002] Laboratory mice are among the most widely used experimental animals in life science research. Due to their high genetic similarity to humans, rapid reproduction rate, and low breeding cost, they are crucial in disease simulation, drug development, and basic biological research. Mice are widely used to simulate human diseases, evaluate drug effects, and explore gene functions. They must be raised in a clean environment free of specific pathogens, with strict control of temperature, humidity, ventilation, and hygiene standards to ensure reliable experimental results. With the advancement of gene editing technology, laboratory mice are continuously driving medical research towards precision.

[0003] In existing technologies, mice need to be fixed during injection. Traditional fixation devices are mostly fixed and cannot be rotated or adjusted, resulting in poor flexibility. If different sites such as the abdomen or back need to be injected, the fixation device needs to be repeatedly disassembled, the mouse's posture readjusted, and then fixed again, which is time-consuming and labor-intensive. This is especially unfriendly to experiments that require frequent changes in injection angle. Repeated restraint can easily lead to strong stress reactions in mice, affecting the accuracy of experimental data. Therefore, to solve the above problems, this utility model proposes a fixation device for laboratory mouse injection. Utility Model Content

[0004] To address the shortcomings of existing technologies, this invention provides a laboratory mouse injection fixation device. A servo motor drives the fixing cylinder to rotate, improving the device's flexibility and facilitating injection of mice through the injection window without requiring readjustment. It is suitable for injections at multiple sites, avoiding animal stress and time-consuming operations caused by repeated fixation. The body parts outside the injection window are restrained by the fixation device, reducing animal injury and experimental errors.

[0005] This utility model provides the following technical solution: a laboratory mouse injection fixation device, comprising a fixation cylinder, an injection window one at the bottom of the fixation cylinder, an upper cover plate movably connected to the upper part of the fixation cylinder via a shaft, an injection window two at the upper part of the upper cover plate, a traction ring movably sleeved on the fixation cylinder and located to the right of the upper cover plate, a connecting block fixedly installed on the left side of the fixation cylinder, a rotating seat provided on the left side of the connecting block, a servo motor disposed in the inner cavity of the rotating seat, the output shaft of the servo motor movably sleeved with the right side of the inner cavity of the rotating seat, the output shaft of the servo motor fixedly connected to the connecting block via a coupling, a fixed seat movably connected to the bottom of the rotating seat via a shaft, a base plate fixedly installed at the bottom of the fixed seat, an electric push rod movably connected to the upper part of the base plate and located to the right of the fixed seat via a shaft, the telescopic end of the electric push rod movably connected to the traction ring via a shaft, the servo motor drives the fixation cylinder to rotate, improving the flexibility of the device, facilitating the experimenter to inject mice through the injection window, suitable for multi-site injection, avoiding animal stress and operation time caused by repeated fixation, reducing animal injury and experimental error.

[0006] Preferably, the front part of the fixing cylinder and the upper cover plate are respectively provided with snap fasteners, and the number of snap fasteners is two and symmetrically distributed on the left and right. Threaded rods are movably sleeved on the upper cover plate on the left and right sides of the injection window. A knob is fixedly installed at the top of the threaded rod, and a pressure plate is movably connected to the bottom of the threaded rod below the upper cover plate via a bearing. Rotating the knob drives the threaded rod to rotate, and the threaded rod drives the pressure plate to descend and fix the neck and tail of the mouse, effectively restricting the mouse's limb movement, preventing the injection site from shifting or the needle from being accidentally injured due to struggling, ensuring accurate drug injection to the target location, reducing experimental errors, and the clamp fixation operation is simple and can be completed quickly, saving the labor cost of manual fixation.

[0007] Preferably, a fixing block is fixedly installed on the upper part of the connecting block. There are two fixing blocks, which are symmetrically distributed front and back. A threaded rod is movably sleeved in the middle of the fixing block. A knob is fixedly installed on the opposite ends of the two threaded rods. A pressure plate is movably connected to the opposite ends of the two threaded rods through bearings. The tail of the mouse is placed on the connecting block. At the same time, the two knobs are rotated to drive the threaded rod to rotate. The threaded rod drives the pressure plate to move towards each other, clamping and fixing the tail of the mouse. The clamping fixation does not require the use of anesthesia, avoiding the interference of anesthesia on the physiological indicators of the mouse and ensuring that the experimental results truly reflect the direct effect of the drug or treatment factor.

[0008] Compared with the prior art, the present invention has the following beneficial effects: 1. The horizontal angle of the device is adjusted by an electric actuator, and the fixed cylinder is rotated by a servo motor, which improves the flexibility of the fixing mechanism. This allows the experimenter to inject mice into the abdomen and back through injection windows one and two. The experimenter can quickly switch to the optimal injection angle without re-fixing the mice. This is suitable for experiments involving multiple injection sites or observation from multiple angles. It avoids animal stress and time-consuming operations caused by repeated fixing. The body parts outside the injection windows are restrained by the fixing device, which prevents the mice from straining and causing abdominal muscle tension or back skin folds, thus reducing animal injury and experimental errors.

[0009] 2. Splints effectively restrict the limb movement of mice, preventing injection site deviation or needle injury caused by struggling, ensuring accurate drug injection at the target location, reducing experimental errors, preventing direct contact between experimental personnel and animals, and reducing the risk of being bitten or scratched. Splint fixation is simple to operate and can be completed quickly, saving the labor costs of manual fixation. In addition, splint fixation does not require the use of anesthetics, avoiding interference with the physiological indicators of mice by anesthesia, and ensuring that experimental results truly reflect the direct effects of drugs or treatments. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the external structure of this utility model; Figure 2 This is a schematic diagram of the opening of the upper cover plate of this utility model; Figure 3 This is a schematic diagram of the rotating structure of this utility model; Figure 4 This is a schematic diagram of the fixing structure of this utility model.

[0011] In the diagram: 1. Fixed cylinder; 2. Injection window one; 3. Top cover plate; 4. Injection window two; 5. Traction ring; 6. Connecting block; 7. Rotating seat; 8. Servo motor; 9. Fixed seat; 10. Base plate; 11. Electric actuator; 12. Snap-fit ​​buckle; 13. Threaded rod one; 14. Knob one; 15. Pressure plate one; 16. Fixed block; 17. Threaded rod two; 18. Knob two; 19. Pressure plate two. Detailed Implementation

[0012] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0013] Please see Figures 1-4A laboratory mouse injection restraint includes a restraining cylinder 1 with an injection window 2 at its bottom. An upper cover 3 is movably connected to the upper part of the restraining cylinder 1 via a shaft. An injection window 4 is also located on the upper part of the upper cover 3. A traction ring 5 is movably sleeved on the upper part of the restraining cylinder 1 to the right of the upper cover 3. A connecting block 6 is fixedly installed on the left side of the restraining cylinder 1, and a rotating seat 7 is located on the left side of the connecting block 6. A servo motor 8 is housed within the rotating seat 7, and its output shaft is movably sleeved to the right side of the rotating seat 7. The output shaft of the servo motor 8 is fixedly connected to the connecting block 6 via a coupling. A fixing seat 9 is movably connected to the bottom of the rotating seat 7 via a shaft. A base plate 10 is fixedly installed at the bottom of the fixing seat 9. An electric push rod 11 is movably connected to the upper part of the base plate 10 to the right of the fixing seat 9 via a shaft. The telescopic end of the electric push rod 11 is movably connected to the traction ring 5 via a shaft. Activating the electric push rod 11 moves its telescopic end, thereby adjusting... The horizontal angle of the device is controlled by the servo motor 8 to drive the connecting block 6 to rotate, and the fixed cylinder 1 is movably connected to the traction ring 5, allowing the fixed cylinder 1 to rotate, improving the flexibility of the fixing mechanism. This makes it easier for the experimenter to inject the mouse's abdomen and back through injection window 1 2 and injection window 2 4. The experimenter can adjust the mouse's position by rotating the fixed cylinder 1 without moving the animal or re-fixing it, and quickly switch to the optimal injection angle. This is especially suitable for experiments that require multiple injection sites or multi-angle observation on the same animal, avoiding animal stress and time-consuming operation caused by repeated fixation. The body parts outside the injection window are tightly fitted and restrained by the fixing device, allowing only slight movement of the skin in the target area. This prevents the mouse from straining and causing abdominal muscle tension or back skin folds, preventing the needle from accidentally piercing non-target tissue, reducing animal injury and experimental error, and ensuring smooth breathing and blood circulation. The front parts of the fixed cylinder 1 and the upper cover plate 3 are respectively provided with two snap fasteners 12, which are symmetrically distributed on the left and right. Threaded rods 13 are movably sleeved on the upper cover plate 3 on both sides of the injection window 2 4. A knob 14 is fixedly installed at the top of the threaded rod 13. A pressure plate 15 is movably connected to the bottom of the threaded rod 13, located below the upper cover plate 3, via a bearing. Two fixing blocks 16 are fixedly installed on the upper part of the connecting block 6, which are symmetrically distributed front and back. Threaded rods 2 17 are movably sleeved in the middle of the fixing blocks 16. A knob 2 18 is fixedly installed at the opposite ends of the two threaded rods 2 17. A pressure plate 2 19 is movably connected to the opposite ends of the two threaded rods 2 17 via a bearing. First, open the upper cover plate 3 and place the mouse into the inner cavity of the fixed cylinder 1, so that the mouse's abdomen is facing the injection window 2. Close the upper cover plate 3 and the fixed cylinder 1 and connect them through the snap fasteners 12, so that the mouse... With the mouse's back facing the injection window 24, rotate knob 14 to rotate threaded rod 13. Threaded rod 13 lowers pressure plate 15 to secure the mouse's neck and tail. Place the mouse's tail on connecting block 6. Simultaneously rotate both knobs 14 to rotate threaded rod 13, which in turn moves pressure plate 15 towards each other, clamping and securing the mouse's tail. This effectively restricts the mouse's limb movement, preventing injection site displacement or needle injury due to struggle, ensuring accurate drug injection at the target location, reducing experimental errors, and preventing direct contact between laboratory personnel and animals, thus reducing the risk of bites or scratches. The splint fixation operation is simple and quick, saving the labor costs of manual fixation. Furthermore, splint fixation does not require the use of anesthesia, avoiding interference with the mouse's physiological indicators and ensuring that experimental results accurately reflect the direct effects of the drug or treatment.

[0014] Working principle: First, open the upper cover plate 3 and place the mouse into the inner cavity of the fixing tube 1, so that the mouse's abdomen is facing the injection window 2. Close the upper cover plate 3 and the fixing tube 1 and connect them through the snap fastener 12, so that the mouse's back is facing the injection window 4. Rotate the knob 14 to drive the threaded rod 13 to rotate. The threaded rod 13 drives the pressure plate 15 to descend and fix the mouse's neck and tail. Place the mouse's tail on the connecting block 6. At the same time, rotate the two knobs 14 to drive the threaded rod 13 to rotate. The threaded rod 13 drives the pressure plate 15, so that the two pressure plates 15 move towards each other to clamp and fix the mouse's tail. Turn on the electric push rod 11 to move its telescopic end, thereby adjusting the horizontal angle of the device. The servo motor 8 drives the connecting block 6 to rotate, and the fixing tube 1 and the traction ring 5 are connected to rotate, so that the fixing tube 1 can rotate, making it convenient for the experimenter to inject the mouse's abdomen and back through the injection window 2 and the injection window 4.

Claims

1. A fixation device for laboratory mouse injection, comprising a fixation cylinder (1), characterized in that: The fixed cylinder (1) has an injection window 1 (2) at its bottom. The upper part of the fixed cylinder (1) is movably connected to an upper cover plate (3) via a shaft. The upper cover plate (3) has an injection window 2 (4) at its top. A traction ring (5) is movably sleeved on the fixed cylinder (1) and located to the right of the upper cover plate (3). A connecting block (6) is fixedly installed on the left side of the fixed cylinder (1). A rotating seat (7) is provided on the left side of the connecting block (6). A servo motor (8) is provided in the inner cavity of the rotating seat (7). The output shaft of the servo motor (8) is movably connected to the right side of the inner cavity of the rotating seat (7). The output shaft of the servo motor (8) is fixedly connected to the connecting block (6) through a coupling. The bottom of the rotating seat (7) is movably connected to the fixed seat (9) through a shaft. The bottom of the fixed seat (9) is fixedly installed with a base plate (10). The upper part of the base plate (10) and located to the right of the fixed seat (9) is movably connected to the electric push rod (11) through a shaft. The telescopic end of the electric push rod (11) is movably connected to the traction ring (5) through a shaft.

2. The laboratory mouse injection fixation device according to claim 1, characterized in that: The front of the fixed cylinder (1) and the upper cover plate (3) are respectively provided with snap fasteners (12). There are two snap fasteners (12) and they are symmetrically distributed on the left and right. The upper cover plate (3) is movably sleeved on the left and right sides of the injection window (4). The top of the threaded rod (13) is fixedly installed with a knob (14). The bottom of the threaded rod (13) and below the upper cover plate (3) is movably connected to a pressure plate (15) through a bearing.

3. The laboratory mouse injection fixation device according to claim 1, characterized in that: The connecting block (6) is fixedly installed with a fixing block (16) on the upper part. There are two fixing blocks (16) and they are symmetrically distributed front and back. A threaded rod (17) is movably sleeved in the middle of the fixing block (16). A knob (18) is fixedly installed on the opposite ends of the two threaded rods (17). A pressure plate (19) is movably connected to the opposite ends of the two threaded rods (17) through a bearing.

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