A gel patch

Abstract

The application provides a gel plaster, and relates to the technical field of plasters. The gel plaster comprises a backing layer, a plaster body layer and a protective layer. The backing layer comprises a sticking part and a drug loading part. The sticking part is arranged at the edge of the backing layer, and the drug loading part is arranged at the center of the backing layer. The sticking part and the drug loading part are arranged on the same side of the backing layer. The plaster body layer comprises a slow-release drug storage part and a fast-release drug part. The slow-release drug storage part is arranged in the drug loading part, and the fast-release drug part is arranged on the side of the slow-release drug storage part away from the backing layer. The protective layer is attached to the backing layer and used for protecting the plaster body layer. The gel plaster can take into account the treatment mode of rapid effect and sustained effect, relieve the pain of the user first, and then treat for a long time, thereby improving the treatment effect of the gel plaster and the use experience of the user.

Description

Technical Field

[0001] This application relates to the field of plaster technology, and more specifically, to a gel plaster. Background Technology

[0002] Gel patches are topical transdermal drug delivery preparations, typically made by mixing a water-soluble polymer matrix with a drug. They possess good biocompatibility, skin adhesion, and drug-carrying capacity. Applied directly to the affected area, they allow the drug to penetrate the skin, exerting local or systemic therapeutic effects. They are commonly used for pain relief, anti-inflammation, and promoting blood circulation.

[0003] In related technologies, gel patches are usually patches with a single matrix and uniform drug loading, which makes it difficult to achieve both rapid onset of action and long-term therapeutic effect, and the level of action is singular. Utility Model Content

[0004] In order to at least address some of the deficiencies mentioned in the related technologies, this application provides a gel patch.

[0005] The gel patch provided in this application includes a backing layer, a paste layer, and a protective layer. The backing layer includes an adhesive portion and a drug-carrying portion. The adhesive portion is located at the edge of the backing layer, and the drug-carrying portion is located at the center of the backing layer, with the adhesive portion and the drug-carrying portion situated on the same side of the backing layer. The paste layer includes a sustained-release drug storage portion and a rapid-release drug release portion. The sustained-release drug storage portion is located within the drug-carrying portion, and the rapid-release drug release portion is located on the sustained-release drug storage portion on a side away from the backing layer. The protective layer is adhered to the backing layer and serves to protect the paste layer and the adhesive portion.

[0006] Furthermore, the rapid-release drug delivery unit and the sustained-release drug storage unit are layered together. The rapid-release drug delivery unit includes a gel matrix and a penetration enhancer, and the sustained-release drug storage unit includes a drug, a gel matrix, and microcapsules.

[0007] Furthermore, multiple microcapsules are disposed within the sustained-release drug storage portion, and the multiple microcapsules are uniformly dispersed within the gel matrix of the sustained-release drug storage portion.

[0008] Furthermore, the ointment layer is coated at the center of the backing layer, and after the sustained-release drug storage portion is coated on the drug-carrying portion, the rapid-release drug storage portion is coated on the sustained-release drug storage portion after the sustained-release drug storage portion dries.

[0009] Furthermore, the sustained-release drug storage portion is coated with multiple layers on the ointment layer, and the rapid-release drug storage portion is coated with multiple layers on the sustained-release drug storage portion.

[0010] Furthermore, the backing layer is made of non-woven fabric or elastic fabric.

[0011] Furthermore, the protective layer includes a backing protective layer and a paste protective layer. The paste protective layer is adhered to the paste layer to protect the paste layer; the backing protective layer is adhered to the backing layer to protect the adhesive portion and the paste layer.

[0012] Furthermore, the paste layer is rectangular, and the adhesive portion is disposed on the backing layer, extending away from the paste layer. Four adhesive portions are provided, each corresponding to an edge of the paste layer.

[0013] With the above technical solution, when using the gel patch of this application, the protective layer is removed, the drug-carrying part is aligned with the user's affected area, the patch layer is adhered to the skin, and the gel patch is fixed in place by the adhesive part of the backing layer. After application, the drug components in the rapid-release part are quickly released to treat the superficial layers of the skin, rapidly and effectively relieving the user's pain. Subsequently, the drug in the sustained-release storage part is gradually and slowly released under the influence of the user's body temperature, delivering medication to deeper tissues for long-term therapeutic effect.

[0014] The gel patch of this application can take into account both rapid and sustained-effect treatment methods, first relieving the user's pain and then providing long-term treatment, thereby improving the therapeutic effect of the gel patch of this application and the user experience.

[0015] Other features and advantages of this application will be described in detail in the following detailed description section. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is a schematic diagram of the structure of the gel patch provided in an embodiment of this application.

[0018] icon: 100 - Backing layer; 110 - Adhesive part; 120 - Drug-carrying part; 200 - Ointment layer; 210 - Sustained-release drug storage part; 220 - Rapid-release drug part. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0020] In the description of this application, it should be noted that the terms "inner" and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of describing this application and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0021] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "setup" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0022] This embodiment provides a gel patch to solve the problem in related technologies where gel patches cannot simultaneously provide both rapid and long-lasting treatment, resulting in poor treatment effects.

[0023] Please see Figure 1 This embodiment provides a gel patch, including a backing layer 100, a patch layer 200, and a protective layer. The backing layer 100 includes an adhesive portion 110 and a drug-carrying portion 120. The adhesive portion 110 is disposed at the edge of the backing layer 100, and the drug-carrying portion 120 is disposed at the center of the backing layer 100, with the adhesive portion 110 and the drug-carrying portion 120 located on the same side of the backing layer 100. The patch layer 200 includes a sustained-release drug storage portion 210 and a rapid-release drug release portion 220. The sustained-release drug storage portion 210 is disposed within the drug-carrying portion 120, and the rapid-release drug release portion 220 is disposed on the side of the sustained-release drug storage portion 210 away from the backing layer 100. The protective layer is adhered to the backing layer 100 to protect the patch layer 200 and the adhesive portion 110.

[0024] Specifically, when using the gel patch of this embodiment, first clean and dry the affected skin to ensure that there is no oil, sweat, or residue that may interfere with the application effect. Remove the patch from the packaging box and check that the protective layer is intact to avoid premature tearing, which could lead to drug contamination or ineffectiveness. Tear the protective layer from the edge to fully expose the backing layer 100 and the patch layer 200. Align the drug-carrying portion 120 of the backing layer 100 with the center of the affected area, ensuring that the patch layer 200 is in direct contact with the skin. Starting from the adhesive portion 110 at the edge of the backing layer 100, smooth it outwards from the center to remove air bubbles and ensure that the adhesive portion 110 adheres tightly to the skin.

[0025] In this embodiment of the gel patch, the rapid-release drug delivery unit 220 allows the drug to quickly reach an effective blood concentration in the superficial layer of the skin within a short period of time, achieving analgesic and anti-swelling effects and rapidly relieving acute pain or inflammation. The sustained-release drug storage unit 210 is equipped with a slowly released component, which gradually disintegrates under the influence of body temperature, maintaining a long-term continuous release and providing sustained drug delivery to deeper tissues, avoiding the abrupt decline in efficacy after a single rapid release. Therefore, this embodiment of the gel patch can achieve multi-stage dynamic drug release, matching the treatment rhythm of complex conditions, making it more convenient and flexible to use, and resulting in better treatment effects.

[0026] In one embodiment, exemplarily, such as Figure 1 As shown, the rapid drug release section 220 and the sustained-release drug storage section 210 are arranged in layers. The rapid drug release section 220 includes a drug, a gel matrix, and a penetration enhancer, while the sustained-release drug storage section 210 includes a gel matrix and microcapsules.

[0027] The rapid-release drug delivery unit 220 and the sustained-release drug storage unit 210 are arranged in layers. The upper rapid-release drug delivery unit 220 contacts the user's skin first. The drug and gel matrix in the rapid-release drug delivery unit 220 will quickly penetrate the skin under the action of the penetration enhancer, acting on the superficial layer of the skin to quickly achieve the purpose of analgesia and swelling reduction, relieving the user's discomfort. The lower sustained-release drug storage unit 210 contacts the user's skin after the rapid-release drug delivery unit 220. Then, under the action of the user's body temperature, the microcapsules slowly dissolve and release. The drug stored in the microcapsules, together with the gel matrix, acts on the user's skin and gradually penetrates into the deep tissues of the skin, delivering medication to the deep tissues and achieving a slow-release and long-lasting therapeutic effect.

[0028] The penetration enhancer in the rapid drug release section 220 enables the drug to quickly penetrate the skin barrier, ensuring rapid drug penetration and guaranteeing the rapid onset of action in this embodiment.

[0029] The microcapsules of the sustained-release drug reservoir 210 have microcapsule walls that form a barrier, requiring the drug within the microcapsules to diffuse slowly through the walls or be released only after the microcapsules have degraded. This allows the sustained-release drug reservoir 210 to take effect after the rapid-release drug reservoir 220. Furthermore, the microcapsules protect the drug within, preventing it from being affected by external factors such as light, oxygen, and humidity, thus extending the drug's shelf life. Moreover, the microcapsules can encapsulate some drugs that are originally in liquid or other fluid form, forming solid particles that facilitate drug processing and dispersion within the gel matrix.

[0030] It should be noted that the microcapsules can be prepared by a two-step ionic crosslinking method. First, sodium alginate is crosslinked with calcium chloride to form primary microspheres, and then immersed in chitosan solution to form a composite membrane. The manufacturing process is simple and convenient. Of course, this embodiment does not limit the preparation method of the microcapsules. As long as the usage requirements of this embodiment can be met, any other method can be used to prepare the microcapsules.

[0031] After preparation, the microcapsules can be made into a wet suspension and directly mixed into the gel matrix as needed. The microcapsules remain wet during the mixing process, avoiding potential impacts on drug activity caused by the drying process or drying environment. Alternatively, the microcapsules can be freeze-dried into powder and then added to the gel matrix. Microcapsule powder, with its better flowability, provides more stable overall properties and is easier to handle, store, and transport.

[0032] Of course, it is worth mentioning that encapsulating drugs in microcapsules can also mask the odor of the drugs themselves, improving the user experience.

[0033] In one embodiment, for example, multiple microcapsules are disposed within the sustained-release drug reservoir 210, and the multiple microcapsules are uniformly dispersed within the gel matrix of the sustained-release drug reservoir 210. Distributing an appropriate number of microcapsules allows the sustained-release drug reservoir 210 to carry an appropriate amount of drug, ensuring the therapeutic effect when the sustained-release drug reservoir 210 releases the drug. Furthermore, the uniformly dispersed microcapsules also ensure that the sustained-release drug reservoir 210 can effectively exert a therapeutic effect whenever it comes into contact with the user.

[0034] In one embodiment, exemplarily, such as Figure 1As shown, the ointment layer 200 is coated at the center of the backing layer 100, and the sustained-release drug storage portion 210 is coated on the drug-carrying portion 120. After the sustained-release drug storage portion 210 dries, the rapid-release drug storage portion 220 is coated on the sustained-release drug storage portion 210. If the rapid-release drug storage portion 220 and the sustained-release drug storage portion 210 are coated simultaneously, the water-soluble components and microcapsules may migrate, diffuse, or become interfacially miscible, causing the rapid components to penetrate into the sustained-release layer, resulting in an initial burst release, or the sustained-release microcapsules may be destroyed by the penetration enhancer, affecting the long-term release stability. In this embodiment, the step-by-step coating and intermediate drying process forms a physical isolation layer between the rapid-release drug storage portion 220 and the sustained-release drug storage portion 210. After the sustained-release drug storage portion 210 dries, it forms a dense gel film, fixing the microcapsules. The rapid-release drug storage portion 220, as an independent upper layer, only acts on the skin contact surface. The functional boundaries between the two are clear, and they do not interfere with each other, strictly realizing the "fast first, slow later" drug release mode.

[0035] In one embodiment, exemplarily, such as Figure 1 As shown, the sustained-release drug reservoir 210 has multiple layers sequentially coated on the paste layer 200, and the rapid-release drug reservoir 220 has multiple layers sequentially coated on the sustained-release drug reservoir 210. Single-layer sustained release can only provide a single release rate, while the multi-layer sustained-release drug reservoir 210 can construct a stepped or pulsed long-acting release. This can be achieved by using different wall material thicknesses, microcapsule sizes, or drug loading concentrations for each sustained-release layer, or by adjusting the sodium alginate-chitosan ratio layer by layer, so that the degradation rate of each layer increases or decreases sequentially. In this way, the drug is released in stages at different times, avoiding plateau phase efficacy decay.

[0036] The multi-layer rapid drug release section 220 can achieve secondary supplementary release after the initial burst release. For example, the outermost layer contains a high concentration of penetration enhancer, which takes effect within 15 minutes, and the next outermost layer contains a medium concentration of penetration enhancer, which maintains an effective concentration for 30 to 60 minutes. This effectively avoids the cliff effect of "rapid drop after rapid effect" and improves the user experience of the gel patch in this embodiment.

[0037] If all the penetration enhancer is concentrated in a single layer, the excessively high local concentration can easily cause stinging or allergies. In this embodiment, a multi-layered rapid-release drug delivery unit 220 is provided, which can evenly distribute the penetration enhancer across multiple layers, with the concentration in each layer controlled within a safe threshold. In this way, the overall efficacy remains unchanged, but the irritation is significantly reduced. Similarly, the layered design of the sustained-release drug storage unit 210 can also avoid local osmotic pressure imbalance or skin dehydration caused by drug accumulation in a single layer.

[0038] In one embodiment, exemplarily, such as Figure 1 As shown, the backing layer 100 is made of non-woven fabric or elastic fabric. The non-woven fabric or elastic fabric backing itself has good macroscopic breathability and flexibility, and can stretch and deform with the skin, improving wearing comfort and further enhancing the user experience.

[0039] In one embodiment, exemplarily, such as Figure 1 As shown, the protective layer includes a backing protective layer and a paste protective layer. The paste protective layer is adhered to the paste layer 200 to protect the paste layer 200. The backing protective layer is adhered to the backing layer 100 to protect the adhesive portion 110 and the paste layer 200.

[0040] The overall shape of the backing protective layer corresponds to that of the backing layer 100. When not in use, the backing protective layer is in a fitted state, and the adhesive portion 110 on the backing layer 100 does not come into contact with the outside world, thus preventing the adhesive portion 110 from being contaminated. When needed, the backing protective layer is peeled off, ensuring that the adhesive portion 110 has sufficient adhesion so that the backing layer 100 can reliably and firmly adhere to the user's skin.

[0041] The protective layer is separately adhered to the surface of the gel layer 200 to protect it from contact with the backing protective layer or other external environments, thus preventing contamination. Furthermore, since the gel layer 200 itself is moist, the protective layer can be made of a waterproof material as needed to keep it moisturized and prevent excessive drying during storage, which could affect its subsequent use.

[0042] In one embodiment, exemplarily, such as Figure 1 As shown, the ointment layer 200 is rectangular, and the adhesive part 110 is disposed on the backing layer 100, extending away from the ointment layer 200. There are four adhesive parts 110, each corresponding to one of the edges of the ointment layer 200. The four adhesive parts 110 correspond to the four sides of the rectangular ointment layer 200. During application, the ointment is smoothed outwards from the center, and each adhesive part 110 is simultaneously stressed, effectively eliminating air bubbles and preventing localized bulging. Especially in curved surfaces or highly mobile areas such as joints, shoulder blades, and the waist, the four-way extending adhesive parts 110 can adaptively deform with slight skin movements, resisting shear and peeling forces, significantly reducing the risk of edge lifting and slippage during use.

[0043] It should be noted that, where there is no conflict, the features in the embodiments of this application can be combined with each other.

[0044] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A gel patch, characterized in that, include: A backing layer (100) includes an adhesive portion (110) and a drug-carrying portion (120). The adhesive portion (110) is disposed at the edge of the backing layer (100), and the drug-carrying portion (120) is disposed at the center of the backing layer (100). The adhesive portion (110) and the drug-carrying portion (120) are disposed on the same side of the backing layer (100). The ointment layer (200) includes a sustained-release drug storage section (210) and a rapid-release drug release section (220). The sustained-release drug storage section (210) is disposed within the drug-carrying section (120), and the rapid-release drug release section (220) is disposed on the side of the sustained-release drug storage section (210) away from the backing layer (100). A protective layer is attached to the backing layer (100) to protect the paste layer (200) and the adhesive portion (110).

2. The gel patch according to claim 1, characterized in that, The rapid drug release section (220) and the sustained drug storage section (210) are arranged in layers; The rapid release section (220) includes a drug, a gel matrix, and a penetration enhancer, and the sustained release storage section (210) includes a gel matrix and microcapsules.

3. The gel patch according to claim 1, characterized in that, The ointment layer (200) is coated and disposed at the center of the backing layer (100), and after the sustained-release drug storage part (210) is coated on the drug-carrying part (120), the rapid-release drug storage part (220) is coated on the sustained-release drug storage part (210) after the sustained-release drug storage part (210) dries.

4. The gel patch according to claim 3, characterized in that, The sustained-release drug storage section (210) has multiple layers sequentially coated on the ointment layer (200), and the rapid-release drug storage section (220) has multiple layers sequentially coated on the sustained-release drug storage section (210).

5. The gel patch according to any one of claims 1 to 4, characterized in that, The backing layer (100) is made of non-woven fabric or elastic fabric.

6. The gel patch according to claim 5, characterized in that, The protective layer includes a backing protective layer and a paste protective layer; The ointment protective layer is attached to the ointment layer (200) to protect the ointment layer (200); the backing protective layer is attached to the backing layer (100) to protect the adhesive part (110) and the ointment layer (200).

7. The gel patch according to claim 1, characterized in that, The paste layer (200) is rectangular, the adhesive part (110) is disposed on the backing layer (100), and the adhesive part (110) extends away from the paste layer (200); The adhesive part (110) is provided in four parts, and the adhesive part (110) is provided one by one at the edge of the paste layer (200).

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