Bilirubin adsorption column shell structure with high adsorption efficiency

Abstract

The utility model provides a kind of bilirubin adsorption column shell structure with high adsorption efficiency, including cylindrical adsorption column shell, the adsorption column shell is provided with reduced diameter portion, and the corresponding adsorption column radius at this reduced diameter portion is less than adsorption column shell port radius.The setting of the reduced diameter portion in the bilirubin adsorption column shell structure increases the flow pressure difference of plasma inside the shell, increases the flow rate of plasma, thereby enhances the propulsive force of plasma to adsorption resin, makes adsorption resin flow, rolls in adsorption column, makes it contact with plasma sufficiently, improves adsorption efficiency.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a bilirubin adsorption column shell structure with high adsorption efficiency. Background Technology

[0002] Bilirubin adsorption columns are a core consumable used in blood purification to remove excessive bilirubin from a patient's blood. However, existing bilirubin adsorption columns have a relatively long, straight cylindrical shell and a large number of tiny resin particles inside. This results in significant resistance to plasma flow and prevents the adsorption resin from tumbling and flowing properly. Consequently, the adsorption resin accumulates, causing plasma to flow out from the empty spaces. The adsorption resin cannot fully contact the plasma, and the accumulated resin is easily broken by the flow pressure, affecting the adsorption effect. Utility Model Content

[0003] In order to overcome the defects in the prior art, the purpose of this utility model is to provide a bilirubin adsorption column shell structure with high adsorption efficiency.

[0004] To achieve the above-mentioned objectives of this utility model, this utility model provides a bilirubin adsorption column shell structure with high adsorption efficiency, including a cylindrical adsorption column shell, wherein the adsorption column shell is provided with a reduced diameter section, and the radius of the adsorption column corresponding to the reduced diameter section is smaller than the radius of the port of the adsorption column shell.

[0005] The reduced diameter section in the shell structure of this bilirubin adsorption column increases the flow pressure difference of plasma inside the shell, increases the flow rate of plasma, thereby enhancing the driving force of plasma on the adsorption resin, causing the adsorption resin inside the adsorption column to flow and tumble, ensuring full contact with the plasma, and improving the adsorption efficiency.

[0006] Optionally, the radius of the adsorption column corresponding to the reduced diameter section is calculated based on the radius of the adsorption column shell, fluid density, adsorption particle density, fluid velocity, and adsorption particle velocity.

[0007] Optionally, the adsorption column radius corresponding to the reduced diameter portion satisfies the following inequality:

[0008]

[0009] Where r is the radius of the adsorption column corresponding to the narrowed section, r1 is the radius of the inlet end of the adsorption column shell, η is the fluid viscosity, and ρ 流 v is the fluid density, v1 is the fluid velocity at the inlet end, v 粒 The velocity of the adsorbed particles.

[0010] This optional solution provides a range of options for the radius of the adsorption column corresponding to the reduced diameter section, which helps to further improve the adsorption efficiency of the adsorption column.

[0011] Optionally, the reduced diameter section is located near the inlet end of the adsorption column housing.

[0012] Optionally, the diameter of the inlet and outlet ports of the adsorption column housing is 56 mm, and the diameter of the adsorption column corresponding to the narrowed section is 42 mm to 54 mm.

[0013] Optionally, the reduced diameter section is 10mm to 18mm from the inlet end of the adsorption column shell.

[0014] The beneficial effects of this utility model are:

[0015] This invention increases the flow pressure difference of plasma inside the adsorption column by setting a narrowed section on the adsorption column shell, thereby promoting the flow and tumbling of the adsorption resin, increasing the contact quantity and contact area between plasma and adsorption resin, and improving adsorption efficiency.

[0016] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0017] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0018] Figure 1 This is a schematic diagram of the structure of this application;

[0019] Figure 2 This is a schematic diagram of the simulation results with the reduced diameter section;

[0020] Figure 3 This is a schematic diagram of the simulation results without the necking section;

[0021] Figure 4 This is a schematic diagram showing the measured results of the reduced diameter section;

[0022] Figure 5 This is a schematic diagram of the measured results without the necking section. Detailed Implementation

[0023] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0024] In the description of this utility model, unless otherwise specified and limited, it should be noted that the terms "installation", "connection" and "linking" should be interpreted broadly. For example, they can refer to mechanical or electrical connections, or internal connections between two components. They can be direct connections or indirect connections through an intermediate medium. Those skilled in the art can understand the specific meaning of the above terms according to the specific circumstances.

[0025] This invention provides a shell structure for a bilirubin adsorption column with high adsorption efficiency. For example... Figure 1 As shown, the bilirubin adsorption column shell structure includes a cylindrical adsorption column shell and an end cap. The adsorption column shell has an inlet end 1 and an outlet end. A narrowed section 2 is provided on the adsorption column shell, and the radius of the adsorption column corresponding to the narrowed section 2 is smaller than the radius of the cylindrical shell port. In this embodiment, the narrowed section 2 is provided on the inner wall of the adsorption column shell.

[0026] During adsorption, the adsorption column shell is filled with adsorption particles. In this embodiment, the adsorption particles are adsorption resin particles. Due to the narrowing section 2, a pressure difference is formed at the narrowing section 2. This pressure difference drives the adsorption resin particles to flow and tumble.

[0027] Theoretically, as long as the radius of the adsorption column corresponding to the reduced diameter section 2 is smaller than the radius of the cylindrical shell port, it is acceptable. However, in practical applications, the radius of the adsorption column corresponding to the reduced diameter section 2 should not be too small, as this can easily lead to a large pressure difference. In practical applications, the pressure difference should not be too large to avoid the particles colliding and being squeezed together, causing them to break. Therefore, the size of the adsorption column radius corresponding to the reduced diameter section 2 needs to be set. Generally, the diameter of the inlet and outlet ports of the adsorption column shell is usually 56mm, and the preferred, but not limited to, diameter of the adsorption column corresponding to the reduced diameter section 2 is 42mm to 54mm.

[0028] Of course, the radius of the adsorption column corresponding to the narrowed section 2 can also be calculated based on the radius of the adsorption column shell, fluid density, adsorption particle density, fluid velocity, adsorption particle velocity, etc.

[0029] Generally, the radius of the adsorption column corresponding to the narrowed section 2 should satisfy the following inequality:

[0030]

[0031] Where r is the radius of the adsorption column corresponding to the narrowed section, r1 is the radius of the inlet end of the adsorption column shell, η is the fluid viscosity, and ρ 流 v is the fluid density, v1 is the fluid velocity at the inlet end, v 粒 The velocity of the adsorbed particles.

[0032] The reasoning process for this inequality is as follows:

[0033] The change in flow velocity can be derived from the continuity equation A1v1=A2v2: Where A1 is the inlet cross-sectional area and A2 is the cross-sectional area of ​​the narrowed section.

[0034] By Bernoulli's equation The pressure difference at the two points of the reduced diameter section can be obtained as follows: Where P1 is the inlet pressure, P2 is the pressure at the narrowed section, v1 is the fluid velocity at the inlet, v2 is the fluid velocity at the narrowed section, and ρ... 流 Let be the fluid density. Therefore, we can know...

[0035] The pressure difference acts on the cross-section of the narrowed section 2, providing the driving force for the fluid to propel the resin particles. If the driving force is greater than (resistance of the resin particles + weight of the resin particles - buoyancy of the resin particles), the resin particles can be made to flow.

[0036] Resin particle resistance (mainly viscous resistance, conforming to Stokes' law at low flow rates): F 阻 =6πηrν 粒 Where r is the sum of the radii of all adsorbed resin particles at the cross-section of the narrowed section 2, which is equivalent to the radius of the adsorbed column corresponding to the narrowed section 2, η is the fluid viscosity, and ν 粒 This represents the velocity of the resin particles.

[0037] Gravity of resin particles: G = m 粒 g;

[0038] buoyancy of resin particles:

[0039] Depend on have to:

[0040] Since the density of resin particles is close to that of blood plasma (fluid), gravity and buoyancy cancel each other out and can be ignored. The above formula can be simplified to: Transformed to: Then the cross-sectional area is converted to be expressed in terms of radius, resulting in:

[0041]

[0042] r1 is the radius of the inlet end of the adsorption column shell. After simplification, the inequality is obtained. The adsorption column radius r corresponding to the narrowed section 2 can satisfy the following inequality.

[0043] Taking an inlet diameter of 5.6 cm and blood plasma as an example, the calculation is as follows:

[0044] If the inlet diameter is 5.6cm, then A1 = 24.6cm. 2The fluid is blood plasma, with a density ρfluid = 1.031 g / cm2. 3 Viscosity η = 2 × 10 -3 Pa·s = 0.02 g / cm·s; given a fluid flow rate of 50 ml / min, the initial fluid velocity v1 = 0.034 cm / s; the particle flow velocity is taken as 25% of the initial plasma velocity (i.e., vparticle = 0.0085 cm / s) to calculate the adsorption column radius r corresponding to the two diameter-reduction sections. Substituting these parameters into... From the middle, we get: 9.86r 4 +16.9r 3 ≤605.16.

[0045] Calculations show that when the maximum adsorption column radius r at the constriction section 2 is 2.45 cm, the diameter is 4.9 cm, which just satisfies the inequality. Therefore, the diameter of the constriction section should be 49 mm.

[0046] The reduced diameter section 2 can be located at any position along the length of the adsorption column shell. In this embodiment, it is preferably, but not limited to, near the inlet end 1 of the adsorption column shell. The distance between the reduced diameter section 2 and the inlet end of the adsorption column shell is preferably, but not limited to, 10mm to 18mm. Figure 1 As shown, the reduced diameter section 2 is 15mm away from the inlet end 1.

[0047] To verify the impact of the design of the narrowed section 2 on the flow velocity of the resin particles, a fluid-structure interaction simulation was performed using CEL (Computational Fluid-Structure Interaction) based on the internal space design. The resin particles were simulated using SPH (Smooth Particles). The results are as follows: Figure 2 and Figure 3 As shown, the resin particles with the internal diameter reduction section 2 are almost in motion, while the resin particles without the internal diameter reduction section 2 are mostly stationary.

[0048] In actual testing, such as Figure 4 and Figure 5 As shown, resin particles with the narrowed diameter section 2 inside begin to flow and tumble, while resin particles without the narrowed diameter section 2 begin to accumulate, block, and stop flowing.

[0049] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0050] Although embodiments of the present invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the claims and their equivalents.

Claims

1. A shell structure for a bilirubin adsorption column with high adsorption efficiency, characterized in that, It includes a cylindrical adsorption column shell, on which a reduced diameter section is provided, and the radius of the adsorption column corresponding to the reduced diameter section is smaller than the radius of the port of the adsorption column shell. The narrowed section is 10 mm to 18 mm from the inlet end of the adsorption column shell.

2. The bilirubin adsorption column shell structure with high adsorption efficiency according to claim 1, characterized in that, The radius of the adsorption column corresponding to the reduced diameter section is calculated based on the radius of the adsorption column shell, fluid density, adsorption particle density, fluid velocity, and adsorption particle velocity.

3. The bilirubin adsorption column shell structure with high adsorption efficiency according to claim 1 or 2, characterized in that, The adsorption column radius corresponding to the narrowed section satisfies the following inequality: ， Where r is the radius of the adsorption column corresponding to the narrowed section, and r1 is the radius of the inlet end of the adsorption column shell. For fluid viscosity, For fluid density, The flow rate of the fluid at the inlet end. The velocity of the adsorbed particles.

4. The bilirubin adsorption column shell structure with high adsorption efficiency according to claim 1, characterized in that, The reduced diameter section is located near the inlet end of the adsorption column shell.

5. The bilirubin adsorption column shell structure with high adsorption efficiency according to claim 1, characterized in that, The diameter of the inlet and outlet ports of the adsorption column shell is 56 mm, and the diameter of the adsorption column corresponding to the narrowed section is 42 mm to 54 mm.

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