A high-performance liquid chromatograph mobile phase filtration device

Abstract

The utility model provides a kind of mobile phase filtration device for high performance liquid chromatograph. The mobile phase filtration device for high performance liquid chromatograph includes: base;Fixed frame is installed in the top of the base;Setting in the fixed frame is used to collect the collection cylinder of filtered mobile phase;Piston plate is installed in the collection cylinder and is used to assist the output mobile phase;Fixed on the collection cylinder is used to output mobile phase and discharges pipe.The utility model provides a kind of mobile phase filtration device for high performance liquid chromatograph, and the linkage design of setting collection cylinder and piston plate and discharges pipe and air pump makes mobile phase filtration directly and conveniently output storage and on-demand quantitative output to high performance liquid chromatography solvent bottle, avoids secondary pollution risk, reduces artificial operation error, realizes filtration and storage function integration by integrating filtering structure on fixed frame, simplifies operation process.

Description

Technical Field

[0001] This utility model relates to the technical field of vacuum filtration devices, and in particular to a mobile phase vacuum filtration device for high performance liquid chromatography. Background Technology

[0002] When using a high-performance liquid chromatography (HPLC) instrument to analyze samples, it is usually necessary to prepare the mobile phase. The preparation of the mobile phase requires manual preparation. First, the mobile phase is added to a vacuum filtration device for filtration. The filtered mobile phase is then transferred to a receiving bottle that is compatible with the vacuum filtration device. Finally, the filtered mobile phase is transferred to an HPLC mobile phase solvent bottle for subsequent HPLC detection operations. When transferring the mobile phase, it is necessary to change the container, and the mobile phase is easily subject to secondary contamination.

[0003] Therefore, it is necessary to provide a new mobile phase filtration device for high performance liquid chromatography to solve the above-mentioned technical problems. Utility Model Content

[0004] To address the technical problem of needing to change the container when transferring the mobile phase, which makes the mobile phase susceptible to secondary contamination, this invention provides a mobile phase filtration device for high-performance liquid chromatography.

[0005] The mobile phase filtration device for high performance liquid chromatography provided by this utility model includes: a base; a fixed frame installed on the top of the base; a collection cylinder disposed in the fixed frame for collecting the filtered mobile phase; a piston plate installed in the collection cylinder for assisting in the output of the mobile phase; a discharge pipe fixed on the collection cylinder for outputting the mobile phase; an air pump disposed on the base for adjusting the gas pressure distribution in the collection cylinder to adjust the position of the piston plate to assist in the output of the mobile phase; and a filter structure disposed on the fixed frame for filtering the mobile phase.

[0006] Preferably, the filtration structure includes a buffer tank mounted on the fixed frame, a negative pressure filter mounted on the inlet of the buffer tank for filtering the mobile phase, a guide hopper detachably mounted on the negative pressure filter, an extension cylinder fixed on the guide hopper for expanding the mobile phase storage space, and an exhaust pipe mounted on the negative pressure filter and connectable to a negative pressure pump.

[0007] Preferably, the top of the extension cylinder is detachably fitted with a protective cover for sealing the extension cylinder to isolate impurities, the protective cover is fitted with a dustproof plate for providing a ventilation channel to balance air pressure, and the protective cover is fitted with a feed pipe for providing a channel for adding mobile phase.

[0008] Preferably, a connecting pipe is provided between the buffer tank and the collecting cylinder for providing a discharge channel for the filtered mobile phase, and the connecting pipe is provided with a regulating valve for adjusting the opening and closing of the pipeline.

[0009] Preferably, the protective cover is equipped with a retaining plate, and the extension tube is fixed with a limiting tube sleeved on the retaining plate to stabilize the retaining plate. The limiting tube is threaded with a limiting bolt, and the retaining plate is provided with a slot for accommodating the limiting bolt.

[0010] Preferably, the limiting bolt is equipped with an anti-loss rope connected to the extension cylinder to prevent the limiting bolt from being lost, and the top inner wall of the protective cover is equipped with an elastic pad that contacts the top of the extension cylinder for shock absorption and noise reduction.

[0011] Preferably, the air pump is detachably equipped with a filter box for filtering air, the buffer tank, the feed hopper and the collection cylinder are all made of transparent glass, the piston plates are arranged in groups, and a connecting rod is installed between two piston plates.

[0012] Compared with related technologies, the mobile phase filtration device for high performance liquid chromatography provided by this utility model has the following advantages:

[0013] This invention provides a mobile phase filtration device for a high-performance liquid chromatograph:

[0014] By setting up a design that links the collection cylinder, piston plate, discharge pipe, and air pump, the mobile phase can be directly and conveniently output and stored after filtration, and quantitatively output to the high-performance liquid chromatography solvent bottle as needed, avoiding the risk of secondary contamination and reducing human operation errors. By integrating the filtration structure into the fixed frame, the filtration and storage functions are integrated, simplifying the operation process. Attached Figure Description

[0015] Figure 1 A front view schematic diagram of a preferred embodiment of the mobile phase filtration device for high performance liquid chromatography provided by this utility model.

[0016] Figure 2 for Figure 1 An enlarged structural diagram of part A shown in the figure;

[0017] Figure 3 This is a schematic diagram of the main cross-sectional structure of the collecting cylinder in this utility model;

[0018] Figure 4 This is a top view of the protective cover in this utility model.

[0019] The following are labeled in the diagram: 1. Base; 2. Fixing frame; 3. Buffer tank; 4. Negative pressure filter; 5. Feed hopper; 6. Extension cylinder; 7. Protective cover; 8. Dustproof plate; 9. Exhaust pipe; 10. Feed pipe; 11. Connecting pipe; 12. Regulating valve; 13. Collection cylinder; 14. Discharge pipe; 15. Piston plate; 16. Air pump; 17. Filter box; 18. Clamping plate; 19. Limiting cylinder; 20. Limiting bolt; 21. Anti-loss rope. Detailed Implementation

[0020] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0021] Please refer to the following: Figures 1-4 ,in, Figure 1 A front view schematic diagram of a preferred embodiment of the mobile phase filtration device for high performance liquid chromatography provided by this utility model. Figure 2 for Figure 1 An enlarged structural diagram of part A shown in the figure; Figure 3 This is a schematic diagram of the main cross-sectional structure of the collecting cylinder in this utility model; Figure 4 This is a top view of the protective cover in this utility model.

[0022] The mobile phase filtration device for high performance liquid chromatography (HPLC) includes: a base 1; a mounting frame 2 installed on top of the base 1; a collection cylinder 13 disposed within the mounting frame 2 for collecting the filtered mobile phase; a piston plate 15 installed within the collection cylinder 13 for assisting in the output of the mobile phase; a discharge pipe 14 fixed on the collection cylinder 13 for outputting the mobile phase; an air pump 16 disposed on the base 1 for adjusting the air pressure distribution within the collection cylinder 13 to adjust the position of the piston plate 15 to assist in the output of the mobile phase; and a filter structure disposed on the mounting frame 2 for filtering the mobile phase. By setting up the collection cylinder 13 and the piston plate 15, the mobile phase can be directly and conveniently output for storage after filtration, avoiding the risk of secondary contamination caused by transferring to other open containers in traditional methods. Through the linkage design of the discharge pipe 14 and the air pump 16, the position of the piston plate 15 is controlled by adjusting the air pressure, so that the mobile phase can be quantitatively output to the HPLC solvent bottle as needed, reducing human operation errors. By integrating the filtration structure onto the mounting frame 2, the functions of filtration and storage are integrated, simplifying the operation process.

[0023] The filtration structure includes a buffer tank 3 mounted on the fixed frame 2, a negative pressure filter 4 mounted on the inlet of the buffer tank 3 for filtering the mobile phase, a guide hopper 5 detachably mounted on the negative pressure filter 4, an extension cylinder 6 fixed on the guide hopper 5 for expanding the mobile phase storage space, and an exhaust pipe 9 mounted on the negative pressure filter 4 and connectable to a negative pressure pump. By setting up the buffer tank 3, the mobile phase is pre-stored and its flow is stabilized, avoiding the impact and splashing that may occur during direct filtration. The detachable connection between the negative pressure filter 4 and the guide hopper 5 facilitates the replacement of filter media and cleaning and maintenance. At the same time, the extension cylinder 6 on the guide hopper 5 expands the storage space, increasing the single filtration volume and improving the processing efficiency. The connection between the exhaust pipe 9 and the negative pressure pump enables a stable negative pressure environment to be formed during the filtration process, accelerating the filtration speed of the mobile phase and reducing the filtration time.

[0024] The top of the extension cylinder 6 is detachably fitted with a protective cover 7 for sealing the extension cylinder 6 to isolate impurities. A dustproof plate 8 is installed on the protective cover 7 to provide a ventilation channel for balancing air pressure. A feed pipe 10 is also installed on the protective cover 7 to provide a channel for adding the mobile phase. By setting the detachable protective cover 7, the extension cylinder 6 is sealed to effectively isolate external impurities, preventing external pollutants from entering the mobile phase during filtration and ensuring its purity. The dustproof plate 8 on the protective cover 7 serves to balance air pressure while blocking dust, avoiding secondary pollution caused by air pressure regulation. The feed pipe 10 on the protective cover 7 allows the mobile phase to be added directly through a dedicated channel, reducing contact with the external environment and lowering the risk of contamination.

[0025] A connecting pipe 11 is provided between the buffer tank 3 and the collection cylinder 13 to provide a discharge channel for the filtered mobile phase. The connecting pipe 11 is equipped with a regulating valve 12 for adjusting the opening and closing of the pipeline. By setting the connecting pipe 11, a stable discharge channel for the filtered mobile phase is provided, so that the mobile phase can be smoothly transferred from the buffer tank 3 to the collection cylinder 13, avoiding the risk of liquid overflow or leakage. By installing the regulating valve 12 on the connecting pipe 11, the opening and closing of the pipeline and the flow rate of the mobile phase can be flexibly controlled. Users can control the liquid transfer speed and close the collection cylinder 13 according to actual needs.

[0026] A retaining plate 18 is installed on the protective cover 7. A limiting cylinder 19, which is sleeved on the retaining plate 18 to stabilize the retaining plate 18, is fixed on the extension cylinder 6. A limiting bolt 20 is threaded on the limiting cylinder 19. The retaining plate 18 is provided with a slot for accommodating the limiting bolt 20. By setting the retaining plate 18 on the protective cover 7 and fixing the limiting cylinder 19 on the extension cylinder 6 to sleeve the retaining plate 18, the protective cover 7 and the extension cylinder 6 are stably connected, effectively preventing the protective cover 7 from falling off due to vibration or operational errors, and ensuring the sealing performance. By threading the limiting bolt 20 on the limiting cylinder 19 and providing a corresponding slot on the retaining plate 18, the position of the protective cover 7 is fixed. Users can quickly lock the cover by tightening the limiting bolt 20 to prevent loosening.

[0027] An anti-loss rope 21 connected to the extension cylinder 6 is installed on the limiting bolt 20 to prevent the limiting bolt 20 from being lost. An elastic pad that contacts the top of the extension cylinder 6 is installed on the inner wall of the top of the protective cover 7 to reduce vibration and noise. By installing the anti-loss rope 21 connected to the extension cylinder 6 on the limiting bolt 20, the limiting bolt 20 is prevented from being lost or mismatched, avoiding the problem of equipment not being able to be assembled normally or sealing failure due to the loss of small parts, and improving the convenience of maintenance. By setting the elastic pad that contacts the extension cylinder 6 on the inner wall of the top of the protective cover 7, the vibration and noise reduction effect is achieved, effectively reducing the noise generated by vibration during equipment operation or handling, while reducing hard collisions between parts and extending the service life of the equipment.

[0028] The air pump 16 is detachably equipped with a filter box 17 for filtering air. The buffer tank 3, the guide hopper 5, and the collection cylinder 13 are all made of transparent glass. The piston plates 15 are arranged in groups, and a connecting rod is installed between the two piston plates 15. By detachably installing the filter box 17 on the air pump 16, the air input to the air pump 16 is filtered, effectively preventing dust and impurities in the air from entering the mobile phase and ensuring the purity of the mobile phase. By designing the buffer tank 3, the guide hopper 5, and the collection cylinder 13 as transparent glass, the mobile phase status and filtration process can be observed in real time, making it easy for users to detect abnormalities and adjust the operation in a timely manner. By arranging the piston plates 15 in groups and installing the connecting rod, the two piston plates 15 can move synchronously, enhancing the stability and controllability of the mobile phase output and reducing flow fluctuations caused by inconsistent movement of the piston plates 15.

[0029] It is worth noting that the circuits, electronic components, and modules involved in this utility model are all existing technologies, which can be fully implemented by those skilled in the art, and need not be elaborated upon. The content protected by this utility model does not involve any improvement to the software and methods.

[0030] The working principle of the mobile phase filtration device for high performance liquid chromatography provided by this utility model is as follows:

[0031] This solution also includes a controller, which is installed on the equipment. During use, each electrical device can be started and operated separately through the controller. The power connection method of each electrical device is a mature existing technology and is well known to those in the field, so it will not be described in detail here.

[0032] In use, the mobile phase is added to the extension cylinder 6 through the feed pipe 10 on the protective cover 7. The protective cover 7 is then closed. The negative pressure pump creates a stable negative pressure environment in the negative pressure filter 4 through the exhaust pipe 9. The mobile phase enters the negative pressure filter 4 through the guide hopper 5 and is then filtered before entering the buffer tank 3 for pre-storage. The regulating valve 12 on the connecting pipe 11 is opened, and the filtered mobile phase enters the collection cylinder 13 through the connecting pipe 11. The regulating valve 12 is then closed. As needed, the air pump 16 (an integrated air pump that can achieve both air extraction and air delivery on a single pipeline, taking the F-series dual-purpose pump as an example) is started to adjust the air pressure in the collection cylinder 13, causing the piston plate 15 to move and output the mobile phase from the discharge pipe 14 to the high-performance liquid chromatography solvent bottle as needed. During use, the guide hopper 5 on the negative pressure filter 4 can be removed to replace the filter membrane.

[0033] Compared with related technologies, the mobile phase filtration device for high performance liquid chromatography provided by this utility model has the following advantages:

[0034] This invention provides a mobile phase filtration device for high performance liquid chromatography (HPLC). By setting up a linkage design between the collection cylinder 13 and the piston plate 15, and the discharge pipe 14 and the air pump 16, the mobile phase can be directly and conveniently output and stored after filtration, and quantitatively output to the HPLC solvent bottle as needed, avoiding the risk of secondary contamination and reducing human operation errors. By integrating the filtration structure into the fixed frame 2, the filtration and storage functions are integrated, simplifying the operation process.

[0035] It should be noted that the device structure and accompanying drawings of this utility model mainly describe the principle of this utility model. In terms of the technical aspects of this design principle, the setting of the power mechanism, power supply system and control system of the device is not fully described. However, those skilled in the art who understand the principle of the above utility model can clearly understand the specific details of its power mechanism, power supply system and control system.

[0036] The above description is merely an embodiment of this utility model and does not limit the patent scope of this utility model. Any equivalent structural or procedural transformations made based on the description and drawings of this utility model, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this utility model.

Claims

1. A mobile phase filtration device for a high-performance liquid chromatograph, characterized in that, include: Base; A mounting bracket installed on top of the base; A collection cylinder is installed inside the fixed frame to collect the filtered mobile phase; A piston plate installed inside the collection cylinder to assist in the output of the mobile phase; A discharge pipe fixed to the collecting cylinder for discharging the mobile phase; An air pump mounted on the base is used to adjust the air pressure distribution inside the collection cylinder to adjust the position of the piston plate and assist in the output of the mobile phase. A filter structure for filtering the mobile phase is mounted on the fixed frame.

2. The mobile phase filtration device for high performance liquid chromatography according to claim 1, characterized in that, The filtration structure includes a buffer tank mounted on the fixed frame, a negative pressure filter mounted on the inlet of the buffer tank for filtering the mobile phase, a guide hopper detachably mounted on the negative pressure filter, an extension cylinder fixed on the guide hopper for expanding the mobile phase storage space, and an exhaust pipe mounted on the negative pressure filter and connectable to a negative pressure pump.

3. The mobile phase filtration device for high performance liquid chromatography according to claim 2, characterized in that, The top of the extension tube is detachably fitted with a protective cover for sealing the extension tube to isolate impurities. The protective cover is fitted with a dustproof plate for providing a ventilation channel to balance air pressure. The protective cover is fitted with a feed pipe for providing a channel for adding mobile phase.

4. The mobile phase filtration device for high performance liquid chromatography according to claim 2, characterized in that, A connecting pipe is provided between the buffer tank and the collection cylinder to provide a discharge channel for the filtered mobile phase, and a regulating valve is provided on the connecting pipe to adjust the opening and closing of the pipeline.

5. The mobile phase filtration device for high performance liquid chromatography according to claim 3, characterized in that, The protective cover is equipped with a clamping plate, and the extension tube is fixed with a limiting tube sleeved on the clamping plate to stabilize the clamping plate. The limiting tube is threaded with a limiting bolt, and the clamping plate is provided with a slot for accommodating the limiting bolt.

6. The mobile phase filtration device for high performance liquid chromatography according to claim 5, characterized in that, The limiting bolt is equipped with an anti-loss rope connected to the extension cylinder to prevent the limiting bolt from being lost, and an elastic pad that contacts the top of the extension cylinder is installed on the inner wall of the top of the protective cover for shock absorption and noise reduction.

7. The mobile phase filtration device for high performance liquid chromatography according to claim 2, characterized in that, The air pump is detachably equipped with a filter box for filtering air. The buffer tank, guide hopper and collection cylinder are all made of transparent glass. The piston plates are arranged in groups, and a connecting rod is installed between two piston plates.

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