An automated device for the purification of medical collagen products

Abstract

The utility model relates to medical collagen purification technical field discloses a kind of medical collagen product purification automation device, including installation component, installation component is used to provide support to the installation of membrane package, installation component includes upper mounting plate, lower mounting plate, fixed arc plate and movable arc plate, structure is completely same between upper mounting plate and lower mounting plate, upper mounting plate and lower mounting plate are fixedly connected fixed arc plate between, upper mounting plate and lower mounting plate are all provided with sliding slot, movable arc plate and sliding slot sliding connection, through the automatic connection and separation of plug-in end and magnetic suction end driven by air cylinder, in combination with the sliding design of movable arc plate, the quick preparation and confirmation of membrane package main body installation position are realized;Whole process reduces the tedious steps such as artificial support, alignment, significantly improves assembly efficiency, using the structure of fixed arc plate and movable arc plate relative arrangement, jointly limit the lateral displacement of membrane package main body, effectively resist horizontal force, prevent it from loosening when working.

Description

Technical Field

[0001] This utility model belongs to the field of medical collagen purification technology, specifically, it relates to an automated device for purifying medical collagen products. Background Technology

[0002] Tangential flow filtration is a commonly used filtration method in pharmaceutical processes, widely applied in clarification filtration, product concentration, pyrogen removal, small molecule impurity removal, desalination, and buffer replacement. Tangential flow filtration refers to a liquid flow direction parallel to the membrane surface. Under pressure, only a portion of the liquid passes through the filter membrane and enters the downstream flow. This operation is called "cross-flow filtration." During the filtration process, the tangential flow continuously "washes" the surface of the membrane, effectively reducing the accumulation of large particles on the membrane. This operation has unique advantages in many applications.

[0003] Especially useful in the field of medical collagen product purification technology, the tangential flow design avoids impurity retention and meets the stringent requirements of Class III medical devices for collagen purity (such as fillers requiring a collagen concentration of 35-75 mg / mL and free of impurities). A document with publication number (CN222658326U) discloses a tangential flow biological separation and purification membrane clamp filtration device, including a membrane support mechanism, membrane packs, and a feed distribution base. The membrane support mechanism includes multiple horizontal support frames arranged sequentially in a vertical direction. The vertically arranged feed distribution base is slidably connected to all the horizontal support frames and can slide left and right along the horizontal support frames. Two membrane packs are installed in each horizontal support frame, and the two membrane packs are symmetrically connected on the left and right sides of the feed distribution base. The horizontal support frames can clamp the membrane packs and the feed distribution base, sealing the flow channels between the membrane packs and the feed distribution base. An inlet channel and a return channel are provided between the feed distribution base and the membrane packs. The inlet channel enters the lowest point of each membrane pack from the feed distribution base at an angle upward, and the return channel is located at the highest point of the membrane pack, returning from the membrane pack at an angle upward back into the feed distribution base. This device can completely drain the feed from the membrane packs, achieving high cleanliness.

[0004] The aforementioned device improves the flow and distribution of the liquid in the membrane pack, but does not improve the installation method of the membrane pack. As a result, the membrane pack still needs to be fixed by the traditional clamping method. This means that the membrane pack lacks guidance and support during the fixing process, and manual support is still required throughout the installation, which affects the installation efficiency.

[0005] In view of this, this utility model is hereby proposed. Utility Model Content

[0006] To solve the technical problem of data integration, the basic concept of the technical solution adopted by this utility model is as follows: An automated purification device for medical collagen products includes an installation component that provides support for the installation of a membrane pack. The installation component includes an upper installation plate, a lower installation plate, a fixed arc plate, and a movable arc plate. The upper and lower installation plates have identical structures. The fixed arc plate is fixedly connected between the upper and lower installation plates. Both the upper and lower installation plates are provided with sliding grooves. The movable arc plate is slidably connected to the sliding grooves. The membrane pack body is installed between the upper and lower installation plates.

[0007] In a preferred embodiment of this utility model, a cylinder is fixedly connected to the movable arc plate, and the output end of the cylinder is connected to a plug-in end via a coupling, with a magnetic suction end provided on the plug-in end.

[0008] In a preferred embodiment of this utility model, the magnetic end and the plug-in end are fixedly connected, and the plug-in end is plugged into the lower mounting plate.

[0009] In a preferred embodiment of this utility model, the magnetic end is magnetically connected to the corresponding position on the lower mounting plate, and a magnetic sensor is installed at the magnetic position of the magnetic end.

[0010] In a preferred embodiment of this utility model, the plug-in end and the magnetic end are connected at two locations on the lower mounting plate, one of which is located opposite to the fixed arc plate, and the other is located close to the fixed arc plate.

[0011] In a preferred embodiment of this utility model, a lead screw is rotatably connected between the upper mounting plate and the lower mounting plate, and a drive motor is fixedly connected to the upper mounting plate. The output end of the drive motor is fixedly connected to the lead screw through a coupling.

[0012] In a preferred embodiment of this utility model, the lead screw is threadedly connected to a sliding block, the sliding block is slidably connected to the side wall of the fixed arc plate, and the sliding block is fixedly connected to a pressure plate.

[0013] In a preferred embodiment of this utility model, the drive motor, lead screw, and sliding block are all located on the side away from the slide groove, and the slide groove is semi-circular.

[0014] Compared with the prior art, the present invention has the following advantages: 1. This automated purification device for medical collagen products automatically connects and separates the plug-in end and the magnetic suction end through a cylinder-driven mechanism. Combined with the sliding design of the movable arc plate, it enables rapid preparation and confirmation of the installation position of the membrane package body. The entire process reduces tedious steps such as manual support and alignment, and significantly improves assembly efficiency.

[0015] 2. This automated purification device for medical collagen products adopts a structure in which fixed and movable arc plates are arranged opposite each other, which together restrict the lateral displacement of the membrane package body, effectively resist lateral forces, and prevent it from loosening during operation; at the same time, the arc plates also form physical protection for the side wall of the membrane package body, ensuring the stability and reliability of the equipment in long-term operation.

[0016] 3. This automated purification device for medical collagen products uses a combination of a drive motor, a lead screw, and a sliding block to drive a pressure plate to apply a uniform clamping force to the membrane package body. This design not only enhances the sealing of the interfaces between the membrane packages and prevents media leakage, but also achieves controllable and consistent clamping force.

[0017] 4. This automated purification device for medical collagen products utilizes the cooperation of a magnetic suction end and a magnetic sensor to automatically detect and confirm the position status during key steps (such as after the movable arc plate is moved away and reset). This avoids human error, ensures that each action is accurate, and improves the automation level and reliability of the entire operation process.

[0018] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings. Attached Figure Description

[0019] In the attached diagram: Figure 1 This is a three-dimensional schematic diagram of the present invention; Figure 2 This is a schematic diagram of the loading and unloading state of this utility model; Figure 3 This is a schematic diagram of the structure between the mounting plates of this utility model; Figure 4 This is a front view of the mounting plate of this utility model; Figure 5 This utility model Figure 3 Enlarged schematic diagram of the structure at point A in the middle.

[0020] In the diagram: 1. Upper mounting plate; 11. Lower mounting plate; 2. Fixed arc plate; 21. Movable arc plate; 3. Membrane wrapping body; 4. Drive motor; 41. Lead screw; 42. Sliding block; 43. Pressure plate; 5. Cylinder; 51. Insertion end; 52. Magnetic suction end. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. The following embodiments are used to illustrate this utility model.

[0022] Please see Figure 1-5An automated purification device for medical collagen products includes an installation assembly for supporting the installation of a membrane pack. The installation assembly includes an upper installation plate 1, a lower installation plate 11, a fixed arc plate 2, and a movable arc plate 21. The upper installation plate 1 and the lower installation plate 11 have identical structures. The fixed arc plate 2 is fixedly connected between the upper installation plate 1 and the lower installation plate 11. Both the upper installation plate 1 and the lower installation plate 11 are provided with sliding grooves. The movable arc plate 21 is slidably connected to the sliding grooves. The membrane pack body 3 is installed between the upper installation plate 1 and the lower installation plate 11. Before installation, the movable arc plate 21 is slid along the grooves on the upper mounting plate 1 and the lower mounting plate 11 to a position close to the fixed arc plate 2. An arc-shaped support structure is formed between the fixed arc plate 2 and the movable arc plate 21. Then, the membrane package body 3 is placed between the upper mounting plate 1 and the lower mounting plate 11 in sequence, and the interfaces between the membrane package bodies 3 are aligned. This provides a support position for the membrane package body 3 during installation, eliminating the need for manual support and positioning during installation and improving installation efficiency.

[0023] It is worth noting that this optimization solution addresses the membrane packing installation technology issue, and therefore does not describe the filtration and purification technology. Since this technology is an existing and mature technology, it is not described in detail in this article and will not be elaborated upon here.

[0024] A cylinder 5 is fixedly connected to the movable arc plate 21. The output end of the cylinder 5 is connected to a plug-in end 51 via a coupling. A magnetic suction end 52 is provided on the plug-in end 51. The magnetic suction end 52 is fixedly connected to the plug-in end 51. The plug-in end 51 is plugged into the lower mounting plate 11. The magnetic suction end 52 is magnetically connected to the corresponding position on the lower mounting plate 11. A magnetic sensor is installed at the magnetic suction position of the magnetic suction end 52. There are two connection positions for the plug-in end 51 and the magnetic suction end 52 on the lower mounting plate 11. One position is set opposite to the fixed arc plate 2, and the other position is set close to the fixed arc plate 2. In operation, the output end of cylinder 5 and the coupling first drive the plug-in end 51 and the magnetic suction end 52 to separate from the lower mounting plate 11. Then, the movable arc plate 21 slides in the groove on the upper mounting plate 1 and the lower mounting plate 11, moving the movable arc plate 21 to a position close to the fixed arc plate 2. Then, the output end of cylinder 5 drives the plug-in end 51 to plug into the lower mounting plate 11, and the magnetic suction end 52 connects with the corresponding magnetic sensor to confirm the loading position. Then, the membrane package body 3 is placed between the upper mounting plate 1 and the lower mounting plate 11 in sequence, and the interfaces between the membrane package bodies 3 are aligned. Thus, during the installation of the membrane package body 3, a support position for the membrane package body 3 is provided, eliminating the need for manual support and positioning of the membrane package body 3 during installation, thereby improving installation efficiency. After installation, cylinder 5 drives the plug-in end 51 and magnetic suction end 52 to separate from the lower mounting plate 11. Then, the movable arc plate 21 is rotated to the working position. Then, cylinder 5 drives the plug-in end 51 to plug into the magnetic suction end 52 and the lower mounting plate 11. The magnetic suction end 52 and the magnetic sensor confirm that the installation is completed. The relative setting of the fixed arc plate 2 and the movable arc plate 21 during operation restricts the side position of the membrane body 3 to avoid lateral force causing the membrane body 3 to fall off and affect the operation of the membrane body 3. The presence of the fixed arc plate 2 and the movable arc plate 21 also protects the side wall of the membrane body 3. It is worth noting that the magnetic sensor includes a magnetic tunneling junction element. The magnetic tunneling junction element is used to sense the external magnetic field in a vertical (Z-axis) magnetic field component perpendicular to the magnetic tunneling junction element, and includes a first fixed magnetic layer, a tunneling layer, and a magnetic sensing layer. The first fixed magnetic layer has a fixed magnetization intensity and is perpendicular to the first fixed magnetic layer. The tunneling layer is disposed on the first fixed magnetic layer. The magnetic sensing layer is disposed on the tunneling layer, wherein the magnetic sensing layer has a predetermined thickness such that a change in magnetic moment results in a superparamagnetic characteristic where the sensitivity of the vertical (Z-axis) magnetic field perpendicular to the magnetic sensing layer is higher than the sensitivity of the horizontal (X, Y-axis) magnetic field, thus sensitively sensing the vertical (Z-axis) magnetic field of the external magnetic field perpendicular to the sensing layer. The fixed magnetic layer, the tunneling layer, and the magnetic sensing layer are stacked sequentially or in reverse order. The magnetic sensor is already fully disclosed in the prior art magnetic sensor CN103185872A, and will not be described further here.

[0025] Among them, a lead screw 41 is rotatably connected between the upper mounting plate 1 and the lower mounting plate 11. A drive motor 4 is fixedly connected to the upper mounting plate 1. The output end of the drive motor 4 is fixedly connected to the lead screw 41 through a coupling. A sliding block 42 is threadedly connected to the lead screw 41. The sliding block 42 is slidably connected to the side wall of the fixed arc plate 2. A pressure plate 43 is fixedly connected to the sliding block 42. The drive motor 4, lead screw 41, and sliding block 42 are all located on the side away from the slide groove, and the slide groove is semi-circular. Once the membrane pack bodies 3 are placed in sequence, the drive motor 4 drives the lead screw 41 to rotate through the output end. The lead screw 41 drives the sliding block 42 to move with the fixed arc plate 2 as a guide through the thread. The sliding block 42 drives the pressure plate 43 to move toward the membrane pack body 3. The pressure plate 43 clamps the membrane pack body 3, thereby tightening the connection between the membrane pack bodies 3 and preventing leakage. Furthermore, the drive motor 4, lead screw 41, and sliding block 42 are located away from the side of the slide groove to avoid interfering with the movement of the movable arc plate 21 and to ensure the stable use of the device.

[0026] Working principle: In operation, the component cylinder 5 first drives the component insertion end 51 and magnetic suction end 52 to separate from the component lower mounting plate 11 via the output end and coupling. Then, the component movable arc plate 21 slides along the grooves on the component upper mounting plate 1 and component lower mounting plate 11, moving it close to the component fixed arc plate 2. Next, the component cylinder 5 drives the component insertion end 51 to insert into the component lower mounting plate 11, while the component magnetic suction end 52 connects to the corresponding magnetic sensor, thus completing the detection and confirmation of the loading position. After position confirmation, the component... The membrane package body 3 is sequentially placed in the space between the upper mounting plate 1 and the lower mounting plate 11 of the component, ensuring accurate alignment of the interfaces between the membrane package bodies 3 of each component. This structure provides reliable support and positioning for the installation of the membrane package body 3 of the component, eliminating the need for manual support during installation and significantly improving assembly efficiency. After installation, the component cylinder 5 drives the component insertion end 51 and magnetic suction end 52 to separate from the lower mounting plate 11 of the component again. Subsequently, the component movable arc plate 21 is rotated to its working position, and the component cylinder 5 drives the component insertion end 51 and magnetic suction end 52 to reconnect with the component. When the mounting plate 11 is inserted, the magnetic suction end 52 of the component communicates with the magnetic sensor again to confirm that the device is in the installation completed state. In this state, the component fixing arc plate 2 and the component movable arc plate 21 are arranged opposite to each other to restrict the lateral displacement of the component membrane body 3, effectively resisting lateral forces and preventing the component membrane body 3 from loosening during operation, thereby ensuring its stable operation. At the same time, the component fixing arc plate 2 and the movable arc plate 21 also protect the side wall of the component membrane body 3. After all the component membrane bodies 3 are installed in place in sequence, the actuator drive motor 4 drives the device through its input... The output drive component screw 41 rotates, and the component screw 41 pushes the component sliding block 42 to move along the guide direction of the component fixed arc plate 2 through thread transmission. This drives the clamping pressure plate 43 to move closer to the component membrane body 3, thereby achieving uniform clamping of the component membrane body 3. This clamping action can enhance the sealing of the interface between the component membrane bodies 3 and prevent media leakage. In addition, the component drive motor 4, screw 41 and sliding block 42 are all arranged on the side away from the slide groove to avoid interference with the movement path of the component movable arc plate 21, ensuring the stability and reliability of the entire device during operation.

[0027] It is understood that this utility model has been described through some embodiments, and those skilled in the art will recognize that various changes or equivalent substitutions can be made to these features and embodiments without departing from the spirit and scope of this utility model. Furthermore, under the teachings of this utility model, these features and embodiments can be modified to adapt to specific situations and materials without departing from the spirit and scope of this utility model. Therefore, this utility model is not limited to the specific embodiments disclosed herein, and all embodiments falling within the scope of the claims of this application are within the protection scope of this utility model.

Claims

1. An automated purification device for medical collagen products, characterized in that, include: The installation assembly provides support for the installation of the membrane pack. The installation assembly includes an upper mounting plate (1), a lower mounting plate (11), a fixed arc plate (2), and a movable arc plate (21). The upper mounting plate (1) and the lower mounting plate (11) have the same structure. The fixed arc plate (2) is fixedly connected between the upper mounting plate (1) and the lower mounting plate (11). The upper mounting plate (1) and the lower mounting plate (11) are both provided with sliding grooves. The movable arc plate (21) is slidably connected to the sliding grooves. The membrane pack body (3) is installed between the upper mounting plate (1) and the lower mounting plate (11).

2. The automated purification device for medical collagen products according to claim 1, characterized in that, A cylinder (5) is fixedly connected to the movable arc plate (21). The output end of the cylinder (5) is connected to a plug end (51) through a coupling. A magnetic suction end (52) is provided on the plug end (51).

3. The automated purification device for medical collagen products according to claim 2, characterized in that, The magnetic end (52) is fixedly connected to the plug end (51), and the plug end (51) is plugged into the lower mounting plate (11).

4. The automated purification device for medical collagen products according to claim 2, characterized in that, The magnetic end (52) is magnetically connected to the corresponding position on the lower mounting plate (11), and a magnetic sensor is installed at the magnetic position of the magnetic end (52).

5. The automated purification device for medical collagen products according to claim 2, characterized in that, The plug-in end (51) and the magnetic end (52) are connected at two locations on the lower mounting plate (11), one of which is located opposite to the fixed arc plate (2), and the other is located close to the fixed arc plate (2).

6. The automated purification device for medical collagen products according to claim 1, characterized in that, A lead screw (41) is rotatably connected between the upper mounting plate (1) and the lower mounting plate (11). A drive motor (4) is fixedly connected to the upper mounting plate (1). The output end of the drive motor (4) is fixedly connected to the lead screw (41) through a coupling.

7. The automated purification device for medical collagen products according to claim 6, characterized in that, The lead screw (41) is connected to a sliding block (42) by a thread. The sliding block (42) is slidably connected to the side wall of the fixed arc plate (2). The sliding block (42) is fixedly connected to a pressure plate (43).

8. The automated purification device for medical collagen products according to claim 7, characterized in that, The drive motor (4), lead screw (41), and sliding block (42) are all located on the side away from the slide groove, and the slide groove is semi-circular.

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