A heparin sodium crude product dissolving kettle

Abstract

The utility model discloses a kind of sodium heparin crude product dissolving kettle, kettle body upper surface is provided with kettle cover, kettle cover upper surface one side is provided with sodium heparin crude product feeding port, kettle cover upper surface other side is provided with salt solution feeding port, alkaline solution adding port and alkaline protease adding port, kettle cover lower surface is below salt solution feeding port, alkaline solution adding port and alkaline protease adding port is provided with arc baffle, arc baffle is close to kettle cover side wall one end and is provided with through slot, kettle body inner wall and below arc baffle are provided with arc guide plate, and gap is left between arc guide plate bottom and kettle body inner wall, the utility model structure is reasonable, salt solution, alkaline solution and alkaline protease can flow into kettle body along kettle body inner wall when adding, more directly fall into the mode of kettle body, greatly reduce the foam production amount of solution, to ensure mass transfer and reaction efficiency, reduce impurity package, reduce the influence to subsequent solid-liquid separation, improve dissolving effect.

Description

Technical Field

[0001] This utility model relates to the field of heparin sodium dissolving kettle technology, specifically a crude heparin sodium dissolving kettle. Background Technology

[0002] Dissolving crude heparin sodium is a crucial preliminary purification step, aimed at extracting heparin from complex tissue mixtures into an aqueous solution while removing as much protein, lipid, and other impurities as possible.

[0003] Crude heparin sodium produces foam during dissolution, a common but concerning phenomenon in actual production and laboratory operations. The generation and persistence of foam can have a range of impacts on subsequent process steps and the quality of the final product.

[0004] Currently, when adding salt solution, alkaline solution, and alkaline protease to the crude heparin sodium dissolving vessel, the corresponding solutions fall directly into the mixed solution inside the vessel, which easily generates a large amount of foam. This leads to an artificial increase in volume, affects mass transfer and reaction efficiency, increases impurity encapsulation, and affects subsequent solid-liquid separation. Therefore, an improved technology is urgently needed to solve this problem in the existing technology. Summary of the Invention

[0005] The purpose of this invention is to provide a crude heparin sodium dissolving vessel to solve the problems mentioned in the background art.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a crude heparin sodium dissolving vessel, comprising a vessel body and a vessel lid. The vessel lid is provided on the upper surface of the vessel body. A motor is mounted on the center of the upper surface of the vessel lid via a motor mount. The output shaft of the motor is connected to the top of a main shaft via a coupling. The bottom end of the main shaft is rotatably mounted inside the vessel body and is provided with several stirring paddles. A crude heparin sodium feeding port is provided on one side of the upper surface of the vessel lid. A salt solution feeding port, an alkaline solution adding port, and an alkaline protease adding port are provided on the other side of the upper surface of the vessel lid. An arc-shaped baffle is provided on the lower surface of the vessel lid below the salt solution feeding port, the alkaline solution adding port, and the alkaline protease adding port. A through groove is provided at one end of the arc-shaped baffle near the side wall of the vessel lid. An arc-shaped guide plate is provided on the inner wall of the vessel body below the arc-shaped baffle. A gap is left between the bottom of the arc-shaped guide plate and the inner wall of the vessel body. The lower part of the arc-shaped guide plate is inclined and the distance to the inner wall of the vessel body gradually decreases from top to bottom. The vessel body is wrapped with a jacket.

[0007] Preferably, in the crude heparin sodium dissolving vessel provided by this utility model, the arc-shaped guide plate is bent on both sides and welded to the inner wall of the vessel.

[0008] Preferably, the present invention provides a crude heparin sodium dissolving vessel, wherein a discharge port is provided at the bottom of the vessel body.

[0009] Preferably, the present invention provides a crude heparin sodium dissolving vessel, wherein the bottom end of the vessel body is provided with a support by a plurality of support rods, and the bottom end of the main shaft is rotatably connected to the support.

[0010] Preferably, the present invention provides a crude heparin sodium dissolving vessel, wherein the bottom of the jacket is provided with a heat exchange medium inlet and the upper side of the jacket is provided with a heat exchange medium outlet.

[0011] Preferably, the present invention provides a crude heparin sodium dissolving vessel, wherein the lower part of the jacket is further provided with several supporting legs.

[0012] Preferably, the present invention provides a crude heparin sodium dissolving vessel, wherein the vessel cover is further provided with a thermometer mounting port, a pressure gauge mounting port, a level gauge mounting port, and a pH meter mounting port.

[0013] Compared with the prior art, the beneficial effects of this utility model are: An arc-shaped baffle is installed on the lower surface of the vessel lid below the salt solution addition port, alkaline solution addition port, and alkaline protease addition port. An arc-shaped guide plate is installed on the inner wall of the vessel below the arc-shaped baffle. When adding salt solution, alkaline solution, and alkaline protease, they first fall into the arc-shaped baffle, flow through the channel to the arc-shaped guide plate, and then flow along the inner wall of the vessel into the vessel body under the guidance of the inclined surface of the arc-shaped guide plate. This method of addition, compared with the method of directly falling into the vessel body, greatly reduces the amount of foam generated by the solution, thereby ensuring mass transfer and reaction efficiency, reducing impurity encapsulation, reducing the impact on subsequent solid-liquid separation, and improving the dissolution effect. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a top view of the vessel body. Figure 3 This is a schematic diagram of the vessel lid viewed from below.

[0015] In the diagram: 1. Reactor body; 2. Reactor cover; 3. Motor base; 4. Motor; 5. Main shaft; 6. Stirring paddle; 7. Crude heparin sodium feed port; 8. Salt solution feed port; 9. Alkaline solution feed port; 10. Alkaline protease feed port; 11. Arc-shaped baffle; 12. Through groove; 13. Arc-shaped guide plate; 14. Jacket; 15. Discharge port; 16. Support rod; 17. Support leg; 18. Thermometer mounting port; 19. Pressure gauge mounting port; 20. Level gauge mounting port; 21. pH meter mounting port; 22. Heat exchange medium inlet; 23. Heat exchange medium outlet. Detailed Implementation

[0016] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model. It should be noted that in the description of this utility model, the terms "inner", "outer", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0017] Please see Figure 1-3 This utility model provides a technical solution: a crude heparin sodium dissolving vessel, including a vessel body 1 and a vessel cover 2. The vessel cover 2 is provided on the upper surface of the vessel body 1. A motor 4 is provided at the center of the upper surface of the vessel cover 2 via a motor base 3. The output shaft of the motor 4 is connected to the top of a main shaft 5 via a coupling. The bottom end of the main shaft 5 is rotatably disposed inside the vessel body 1 and is provided with several stirring paddles 6. The bottom end inside the vessel body 1 is provided with a support 17 via several support rods 16. The bottom end of the main shaft 5 is rotatably connected to the support 17 to improve the support of the main shaft 5 and ensure the stability of the main shaft 5 and the stirring paddles 6. A crude heparin sodium feeding port 7 is provided on one side of the upper surface of the vessel cover 2, and a salt solution feeding port 8, an alkaline solution adding port 9, and an alkaline protease adding port 10 are provided on the other side of the upper surface of the vessel cover 2. An arc-shaped baffle 11 is provided on the lower surface of the vessel cover 2 below the salt solution feeding port 8, the alkaline solution adding port 9, and the alkaline protease adding port 10. The edge of the arc-shaped baffle 11 is welded to the bottom of the vessel cover 2. A through groove 12 is provided at one end of the arc-shaped baffle 11 near the side wall of the vessel cover 2. An arc-shaped guide plate 13 is provided on the inner wall of the vessel body 1 below the arc-shaped baffle 11. A gap is left between the bottom of the arc-shaped guide plate 13 and the inner wall of the vessel body 1. The lower part of the arc-shaped guide plate 13 is inclined and the distance to the inner wall of the vessel body 1 gradually decreases from top to bottom. The two sides of the arc-shaped guide plate 13 are bent and welded to the inner wall of the vessel body 1 to realize the connection between the arc-shaped guide plate 13 and the vessel body 1. The vessel body 1 is wrapped with a jacket 14. A discharge port 15 is provided at the bottom of the vessel body 1 to realize the discharge of the dissolved material. Several support legs 18 are also provided at the lower part of the jacket 14 to realize the overall lifting and support. A heat exchange medium inlet 23 is provided at the bottom of the jacket 14, and a heat exchange medium outlet 24 is provided on one side of the upper part of the jacket 14 to realize the entry and exit of the heat exchange medium (hot water / oil or steam) into and out of the jacket 14 respectively. The vessel lid 2 is also equipped with a thermometer mounting port 19, a pressure gauge mounting port 20, a level gauge mounting port 21, and a pH meter mounting port 22, so as to install a thermometer, a pressure gauge, a level gauge, and an insertion pH meter respectively, thereby realizing the monitoring of temperature, pressure, level, and pH.

[0018] Installation method and operating principle: Crude heparin sodium is fed into the reactor body 1 through the crude heparin sodium feed port 7. Then, dilute hydrochloric acid (2-5% sodium chloride solution) is added through the salt solution addition port, with a solid-liquid ratio of 1:10 to 1:15. The salt solution first falls onto the arc-shaped baffle 11 and flows into the arc-shaped guide plate 13 through the channel 12. It then slides down the arc-shaped guide plate 13 and flows along the inclined surface to the inner wall of the reactor body 1, and then flows into the reactor body 1. Subsequently, hot water is introduced into the jacket 14 to control the temperature inside the reactor body 1 at 50-60℃. The motor 4 is started, and the motor 4 drives the main shaft 5 and the stirring paddle 6 to rotate at low speed, thereby achieving stirring and dissolution. The pH value is then measured using an insertion pH meter installed at the pH meter mounting port 22. Alkaline solution (dilute hydrochloric acid or dilute sodium hydroxide solution) is added through the alkaline solution addition port 9 to adjust the pH value to 8.0~9.0. Similarly, the alkaline solution first falls onto the arc-shaped baffle 11, then through the channel 12 into the arc-shaped guide plate 13, and then flows along the inclined surface of the arc-shaped guide plate 13 to the inner wall of the vessel body 1 and into the vessel body 1. Stirring is continued for 2~4 hours, followed by the dissolution step. The temperature is maintained at 50~55°C, and a certain amount of alkaline protease (such as trypsin, 1398 protease, etc.) is added. The alkaline protease also falls through the arc-shaped baffle 11 into the arc-shaped guide plate 13 and flows along the inner wall of the vessel body 1 into the vessel body 1. The enzymatic hydrolysis is carried out for 1~2 hours. The protease can hydrolyze proteins and peptides bound to heparin into small molecule amino acids or short peptides, thereby releasing heparin and greatly reducing impurities, thus completing the dissolution. Finally, the solution is heated to 80-85°C and maintained for 15-20 minutes to inactivate the protease. It is then discharged while hot for solid-liquid separation. The arc-shaped baffle 11 is welded to the vessel lid 2, and the arc-shaped guide plate 13 is bent on both sides and welded to the vessel body 1. This invention has a reasonable structure. An arc-shaped baffle 11 is positioned below the salt solution addition port 9, alkaline solution addition port 9, and alkaline protease addition port 10 on the lower surface of the vessel lid 2. An arc-shaped guide plate 13 is positioned on the inner wall of the vessel body 1 below the arc-shaped baffle 11. When adding the salt solution, alkaline solution, and alkaline protease, they first fall into the arc-shaped baffle 11, flow through the channel 12 to the arc-shaped guide plate 13, and then, guided by the inclined surface of the arc-shaped guide plate 13, flow along the inner wall of the vessel body 1 into the vessel body 1. This addition method, compared to directly falling into the vessel body 1, significantly reduces the amount of foam generated in the solution, thereby ensuring mass transfer and reaction efficiency, reducing impurity encapsulation, minimizing the impact on subsequent solid-liquid separation, and improving the dissolution effect.

[0019] Any aspects of this utility model not described in detail are well-known technologies to those skilled in the art.

[0020] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to the embodiments, those skilled in the art should understand that modifications and equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model.

Claims

1. A dissolving vessel for crude heparin sodium, characterized in that: The vessel includes a vessel body (1) and a vessel lid (2). The vessel lid (2) is provided on the upper surface of the vessel body (1). A motor (4) is provided at the center of the upper surface of the vessel lid (2) via a motor base (3). The output shaft of the motor (4) is connected to the top of the main shaft (5) via a coupling. The bottom end of the main shaft (5) is rotatably located inside the vessel body (1) and is provided with several stirring paddles (6). A crude heparin sodium feeding port (7) is provided on one side of the upper surface of the vessel lid (2). A salt solution feeding port (8), an alkaline solution adding port (9), and an alkaline protease adding port (10) are provided on the other side of the upper surface of the vessel lid (2). (2) An arc-shaped baffle (11) is provided on the lower surface below the salt solution inlet (8), the alkaline solution inlet (9) and the alkaline protease inlet (10). A through groove (12) is provided on one end of the arc-shaped baffle (11) near the side wall of the lid (2). An arc-shaped guide plate (13) is provided on the inner wall of the vessel body (1) below the arc-shaped baffle (11). A gap is left between the bottom of the arc-shaped guide plate (13) and the inner wall of the vessel body (1). The lower part of the arc-shaped guide plate (13) is inclined and the distance from top to bottom to the inner wall of the vessel body (1) gradually decreases. The vessel body (1) is wrapped with a jacket (14).

2. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The arc-shaped guide plate (13) is bent on both sides and welded to the inner wall of the vessel body (1).

3. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The bottom of the vessel body (1) is provided with a discharge port (15).

4. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The bottom of the vessel body (1) is provided with a support (17) by a number of support rods (16), and the bottom of the main shaft (5) is rotatably connected to the support (17).

5. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The lower part of the sleeve (14) is also provided with several support legs (18).

6. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The vessel cover (2) is also provided with a thermometer mounting port (19), a pressure gauge mounting port (20), a level gauge mounting port (21), and a pH meter mounting port (22).

7. The heparin sodium crude product dissolving vessel according to claim 1, characterized in that: The jacket (14) has a heat exchange medium inlet (23) at the bottom and a heat exchange medium outlet (24) on one side of the upper part of the jacket (14).

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