A suspension mixing device

Abstract

The utility model discloses a kind of suspension uniform mixing devices, including sample container, ultrasonic transducer is equipped on the outside of sample container, and the suspension in sample container is mixed uniformly using the sound wave generated by ultrasonic transducer;Sample container inside is equipped with the cavity for accommodating suspension, cavity includes accommodating part and mixing part, and mixing part is set to the end far from cavity entrance, and mixing part reduces towards the end far from cavity entrance Diameters.This utility model discloses suspension uniform mixing device using ultrasonic transducer generated ultrasonic wave directly through the sidewall of sample container to the suspension in sample container and mixes, realizes the purpose of not introducing any mechanical structure in cavity to carry out fluid mixing, can effectively avoid cross contamination, while sound wave mixing has the advantage of low shear, can effectively reduce the harm caused to particle in mixing process.

Description

Technical Field

[0001] This utility model relates to the field of biotechnology, and in particular to a suspension mixing device. Background Technology

[0002] In biomedical fields such as cancer cell screening, single-cell cloning and cell differentiation mechanism research, drug development, and single-cell sequencing, liquid samples containing particles, i.e., suspensions, often require the use of cell sorting devices to separate individual target particles from one or more liquids. Since particles frequently settle at the bottom of the sample container, it is necessary to mix the suspension sample in the container to address this issue.

[0003] Currently, mixing is achieved manually by using a pipette to aspirate liquids. However, this method is overly reliant on manual labor and cannot meet the needs of automation. Another method involves using containers with mixing channels. In practice, the liquid in the container is mixed by connecting the mixing channels. However, in this method, the mixing channels and the container are directly connected, which poses a risk of cross-contamination between the fluid in the container and the flow channels of the mixing channels. Utility Model Content

[0004] To address the problems existing in the prior art, this utility model discloses a suspension mixing device.

[0005] A suspension mixing device includes a sample container, and an ultrasonic transducer is provided on the outside of the sample container to mix the suspension in the sample container using the sound waves generated by the ultrasonic transducer.

[0006] The sample container has a cavity for containing the suspension. The cavity includes a containing part and a mixing part. The mixing part is located at one end away from the cavity inlet, and the diameter of the mixing part decreases towards the end away from the cavity inlet.

[0007] Specifically, ultrasonic waves generated by an ultrasonic transducer directly penetrate the side wall of the sample container to mix the suspension in the sample container. This achieves the purpose of fluid mixing without introducing any mechanical structure into the cavity, effectively avoiding cross-contamination. At the same time, acoustic mixing has the advantage of low shear, which can effectively reduce the damage to particles during the mixing process.

[0008] Preferably, the diameter of the receiving portion is 2-3 times the wavelength of the sound wave emitted by the ultrasonic transducer.

[0009] The structure with a diameter of 2-3 times the wavelength of the sound waves emitted by the ultrasonic transducer generates an effective sound field with multiple pressure nodes and pressure counter-nodes in the cavity, thereby forming a complex fluid vortex in the cavity. The vortex can effectively pick up the particles at the bottom of the cavity and prevent them from sinking, thus achieving the purpose of mixing the suspension.

[0010] Preferably, it also includes an ultrasonic wave transmission mechanism, wherein the ultrasonic transducer is fixed on the ultrasonic wave transmission mechanism, and the ultrasonic wave transmission mechanism is in close contact with the outer wall of the sample container.

[0011] Specifically, an ultrasonic wave transmission mechanism is used to transmit sound waves, and the close contact between the ultrasonic wave transmission mechanism and the outer wall of the sample container can effectively reduce the loss of sound waves.

[0012] Preferably, the ultrasonic transmission mechanism includes an ultrasonic transmission head, which is in close contact with the outer wall of the sample container, and the mixing part is located in the plane covered by the contact surface between the ultrasonic transmission head and the outer wall of the sample container.

[0013] Specifically, by utilizing the structure of the ultrasonic transmission head, sound waves can be transmitted more precisely, enabling the sound waves to accurately mix the suspension in the mixing section. This structure not only mixes the suspension in the mixing section more effectively, but also effectively reduces energy consumption.

[0014] Preferably, it further includes a fixing mechanism that fixes the ultrasonic transducer to the side wall of the sample container, and the mixing part is located in the plane covered by the contact surface between the ultrasonic transducer and the outer side wall of the sample container.

[0015] Specifically, in this structure, the sound waves generated by the ultrasonic transducer are directly transmitted to the mixing section through the side wall of the sample container, which consumes less energy and can accurately mix the suspension in the mixing section.

[0016] Preferably, it also includes a microfluidic chip, through which the mixed suspension is discharged, and the microfluidic chip is connected to the mixing section through a mixing channel;

[0017] It also includes an on-demand titration mechanism, which controls the communication state between the microfluidic chip and the outside by controlling the internal pressure of the microfluidic chip.

[0018] Specifically, the internal pressure of the microfluidic chip can be changed by tapping the on-demand titration mechanism; that is, each time the on-demand titration mechanism is tapped, the suspension in the microfluidic chip is discharged.

[0019] Furthermore, other methods of altering the internal pressure of a microfluidic chip should be considered equivalent to this method.

[0020] Preferably, the mixing channel and the mixing section are located on the same horizontal plane.

[0021] Specifically, with this structure, the suspension remains within the effective range of the sound waves until it enters the microfluidic chip, ensuring that the suspension entering the microfluidic chip is a uniformly mixed suspension.

[0022] Compared with the prior art, the advantages of this utility model are:

[0023] By using ultrasonic transducers to generate ultrasonic waves that directly penetrate the side wall of the sample container, the suspension in the sample container can be mixed. This achieves the purpose of fluid mixing without introducing any mechanical structure into the cavity, which can effectively avoid cross-contamination. At the same time, acoustic mixing has the advantage of low shear, which can effectively reduce the damage to particles during the mixing process. Attached Figure Description

[0024] Figure 1 This is a schematic diagram of the suspension mixing device disclosed in this utility model (with an ultrasonic transmission mechanism).

[0025] Figure 2 This is a cross-sectional schematic diagram of the suspension mixing device disclosed in this utility model (with an ultrasonic transmission mechanism).

[0026] Figure 3 This is a cross-sectional view of the suspension mixing device disclosed in this utility model from another angle.

[0027] Figure 4 This is a schematic diagram of the suspension mixing device disclosed in this utility model (with fixing device). Detailed Implementation

[0028] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0029] like Figure 1-3 As shown, a suspension mixing device includes a sample container 10, and an ultrasonic transducer 20 is provided on the outside of the sample container 10. The ultrasonic transducer 20 generates sound waves to mix the suspension in the sample container 10.

[0030] The sample container 10 has a cavity for containing the suspension. The cavity includes a containing part 11 and a mixing part 12. The mixing part 12 is located at one end away from the cavity inlet, and the diameter of the mixing part 12 decreases towards the end away from the cavity inlet.

[0031] The ultrasonic waves generated by the ultrasonic transducer 20 directly pass through the side wall of the sample container 10 to mix the suspension in the sample container 10. This achieves the purpose of fluid mixing without introducing any mechanical structure into the cavity, which can effectively avoid cross-contamination. At the same time, the ultrasonic mixing has the advantage of low shear, which can effectively reduce the damage to particles during the mixing process.

[0032] The diameter of the receiving part 11 is 2-3 times the wavelength of the sound waves emitted by the ultrasonic transducer 20.

[0033] The containment section 11 has a diameter that is 2-3 times the wavelength of the sound waves emitted by the ultrasonic transducer 20. It generates an effective sound field with multiple pressure nodes and pressure counter-nodes in the cavity, thereby forming a complex fluid vortex in the cavity. The vortex can effectively pick up the particles at the bottom of the cavity and prevent them from sinking to the bottom, thus achieving the purpose of mixing the suspension.

[0034] It also includes an ultrasonic transmission mechanism 30, on which an ultrasonic transducer 20 is fixed, and the ultrasonic transmission mechanism 30 is in close contact with the outer wall of the sample container 10.

[0035] The ultrasonic wave transmission mechanism 30 is used to transmit sound waves, and the ultrasonic wave transmission mechanism 30 is in close contact with the outer wall of the sample container 10, which can effectively reduce the loss of sound waves.

[0036] The ultrasonic transmission mechanism 30 includes an ultrasonic transmission head 31, which is in close contact with the outer wall of the sample container 10, and the mixing part 12 is located in the plane covered by the contact surface between the ultrasonic transmission head 31 and the outer wall of the sample container 10.

[0037] By utilizing the structure of the ultrasonic transducer 31, sound waves can be transmitted more precisely, enabling the sound waves to accurately mix the suspension in the mixing section 12. This structure not only mixes the suspension in the mixing section 12 more effectively, but also effectively reduces energy consumption.

[0038] like Figure 4 As shown, it also includes a fixing mechanism 40, which fixes the ultrasonic transducer 20 to the side wall of the sample container 10, and the mixing part 12 is located in the plane covered by the contact surface between the ultrasonic transducer 20 and the outer side wall of the sample container 10.

[0039] In this structure, the sound waves generated by the ultrasonic transducer 20 are directly transmitted to the mixing section 12 through the side wall of the sample container 10, which consumes less energy and can accurately mix the suspension in the mixing section 12.

[0040] It also includes a microfluidic chip 51, through which the mixed suspension is discharged, and the microfluidic chip 51 is connected to the mixing section 12 through the mixing channel 13.

[0041] It also includes an on-demand titration mechanism 52, which controls the communication state between the microfluidic chip 51 and the outside by controlling the internal pressure of the microfluidic chip 51.

[0042] The internal pressure of the microfluidic chip 51 can be changed by tapping the on-demand titration mechanism 52. That is, each time the on-demand titration mechanism 52 is tapped, the suspension in the microfluidic chip 51 is discharged.

[0043] Furthermore, other methods of altering the internal pressure of the microfluidic chip 51 should be considered equivalent to this method.

[0044] The mixing channel 13 and the mixing section 12 are located on the same horizontal plane.

[0045] With this structure, the suspension remains within the effective range of the sound waves until it enters the microfluidic chip 51, which ensures that the suspension entering the microfluidic chip 51 is a uniformly mixed suspension.

Claims

1. A suspension mixing device, comprising a sample container, characterized in that, An ultrasonic transducer is provided on the outside of the sample container, and the sound waves generated by the ultrasonic transducer are used to mix the suspension in the sample container. The sample container has a cavity for containing the suspension. The cavity includes a containing part and a mixing part. The mixing part is located at one end away from the cavity inlet, and the diameter of the mixing part decreases towards the end away from the cavity inlet.

2. The suspension mixing device according to claim 1, characterized in that, The diameter of the receiving part is 2-3 times the wavelength of the sound wave emitted by the ultrasonic transducer.

3. The suspension mixing device according to claim 1, characterized in that, It also includes an ultrasonic wave transmission mechanism, on which the ultrasonic transducer is fixed and which is in close contact with the outer wall of the sample container.

4. The suspension mixing device according to claim 3, characterized in that, The ultrasonic transmission mechanism includes an ultrasonic transmission head, which is in close contact with the outer wall of the sample container.

5. The suspension mixing device according to claim 4, characterized in that, The mixing section is located within the plane covered by the contact surface between the ultrasonic transducer and the outer wall of the sample container.

6. The suspension mixing device according to claim 1, characterized in that, It also includes a fixing mechanism that fixes the ultrasonic transducer to the side wall of the sample container.

7. The suspension mixing device according to claim 6, characterized in that, The mixing section is located within the plane covered by the contact surface between the ultrasonic transducer and the outer wall of the sample container.

8. The suspension mixing device according to claim 1, characterized in that, It also includes a microfluidic chip, through which the mixed suspension is discharged, and the microfluidic chip is connected to the mixing section through a mixing channel.

9. The suspension mixing device according to claim 8, characterized in that, It also includes an on-demand titration mechanism, which controls the communication state between the microfluidic chip and the outside by controlling the internal pressure of the microfluidic chip.

10. The suspension mixing device according to claim 8, characterized in that, The mixing channel and the mixing section are located on the same horizontal plane.

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