A microfluidic droplet generation device

Abstract

The utility model belongs to micro -fluidic technology field discloses a kind of micro -fluidic droplet preparation device, including liquid supplementing pool, automatic liquid supplementing injection pump, controller module, micro -fluidic chip and reflux pool, the liquid supplementing pool is communicated with the liquid inlet end of automatic liquid supplementing injection pump by pipeline, the liquid outlet end of automatic liquid supplementing injection pump is communicated with micro -fluidic chip by pipeline, signal output end of automatic liquid supplementing injection pump and signal input end of controller module are connected.The utility model can realize alternate liquid supplementing and liquid supply by the design of double liquid guide cylinder, ensure that syringe continuously outputs liquid, avoid micro -fluidic chip broken flow, first solenoid valve can accurately control liquid outlet time, prevent backflow, also can avoid syringe leakage, cause waste to occur, syringe and injection drive assembly are integrated on mounting plate, compact structure, by the switching of controller module and solenoid valve cooperation, realize zero interruption supply, significantly improve the stability and efficiency of droplet preparation.

Description

Technical Field

[0001] This utility model relates to the field of microfluidics, and in particular to a microfluidic droplet preparation device. Background Technology

[0002] Microfluidics is a technology for precisely controlling and manipulating fluids at the microscale, characterized by the control of fluids in micro- and nano-scale spaces. The principle of microfluidics is primarily based on the precise control and manipulation of microscale fluids. Through fluid flow on a microfluidic chip, laminar flow effects in aqueous and organic phases can be achieved, and the self-assembly reactions of effective components in two phases can be controlled, allowing for rapid reactions at extremely small phase interfaces. A microfluidic chip integrates the basic operational units of biological, chemical, and medical analysis processes—including sample preparation, reaction, separation, and detection—on a single micrometer-scale chip, automating the entire analytical process.

[0003] In existing microfluidic droplet fabrication technologies, continuous fluid control is crucial for ensuring droplet uniformity. Traditional syringe pumps require interruption of operation during fluid changes or replenishment, leading to fluid interruptions, droplet size fluctuations, and complex, costly multi-channel systems. While patent CN202422486270.X proposes a multi-stage microchannel structure to optimize droplet generation, it does not address the issue of continuous fluid supply. Utility Model Content

[0004] To overcome the technical defects of the existing technology, this utility model provides a microfluidic droplet preparation device.

[0005] The technical solution adopted by this utility model is: a microfluidic droplet preparation device, including a replenishment tank, an automatic replenishment injection pump, a controller module, a microfluidic chip, and a reflux tank. The replenishment tank is connected to the inlet end of the automatic replenishment injection pump through a pipe, and the outlet end of the automatic replenishment injection pump is connected to the microfluidic chip through a pipe. The signal output end of the automatic replenishment injection pump is communicatively connected to the signal input end of the controller module, and the signal output end of the controller module is communicatively connected to the signal input end of the automatic replenishment injection pump. The automatic replenishment injection pump includes a mounting plate, on one side of which a syringe is mounted. The mounting plate is provided with an injection drive component for driving the syringe. On the other side of the mounting plate, there is a fixing plate perpendicular to the mounting plate. The fixing plate is provided with two liquid guide tubes. The bottom ends of the two liquid guide tubes are connected to the bottom end of the syringe through a replenishment tube. A first solenoid valve is provided on the outlet tube at the bottom end of the syringe.

[0006] Preferably, the syringe is fixedly mounted on the mounting plate by a clamp.

[0007] Preferably, the injection drive assembly includes two fixing blocks mounted on a mounting plate, with a lead screw and a guide rod between the two fixing blocks. The injection rod of the syringe is provided with a push plate that is threadedly connected to the lead screw, and the push plate is provided with a guide hole for the guide rod to pass through. One of the fixing blocks is equipped with a stepper motor that drives the lead screw to rotate.

[0008] Preferably, an electromagnetic check valve is installed on the end of the rehydration tube near the syringe.

[0009] Preferably, the bottom end of the liquid guiding cylinder is provided with a connecting pipe that communicates with the liquid replenishment pipe.

[0010] Preferably, a second solenoid valve is installed on the connecting pipe.

[0011] Preferably, the mounting plate is T-shaped.

[0012] The beneficial effects of this invention are as follows: the design of dual liquid guide tubes enables alternating liquid replenishment and supply, ensuring continuous liquid output from the syringe and preventing flow interruption in the microfluidic chip. The first solenoid valve can precisely control the timing of liquid dispensing, preventing backflow and avoiding syringe leakage that could lead to waste. The mounting plate integrates the syringe and injection drive components, resulting in a compact structure. Through the controller module coordinating with the switching of the solenoid valve, zero-interruption supply is achieved, significantly improving the stability and efficiency of droplet preparation. Liquid replenishment from the bottom of the syringe provides better replenishment results. Attached Figure Description

[0013] One or more embodiments are illustrated by way of example with reference numerals in the accompanying drawings. These illustrations do not constitute a limitation on the embodiments. Elements with the same reference numerals in the drawings are denoted as similar elements. Unless otherwise stated, the figures in the drawings are not to be limited by scale.

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a cross-sectional view of the automatic fluid replenishment injection pump of this utility model; Figure 3 This is a cross-sectional view of the injection driving component of this utility model.

[0015] Explanation of reference numerals in the attached figures: 1. Replenishment tank; 2. Automatic replenishment injection pump; 3. Controller module; 4. Microfluidic chip; 5. Return tank; 6. Mounting plate; 7. Syringe; 8. Injection drive assembly; 9. Fixing plate; 10. Liquid guide tube; 11. Replenishment tube; 12. First solenoid valve; 13. Clamp; 14. Fixing block; 15. Lead screw; 16. Guide rod; 17. Push plate; 18. Solenoid check valve; 19. Connecting pipe; 20. Second solenoid valve; 21. Stepper motor. Detailed Implementation

[0016] To make the objectives, technical solutions, and advantages of this utility model clearer, the various embodiments of this utility model will be described in detail below with reference to the accompanying drawings. However, those skilled in the art will understand that many technical details have been provided in the various embodiments of this utility model to facilitate a better understanding of this application. However, the technical solutions claimed in the claims of this application can be implemented even without these technical details and with various variations and modifications based on the following embodiments.

[0017] like Figures 1-3 As shown, this embodiment provides a microfluidic droplet preparation device, including a replenishment tank 1, an automatic replenishment injection pump 2, a controller module 3, a microfluidic chip 4, and a reflux tank 5. The replenishment tank 1 is connected to the inlet end of the automatic replenishment injection pump 2 via a pipe, and the outlet end of the automatic replenishment injection pump 2 is connected to the microfluidic chip 4 via a pipe. The signal output end of the automatic replenishment injection pump 2 is communicatively connected to the signal input end of the controller module 3, and the signal output end of the controller module 3 is communicatively connected to the signal input end of the automatic replenishment injection pump 2. The automatic replenishment injection pump 2 includes a mounting plate 6, on one side of which a syringe 7 is mounted. The mounting plate 6 is provided with an injection actuator for driving the syringe 7. The moving component 8 and the mounting plate 6 have a fixed plate 9 perpendicular to the mounting plate 6 on the other side. The fixed plate 9 has two liquid guide tubes 10. The bottom ends of the two liquid guide tubes 10 are connected to the bottom end of the syringe 7 via a replenishment tube 11. The liquid outlet tube at the bottom end of the syringe 7 is equipped with a first solenoid valve 12. The dual liquid guide tube 10 design can realize alternating replenishment and supply of liquid, ensuring that the syringe 7 continuously outputs liquid and avoids the microfluidic chip 4 from being interrupted. The first solenoid valve 12 can accurately control the timing of liquid dispensing, prevent backflow, and also prevent the syringe 7 from leaking and causing waste. The mounting plate 6 integrates the syringe 7 and the injection drive component 8, with a compact structure. The replenishment is from the bottom end of the syringe 7, resulting in better replenishment effect.

[0018] The syringe 7 is fixedly installed on the mounting plate 6 by the clamp 13, allowing for quick assembly and disassembly of the syringe 7, facilitating maintenance and replacement, and reducing downtime.

[0019] The injection drive assembly 8 includes two fixing blocks 14 mounted on the mounting plate 6. A lead screw 15 and a guide rod 16 are provided between the two fixing blocks 14. The injection rod of the syringe 7 is provided with a push plate 17 threadedly connected to the lead screw 15. The push plate 17 is provided with a guide hole for the guide rod 16 to pass through. One of the fixing blocks 14 is equipped with a stepper motor 21 that drives the lead screw 15 to rotate. The output shaft of the stepper motor 21 drives the lead screw 15 to rotate, and under the guidance of the guide rod 16, the push plate 17 pushes the injection rod of the syringe 7 to move and inject.

[0020] An electromagnetic check valve 18 is installed on the end of the replenishment tube 11 near the syringe 7, providing double backflow protection to avoid cross-contamination.

[0021] The bottom end of the liquid guide cylinder 10 is provided with a connecting pipe 19 that is connected to the liquid replenishment pipe 11. A second solenoid valve 20 is installed on the connecting pipe 19 to independently control the opening and closing of each liquid guide cylinder 10, so as to achieve seamless switching between liquid replenishment and liquid supply modes. The second solenoid valve 20 can accurately adjust the liquid replenishment flow rate to avoid overflow.

[0022] During operation, the dual liquid guide tube 10 design enables alternating liquid replenishment and supply, ensuring continuous liquid output from the syringe 7 and preventing flow interruption from the microfluidic chip 4. The first solenoid valve 12 can precisely control the timing of liquid dispensing, preventing backflow and avoiding leakage from the syringe 7, thus preventing waste. The syringe 7 and injection drive assembly 8 are integrated on the mounting plate 6, which has a compact structure. Through the controller module 3 and the switching of the solenoid valve, zero-interruption supply is achieved, significantly improving the stability and efficiency of droplet preparation.

[0023] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0024] Those skilled in the art will understand that the above embodiments are specific examples of implementing the present invention, and in practical applications, various changes can be made to them in form and detail without departing from the spirit and scope of the present invention.

Claims

1. A microfluidic droplet preparation device, comprising a replenishment tank (1), an automatic replenishment injection pump (2), a controller module (3), a microfluidic chip (4), and a reflux tank (5), wherein the replenishment tank (1) is connected to the inlet end of the automatic replenishment injection pump (2) via a pipe, the outlet end of the automatic replenishment injection pump (2) is connected to the microfluidic chip (4) via a pipe, the signal output end of the automatic replenishment injection pump (2) is communicatively connected to the signal input end of the controller module (3), and the signal output end of the controller module (3) is communicatively connected to the signal input end of the automatic replenishment injection pump (2), characterized in that: The automatic fluid replenishment injection pump (2) includes a mounting plate (6), a syringe (7) is mounted on one side of the mounting plate (6), an injection drive assembly (8) for driving the syringe (7) is provided on the mounting plate (6), a fixing plate (9) perpendicular to the mounting plate (6) is provided on the other side of the mounting plate (6), two liquid guide tubes (10) are provided on the fixing plate (9), the bottom ends of the two liquid guide tubes (10) are connected to the bottom end of the syringe (7) through a replenishment tube (11), and a first solenoid valve (12) is provided on the liquid outlet tube at the bottom end of the syringe (7).

2. The microfluidic droplet preparation device according to claim 1, characterized in that: The syringe (7) is fixedly mounted on the mounting plate (6) by a clamp (13).

3. The microfluidic droplet preparation device according to claim 1, characterized in that: The injection drive assembly (8) includes two fixing blocks (14) on the mounting plate (6), a lead screw (15) and a guide rod (16) are provided between the two fixing blocks (14), the injection rod of the syringe (7) is provided with a push plate (17) threadedly connected to the lead screw (15), the push plate (17) is provided with a guide hole for the guide rod (16) to pass through, and a stepper motor (21) for driving the lead screw (15) to rotate is installed on one of the fixing blocks (14).

4. The microfluidic droplet preparation device according to claim 1, characterized in that: An electromagnetic check valve (18) is installed on one end of the replenishment tube (11) near the syringe (7).

5. The microfluidic droplet preparation device according to claim 1, characterized in that: The bottom end of the liquid guide tube (10) is provided with a connecting pipe (19) that is connected to the liquid replenishment pipe (11).

6. The microfluidic droplet preparation device according to claim 5, characterized in that: A second solenoid valve (20) is installed on the connecting pipe (19).

7. The microfluidic droplet preparation device according to claim 1, characterized in that: The mounting plate (6) is T-shaped.

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