An inactivated post-embryonic antigen online sterilization and dispensing system

Abstract

The utility model discloses a kind of inactivated embryo poison antigen online sterilization dispensing systems, including liquid supply device, sterilization module before dispensing, dispensing module, end tank body assembly and detection module.Liquid supply device transports inactivated antigen by dispensing main pipe;Dispensing module includes four-way valve, and its three export ends form first, second dispensing branch and third standby branch, and each branch is connected with terminal drainage valve;Sterilization module before dispensing is connected with dispensing main pipe by steam main pipe, realizes system online sterilization;End tank body assembly includes first, second tank body group, and each group contains at least one turnover tank, and third standby branch is simultaneously connected with two groups of last turnover tank;Detection module contains temperature probe arranged at the end of each dispensing branch and before drainage valve, and pressure gauge arranged at the end of first, second dispensing branch.The utility model realizes multi-path parallel efficient dispensing and online reliable sterilization, effectively avoids pollution risk, significantly improves the automation level and product quality of vaccine production.

Description

Technical Field

[0001] This utility model relates to the field of poultry vaccine production, and in particular to an online sterilization and dispensing system for inactivated embryonic antigen. Background Technology

[0002] In the industrial production of poultry vaccines, embryotoxic antigens, after being chemically inactivated, need to be dispensed into transfer tanks under strictly aseptic conditions as feedstock for subsequent finished product formulation. The efficiency and aseptic assurance level of this dispensing process directly affect the quality, cost, and production capacity of the final vaccine product. Currently, the end-of-pipe dispensing and sterilization methods commonly used in the industry have many technical shortcomings. First, in the packaging process, most still rely on the operation mode of connecting single tanks in series and manually disassembling and reconnecting pipelines. This not only results in low packaging efficiency, but also takes more than ten minutes to process the material in a single tank, making it difficult to meet the needs of large-scale continuous production. More seriously, the repeated disassembly and reconnection of pipeline interfaces greatly increases the risk of cross-contamination, threatening the sterile state of the inactivated antigens.

[0003] Secondly, existing technologies are particularly inadequate in the sterilization of the pipeline system before repackaging. Traditional sterilization processes often require operators to open the plugs of the transfer tanks to release steam. This process lacks effective protection such as filters, making it easy for external air pollutants to enter the system. Furthermore, the sterilization process generally lacks real-time, online monitoring and control of temperature and steam pressure at key points, making it impossible to confirm whether the entire pipeline system has reached the effective sterilization temperature. This may result in incomplete sterilization, creating a potential for microbial contamination of the repackaged materials.

[0004] Furthermore, the dispensing operation and sterilization preparation process are disconnected, requiring a large amount of manpower to disassemble, disinfect, and reassemble the pipelines. The operation is cumbersome and inconsistent, which further reduces production efficiency and introduces additional quality risks due to the increased human factors.

[0005] In summary, existing technologies struggle to simultaneously achieve both high efficiency and high reliability in the end-packaging of inactivated embryonic antigens, which has become a key technological bottleneck restricting the improvement of vaccine production quality and efficacy. Utility Model Content

[0006] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes an online sterilization and dispensing system for inactivated embryogenic antigen. Through integrated pipeline design and online sterilization function, it achieves efficient multi-path parallel dispensing while ensuring a sterile state throughout the entire process from dispensing pipelines to the final transfer tank. This effectively avoids the contamination risk caused by frequent pipeline disassembly in traditional operations. Furthermore, by monitoring the temperature and pressure at key points in real time, it ensures the reliability and consistency of the sterilization process, thereby significantly improving the quality control level and operational efficiency of vaccine production.

[0007] The technical solution adopted by this utility model to solve its technical problem is: An online sterilization and dispensing system for inactivated embryotoxin antigens, comprising: A liquid supply device is used to deliver embryotoxin antigen that has been inactivated by chemical methods, and the outlet end of the liquid supply device is connected to a dispensing manifold. The pre-dispensing sterilization module includes a steam main pipe connected to the dispensing main pipe; The dispensing module includes a four-way valve connected to the dispensing main pipe. The other three outlets of the four-way valve define a first dispensing branch, a second dispensing branch, and a third spare branch, respectively. The first dispensing branch, the second dispensing branch, and the third spare branch are all connected to a drain valve for discharging steam moisture. The end tank assembly includes a first tank group connected to the first dispensing branch and a second tank group connected to the second dispensing branch. Both the first tank group and the second tank group include at least one turnover tank. The third backup branch connects the turnover tanks at the very end of both the first tank group and the second tank group. The detection module includes a temperature detection unit and a pressure detection unit. The temperature detection unit includes a first temperature probe located at the end of the first dispensing branch, a second temperature probe located at the end of the second dispensing branch, a third temperature probe located at the end of the third backup branch, and a fourth temperature probe located before the drain valve. The pressure detection unit includes a first pressure gauge and a second pressure gauge located at the ends of the first dispensing branch and the second dispensing branch.

[0008] An online sterilization and dispensing system for inactivated embryotoxin antigen according to an embodiment of this utility model has at least the following beneficial effects: This utility model organically combines liquid supply, dispensing, sterilization, and detection functional modules through an integrated pipeline design. Utilizing a four-way valve, it achieves parallel dispensing across multiple branches, significantly improving the efficiency and flexibility of the dispensing operation. The system's pre-dispensing sterilization module can perform online steam sterilization of the entire pipeline and tank without manual disassembly, fundamentally avoiding the risk of secondary contamination. The detection module monitors the temperature and pressure at key points in real time, ensuring the reliability and consistency of the sterilization process. The design of the terminal tank components supports parallel and series dispensing modes to adapt to different production scales. The entire system achieves a fully closed and aseptic operation from antigen delivery to dispensing completion, greatly improving the automation level of vaccine production and product quality assurance capabilities.

[0009] According to some embodiments of the present invention, both the first and second dispensing branches are provided with filter components, while the third backup branch is not provided with a filter component.

[0010] The advantages are: this configuration enables the main dispensing pipeline to filter impurities, ensuring the cleanliness of the antigen liquid, while the filterless design of the backup pipeline ensures that the backup passage can be quickly activated when the main pipeline filter is blocked, maintaining production continuity and improving the system's ability to cope with abnormal operating conditions.

[0011] According to some embodiments of the present invention, the filtration assembly includes a filter cartridge and a filter bag installed inside the filter cartridge.

[0012] The advantages are: the combination structure of filter cartridge and filter bag facilitates the installation, replacement and disposal of filter bag, while the filter cartridge provides a stable support and sealing environment, ensuring the reliability of the filtration process and the convenience of operation and maintenance.

[0013] According to some embodiments of the present invention, a drain valve is provided and is located at the connection between the third spare branch and the end of the first and second sub-packaging branches.

[0014] The benefits are: the centralized drainage design with a shared drain valve simplifies the piping structure, reduces equipment costs and potential leak points, and effectively drains condensate from the system during sterilization, ensuring smooth steam flow and sterilization effect.

[0015] According to some embodiments of the present invention, sampling tubes are provided at the ends of the first dispensing branch and the second dispensing branch.

[0016] The advantage is that this structure allows for aseptic sampling of antigen samples from specific branches during the dispensing process, facilitating intermediate product quality monitoring.

[0017] According to some embodiments of this utility model, when the number of turnover tanks in the first tank group and the second tank group exceeds two, they are connected in series.

[0018] The advantages are: the series connection method allows a single dispensing branch to serve multiple transfer tanks, greatly expanding the overall capacity of a single dispensing operation, adapting to the processing needs of large batches of antigens, and improving equipment utilization and dispensing efficiency.

[0019] According to some embodiments of this utility model, the series-connected turnover tanks are sequentially connected top and bottom by detachable flexible connecting pipes.

[0020] The advantages are: the flexible connecting pipe is easy to install and adjust, adapts to positional differences and alignment errors between tanks in series, and its detachable nature facilitates the assembly, disassembly and daily cleaning and maintenance of the tanks, thus improving operational flexibility.

[0021] According to some embodiments of this utility model, the turnover tank is provided with material valves at both the top and bottom.

[0022] The advantages are that the material valves at both the top and bottom provide more flexible feeding and discharging control, making it easier to adapt to different process requirements, such as bottom feeding or top feeding, and enhancing the system's ability to connect with upstream and downstream processes.

[0023] According to some embodiments of the present invention, the top of the turnover tank is provided with an exhaust port, and the exhaust port is equipped with a breathing filter and a pressure-holding valve.

[0024] The benefits are that the breathing filter effectively blocks the intrusion of environmental microorganisms while maintaining the pressure balance inside and outside the tank, and the pressure-holding valve can maintain positive pressure inside the tank when necessary, together ensuring the sterility and quality stability of the antigen during storage.

[0025] According to some embodiments of the present invention, the bottom of the turnover tank is provided with a support leg, and the support leg is provided with a traveling wheel with a stopping structure.

[0026] The advantages are: the braked wheels allow fully loaded transfer containers to be easily moved and positioned within the workshop, and can be reliably fixed in designated locations, greatly reducing the labor intensity of operators and improving the efficiency and safety of material transfer.

[0027] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0028] To more clearly illustrate the technical solutions of the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0029] Figure 1 This is a schematic diagram of an embodiment of the present utility model; Figure 2 for Figure 1 Enlarged view of point A in the middle; Figure 3 for Figure 1 A schematic diagram of one of the turnover tanks.

[0030] Reference numerals: Liquid supply device 100, main dispensing pipe 110, steam main pipe 120, four-way valve 130, first dispensing branch 140, second dispensing branch 150, third backup branch 160, first tank assembly 170, second tank assembly 180, transfer tank 190, first temperature probe 200, second temperature probe 210, third temperature probe 220, fourth temperature probe 230, first pressure gauge 240, second pressure gauge 250, filter assembly 260, drain valve 270, sampling tube 280, material valve 290, breather filter element 300, pressure holding valve 310, support leg 320, traveling wheel 330. Detailed Implementation

[0031] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0032] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0033] In the description of this utility model, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. If "first" and "second" are mentioned, it is only for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance or implicitly indicating the number of indicated technical features or the order of the indicated technical features.

[0034] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation, connection, and linkage" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0035] The following is for reference. Figures 1-3 A specific embodiment of an online sterilization and dispensing system for inactivated embryotoxin antigens is described in detail below. It is to be understood that the following description is merely illustrative and not intended to limit the scope of the invention.

[0036] like Figures 1-3 As shown, an online sterilization and dispensing system for inactivated embryotoxin antigen includes a liquid supply device 100, a pre-dispensing sterilization module, a dispensing module, an end tank assembly, and a detection module.

[0037] The system originates from the supply device 100, which receives and delivers sterile embryotoxin antigen from upstream processes that have undergone chemical inactivation. The outlet of the supply device 100 is connected to the system's central component—the dispensing module—via a dispensing manifold 110. The core component of the dispensing module is a four-way valve 130. The inlet of this valve connects to the dispensing manifold 110, while its three outlets form the first dispensing branch 140, the second dispensing branch 150, and the third backup branch 160, respectively. This design allows for effective distribution of the antigen liquid flow. The first and second dispensing branches 140 and 150, serving as the main dispensing channels, are both equipped with filter assemblies 260. These filter assemblies 260 typically consist of a filter cartridge and an internal filter bag, used to intercept any minute impurities that may be present in the antigen liquid, ensuring the cleanliness of the dispensed material. The third backup branch 160 does not have a filter structure. Its purpose is to be able to be quickly activated when the filter bag of the main branch is blocked due to antigen turbidity, so as to ensure that the dispensing operation is not interrupted. This greatly improves the system's robustness in dealing with abnormal working conditions and the continuity of production.

[0038] To ensure absolute sterility throughout the entire dispensing path before contact with the antigen, the system integrates a pre-dispensing sterilization module. The module's steam main 120 is connected to the aforementioned dispensing main 110, allowing high-temperature steam to enter the system from a single inlet and flow through all subsequent pipes. During sterilization, the drain valves 270 connected to each dispensing branch need to be opened to provide a path for steam flow and condensate drainage. An optimized design is to centrally locate the drain valves 270 at the connection points between the third backup branch 160 and the ends of the first and second dispensing branches 140 and 150. This centralized drainage scheme simplifies the piping layout and reduces potential leakage points. The sterilization effect is rigorously monitored through a detection module. Figure 3 As shown, the temperature detection unit includes a first temperature probe 200 located at the end of the first dispensing branch 140, a second temperature probe 210 located at the end of the second dispensing branch 150, a third temperature probe 220 located at the end of the third backup branch 160, and a fourth temperature probe 230 located at the drain valve 270. It monitors the temperatures of these points, considered the "coldest points," in real time to ensure that the entire sterilization space reaches the effective temperature without any blind spots. Simultaneously, the first pressure gauge 240 and the second pressure gauge 250 of the pressure detection unit are installed at the ends of the first dispensing branch 140 and the second dispensing branch 150, working in conjunction with the temperature probes to form a dual "temperature-pressure" monitoring system. This system jointly ensures the reliability and consistency of the sterilization process, effectively avoiding biosafety risks and equipment malfunctions caused by incomplete sterilization or pressure runaway.

[0039] After sterilization and confirmation of sterility, the system can proceed to the dispensing operation. The antigen enters the first dispensing branch 140 and the second dispensing branch 150 simultaneously via the four-way valve 130, enabling parallel dispensing of at least two transfer tanks 190. The dispensing flow rate can be balanced by manually adjusting the valve, avoiding a situation where one route is fast while another is slow, significantly improving efficiency compared to traditional single-tank dispensing. For large production demands, the system also supports a series dispensing mode. That is, the first tank group 170 or the second tank group 180 can contain multiple transfer tanks 190, which are connected in series via detachable flexible silicone tubing. When the current tank on a branch is about to fill, the antigen can be forced into the next tank in the series pipeline using system pressure. In this mode, the last transfer tank 190 in the series needs to open its top breather valve to balance the internal pressure and prevent leakage due to excessive pressure. Each turnover tank 190 is equipped with a breather filter 300 and a pressure-holding valve 310 at its top exhaust port. The breather filter 300 effectively blocks environmental microorganisms while maintaining pressure balance, while the pressure-holding valve 310 maintains positive pressure inside the tank during storage, jointly protecting the sterility of the antigens inside. Material valves 290 are typically installed at the top and bottom of the tank, providing flexible inlet and outlet control. To facilitate material flow within the workshop, the bottom of the turnover tank 190 is typically equipped with support legs 320 and casters 330 with a stopping mechanism for easy movement and positioning. Furthermore, to facilitate intermediate product quality control, sampling tubes 280 can be installed at the ends of the first dispensing branch 140 and the second dispensing branch 150. Sampling tubes 280 are equipped with on / off valves before and after them, allowing operators to perform aseptic sampling while maintaining the main pipeline's airtightness.

[0040] The overall working process of the system can be summarized as follows: First, online sterilization is performed before dispensing. Steam enters through the steam main pipe 120 and the dispensing main pipe 110, flows through the four-way valve 130, each dispensing branch, and all series- or parallel-connected turnover tanks 190. Finally, the condensate is discharged through the drain valve 270. During this process, temperature and pressure probes are used to closely monitor the process and ensure thorough sterilization. After sterilization, the system switches to dispensing mode. The inactivated antigen is distributed through the liquid supply device 100, the dispensing main pipe 110, and the four-way valve 130, and then dispensed into each turnover tank 190 in parallel through the first and second branches after filtration, or into multiple tanks in series on a single branch. The design of the third backup branch 160 plays a key role. When the filter bag of the main dispensing branch is blocked due to antigen turbidity, this backup branch can be immediately activated to continue the dispensing operation, effectively avoiding production interruption and ensuring the continuity and stability of the production process. After dispensing, the turnover tanks 190 can be sealed and transferred for subsequent finished product feeding.

[0041] In summary, this utility model, through modular and integrated design, seamlessly connects the functions of liquid supply, dispensing, online sterilization, and real-time monitoring, creating an efficient, sealed, and reliable aseptic dispensing environment. Its beneficial effects are comprehensive and significant: it greatly improves the efficiency and flexibility of dispensing operations, supporting multi-mode dispensing to meet the needs of different production scales; in particular, the setting of the third backup branch 160 provides an effective emergency guarantee mechanism, enabling rapid switching in case of abnormalities in the main dispensing branch, minimizing production downtime, and improving the system's reliability and fault tolerance; through reliable online sterilization and a rigorous monitoring system, it fundamentally eliminates the risk of secondary contamination during the dispensing process, ensuring the core quality of vaccine products; simultaneously, the system reduces the reliance on manual disassembly and installation of pipelines in traditional methods, lowering operational intensity and human error rates, and improving the level of production automation and overall safety.

[0042] In the description of this specification, references to terms such as "an embodiment," "some embodiments," "illustrative embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0043] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. An online sterilization and dispensing system for inactivated embryotoxin antigen, characterized in that, include: A liquid supply device (100) is used to deliver embryotoxin antigen that has been chemically inactivated, and the outlet end of the liquid supply device (100) is connected to a dispensing manifold (110). The pre-dispensing sterilization module includes a steam main (120) connected to the dispensing main (110). The dispensing module includes a four-way valve (130) connected to the dispensing main pipe (110). The other three outlets of the four-way valve (130) define a first dispensing branch (140), a second dispensing branch (150), and a third spare branch (160), respectively. The first dispensing branch (140), the second dispensing branch (150), and the third spare branch (160) are all connected to a drain valve (270) for discharging steam moisture. The end tank assembly includes a first tank group (170) connected to the first dispensing branch (140) and a second tank group (180) connected to the second dispensing branch (150). Both the first tank group (170) and the second tank group (180) include at least one turnover tank (190). The third backup branch (160) connects to the turnover tank (190) at the very end of both the first tank group (170) and the second tank group (180). The detection module includes a temperature detection unit and a pressure detection unit. The temperature detection unit includes a first temperature probe (200) located at the end of the first dispensing branch (140), a second temperature probe (210) located at the end of the second dispensing branch (150), a third temperature probe (220) located at the end of the third backup branch (160), and a fourth temperature probe (230) located before the drain valve (270). The pressure detection unit includes a first pressure gauge (240) and a second pressure gauge (250) located at the ends of the first dispensing branch (140) and the second dispensing branch (150).

2. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, The first dispensing branch (140) and the second dispensing branch (150) are both equipped with filter components (260), while the third backup branch (160) is not equipped with filter components (260).

3. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 2, characterized in that, The filter assembly (260) includes a filter cartridge and a filter bag installed inside the filter cartridge.

4. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, The drain valve (270) is provided and is located at the connection between the third backup branch (160) and the end of the first dispensing branch (140) and the second dispensing branch (150).

5. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, Sampling tubes (280) are provided at the end of the first dispensing branch (140) and the end of the second dispensing branch (150).

6. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, When the number of turnover tanks (190) in the first tank group (170) and the second tank group (180) exceeds two, they are connected in series.

7. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 6, characterized in that, The turnover tanks (190) connected in series are sequentially connected top and bottom by detachable flexible connecting pipes.

8. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, Material valves (290) are provided at the top and bottom of the turnover tank (190).

9. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, The top of the turnover tank (190) is provided with an exhaust port, which is equipped with a breathing filter (300) and a pressure holding valve (310).

10. The online sterilization and dispensing system for inactivated embryotoxin antigen according to claim 1, characterized in that, The bottom of the turnover tank (190) is provided with a support leg (320), and the support leg (320) is provided with a traveling wheel (330) with a stopping structure.

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