bioreactor

Abstract

The application relates to a bioreactor, comprising a tank body and an anti-skid film, the tank body comprising a cylindrical main body part and a supporting part arranged at the lower end of the main body part, the supporting part being conical with the upper end being larger and the lower end being smaller, and the anti-skid film being arranged on the inner surface of the tank body, and the surface friction coefficient of the anti-skid film being larger than the inner surface friction coefficient of the tank body. The bioreactor provided by the application can prevent the risk of displacement of medical consumables and the tank body and the risk of liquid leakage by arranging the anti-skid film on the inner surface of the tank body and making the anti-skid film contact the medical consumables when the medical consumables such as culture bags are put into the tank body for cultivation of active substances, because the surface friction coefficient of the anti-skid film is larger than the inner surface friction coefficient of the tank body, the surface of the medical consumables and the surface of the anti-skid film can be closely attached, thereby reducing the risk of displacement of the medical consumables and the tank body and the risk of liquid leakage.

Description

[0001] This application claims priority to Chinese Patent Application No. 202520954460.1, filed on May 14, 2025, entitled "Bioreactor", the entire contents of which are incorporated herein by reference. Technical Field

[0002] This application relates to the field of bioreactor technology, and in particular to a bioreactor. Background Technology

[0003] A bioreactor is a device or system used to support biochemical reactions of biologically active substances (such as microorganisms, cells, enzymes, etc.). It achieves large-scale production of target products (such as drugs, chemicals, fuels, etc.) or treatment of specific substances (such as wastewater) by simulating and optimizing the growth environment of organisms.

[0004] When culturing active substances, medical consumables (such as culture bags) are placed inside a container. The container provides a suitable temperature and rotational environment for culturing the active substances within the medical consumables. However, the container is usually made of stainless steel, which has a low surface roughness. The medical consumables also have a low surface roughness and are relatively hard, resulting in poor adhesion between the surface of the medical consumables and the container. Consequently, when the container rotates, the contact area between the surface of the medical consumables and the inner surface of the container can easily shift, posing a risk of leakage. Utility Model Content

[0005] Therefore, it is necessary to provide a bioreactor that can reduce the displacement of medical consumables and tanks.

[0006] A bioreactor includes a tank and an anti-slip membrane. The tank includes a cylindrical main body and a support portion disposed at the lower end of the main body. The support portion is conical in shape, wider at the top and narrower at the bottom. The anti-slip membrane is disposed on the inner surface of the tank, and the surface friction coefficient of the anti-slip membrane is greater than the inner surface friction coefficient of the tank.

[0007] In one embodiment, the tank includes a cylindrical main body and a support portion disposed at the lower end of the main body. The support portion is conical in shape, wider at the top and narrower at the bottom. The anti-slip film includes a first film and a second film. The first film is disposed on the inner surface of the main body, and the second film is disposed on the inner surface of the support portion.

[0008] In one embodiment, the first membrane covers the inner surface of the body portion circumferentially.

[0009] In one embodiment, the second membrane includes multiple membrane strips, which are arranged radially with the center of the support portion as the radial center point, and the joints of the multiple membrane strips form an annular joint.

[0010] In one embodiment, the membrane strip is a continuous strip membrane, or the membrane strip is a multi-segmented strip membrane with discontinuous arrangement.

[0011] In one embodiment, the tank body is provided with an inner cavity, and the bioreactor further includes a heat exchange jacket disposed in the inner cavity. The heat exchange jacket includes a first jacket disposed corresponding to the main body and a second jacket disposed corresponding to the support. The second jacket includes a main heat exchange zone with heat exchange holes and a secondary heat exchange zone without heat exchange holes. At least a portion of the membrane strips are projected onto the second jacket in the secondary heat exchange zone.

[0012] In one embodiment, the anti-slip film has anti-slip protrusions on the side of the surface opposite to the tank body.

[0013] In one embodiment, the anti-slip film is adhered to the inner surface of the tank.

[0014] In one embodiment, the surface friction coefficient of the anti-slip film is greater than or equal to 0.8.

[0015] In one embodiment, the anti-slip film is made of silicone material; and / or, the thickness of the anti-slip film is 0.5mm to 1.5mm.

[0016] Compared with the prior art, the bioreactor provided in this application, by setting an anti-slip film on the inner surface of the tank, allows medical consumables such as culture bags to be placed inside the tank to culture active substances. When the anti-slip film and the medical consumables come into contact, the surface friction coefficient of the anti-slip film is greater than that of the inner surface friction coefficient of the tank. Therefore, the surface of the medical consumables and the surface of the anti-slip film can be tightly attached, thereby reducing the risk of displacement of the medical consumables and the tank, and thus reducing the risk of leakage. Attached Figure Description

[0017] To more clearly illustrate the technical solutions in the embodiments of this application or the conventional technology, the drawings used in the description of the embodiments or the conventional technology will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a perspective view of a bioreactor according to an embodiment of this application;

[0019] Figure 2 for Figure 1 An exploded view of the bioreactor shown.

[0020] Figure 3 for Figure 1 A cross-sectional view of the bioreactor shown.

[0021] Figure 4 for Figure 1 Top view of the bioreactor shown;

[0022] Figure 5 for Figure 4 The diagram shown illustrates the positional relationship between the membrane strips and the heat exchange holes.

[0023] Reference numerals: 10, tank body; 11, main body; 12, support; 121, clearance opening; 13, inner cavity; 14, inner wall; 15, outer wall; 20, heat exchange jacket; 21, first jacket; 22, second jacket; 221, main heat exchange zone; 2211, heat exchange hole; 222, secondary heat exchange zone; 30, anti-slip membrane; 31, first membrane; 32, second membrane; 321, membrane strip; 322, connecting part. Detailed Implementation

[0024] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0025] It should be noted that when a component is referred to as being "fixed to" or "set on" another component, it can be directly on the other component or there may be an intermediate component. When a component is considered to be "connected to" another component, it can be directly connected to the other component or there may be an intermediate component present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application's specification are for illustrative purposes only and do not represent the only possible implementation.

[0026] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0027] In this application, unless otherwise expressly specified and limited, "above" or "below" the second feature can mean that the first feature is in direct contact with the second feature, or that the first feature and the second feature are in indirect contact through an intermediate medium. Furthermore, "above," "over," and "on top" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0028] Unless otherwise defined, all technical and scientific terms used in this application have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in this application is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. The term "and / or" as used in this application includes any and all combinations of one or more of the associated listed items.

[0029] Please see Figures 1 to 5 One embodiment of this application provides a bioreactor, including a tank 10 and an anti-slip membrane 30. The anti-slip membrane 30 is disposed on the inner surface of the tank 10, and the surface friction coefficient of the anti-slip membrane 30 is greater than the surface friction coefficient of the inner surface of the tank 10. Thus, by providing the anti-slip membrane 30 on the inner surface of the tank 10, when medical consumables such as culture bags are placed inside the tank 10 to culture active substances, the anti-slip membrane 30 and the medical consumables come into contact. Because the surface friction coefficient of the anti-slip membrane 30 is greater than the surface friction coefficient of the inner surface of the tank 10, the surface of the medical consumables and the surface of the anti-slip membrane 30 can be tightly adhered, thereby reducing the risk of displacement between the medical consumables and the tank 10, and consequently reducing the risk of leakage.

[0030] Furthermore, the coefficient of friction of the anti-slip film 30 surface is greater than or equal to 0.8, so that the anti-slip film 30 can better adhere to the medical consumables and prevent the medical consumables (hereinafter referred to as "culture bag" as an example) from shifting relative to the tank 10.

[0031] According to the above embodiments of this application, as Figures 1 to 3 As shown, the tank 10 includes a cylindrical main body 11 and a support portion 12 located at the lower end of the main body 11. The support portion 12 is conical, wider at the top and narrower at the bottom. It is understood that the main body 11 mentioned in this application has a cylindrical structure, and the support portion 12 mentioned in this application has a conical structure.

[0032] Preferably, the anti-slip film 30 includes a first film 31 and a second film 32. The first film 31 is disposed on the inner surface of the main body 11, and the second film 32 is disposed on the inner surface of the support 12. In this way, when a culture bag is placed in the tank 10, it can fit well against the inner surface of the tank 10, and the culture bag is less likely to shift relative to the tank 10.

[0033] In one embodiment, the first membrane 31 covers the inner surface of the main body 11 circumferentially. In this way, the periphery of the culture bag can be tightly fitted to the inner side of the main body 11, ensuring the stability of the culture bag.

[0034] like Figure 4 As shown, the second membrane 32 includes multiple membrane strips 321, which are arranged radially with the center of the support portion 12 as the radial center point. The joints of the multiple membrane strips 321 form an annular connecting portion 322. The radial arrangement of the multiple membrane strips 321 ensures a tight fit to the bottom of the culture bag and saves material on the anti-slip membrane 30. The connecting portion 322 is annular, and its inner ring can avoid the interface at the bottom of the culture bag. In this embodiment, the number of membrane strips 321 is 6, but it is not limited to this. The number of membrane strips 321 can also be 4, 5, 7, 8, or other numbers. When there are 4 membrane strips 321, the second membrane 32 is approximately cross-shaped; when there are 8 membrane strips 321, the second membrane 32 is approximately star-shaped.

[0035] Furthermore, the membrane strip 321 can be a continuous strip-shaped membrane, but it is not limited thereto. The membrane strip 321 can also be a multi-segmented membrane with discontinuous arrangement. This application does not limit this. Figure 4 As shown, in this embodiment, three membrane strips 321 are continuous strip membranes, and the other three membrane strips 321 are discontinuous multi-segment strip membranes.

[0036] It is worth mentioning that, for the needs of feeding and testing, the culture bag is provided with multiple interfaces, and the support part 12 is provided with a clearance opening 121 for the corresponding interface. In this embodiment, some membrane strips 321 are set as intermittently arranged multi-segmented membranes, and the discontinuities can avoid the clearance opening 121, thereby avoiding affecting the installation of the culture bag in the tank 10.

[0037] According to the above embodiments of the application, the bioreactor may further include a heat exchange jacket 20 disposed on the tank 10 for heat exchange with the tank 10.

[0038] Preferably, such as Figure 3 As shown, the tank 10 has an inner cavity 13, and the heat exchange jacket 20 is located in the inner cavity 13. This allows the heat exchange jacket 20 to exchange heat more effectively with the tank 10, thus providing a suitable temperature environment for the bioactive substances in the culture bag through the tank 10. Simultaneously, the tank 10 also protects the heat exchange jacket 20. Please refer to... Figure 2 and Figure 3 As shown, it can be understood that the tank body 10 is provided with an outer wall 15 and an inner wall 14, and an inner cavity 13 is formed between the outer wall 15 and the inner wall 14.

[0039] Please see Figure 2 , Figure 3 and Figure 5 The heat exchange jacket 20 includes a first jacket 21 corresponding to the main body 11 and a second jacket 22 corresponding to the support 12. The second jacket 22 includes a main heat exchange zone 221 with heat exchange holes 2211 and a secondary heat exchange zone 222 without heat exchange holes 2211. At least a portion of the membrane strips 321 have their orthogonal projections on the second jacket 22 located in the secondary heat exchange zone 222. It is understood that the heat transfer effect of the main heat exchange zone 221 is better than that of the secondary heat exchange zone 222. In this embodiment, at least a portion of the membrane strips 321 have their orthogonal projections on the second jacket 22 located in the secondary heat exchange zone 222, which reduces the area occupied by the membrane strips 321 in the heat exchange area. Therefore, while increasing the friction between the tank 10 and the culture bag, it does not significantly affect the heat exchange between the tank 10 and the culture bag. The heat exchange holes 2211 are circular through holes distributed in a honeycomb pattern. It is understood that the first jacket 21 also has heat exchange holes 2211, which are also distributed in a honeycomb pattern.

[0040] Furthermore, the anti-slip membrane 30 has anti-slip protrusions on the surface facing away from the tank 10. This increases the friction between the anti-slip membrane 30 and the culture bag, making the culture bag less likely to shift relative to the tank 10. The cross-section of the anti-slip protrusion can be any shape, such as circular, elliptical, quadrilateral, or hexagonal, and this application does not impose any limitation on this. It is understood that anti-slip protrusions can be provided on both the first membrane 31 and the second membrane 32.

[0041] Furthermore, the anti-slip film 30 is adhered to the inner surface of the tank 10. In this way, the anti-slip film 30 and the tank 10 are firmly connected, thereby allowing the culture bag to fit tightly against the inner surface of the tank 10.

[0042] In one embodiment, the anti-slip film 30 is made of silicone. Silicone has good biocompatibility, is suitable for the medical field, is chemically stable, high temperature resistant, corrosion resistant, disinfection resistant, easy to clean, and has a high coefficient of friction, which allows the culture bag to fit tightly against the inner surface of the tank 10.

[0043] Furthermore, the thickness of the anti-slip film 30 is 0.5mm to 1.5mm. This moderate thickness ensures a tight fit with the culture bag without excessive material waste. Indicatively, the thickness of the anti-slip film 30 can be 0.5mm, 0.6mm, 0.8mm, 1mm, 1.2mm, 1.3mm, 1.5mm, etc., and this application does not impose any limitations on this.

[0044] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0045] The above embodiments are merely illustrative of several implementation methods of this application, and their descriptions are quite specific and detailed. However, they should not be construed as limiting the scope of the patent application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this application, and these modifications and improvements all fall within the protection scope of this application.

Claims

1. A bioreactor, characterized in that, include: The tank body and the anti-slip film, wherein the tank body includes a cylindrical main body and a support part located at the lower end of the main body, the support part being conical with a larger upper part and a smaller lower part, and the anti-slip film is disposed on the inner surface of the tank body, the surface friction coefficient of the anti-slip film being greater than the inner surface friction coefficient of the tank body.

2. The bioreactor according to claim 1, characterized in that, The anti-slip film includes a first film and a second film, the first film being disposed on the inner surface of the main body and the second film being disposed on the inner surface of the support.

3. The bioreactor according to claim 2, characterized in that, The first membrane covers the inner surface of the main body in the circumferential direction.

4. The bioreactor according to claim 2, characterized in that, The second membrane includes multiple membrane strips, which are arranged radially with the center of the support portion as the radial center point, and the joints of the multiple membrane strips form an annular joint.

5. The bioreactor according to claim 4, characterized in that, The membrane strip is a continuous strip-shaped membrane, or the membrane strip is a multi-segment strip-shaped membrane with discontinuous arrangement.

6. The bioreactor according to claim 4, characterized in that, The tank body has an inner cavity, and the bioreactor further includes a heat exchange jacket disposed within the inner cavity. The heat exchange jacket includes a first jacket corresponding to the main body and a second jacket corresponding to the support. The second jacket includes a main heat exchange zone with heat exchange holes and a secondary heat exchange zone without heat exchange holes. At least a portion of the membrane strips are projected onto the second jacket in the secondary heat exchange zone.

7. The bioreactor according to any one of claims 1 to 6, characterized in that, The anti-slip film has anti-slip protrusions on the side of its surface facing away from the tank.

8. The bioreactor according to any one of claims 1 to 6, characterized in that, The anti-slip film is adhered to the inner surface of the tank.

9. The bioreactor according to any one of claims 1 to 6, characterized in that, The surface friction coefficient of the anti-slip film is greater than or equal to 0.

8.

10. The bioreactor according to any one of claims 1 to 6, characterized in that, The anti-slip film is made of silicone material; And / or, the thickness of the anti-slip film is 0.5mm to 1.5mm.

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